Article(id=1322928277354054591, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926740955341011, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.10.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793340280140, onlineDateStr=2026-10-30, pubDate=1760025600000, pubDateStr=2025-10-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793340280140, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793340280140, creator=13701087609, updateTime=1793340280140, updator=13701087609, issue=Issue{id=1322926740955341011, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='10', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1760025600000', pubDateStr='2025-10-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339913834, creator='13701087609', updateTime=1793340753123, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322930261259846420, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926740955341011, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322930261259846421, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926740955341011, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=102, endPage=107, ext={EN=ArticleExt(id=1322928277555381184, articleId=1322928277354054591, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress of Mechanism of Danggui Buxue Decoction（当归补血汤）in Organ Fibrosis, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Organ fibrosis is considered as a kind of tumor lesion with complex mechanism and difficult prevention and treatment，which is the focus and difficulty of medical research.Due to its multi-target and multi-mechanism characteristics，traditional Chinese medicine has been widely concerned in organ fibrosis，especially the role of invigorating Qi and activating blood.Danggui Buxue Decoction（当归补血汤，DBD），composed of Huangqi（Astragali Radix）and Danggui（Angelicae Sinensis Radix），is a representative prescription of invigorating Qi and activating blood，and has shown therapeutic effects in a variety of organ fibrosis.Therefore，this paper summarized the research progress of DBD in organ fibrosis of lung，kidney，liver and heart in recent 20 years.It is found that the mechanism of action of DBD against organ fibrosis is related to the regulation of TGF-β1/Smad signaling pathway，the improvement of extracellular matrix deposition，the regulation of neovascularization，anti-oxidative stress，anti-inflammation and the regulation of apoptosis.It provides a reference for the clinical application and mechanism study of DBD in organ fibrosis.

, authors=Yuwei ZHANG, Ganggang LI, Yanwei HAO, Wenjia XIAN, Yutong ZOU, Fei WANG, Quanyu DU, authorsList=Yuwei ZHANG, Ganggang LI, Yanwei HAO, Wenjia XIAN, Yutong ZOU, Fei WANG, Quanyu DU, authorCompany=null, correspAuthors=Fei WANG, Quanyu DU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322928278209692609, articleId=1322928277354054591, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=当归补血汤在器官纤维化中的作用机制进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

器官纤维化被认为是一种类肿瘤病变，其机制复杂，防治困难，是医学研究的重点与难点。中医药因其多靶点、多机制的特点，在器官纤维化中受到广泛关注，其中尤以益气活血类中药的作用最为突出。由黄芪、当归配伍组成的当归补血汤，是益气活血法的代表性方剂，在多种器官纤维化中都表现出治疗作用。因此，总结了最近20年当归补血汤在肺、肾、肝、心等器官纤维化中的研究进展。发现当归补血汤抗器官纤维化的作用机制与调控TGF-β1/Smad信号通路、改善细胞外基质沉积、调节血管新生、抗氧化应激、抗炎、调控细胞凋亡等相关。为当归补血汤在器官纤维化的临床应用和机制研究提供参考。

, authors=张雨薇, 李刚刚, 郝彦伟, 鲜文佳, 邹雨彤, 王飞, 杜全宇, authorsList=张雨薇, 李刚刚, 郝彦伟, 鲜文佳, 邹雨彤, 王飞, 杜全宇, authorCompany=null, correspAuthors=王飞, 杜全宇, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=obfvgxBpZFZJLZjrVYAooQ==, magXml=5c90X99fiKDvOmNMK/W0eg==, pdfUrl=null, pdf=0bN3oj6UAxFva0sCDIl/4Q==, pdfFileSize=1724849, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=zfgZtAuRNmbjxCLGwgp6Eg==, mapNumber=null, fund=null)}, authors=[Author(id=1322928278767535046, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322928279048553416, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928278767535046, language=EN, stringName=Yuwei ZHANG, firstName=Yuwei, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322928279128245193, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928278767535046, language=CN, stringName=张雨薇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川 成都 610072, bio={"content":"

张雨薇（1992-），女，四川宜宾人，主治医师，硕士，研究方向：中医药防治呼吸病的临床与基础。

"}, bioImg=null, bioContent=

张雨薇（1992-），女，四川宜宾人，主治医师，硕士，研究方向：中医药防治呼吸病的临床与基础。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322928278683648962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, xref=null, ext=[AuthorCompanyExt(id=1322928278692037571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1322928278700426180, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川 成都 610072)])]), Author(id=1322928279459595212, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322928279535092686, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928279459595212, language=EN, stringName=Ganggang LI, firstName=Ganggang, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322928279870637007, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928279459595212, language=CN, stringName=李刚刚, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川 成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322928278683648962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, xref=null, ext=[AuthorCompanyExt(id=1322928278692037571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1322928278700426180, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川 成都 610072)])]), Author(id=1322928281401557969, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322928281481249747, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928281401557969, language=EN, stringName=Yanwei HAO, firstName=Yanwei, middleName=null, lastName=HAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322928281560941524, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928281401557969, language=CN, stringName=郝彦伟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川 成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322928278683648962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, xref=null, ext=[AuthorCompanyExt(id=1322928278692037571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1322928278700426180, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川 成都 610072)])]), Author(id=1322928281632244694, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322928281711936472, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928281632244694, language=EN, stringName=Wenjia XIAN, firstName=Wenjia, middleName=null, lastName=XIAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322928281783239641, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928281632244694, language=CN, stringName=鲜文佳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川 成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322928278683648962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, xref=null, ext=[AuthorCompanyExt(id=1322928278692037571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1322928278700426180, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川 成都 610072)])]), Author(id=1322928281858737115, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322928281934234589, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928281858737115, language=EN, stringName=Yutong ZOU, firstName=Yutong, middleName=null, lastName=ZOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322928282001343454, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928281858737115, language=CN, stringName=邹雨彤, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川 成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322928278683648962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, xref=null, ext=[AuthorCompanyExt(id=1322928278692037571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1322928278700426180, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川 成都 610072)])]), Author(id=1322928282064258016, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wangfei896@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322928282185892834, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928282064258016, language=EN, stringName=Fei WANG, firstName=Fei, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322928282261390307, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928282064258016, language=CN, stringName=王飞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川 成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322928278683648962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, xref=null, ext=[AuthorCompanyExt(id=1322928278692037571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1322928278700426180, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川 成都 610072)])]), Author(id=1322928282324304869, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=quanydu@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322928282395608039, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928282324304869, language=EN, stringName=Quanyu DU, firstName=Quanyu, middleName=null, lastName=DU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322928282462716904, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, authorId=1322928282324304869, language=CN, stringName=杜全宇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川 成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322928278683648962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, xref=null, ext=[AuthorCompanyExt(id=1322928278692037571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1322928278700426180, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川 成都 610072)])])], keywords=[Keyword(id=1322928282542408681, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=EN, orderNo=1, keyword=Danggui Buxue Decoction（当归补血汤）), Keyword(id=1322928282605323242, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=EN, orderNo=2, keyword=invigorating Qi and activating blood circulation), Keyword(id=1322928282676626411, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=EN, orderNo=3, keyword=pulmonary fibrosis), Keyword(id=1322928282735346668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=EN, orderNo=4, keyword=renal fibrosis), Keyword(id=1322928282806649837, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=EN, orderNo=5, keyword=hepatic fibrosis), Keyword(id=1322928282882147310, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=CN, orderNo=1, keyword=当归补血汤), Keyword(id=1322928282945061871, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=CN, orderNo=2, keyword=益气活血法), Keyword(id=1322928283012170736, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=CN, orderNo=3, keyword=肺纤维化), Keyword(id=1322928283075085297, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=CN, orderNo=4, keyword=肾纤维化), Keyword(id=1322928283142194162, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=CN, orderNo=5, keyword=肝纤维化)], refs=[Reference(id=1322928283658093559, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2020, volume=587, issue=7835, pageStart=555, pageEnd=566, url=null, language=null, rfNumber=［1］, rfOrder=0, authorNames=HENDERSON N C, RIEDER F, WYNN T A, journalName=Nature, refType=null, unstructuredReference=HENDERSON N C，RIEDER F，WYNN T A. Fibrosis：from mechanisms to medicines［J］. Nature，2020，587（7835）：555-566., articleTitle=Fibrosis：from mechanisms to medicines, refAbstract=null), Reference(id=1322928283716813816, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2023, volume=25, issue=6, pageStart=2122, pageEnd=2131, url=null, language=null, rfNumber=［2］, rfOrder=1, authorNames=安丽萍, 杜全宇, 杨晗, journalName=世界科学技术-中医药现代化, refType=null, unstructuredReference=安丽萍，杜全宇，杨晗，等. 益气活血法治疗特发性肺纤维化的机制研究进展［J］. 世界科学技术-中医药现代化，2023，25（6）：2122-2131., articleTitle=益气活血法治疗特发性肺纤维化的机制研究进展, refAbstract=null), Reference(id=1322928283804894201, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=35, issue=1, pageStart=68, pageEnd=71, url=null, language=null, rfNumber=［3］, rfOrder=2, authorNames=李子航, 朱景天, 尹凯, journalName=时珍国医国药, refType=null, unstructuredReference=李子航，朱景天，尹凯，等. 当归补血汤通过调控Sirt1/ER Stress通路改善糖尿病脑病的机制研究［J］. 时珍国医国药，2024，35（1）：68-71., articleTitle=当归补血汤通过调控Sirt1/ER Stress通路改善糖尿病脑病的机制研究, refAbstract=null), Reference(id=1322928283867808762, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2022, volume=40, issue=2, pageStart=151, pageEnd=155, url=null, language=null, rfNumber=［4］, rfOrder=3, authorNames=张淑娟, 张育贵, 牛江涛, journalName=中华中医药学刊, refType=null, unstructuredReference=张淑娟，张育贵，牛江涛，等. 黄芪的研究进展及其质量标志物预测分析［J］. 中华中医药学刊，2022，40（2）：151-155., articleTitle=黄芪的研究进展及其质量标志物预测分析, refAbstract=null), Reference(id=1322928283943306235, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2017, volume=28, issue=1, pageStart=199, pageEnd=201, url=null, language=null, rfNumber=［5］, rfOrder=4, authorNames=任春贞, 骆亚莉, 刘永琦, journalName=时珍国医国药, refType=null, unstructuredReference=任春贞，骆亚莉，刘永琦，等. 当归防治肺纤维化的研究进展［J］. 时珍国医国药，2017，28（1）：199-201., articleTitle=当归防治肺纤维化的研究进展, refAbstract=null), Reference(id=1322928284010415100, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=357, issue=10, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［6］, rfOrder=5, authorNames=SHI Z, ZHOU M, ZHAI J, journalName=Arch Pharm（Weinheim）, refType=null, unstructuredReference=SHI Z，ZHOU M，ZHAI J，et al. Novel therapeutic strategies and drugs for idiopathic pulmonary fibrosis［J］. Arch Pharm（Weinheim），2024，357（10）：e2400192., articleTitle=Novel therapeutic strategies and drugs for idiopathic pulmonary fibrosis, refAbstract=null), Reference(id=1322928284077523965, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=18, issue=6, pageStart=397, pageEnd=407, url=null, language=null, rfNumber=［7］, rfOrder=6, authorNames=NAQVI M, HANNAH J, LAWRENCE A, journalName=Expert Rev Respir Med, refType=null, unstructuredReference=NAQVI M，HANNAH J，LAWRENCE A，et al. Antifibrotic therapy in progressive pulmonary fibrosis：a review of recent advances［J］. Expert Rev Respir Med，2024，18（6）：397-407., articleTitle=Antifibrotic therapy in progressive pulmonary fibrosis：a review of recent advances, refAbstract=null), Reference(id=1322928284178187262, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2004, volume=55, issue=null, pageStart=395, pageEnd=417, url=null, language=null, rfNumber=［8］, rfOrder=7, authorNames=THANNICKAL V J, TOEWSG B, WHITE E S, journalName=Annu Rev Med, refType=null, unstructuredReference=THANNICKAL V J，TOEWSG B，WHITE E S，et al. Mechanisms of pulmonary fibrosis［J］. Annu Rev Med，2004，55：395-417., articleTitle=Mechanisms of pulmonary fibrosis, refAbstract=null), Reference(id=1322928284245296127, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2020, volume=5, issue=4, pageStart=238, pageEnd=251, url=null, language=null, rfNumber=［9］, rfOrder=8, authorNames=ZHAO C P, LI H, LIU X H, journalName=Tradit Med Res, refType=null, unstructuredReference=ZHAO C P，LI H，LIU X H，et al. Dissecting the underlying pharmaceutical mechanism of Danggui Buxue decoction acting on idiopathic pulmonary fibrosis with network pharmacology［J］. Tradit Med Res，2020，5（4）：238-251., articleTitle=Dissecting the underlying pharmaceutical mechanism of Danggui Buxue decoction acting on idiopathic pulmonary fibrosis with network pharmacology, refAbstract=null), Reference(id=1322928285918822400, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2020, volume=15, issue=12, pageStart=1719, pageEnd=1723，1728, url=null, language=null, rfNumber=［10］, rfOrder=9, authorNames=彭艳芳, 张莹雯, 张亚兵, journalName=世界中医药, refType=null, unstructuredReference=彭艳芳，张莹雯，张亚兵，等. 芪归方有效组分治疗特发性肺纤维化的实验研究［J］. 世界中医药，2020，15（12）：1719-1723，1728., articleTitle=芪归方有效组分治疗特发性肺纤维化的实验研究, refAbstract=null), Reference(id=1322928285981736961, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2011, volume=46, issue=10, pageStart=1018, pageEnd=1022, url=null, language=null, rfNumber=［11］, rfOrder=10, authorNames=刘干, 李俊, 高建, journalName=安徽医科大学学报, refType=null, unstructuredReference=刘干，李俊，高建，等. 当归补血总苷抑制TGF-β₁诱导的人胚肺成纤维细胞转分化及胶原表达［J］. 安徽医科大学学报，2011，46（10）：1018-1022., articleTitle=当归补血总苷抑制TGF-β₁诱导的人胚肺成纤维细胞转分化及胶原表达, refAbstract=null), Reference(id=1322928286053040130, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2012, volume=64, issue=6, pageStart=811, pageEnd=820, url=null, language=null, rfNumber=［12］, rfOrder=11, authorNames=GAO J, YAN H, PING L, journalName=J Pharm Pharmacol, refType=null, unstructuredReference=GAO J，YAN H，PING L，et al. Total glucosides of Danggui Buxue Tang attenuates bleomycin-induced pulmonary fibrosis via inhibition of extracellular matrix remodelling［J］. J Pharm Pharmacol，2012，64（6）：811-820., articleTitle=Total glucosides of Danggui Buxue Tang attenuates bleomycin-induced pulmonary fibrosis via inhibition of extracellular matrix remodelling, refAbstract=null), Reference(id=1322928286132731907, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2020, volume=40, issue=2, pageStart=236, pageEnd=244, url=null, language=null, rfNumber=［13］, rfOrder=12, authorNames=WANG J, FANG C, WANG S, journalName=J Tradit Chin Med, refType=null, unstructuredReference=WANG J，FANG C，WANG S，et al. Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis in rats through inhibiting transforming growth factor-β1/Smad3/plasminogen activator inhibitor-1 signaling pathway［J］. J Tradit Chin Med，2020，40（2）：236-244., articleTitle=Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis in rats through inhibiting transforming growth factor-β1/Smad3/plasminogen activator inhibitor-1 signaling pathway, refAbstract=null), Reference(id=1322928286199840772, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2020, volume=217, issue=3, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［14］, rfOrder=13, authorNames=FRANGOGIANNIS N, journalName=J Exp Med, refType=null, unstructuredReference=FRANGOGIANNIS N. Transforming growth factor-βin tissue fibrosis［J］. J Exp Med，2020，217（3）：e20190103., articleTitle=Transforming growth factor-βin tissue fibrosis, refAbstract=null), Reference(id=1322928286376001541, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=135, issue=3, pageStart=453, pageEnd=469, url=null, language=null, rfNumber=［15］, rfOrder=14, authorNames=HUMERES C, SHINDE A V, TULETA I, journalName=Circ Res, refType=null, unstructuredReference=HUMERES C，SHINDE A V，TULETA I，et al. Fibroblast Smad7 induction protects the remodeling pressure-overloaded heart［J］. Circ Res，2024，135（3）：453-469., articleTitle=Fibroblast Smad7 induction protects the remodeling pressure-overloaded heart, refAbstract=null), Reference(id=1322928286455693318, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2009, volume=44, issue=5, pageStart=594, pageEnd=598, url=null, language=null, rfNumber=［16］, rfOrder=15, authorNames=刘勇, 李俊, 高建, journalName=安徽医科大学学报, refType=null, unstructuredReference=刘勇，李俊，高建，等当归补血汤总苷抗大鼠肺纤维化的实验研究［J］. 安徽医科大学学报，2009，44（5）：594-598., articleTitle=当归补血汤总苷抗大鼠肺纤维化的实验研究, refAbstract=null), Reference(id=1322928286526996487, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2020, volume=31, issue=9, pageStart=2116, pageEnd=2120, url=null, language=null, rfNumber=［17］, rfOrder=16, authorNames=彭艳芳, 张莹雯, 夏玉坤, journalName=时珍国医国药, refType=null, unstructuredReference=彭艳芳，张莹雯，夏玉坤，等. 芪归方有效组分对肺纤维化大鼠的抑制作用及机制［J］. 时珍国医国药，2020，31（9）：2116-2120., articleTitle=芪归方有效组分对肺纤维化大鼠的抑制作用及机制, refAbstract=null), Reference(id=1322928286610882568, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2019, volume=65, issue=null, pageStart=2, pageEnd=15, url=null, language=null, rfNumber=［18］, rfOrder=17, authorNames=WEISKIRCHEN R, WEISKIRCHEN S, TACKE F, journalName=Mol Aspects Med, refType=null, unstructuredReference=WEISKIRCHEN R，WEISKIRCHEN S，TACKE F. Organ and tissue fibrosis：Molecular signals，cellular mechanisms and translational implications［J］. Mol Aspects Med，2019，65：2-15., articleTitle=Organ and tissue fibrosis：Molecular signals，cellular mechanisms and translational implications, refAbstract=null), Reference(id=1322928286698962953, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2015, volume=8, issue=12, pageStart=1441, pageEnd=1445, url=null, language=null, rfNumber=［19］, rfOrder=18, authorNames=李丽君, 范盎然, 葛东宇, journalName=环球中医药, refType=null, unstructuredReference=李丽君，范盎然，葛东宇，等. 黄芪当归对药对特发性肺纤维化小鼠生存状况及组织修复相关基因表达水平的影响［J］. 环球中医药，2015，8（12）：1441-1445., articleTitle=黄芪当归对药对特发性肺纤维化小鼠生存状况及组织修复相关基因表达水平的影响, refAbstract=null), Reference(id=1322928286770266122, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2021, volume=36, issue=3, pageStart=1683, pageEnd=1687, url=null, language=null, rfNumber=［20］, rfOrder=19, authorNames=鲁辰希, 王杰鹏, 刘娜, journalName=中华中医药杂志, refType=null, unstructuredReference=鲁辰希，王杰鹏，刘娜，等. 当归补血汤对特发性肺纤维化大鼠血管新生因子HIF-1α和endostatin的影响［J］. 中华中医药杂志，2021，36（3）：1683-1687., articleTitle=当归补血汤对特发性肺纤维化大鼠血管新生因子HIF-1α和endostatin的影响, refAbstract=null), Reference(id=1322928286841569291, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2020, volume=32, issue=3, pageStart=24, pageEnd=28, url=null, language=null, rfNumber=［21］, rfOrder=20, authorNames=王杰鹏, 王少贤, 方朝义, journalName=解放军医药杂志, refType=null, unstructuredReference=王杰鹏，王少贤，方朝义，等. 当归补血汤干预肺纤维化大鼠气虚血瘀状态机制初探［J］. 解放军医药杂志，2020，32（3）：24-28., articleTitle=当归补血汤干预肺纤维化大鼠气虚血瘀状态机制初探, refAbstract=null), Reference(id=1322928286900289548, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2021, volume=12, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［22］, rfOrder=21, authorNames=ZHANG W J, CHEN S J, ZHOU S C, journalName=Front Immunol, refType=null, unstructuredReference=ZHANG W J，CHEN S J，ZHOU S C，et al. Inflammasomes and fibrosis［J］. Front Immunol，2021，12：643149., articleTitle=Inflammasomes and fibrosis, refAbstract=null), Reference(id=1322928286984175629, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2021, volume=2021, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［23］, rfOrder=22, authorNames=WANG J, WANG H, FANG F, journalName=Evid Based Complement Alternat Med, refType=null, unstructuredReference=WANG J，WANG H，FANG F，et al. Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis by suppressing the TLR4/NLRP3 signaling pathway in rats［J］. Evid Based Complement Alternat Med，2021，2021：8030143., articleTitle=Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis by suppressing the TLR4/NLRP3 signaling pathway in rats, refAbstract=null), Reference(id=1322928287055478799, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2022, volume=9, issue=1, pageStart=21, pageEnd=null, url=null, language=null, rfNumber=［24］, rfOrder=23, authorNames=NIE Y J, WU SH, XUAN Y H, journalName=Mil Med Res, refType=null, unstructuredReference=NIE Y J，WU SH，XUAN Y H，et al. Role of IL-17 family cytokines in the progression of IPFfrom inflammation to fibrosis［J］. Mil Med Res，2022，9（1）：21., articleTitle=Role of IL-17 family cytokines in the progression of IPFfrom inflammation to fibrosis, refAbstract=null), Reference(id=1322928287118393360, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2011, volume=136, issue=1, pageStart=21, pageEnd=26, url=null, language=null, rfNumber=［25］, rfOrder=24, authorNames=GAO J, HUANG Y, LI P, journalName=J Ethnopharmacol, refType=null, unstructuredReference=GAO J，HUANG Y，LI P，et al. Antifibrosis effects of total glucosides of Danggui-Buxue-Tang in a rat model of bleomycin-induced pulmonary fibrosis［J］. J Ethnopharmacol，2011，136（1）：21-26., articleTitle=Antifibrosis effects of total glucosides of Danggui-Buxue-Tang in a rat model of bleomycin-induced pulmonary fibrosis, refAbstract=null), Reference(id=1322928287193890833, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2018, volume=13, issue=8, pageStart=1908, pageEnd=1912，1917, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=彭艳芳, 岳莹莹, 张莹雯, journalName=世界中医药, refType=null, unstructuredReference=彭艳芳，岳莹莹，张莹雯，等. 芪归方联合泼尼松治疗特发性肺纤维化的临床研究［J］. 世界中医药，2018，13（8）：1908-1912，1917., articleTitle=芪归方联合泼尼松治疗特发性肺纤维化的临床研究, refAbstract=null), Reference(id=1322928287260999698, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2015, volume=17, issue=7, pageStart=42, pageEnd=46, url=null, language=null, rfNumber=［27］, rfOrder=26, authorNames=李丽君, 范盎然, 葛东宇, journalName=辽宁中医药大学学报, refType=null, unstructuredReference=李丽君，范盎然，葛东宇，等. 黄芪当归对药不同剂量与配比对IPF小鼠生存状况及TGF-β、IL-6、Foxp3、RORγt基因表达水平影响［J］. 辽宁中医药大学学报，2015，17（7）：42-46., articleTitle=黄芪当归对药不同剂量与配比对IPF小鼠生存状况及TGF-β、IL-6、Foxp3、RORγt基因表达水平影响, refAbstract=null), Reference(id=1322928287328108563, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2020, volume=10, issue=2, pageStart=509, pageEnd=547, url=null, language=null, rfNumber=［28］, rfOrder=27, authorNames=OTOUPALOVA E, SMITH S, CHENG G, journalName=Compr Physiol, refType=null, unstructuredReference=OTOUPALOVA E，SMITH S，CHENG G，et al. Oxidative stress in pulmonary fibrosis［J］. Compr Physiol，2020，10（2）：509-547., articleTitle=Oxidative stress in pulmonary fibrosis, refAbstract=null), Reference(id=1322928287391023124, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2015, volume=2015, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［29］, rfOrder=28, authorNames=ZHAO P, ZHOU W C, LI D L, journalName=Oxid Med Cell Longev, refType=null, unstructuredReference=ZHAO P，ZHOU W C，LI D L，et al. Total glucosides of Danggui Buxue Tang attenuate BLM-induced pulmonary fibrosis via regulating oxidative stress by inhibiting NOX4［J］. Oxid Med Cell Longev，2015，2015：645814., articleTitle=Total glucosides of Danggui Buxue Tang attenuate BLM-induced pulmonary fibrosis via regulating oxidative stress by inhibiting NOX4, refAbstract=null), Reference(id=1322928287458131989, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2020, volume=26, issue=13, pageStart=66, pageEnd=72, url=null, language=null, rfNumber=［30］, rfOrder=29, authorNames=刘娜, 王杰鹏, 鲁辰希, journalName=中国实验方剂学杂志, refType=null, unstructuredReference=刘娜，王杰鹏，鲁辰希，等. 当归补血汤对博莱霉素致肺纤维化大鼠PKD1/NF-κB/MnSOD信号通路的影响［J］. 中国实验方剂学杂志，2020，26（13）：66-72., articleTitle=当归补血汤对博莱霉素致肺纤维化大鼠PKD1/NF-κB/MnSOD信号通路的影响, refAbstract=null), Reference(id=1322928287521046550, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=59, issue=12, pageStart=1120, pageEnd=1128, url=null, language=null, rfNumber=［31］, rfOrder=30, authorNames=许文奇, 肖雷, 徐炜, journalName=中国药学杂志, refType=null, unstructuredReference=许文奇，肖雷，徐炜，等. 埃克替尼抑制肺泡上皮细胞上皮间充质转化进程改善博来霉素诱导的肺纤维化［J］. 中国药学杂志，2024，59（12）：1120-1128., articleTitle=埃克替尼抑制肺泡上皮细胞上皮间充质转化进程改善博来霉素诱导的肺纤维化, refAbstract=null), Reference(id=1322928287596544023, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=44, issue=12, pageStart=2934, pageEnd=2940, url=null, language=null, rfNumber=［32］, rfOrder=31, authorNames=王晓倩, 魏兆轩, 曹珊珊, journalName=中国老年学杂志, refType=null, unstructuredReference=王晓倩，魏兆轩，曹珊珊，等. 当归补血汤联合针灸对肺纤维化大鼠肺上皮细胞的保护作用及PI3K/Akt通路的影响［J］. 中国老年学杂志，2024，44（12）：2934-2940., articleTitle=当归补血汤联合针灸对肺纤维化大鼠肺上皮细胞的保护作用及PI3K/Akt通路的影响, refAbstract=null), Reference(id=1322928287663652888, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2018, volume=80, issue=null, pageStart=309, pageEnd=326, url=null, language=null, rfNumber=［33］, rfOrder=32, authorNames=HUMPHREYS B D, journalName=Annu Rev Physiol, refType=null, unstructuredReference=HUMPHREYS B D. Mechanisms of renal fibrosis［J］. Annu Rev Physiol，2018，80：309-326., articleTitle=Mechanisms of renal fibrosis, refAbstract=null), Reference(id=1322928287722373145, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=12, issue=5, pageStart=1098, pageEnd=null, url=null, language=null, rfNumber=［34］, rfOrder=33, authorNames=JHA R, LOPEZ-TREVINO S, KANKANAMALAGE H R, journalName=Biomedicines, refType=null, unstructuredReference=JHA R，LOPEZ-TREVINO S，KANKANAMALAGE H R，et al. Diabetes and renal complications：an overview on pathophysiology，biomarkers and therapeutic interventions［J］. Biomedicines，2024，12（5）：1098., articleTitle=Diabetes and renal complications：an overview on pathophysiology，biomarkers and therapeutic interventions, refAbstract=null), Reference(id=1322928287785287706, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2018, volume=29, issue=11, pageStart=2619, pageEnd=2622, url=null, language=null, rfNumber=［35］, rfOrder=34, authorNames=叶太生, 张莹雯, 王秀萍, journalName=时珍国医国药, refType=null, unstructuredReference=叶太生，张莹雯，王秀萍，等. 当归补血汤醇提物和水提物调控BMP-7、TGF-β₁表达对腺嘌呤诱导的肾间质纤维化大鼠保护作用的比较［J］. 时珍国医国药，2018，29（11）：2619-2622., articleTitle=当归补血汤醇提物和水提物调控BMP-7、TGF-β₁表达对腺嘌呤诱导的肾间质纤维化大鼠保护作用的比较, refAbstract=null), Reference(id=1322928287848202267, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2023, volume=43, issue=3, pageStart=507, pageEnd=513, url=null, language=null, rfNumber=［36］, rfOrder=35, authorNames=YEZ, XIANW, LINGG, journalName=J Tradit Chin Med, refType=null, unstructuredReference=YEZ，XIANW，LINGG，et al. Efficacy of Danggui Buxue decoction on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism［J］. J Tradit Chin Med，2023，43（3）：507-513., articleTitle=Efficacy of Danggui Buxue decoction on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism, refAbstract=null), Reference(id=1322928287911116828, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2011, volume=162, issue=8, pageStart=1805, pageEnd=1818, url=null, language=null, rfNumber=［37］, rfOrder=36, authorNames=MENG L Q, TANG J W, WANG Y, journalName=Br J Pharmacol, refType=null, unstructuredReference=MENG L Q，TANG J W，WANG Y，et al. Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy［J］. Br J Pharmacol，2011，162（8）：1805-1818., articleTitle=Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy, refAbstract=null), Reference(id=1322928287974031389, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2021, volume=24, issue=27, pageStart=3477, pageEnd=3483, url=null, language=null, rfNumber=［38］, rfOrder=37, authorNames=程丽颖, 王梦玺, 张翥, journalName=中国全科医学, refType=null, unstructuredReference=程丽颖，王梦玺，张翥，等. 当归补血汤辅助治疗糖尿病肾病临床疗效的Meta分析［J］. 中国全科医学，2021，24（27）：3477-3483., articleTitle=当归补血汤辅助治疗糖尿病肾病临床疗效的Meta分析, refAbstract=null), Reference(id=1322928288036945950, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2022, volume=42, issue=11, pageStart=1720, pageEnd=1723, url=null, language=null, rfNumber=［39］, rfOrder=38, authorNames=钟丹, 罗启明, 黄宇清, journalName=河南中医, refType=null, unstructuredReference=钟丹，罗启明，黄宇清，等. 当归补血汤对糖尿病肾病气虚血瘀证疗效及肾脏纤维化的影响［J］. 河南中医，2022，42（11）：1720-1723., articleTitle=当归补血汤对糖尿病肾病气虚血瘀证疗效及肾脏纤维化的影响, refAbstract=null), Reference(id=1322928288104054815, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=11, issue=5, pageStart=432, pageEnd=null, url=null, language=null, rfNumber=［40］, rfOrder=39, authorNames=NIU X, XU X, XU C, journalName=Bioengineering（Basel）, refType=null, unstructuredReference=NIU X，XU X，XU C，et al. Recent advances of MSCs in renal IRI：from injury to renal fibrosis［J］. Bioengineering（Basel），2024，11（5）：432., articleTitle=Recent advances of MSCs in renal IRI：from injury to renal fibrosis, refAbstract=null), Reference(id=1322928288162775072, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2017, volume=17, issue=1, pageStart=283, pageEnd=null, url=null, language=null, rfNumber=［41］, rfOrder=40, authorNames=REN X D, ZHANGY W, WANG X P, journalName=BMC Complement Altern Med, refType=null, unstructuredReference=REN X D，ZHANGY W，WANG X P，et al. Effects of Dangguibuxue decoction on rat glomerular mesangial cells cultured under high glucose conditions［J］. BMC Complement Altern Med，2017，17（1）：283., articleTitle=Effects of Dangguibuxue decoction on rat glomerular mesangial cells cultured under high glucose conditions, refAbstract=null), Reference(id=1322928288225689633, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2022, volume=38, issue=7, pageStart=592, pageEnd=598, url=null, language=null, rfNumber=［42］, rfOrder=41, authorNames=赵烨, 葛凡, 李子航, journalName=南京中医药大学学报, refType=null, unstructuredReference=赵烨，葛凡，李子航，等. 当归补血汤通过miR-27a/TGF-β1/Smad3通路抑制HK-2细胞纤维化作用及机制研究［J］. 南京中医药大学学报，2022，38（7）：592-598., articleTitle=当归补血汤通过miR-27a/TGF-β1/Smad3通路抑制HK-2细胞纤维化作用及机制研究, refAbstract=null), Reference(id=1322928288288604194, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2016, volume=2016, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［43］, rfOrder=42, authorNames=WANG L, MA J, GUO C, journalName=Biomed Res Int, refType=null, unstructuredReference=WANG L，MA J，GUO C，et al. Danggui Buxue Tang attenuates tubulointerstitial fibrosis viasuppressing NLRP3 inflammasome in a rat model of unilateral ureteral obstruction［J］. Biomed Res Int，2016，2016：9368483., articleTitle=Danggui Buxue Tang attenuates tubulointerstitial fibrosis viasuppressing NLRP3 inflammasome in a rat model of unilateral ureteral obstruction, refAbstract=null), Reference(id=1322928288355713059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=40, issue=7, pageStart=1226, pageEnd=1230, url=null, language=null, rfNumber=［44］, rfOrder=43, authorNames=周鑫, 邢露, 李鹏权, journalName=中国药理学通报, refType=null, unstructuredReference=周鑫，邢露，李鹏权，等. 血管钙化抑制因子BMP-7的研究进展［J］. 中国药理学通报，2024，40（7）：1226-1230., articleTitle=血管钙化抑制因子BMP-7的研究进展, refAbstract=null), Reference(id=1322928288431210532, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2005, volume=26, issue=4, pageStart=491, pageEnd=493，552, url=null, language=null, rfNumber=［45］, rfOrder=44, authorNames=胡家才, 夏明珠, 万青松, journalName=武汉大学学报（医学版）, refType=null, unstructuredReference=胡家才，夏明珠，万青松. 归芪口服液抗大鼠肾间质纤维化的实验研究［J］. 武汉大学学报（医学版），2005，26（4）：491-493，552., articleTitle=归芪口服液抗大鼠肾间质纤维化的实验研究, refAbstract=null), Reference(id=1322928288498319397, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2006, volume=38, issue=2, pageStart=82, pageEnd=88, url=null, language=null, rfNumber=［46］, rfOrder=45, authorNames=ZHANG Y W, XIE D, XIA B, journalName=Horm Metab Res, refType=null, unstructuredReference=ZHANG Y W，XIE D，XIA B，et al. Suppression of transforming growth factor-β₁ Gene expression by Danggui Buxue Tang，a traditional Chinese herbal preparation，in retarding the progress of renal damage in streptozotocin-induced diabetic rats［J］. Horm Metab Res，2006，38（2）：82-88., articleTitle=Suppression of transforming growth factor-β₁ Gene expression by Danggui Buxue Tang，a traditional Chinese herbal preparation，in retarding the progress of renal damage in streptozotocin-induced diabetic rats, refAbstract=null), Reference(id=1322928288565428262, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2019, volume=65, issue=null, pageStart=37, pageEnd=55, url=null, language=null, rfNumber=［47］, rfOrder=46, authorNames=PAROLA M, PINZANI M, journalName=Mol Aspects Med, refType=null, unstructuredReference=PAROLA M，PINZANI M. Liver fibrosis：Pathophysiology，pathogenetic targets and clinical issues［J］. Mol Aspects Med，2019，65：37-55., articleTitle=Liver fibrosis：Pathophysiology，pathogenetic targets and clinical issues, refAbstract=null), Reference(id=1322928288636731431, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2009, volume=15, issue=6, pageStart=435, pageEnd=441, url=null, language=null, rfNumber=［48］, rfOrder=47, authorNames=CHEN Y, CHEN Q, LU J, journalName=Chin J Integr Med, refType=null, unstructuredReference=CHEN Y，CHEN Q，LU J，et al. Effects of Danggui Buxue Decoction（当归补血汤）on lipid peroxidation and MMP-2/9 activities of fibrotic liver in rats［J］. Chin J Integr Med，2009，15（6）：435-441., articleTitle=Effects of Danggui Buxue Decoction（当归补血汤）on lipid peroxidation and MMP-2/9 activities of fibrotic liver in rats, refAbstract=null), Reference(id=1322928288699645992, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2014, volume=30, issue=2, pageStart=150, pageEnd=152, url=null, language=null, rfNumber=［49］, rfOrder=48, authorNames=孙丽霞, 方南元, 周玲玲, journalName=南京中医药大学学报, refType=null, unstructuredReference=孙丽霞，方南元，周玲玲，等. 当归补血汤及拆方对大鼠免疫性肝损伤的治疗作用［J］. 南京中医药大学学报，2014，30（2）：150-152., articleTitle=当归补血汤及拆方对大鼠免疫性肝损伤的治疗作用, refAbstract=null), Reference(id=1322928290339618857, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=46, issue=2, pageStart=651, pageEnd=657, url=null, language=null, rfNumber=［50］, rfOrder=49, authorNames=陶柏楠, 王咏兰, 刘道忠, journalName=中成药, refType=null, unstructuredReference=陶柏楠，王咏兰，刘道忠，等. 基于网络药理学和动物实验探讨当归补血汤抗肝纤维化的作用［J］. 中成药，2024，46（2）：651-657., articleTitle=基于网络药理学和动物实验探讨当归补血汤抗肝纤维化的作用, refAbstract=null), Reference(id=1322928290427699242, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2018, volume=39, issue=9, pageStart=1483, pageEnd=1492, url=null, language=null, rfNumber=［51］, rfOrder=50, authorNames=GUO T, LIU Z L, ZHAO Q, journalName=Acta Pharmacol Sin, refType=null, unstructuredReference=GUO T，LIU Z L，ZHAO Q，et al. A combination of astragaloside I，levistilide A and calycosin exerts anti-liver fibrosis effects in vitro and in vivo［J］. Acta Pharmacol Sin，2018，39（9）：1483-1492., articleTitle=A combination of astragaloside I，levistilide A and calycosin exerts anti-liver fibrosis effects in vitro and in vivo, refAbstract=null), Reference(id=1322928290499002411, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2010, volume=81, issue=7, pageStart=793, pageEnd=798, url=null, language=null, rfNumber=［52］, rfOrder=51, authorNames=WANG P, LIANG Y Z, journalName=Fitoterapia, refType=null, unstructuredReference=WANG P，LIANG Y Z. Chemical composition and inhibitory effect on hepatic fibrosis of Danggui Buxue Decoction［J］. Fitoterapia，2010，81（7）：793-798., articleTitle=Chemical composition and inhibitory effect on hepatic fibrosis of Danggui Buxue Decoction, refAbstract=null), Reference(id=1322928290566111276, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2012, volume=2012, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［53］, rfOrder=52, authorNames=LV J, ZHAO Z M, CHEN Y, journalName=Evid Based Complementary Altern Med, refType=null, unstructuredReference=LV J，ZHAO Z M，CHEN Y，et al. The Chinese herbal decoction Danggui Buxue Tang inhibits angiogenesis in a rat model of liver fibrosis［J］. Evid Based Complementary Altern Med，2012，2012：284963., articleTitle=The Chinese herbal decoction Danggui Buxue Tang inhibits angiogenesis in a rat model of liver fibrosis, refAbstract=null), Reference(id=1322928290637414445, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2014, volume=30, issue=4, pageStart=324, pageEnd=329, url=null, language=null, rfNumber=［54］, rfOrder=53, authorNames=郭涛, 赵志敏, 杨烁慧, journalName=临床肝胆病杂志, refType=null, unstructuredReference=郭涛，赵志敏，杨烁慧，等. 当归补血汤及其拆方影响肝脏血管新生的药效特点及作用机制［J］. 临床肝胆病杂志，2014，30（4）：324-329., articleTitle=当归补血汤及其拆方影响肝脏血管新生的药效特点及作用机制, refAbstract=null), Reference(id=1322928290712911918, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2024, volume=25, issue=14, pageStart=7873, pageEnd=null, url=null, language=null, rfNumber=［55］, rfOrder=54, authorNames=AKK Z H, GIESELER R K, CANBAY A, journalName=Int J Mol Sci, refType=null, unstructuredReference=AKK Z H，GIESELER R K，CANBAY A. Liver fibrosis：from basic science towards clinical progress，focusing on the central role of hepatic stellate cells［J］. Int J Mol Sci，2024，25（14）：7873., articleTitle=Liver fibrosis：from basic science towards clinical progress，focusing on the central role of hepatic stellate cells, refAbstract=null), Reference(id=1322928290784215087, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2018, volume=36, issue=9, pageStart=2134, pageEnd=2137, url=null, language=null, rfNumber=［56］, rfOrder=55, authorNames=徐天娇, 张英博, 杨莹, journalName=中华中医药学刊, refType=null, unstructuredReference=徐天娇，张英博，杨莹，等. 当归补血汤有效组分配伍对肝星状细胞氧化应激和Ⅱ相酶的影响［J］. 中华中医药学刊，2018，36（9）：2134-2137., articleTitle=当归补血汤有效组分配伍对肝星状细胞氧化应激和Ⅱ相酶的影响, refAbstract=null), Reference(id=1322928290855518256, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2021, volume=117, issue=6, pageStart=1450, pageEnd=1488, url=null, language=null, rfNumber=［57］, rfOrder=56, authorNames=FRANGOGIANNIS N G, journalName=Cardiovasc Res, refType=null, unstructuredReference=FRANGOGIANNIS N G. Cardiac fibrosis［J］. Cardiovasc Res，2021，117（6）：1450-1488., articleTitle=Cardiac fibrosis, refAbstract=null), Reference(id=1322928290918432817, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2015, volume=36, issue=7, pageStart=17, pageEnd=21, url=null, language=null, rfNumber=［58］, rfOrder=57, authorNames=曾宇, 张三印, journalName=云南中医中药杂志, refType=null, unstructuredReference=曾宇，张三印. 当归补血汤对异丙肾上腺素诱导大鼠心肌纤维化的影响［J］. 云南中医中药杂志，2015，36（7）：17-21., articleTitle=当归补血汤对异丙肾上腺素诱导大鼠心肌纤维化的影响, refAbstract=null), Reference(id=1322928290985541682, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2017, volume=33, issue=18, pageStart=3009, pageEnd=3012, url=null, language=null, rfNumber=［59］, rfOrder=58, authorNames=范智文, 赵一俏, 凌龙, journalName=实用医学杂志, refType=null, unstructuredReference=范智文，赵一俏，凌龙，等. miR-34a在当归补血汤抗小鼠心肌梗死后心室重塑中的表达［J］. 实用医学杂志，2017，33（18）：3009-3012., articleTitle=miR-34a在当归补血汤抗小鼠心肌梗死后心室重塑中的表达, refAbstract=null), Reference(id=1322928291077816371, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2018, volume=34, issue=5, pageStart=18, pageEnd=21, url=null, language=null, rfNumber=［60］, rfOrder=59, authorNames=崔红燕, 张晓晨, 谭梦晖, journalName=中药药理与临床, refType=null, unstructuredReference=崔红燕，张晓晨，谭梦晖. 当归补血汤对腹主动脉不完全结扎大鼠心肌纤维化的影响［J］. 中药药理与临床，2018，34（5）：18-21., articleTitle=当归补血汤对腹主动脉不完全结扎大鼠心肌纤维化的影响, refAbstract=null), Reference(id=1322928291153313844, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2015, volume=25, issue=30, pageStart=7, pageEnd=12, url=null, language=null, rfNumber=［61］, rfOrder=60, authorNames=王琳娜, 陈常勇, 陈小永, journalName=中国现代医学杂志, refType=null, unstructuredReference=王琳娜，陈常勇，陈小永，等. 当归补血汤对尿毒症大鼠心肌纤维化组织瞬时受体电位M7通道表达及胶原蛋白合成的影响［J］. 中国现代医学杂志，2015，25（30）：7-12., articleTitle=当归补血汤对尿毒症大鼠心肌纤维化组织瞬时受体电位M7通道表达及胶原蛋白合成的影响, refAbstract=null), Reference(id=1322928291224617013, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2016, volume=22, issue=20, pageStart=112, pageEnd=116, url=null, language=null, rfNumber=［62］, rfOrder=61, authorNames=杜丽东, 吴国泰, 王霞, journalName=中国实验方剂学杂志, refType=null, unstructuredReference=杜丽东，吴国泰，王霞，等. 当归补血汤对腹膜透析相关性大鼠腹膜功能衰竭的影响［J］. 中国实验方剂学杂志，2016，22（20）：112-116., articleTitle=当归补血汤对腹膜透析相关性大鼠腹膜功能衰竭的影响, refAbstract=null), Reference(id=1322928291300114486, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2021, volume=48, issue=8, pageStart=32, pageEnd=35, url=null, language=null, rfNumber=［63］, rfOrder=62, authorNames=夏芸芸, 马立明, journalName=辽宁中医杂志, refType=null, unstructuredReference=夏芸芸，马立明. 刘宝文治疗原发性骨髓纤维化临床经验总结［J］. 辽宁中医杂志，2021，48（8）：32-35., articleTitle=刘宝文治疗原发性骨髓纤维化临床经验总结, refAbstract=null), Reference(id=1322928291367223351, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2012, volume=26, issue=11, pageStart=1022, pageEnd=1026, url=null, language=null, rfNumber=［64］, rfOrder=63, authorNames=KE H L, ZHANG Y W, ZHOU B F, journalName=Nat Prod Res, refType=null, unstructuredReference=KE H L，ZHANG Y W，ZHOU B F，et al. Effects of Danggui Buxue Tang，a traditional Chinese herbal decoction，on high glucose-induced proliferation and expression of extracellular matrix proteins in glomerular mesangial cells［J］. Nat Prod Res，2012，26（11）：1022-1026., articleTitle=Effects of Danggui Buxue Tang，a traditional Chinese herbal decoction，on high glucose-induced proliferation and expression of extracellular matrix proteins in glomerular mesangial cells, refAbstract=null), Reference(id=1322928291442720824, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2008, volume=29, issue=4, pageStart=476, pageEnd=481，488, url=null, language=null, rfNumber=［65］, rfOrder=64, authorNames=周必发, 张莹雯, journalName=武汉大学学报（医学版）, refType=null, unstructuredReference=周必发，张莹雯. 当归补血汤对高糖条件下系膜细胞增殖及细胞外基质表达的影响［J］. 武汉大学学报（医学版），2008，29（4）：476-481，488., articleTitle=当归补血汤对高糖条件下系膜细胞增殖及细胞外基质表达的影响, refAbstract=null), Reference(id=1322928291509829689, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, doi=null, pmid=null, pmcid=null, year=2005, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［66］, rfOrder=65, authorNames=王亚丽, journalName=null, refType=null, unstructuredReference=王亚丽. 当归和当归补血汤指纹图谱及对兔血吸虫病肝纤维化的药理药效研究［D］. 长沙：中南大学，2005., articleTitle=当归和当归补血汤指纹图谱及对兔血吸虫病肝纤维化的药理药效研究, refAbstract=null)], funds=[Fund(id=1322928283477738485, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, awardId=2020YFC2003104, language=CN, fundingSource=国家重点研发计划项目(2020YFC2003104), fundOrder=null, country=null), Fund(id=1322928283540653046, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, awardId=82174347, language=CN, fundingSource=国家自然科学基金项目(82174347), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322928278683648962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, xref=null, ext=[AuthorCompanyExt(id=1322928278692037571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1322928278700426180, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, companyId=1322928278683648962, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川 成都 610072)])], figs=[ArticleFig(id=1322928283259634675, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

器官	模型	干预物	作用及机制	参考文献
肺脏	BLM诱导的PF大鼠	DBDG/DBD	血清HA、LN、PCⅢ、COL-Ⅳ、MMP-9、TIMP-1 mRNA下降，平衡MMP/TIMP系统	[12-13, 20-21, 23, 25, 29-30, 32]
			MDA、NADPH氧化酶4下降，GSH-Px、SOD上升，改善脂质过氧化
			肺指数、炎症评分、Ashcroft评分、胶原体积分数、HYP、α-SMA、COL-I、COL-Ⅲ、TNF-α、IL-6、IL-1 β、TGF-β1、Smad3、纤溶酶原激活物抑制因子-1下降
			HIF-1 α、血小板源生长因子下降，色素上皮衍生因子、重组人血管内皮抑制素上升
			NLRP3、Toll样受体4、髓样分化因子88、NF-κB、凋亡相关斑点样蛋白和含半胱氨酸的天冬氨酸蛋白水解酶1下降
			B淋巴细胞瘤-2相关X蛋白、PI3K、AKT、mTOR下降，B淋巴细胞瘤-2上升
	TGF-β1诱导的HLF-1细胞	DBDG	HYP、α-SMA、COL-Ⅰ、COL-ⅢmRNA下降，MMP-9上升，抑制细胞增殖	[11]
	平阳霉素诱导的PF大鼠	DBDG	MDA、TGF-β1、HYP下降，GSH-Px、SOD上升	[16]
	BLM诱导的PF大鼠、TGF-β1诱导MRC-5细胞	黄芪甲苷、阿魏酸	Smad泛素化调节因子2下降，Smad7、Smad核转录共抑制因子上升，抑制细胞增殖，调控TGF-β1/Smad通路	[10, 17]
	TGF-β1诱导的肌成纤维细胞	槲皮素和山柰酚	肌成纤维细胞活化下降	[9]
	IPF患者	DBD联合泼尼松	炎性因子下降，改善患者的中医证候，提高运动耐力和生命质量	[26]
	BLM诱导的PF小鼠	黄芪当归药对	VEGF mRNA下降，c-kit原癌基因，碱性成纤维细胞生长因子2 mRNA上升	[19, 27]
			TGF-β、IL-6、维甲酸相关孤儿受体γt mRNA下降
肾脏	腺嘌呤诱导的RF大鼠	DBD水、醇提取物	骨形态发生蛋白-7及mRNA上升，TGF-β1蛋白及mRNA降低	[35]
	高脂饮食诱发的糖尿病肾病GK大鼠	DBD	IL-6、IL-10、TNF-α、TGF-β1、Smad3、COL-Ⅳ、α-SMA、C-反应蛋白和波形蛋白下降，Smad5上升，调控TGF-β1/Smad信号通路	[36]
	UUO大鼠	黄芪甲苷Ⅳ和阿魏酸	肾小管上皮间质转化和成纤维细胞活化减少	[37]
		DBD	NLRP3、IL-1 β、肾间质纤维化评分降低	[43]
		归芪口服液	TGF-β1、α-SMA、血管紧张素Ⅱ减少	[45]
	高糖诱导的GMC	DBD	FN、LN、COL-Ⅳ下降，细胞增殖减少	[41, 64-65]
	高糖诱导的HK-2	DBD	COL-Ⅳ、α-SMA、TGF-β1、波形蛋白、miR-27a降低，细胞增殖减少，调控miR-27a/TGF-β1/Smad3信号通路	[42]
	DN气虚血瘀证患者	DBD	空腹血糖、糖化血红蛋白、24 h尿蛋白、血尿素氮、尿蛋白、COL-Ⅳ、LN下降	[39]
肝脏	CCL 4致HF大鼠、小鼠	DBD	MDA、MMP-2/9、HIF-1α下降，SOD上升，调节脂质过氧化，改善肝功能VEGF、血管生成素1下降，抑制肝血管新生	[53-54]
			IL-6、TNF-α、IL-1 β、PI3K、AKT、c-Jun、JNK、p38 MAPK下降	[50]
	LX-2细胞，二甲基亚硝胺诱导的HF小鼠	黄芪甲苷Ⅰ、欧当归内酯A、毛蕊异黄酮	α-SMA、COL-Ⅰ、HYP降低	[51]
	血吸虫病HF家兔	DBD	血清HYP及HA下降，B超声像、组织病理学改善	[52, 66]
心脏	异丙肾上腺素诱导MF大鼠	DBD	HYP降低，左心功能改善	[58]
	心肌梗死后MF小鼠	DBD	心肌胶原容积分数降低，心室重塑减少	[59]
	经腹主动脉不完全结扎诱发的MF大鼠	DBD	COL-Ⅰ、COL-Ⅲ、COL-Ⅳ减少，抑制肾素-血管紧张素-醛固酮系统活性	[60]
	尿毒症MF大鼠	DBD	TGF-β1、瞬时受体电位M7降低	[61]
其他	腹膜透析的大鼠	DBD	间皮细胞脱落、成纤维细胞、炎症细胞、血管增生减少，腹膜增厚程度减轻	[62]

), ArticleFig(id=1322928283356103668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322928277354054591, language=CN, label=表1, caption=

当归补血汤的抗纤维化作用及机制

, figureFileSmall=null, figureFileBig=null, tableContent=

器官	模型	干预物	作用及机制	参考文献
肺脏	BLM诱导的PF大鼠	DBDG/DBD	血清HA、LN、PCⅢ、COL-Ⅳ、MMP-9、TIMP-1 mRNA下降，平衡MMP/TIMP系统	[12-13, 20-21, 23, 25, 29-30, 32]
			MDA、NADPH氧化酶4下降，GSH-Px、SOD上升，改善脂质过氧化
			肺指数、炎症评分、Ashcroft评分、胶原体积分数、HYP、α-SMA、COL-I、COL-Ⅲ、TNF-α、IL-6、IL-1 β、TGF-β1、Smad3、纤溶酶原激活物抑制因子-1下降
			HIF-1 α、血小板源生长因子下降，色素上皮衍生因子、重组人血管内皮抑制素上升
			NLRP3、Toll样受体4、髓样分化因子88、NF-κB、凋亡相关斑点样蛋白和含半胱氨酸的天冬氨酸蛋白水解酶1下降
			B淋巴细胞瘤-2相关X蛋白、PI3K、AKT、mTOR下降，B淋巴细胞瘤-2上升
	TGF-β1诱导的HLF-1细胞	DBDG	HYP、α-SMA、COL-Ⅰ、COL-ⅢmRNA下降，MMP-9上升，抑制细胞增殖	[11]
	平阳霉素诱导的PF大鼠	DBDG	MDA、TGF-β1、HYP下降，GSH-Px、SOD上升	[16]
	BLM诱导的PF大鼠、TGF-β1诱导MRC-5细胞	黄芪甲苷、阿魏酸	Smad泛素化调节因子2下降，Smad7、Smad核转录共抑制因子上升，抑制细胞增殖，调控TGF-β1/Smad通路	[10, 17]
	TGF-β1诱导的肌成纤维细胞	槲皮素和山柰酚	肌成纤维细胞活化下降	[9]
	IPF患者	DBD联合泼尼松	炎性因子下降，改善患者的中医证候，提高运动耐力和生命质量	[26]
	BLM诱导的PF小鼠	黄芪当归药对	VEGF mRNA下降，c-kit原癌基因，碱性成纤维细胞生长因子2 mRNA上升	[19, 27]
			TGF-β、IL-6、维甲酸相关孤儿受体γt mRNA下降
肾脏	腺嘌呤诱导的RF大鼠	DBD水、醇提取物	骨形态发生蛋白-7及mRNA上升，TGF-β1蛋白及mRNA降低	[35]
	高脂饮食诱发的糖尿病肾病GK大鼠	DBD	IL-6、IL-10、TNF-α、TGF-β1、Smad3、COL-Ⅳ、α-SMA、C-反应蛋白和波形蛋白下降，Smad5上升，调控TGF-β1/Smad信号通路	[36]
	UUO大鼠	黄芪甲苷Ⅳ和阿魏酸	肾小管上皮间质转化和成纤维细胞活化减少	[37]
		DBD	NLRP3、IL-1 β、肾间质纤维化评分降低	[43]
		归芪口服液	TGF-β1、α-SMA、血管紧张素Ⅱ减少	[45]
	高糖诱导的GMC	DBD	FN、LN、COL-Ⅳ下降，细胞增殖减少	[41, 64-65]
	高糖诱导的HK-2	DBD	COL-Ⅳ、α-SMA、TGF-β1、波形蛋白、miR-27a降低，细胞增殖减少，调控miR-27a/TGF-β1/Smad3信号通路	[42]
	DN气虚血瘀证患者	DBD	空腹血糖、糖化血红蛋白、24 h尿蛋白、血尿素氮、尿蛋白、COL-Ⅳ、LN下降	[39]
肝脏	CCL 4致HF大鼠、小鼠	DBD	MDA、MMP-2/9、HIF-1α下降，SOD上升，调节脂质过氧化，改善肝功能VEGF、血管生成素1下降，抑制肝血管新生	[53-54]
			IL-6、TNF-α、IL-1 β、PI3K、AKT、c-Jun、JNK、p38 MAPK下降	[50]
	LX-2细胞，二甲基亚硝胺诱导的HF小鼠	黄芪甲苷Ⅰ、欧当归内酯A、毛蕊异黄酮	α-SMA、COL-Ⅰ、HYP降低	[51]
	血吸虫病HF家兔	DBD	血清HYP及HA下降，B超声像、组织病理学改善	[52, 66]
心脏	异丙肾上腺素诱导MF大鼠	DBD	HYP降低，左心功能改善	[58]
	心肌梗死后MF小鼠	DBD	心肌胶原容积分数降低，心室重塑减少	[59]
	经腹主动脉不完全结扎诱发的MF大鼠	DBD	COL-Ⅰ、COL-Ⅲ、COL-Ⅳ减少，抑制肾素-血管紧张素-醛固酮系统活性	[60]
	尿毒症MF大鼠	DBD	TGF-β1、瞬时受体电位M7降低	[61]
其他	腹膜透析的大鼠	DBD	间皮细胞脱落、成纤维细胞、炎症细胞、血管增生减少，腹膜增厚程度减轻	[62]

)], attaches=null, journal=Journal(id=1255846881855815682, delFlag=0, nameCn=中华中医药学刊, nameEn=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, issn=1673-7717, eissn=null, cn=21-1546/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=v4T+dd+NLAnioIpGAbkcEQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Archives of Traditional Chinese Medicine, journalRemark=null, publicationField=null, createdTime=1777346829146, updatedTime=1788949222391, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=v4T+dd+NLAnioIpGAbkcEQ==, picEn=RAy5vuC40hwJB+Y0pEARug==, jcr=null, cjcr=null, exts=[JournalExt(id=1304510846391050374, language=CN, name=中华中医药学刊, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222419, updatedTime=1788949222419, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304510846449770631, language=EN, name=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222433, updatedTime=1788949222433, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1255847919539208197, websiteList=[Website(id=1255847989868900719, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN, language=CN, createTime=1777347093312, createBy=18614031015, updateTime=1777347427646, updateBy=18614031015, name=中华中医药学刊-中文, tplId=1146099689490845704, title=中华中医药学刊, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849512594170105, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=articleTextType, value=kx, createTime=1777347456358, updateTime=1777347456358, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512564809974, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=banner, value=null, createTime=1777347456352, updateTime=1777347456352, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512631918844, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=grayFlag, value=0, createTime=1777347456367, updateTime=1777347456367, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512552227061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347456348, updateTime=1777347456348, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512657084670, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=minRunFlag, value=0, createTime=1777347456373, updateTime=1777347456373, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512589975800, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic, createTime=1777347456357, updateTime=1777347456357, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512648696061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=silenceFlag, value=0, createTime=1777347456371, updateTime=1777347456371, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512581587191, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1777347456355, updateTime=1777347456355, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512619335930, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeColor, value=null, createTime=1777347456364, updateTime=1777347456364, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512627724539, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeStyle, value=null, createTime=1777347456366, updateTime=1777347456366, creator=18614031015, updator=18614031015)]), Website(id=1255847989944398211, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN, language=EN, createTime=1777347093330, createBy=18614031015, updateTime=1777347417860, updateBy=18614031015, name=中华中医药学刊-英文, tplId=1146101810881728533, title=Chinese Archives of Traditional Chinese Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849538993119491, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=articleTextType, value=kx, createTime=1777347462652, updateTime=1777347462652, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538972147968, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=banner, value=null, createTime=1777347462647, updateTime=1777347462647, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539047645446, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=grayFlag, value=0, createTime=1777347462665, updateTime=1777347462665, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538930204927, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347462637, updateTime=1777347462637, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539064422664, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=minRunFlag, value=0, createTime=1777347462669, updateTime=1777347462669, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538988925186, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic, createTime=1777347462651, updateTime=1777347462651, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539060228359, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=silenceFlag, value=0, createTime=1777347462668, updateTime=1777347462668, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538980536577, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1777347462649, updateTime=1777347462649, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539001508100, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeColor, value=null, createTime=1777347462654, updateTime=1777347462654, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539039256837, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeStyle, value=null, createTime=1777347462663, updateTime=1777347462663, creator=18614031015, updator=18614031015)])], journalTitle=中华中医药学刊, weixinUrl=null, journalUrl=https://castjournals.cast.org.cn/zhzyyxk, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Archives of Traditional Chinese Medicine, journalPhotoCn=v4T+dd+NLAnioIpGAbkcEQ==, journalPhotoEn=RAy5vuC40hwJB+Y0pEARug==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2025.10.021, detailUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2025.10.021, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/PDF/10.13193/j.issn.1673-7717.2025.10.021, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/PDF/10.13193/j.issn.1673-7717.2025.10.021, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1760025600000, fullTextJson=null, articleText=null, reference=null)