Article(id=1322927796032504049, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.08.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793340165384, onlineDateStr=2026-10-30, pubDate=1754755200000, pubDateStr=2025-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793340165384, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793340165384, creator=13701087609, updateTime=1793340165384, updator=13701087609, issue=Issue{id=1322926217711726961, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1754755200000', pubDateStr='2025-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339789083, creator='13701087609', updateTime=1793340517761, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929274071679978, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929274071679979, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=116, endPage=118, ext={EN=ArticleExt(id=1322927796326105330, articleId=1322927796032504049, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Arctigenin Plays an Anti-inflammatory Role in Inhibiting Pyroptosis Mediated by NLRP3 Inflammasome, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the protective effect and intervention mechanism of arctigenin on lipopolysaccharide（LPS）combined with adenosine triphosphate（ATP）-stimulated pyroptosis in RAW264.7 cells.
Methods CCK8 assay was used to detect the effects of different concentrations of arctigenin on the viability of RAW264.7 cells；CCK8 assay was used to detect the effects of intervention of arctigenin（20，40，80μmol/L）on the viability of RAW264.7 cells induced by LPS+ATP；LDH release was used to detect the cellular membrane damage；ELISA was used to detect tumour necrosis factor-α（TNF-α），interleukin-6（IL-6）and IL-1βin cell supernatant；Western blotting was used to detect intracellular NLRP3，Caspase-1 p20，Caspase-1 p45，GSDMD-N and GSDMD-FL protein expression；the number of positive cells stained with propidium iodide（PI）was observed by forward and inverted fluorescence microscopy.
Results Arctigenin concentration less than 160μmol/L had little effect on cell viability；arctigenin（20，40，80μmol/L）intervention reversed the LPS+ATP-induced decrease in cell viability；arctigenin reduced LPS+ATP-induced release of LDH from pyroptosis cells as well as the number of PI-positive cells；arctigenin reduced LPS+ATP-induced LDH release from pyroptosis cells as well as the number of PI-positive cells；arctigenin inhibited the secretion of pro-inflammatory cytokines TNF-α，IL-6 and IL-1βby pyroptosis cells；arctigenin inhibited the expression of NLRP3，Caspase-1 p20，Caspase-1 p45，GSDMD-N and GSDMD-FL proteins in pyroptosis cells that inhibited the activation of NLRP3 inflammasome.
Conclusion Arctigenin inhibits NLRP3 inflammasome activation to improve pyroptosis and alleviate inflammatory responses.
, authors=Yuhui MA, Jialei MENG, Luyao QI, Yuan LIU, Xiaoxiao LI, Ming LEI, authorsList=Yuhui MA, Jialei MENG, Luyao QI, Yuan LIU, Xiaoxiao LI, Ming LEI, authorCompany=null, correspAuthors=Ming LEI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322927801006948610, articleId=1322927796032504049, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=牛蒡子苷元抑制NLRP3炎症小体介导的细胞焦亡发挥抗炎作用, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探讨牛蒡子苷元对脂多糖（LPS）联合三磷酸腺苷（ATP）刺激的RAW264.7细胞焦亡的保护作用及干预机制。
方法 CCK8法检测不同浓度的牛蒡子苷元对RAW264.7细胞活力的影响；CCK8法检测牛蒡子苷元（20、40、80 μmol/L）干预对LPS+ATP诱导的RAW264.7细胞活力的影响；乳酸脱氢酶（LDH）释放检测细胞膜损伤；ELISA法检测细胞上清液中肿瘤坏死因子-α（Tumor necrosis factor-α，TNF-α）、白细胞介素（Interleukin，IL）-6和IL-1β的含量；蛋白免疫印迹法（Western blotting）检测细胞内寡聚化结构域样受体蛋白3（NOD-like receptor thermal protein domain associated protein 3，NLRP3）、半胱天冬酶-1（Caspase-1）p20、Caspase-1 p45、GSDMD-N和GSDMD-FL蛋白的表达；正倒置荧光显微镜观察碘化丙啶（PI）染色阳性细胞数量。
结果 牛蒡子苷元浓度小于160μmol/L时对细胞活性影响较小；牛蒡子苷元（20、40、80μmol/L）干预逆转了LPS+ATP诱导的细胞活力降低；牛蒡子苷元减少了LPS+ATP诱导的焦亡细胞LDH的释放以及PI阳性细胞数量；牛蒡子苷元抑制焦亡细胞分泌促炎细胞因子TNF-α、IL-6和IL-1β；牛蒡子苷元抑制焦亡细胞NLRP3、Caspase-1 p20、Caspase-1 p45、GSDMD-N和GSDMD-FL蛋白的表达，抑制NLRP3炎症小体的激活。
结论 牛蒡子苷元抑制NLRP3炎症小体激活改善细胞焦亡，缓解炎症反应。
, authors=马宇慧, 孟佳磊, 齐璐瑶, 刘愿, 李笑笑, 雷鸣, authorsList=马宇慧, 孟佳磊, 齐璐瑶, 刘愿, 李笑笑, 雷鸣, authorCompany=null, correspAuthors=雷鸣, authorNote=
马宇慧（1996-），女，安徽阜阳人，博士在读，研究方向：中西医结合急危重症。
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=oJIHLDpanb3EinkM/c3MVA==, magXml=f9rW04TdcVbadIWb5ATc5Q==, pdfUrl=null, pdf=sXJxaAQkdSdzdICr+nr+sg==, pdfFileSize=3435575, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=0Nqxey3cQfMPh/ajsst3Ig==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=1fySouQ8UOZyXTreYzDazA==, mapNumber=null, fund=null)}, authors=[Author(id=1322927801485099271, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322927801556402441, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927801485099271, language=EN, stringName=Yuhui MA, firstName=Yuhui, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322927801619317002, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927801485099271, language=CN, stringName=马宇慧, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海中医药大学附属第七人民医院，上海 200137, bio={"content":"
马宇慧（1996-），女，安徽阜阳人，博士在读，研究方向：中西医结合急危重症。
"}, bioImg=null, bioContent=
马宇慧（1996-），女，安徽阜阳人，博士在读，研究方向：中西医结合急危重症。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322927801371853059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, xref=null, ext=[AuthorCompanyExt(id=1322927801380241668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China), AuthorCompanyExt(id=1322927801388630277, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=上海中医药大学附属第七人民医院，上海 200137)])]), Author(id=1322927801686425868, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322927801766117646, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927801686425868, language=EN, stringName=Jialei MENG, firstName=Jialei, middleName=null, lastName=MENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322927801845809423, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927801686425868, language=CN, stringName=孟佳磊, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海中医药大学附属第七人民医院，上海 200137, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322927801371853059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, xref=null, ext=[AuthorCompanyExt(id=1322927801380241668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China), AuthorCompanyExt(id=1322927801388630277, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=上海中医药大学附属第七人民医院，上海 200137)])]), Author(id=1322927801921306897, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322927802009387283, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927801921306897, language=EN, stringName=Luyao QI, firstName=Luyao, middleName=null, lastName=QI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322927802072301844, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927801921306897, language=CN, stringName=齐璐瑶, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海中医药大学附属第七人民医院，上海 200137, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322927801371853059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, xref=null, ext=[AuthorCompanyExt(id=1322927801380241668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China), AuthorCompanyExt(id=1322927801388630277, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=上海中医药大学附属第七人民医院，上海 200137)])]), Author(id=1322927802135216406, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322927803796160792, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927802135216406, language=EN, stringName=Yuan LIU, firstName=Yuan, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322927803896824089, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927802135216406, language=CN, stringName=刘愿, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海中医药大学附属第七人民医院，上海 200137, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322927801371853059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, xref=null, ext=[AuthorCompanyExt(id=1322927801380241668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China), AuthorCompanyExt(id=1322927801388630277, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=上海中医药大学附属第七人民医院，上海 200137)])]), Author(id=1322927803980710171, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322927804081373469, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927803980710171, language=EN, stringName=Xiaoxiao LI, firstName=Xiaoxiao, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322927804177842462, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927803980710171, language=CN, stringName=李笑笑, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海中医药大学附属第七人民医院，上海 200137, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322927801371853059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, xref=null, ext=[AuthorCompanyExt(id=1322927801380241668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China), AuthorCompanyExt(id=1322927801388630277, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=上海中医药大学附属第七人民医院，上海 200137)])]), Author(id=1322927804270117152, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=leiming6891@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322927804341420322, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927804270117152, language=EN, stringName=Ming LEI, firstName=Ming, middleName=null, lastName=LEI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322927804408529187, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, authorId=1322927804270117152, language=CN, stringName=雷鸣, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海中医药大学附属第七人民医院，上海 200137, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322927801371853059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, xref=null, ext=[AuthorCompanyExt(id=1322927801380241668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China), AuthorCompanyExt(id=1322927801388630277, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=上海中医药大学附属第七人民医院，上海 200137)])])], keywords=[Keyword(id=1322927804500803876, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, orderNo=1, keyword=Arctigenin), Keyword(id=1322927804567912741, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, orderNo=2, keyword=Macrophage), Keyword(id=1322927804635021606, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, orderNo=3, keyword=Pyroptosis), Keyword(id=1322927804697936167, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, orderNo=4, keyword=NLRP3 inflammasome), Keyword(id=1322927804769239336, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, orderNo=1, keyword=牛蒡子苷元), Keyword(id=1322927804853125417, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, orderNo=2, keyword=巨噬细胞), Keyword(id=1322927804916039978, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, orderNo=3, keyword=细胞焦亡), Keyword(id=1322927804974760235, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, orderNo=4, keyword=NLRP3炎症小体)], refs=[Reference(id=1322927806375657788, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2019, volume=26, issue=1, pageStart=99, pageEnd=114, url=null, language=null, rfNumber=［1］, rfOrder=0, authorNames=FRANK D, VINCE J E, journalName=Cell Death Differ, refType=null, unstructuredReference=FRANK D，VINCE J E. Pyroptosis versus necroptosis：similarities，differences，and crosstalk［J］.
Cell Death Differ，
2019，
26（1）：99-114., articleTitle=Pyroptosis versus necroptosis：similarities，differences，and crosstalk, refAbstract=null), Reference(id=1322927806438572349, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2021, volume=6, issue=1, pageStart=128, pageEnd=null, url=null, language=null, rfNumber=［2］, rfOrder=1, authorNames=YU P, ZHANG X, LIU N, journalName=Signal Transduct Target Ther, refType=null, unstructuredReference=YU P，ZHANG X，LIU N，
et al. Pyroptosis：mechanisms and diseases［J］.
Signal Transduct Target Ther，
2021，
6（1）：128., articleTitle=Pyroptosis：mechanisms and diseases, refAbstract=null), Reference(id=1322927806501486910, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2019, volume=40, issue=11, pageStart=1035, pageEnd=1052, url=null, language=null, rfNumber=［3］, rfOrder=2, authorNames=XUE Y S, ENOSITUIPULOTU D, TAN W H, journalName=Trends Immunol, refType=null, unstructuredReference=XUE Y S，ENOSITUIPULOTU D，TAN W H，
et al. Emerging activators and regulators of inflammasomes and pyroptosis［J］.
Trends Immunol，
2019，
40（11）：1035-1052., articleTitle=Emerging activators and regulators of inflammasomes and pyroptosis, refAbstract=null), Reference(id=1322927806564401471, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2022, volume=43, issue=8, pageStart=653, pageEnd=668, url=null, language=null, rfNumber=［4］, rfOrder=3, authorNames=COLL R C, SCHRODER K, PELEGRÍN P, journalName=Trends Pharmacol Sci, refType=null, unstructuredReference=COLL R C，SCHRODER K，PELEGRÍN P. NLRP3 and pyroptosis blockers for treating inflammatory diseases［J］.
Trends Pharmacol Sci，
2022，
43（8）：653-668., articleTitle=NLRP3 and pyroptosis blockers for treating inflammatory diseases, refAbstract=null), Reference(id=1322927806631510336, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2017, volume=68, issue=1, pageStart=185, pageEnd=197, url=null, language=null, rfNumber=［5］, rfOrder=4, authorNames=SONG N, LIU Z S, XUE W, journalName=Mol Cell, refType=null, unstructuredReference=SONG N，LIU Z S，XUE W，
et al. NLRP3 phosphorylation is an essential priming event for inflammasome activation［J］.
Mol Cell，
2017，
68（1）：185-197., articleTitle=NLRP3 phosphorylation is an essential priming event for inflammasome activation, refAbstract=null), Reference(id=1322927808296649025, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2018, volume=15, issue=4, pageStart=203, pageEnd=214, url=null, language=null, rfNumber=［6］, rfOrder=5, authorNames=TOLDO S, ABBATE A, journalName=Nat Rev Cardiol, refType=null, unstructuredReference=TOLDO S，ABBATE A. The NLRP3 inflammasome in acute myocardial infarction［J］.
Nat Rev Cardiol，
2018，
15（4）：203-214., articleTitle=The NLRP3 inflammasome in acute myocardial infarction, refAbstract=null), Reference(id=1322927808430866754, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=56, issue=4, pageStart=753, pageEnd=767, url=null, language=null, rfNumber=［7］, rfOrder=6, authorNames=ZHU F R, MA J, LI W T, journalName=Immunity, refType=null, unstructuredReference=ZHU F R，MA J，LI W T，
et al. The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome［J］.
Immunity，
2023，
56（4）：753-767., articleTitle=The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome, refAbstract=null), Reference(id=1322927808518947139, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2017, volume=27, issue=9, pageStart=673, pageEnd=684, url=null, language=null, rfNumber=［8］, rfOrder=7, authorNames=KOVACSSB, MIAO E A, journalName=Trends Cell Biol, refType=null, unstructuredReference=KOVACSSB，MIAO E A. Gasdermins：effectors of pyroptosis［J］.
Trends Cell Biol，
2017，
27（9）：673-684., articleTitle=Gasdermins：effectors of pyroptosis, refAbstract=null), Reference(id=1322927808586056004, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2017, volume=277, issue=1, pageStart=61, pageEnd=75, url=null, language=null, rfNumber=［9］, rfOrder=8, authorNames=MAN SM, KARKI R, KANNEGANTI T D, journalName=Immunol Rev, refType=null, unstructuredReference=MAN SM，KARKI R，KANNEGANTI T D. Molecular mechanisms and functions of pyroptosis，inflammatory caspases and inflammasomes in infectious diseases［J］.
Immunol Rev，
2017，
277（1）：61-75., articleTitle=Molecular mechanisms and functions of pyroptosis，inflammatory caspases and inflammasomes in infectious diseases, refAbstract=null), Reference(id=1322927808648970565, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2021, volume=18, issue=9, pageStart=2114, pageEnd=2127, url=null, language=null, rfNumber=［10］, rfOrder=9, authorNames=HUANG Y, XU W, ZHOU R B, journalName=Cell Mol Immunol, refType=null, unstructuredReference=HUANG Y，XU W，ZHOU R B. NLRP3 inflammasome activation and cell death［J］.
Cell Mol Immunol，
2021，
18（9）：2114-2127., articleTitle=NLRP3 inflammasome activation and cell death, refAbstract=null), Reference(id=1322927808711885126, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2021, volume=909, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［11］, rfOrder=10, authorNames=SHABGAH A G, SUKSATAN W, ACHMAD M H, journalName=Eur J Pharmacol, refType=null, unstructuredReference=SHABGAH A G，SUKSATAN W，ACHMAD M H，
et al. Arctigenin，an anti-tumor agent；a cutting-edge topic and up-tothe-minute approach in cancer treatment［J］.
Eur J Pharmacol，
2021，
909：174419., articleTitle=Arctigenin，an anti-tumor agent；a cutting-edge topic and up-tothe-minute approach in cancer treatment, refAbstract=null), Reference(id=1322927808904823111, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=110, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［12］, rfOrder=11, authorNames=WANGG, GE L, LIU T, journalName=Phytomedicine, refType=null, unstructuredReference=WANGG，GE L，LIU T，
et al. The therapeutic potential of arctigenin against multiple human diseases：a mechanistic review［J］.
Phytomedicine，
2023，
110：154647., articleTitle=The therapeutic potential of arctigenin against multiple human diseases：a mechanistic review, refAbstract=null), Reference(id=1322927808967737672, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2020, volume=177, issue=22, pageStart=5224, pageEnd=5245, url=null, language=null, rfNumber=［13］, rfOrder=12, authorNames=XU X, PIAO H N, AOSAI F M, journalName=Br JPharmacol, refType=null, unstructuredReference=XU X，PIAO H N，AOSAI F M，
et al. Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation
via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways［J］.
Br JPharmacol，
2020，
177（22）：5224-5245., articleTitle=Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation
via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways, refAbstract=null), Reference(id=1322927809064206665, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2020, volume=491, issue=null, pageStart=162, pageEnd=179, url=null, language=null, rfNumber=［14］, rfOrder=13, authorNames=QIAO SM, LV C J, TAO Y, journalName=Cancer Lett, refType=null, unstructuredReference=QIAO SM，LV C J，TAO Y，
et al. Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages
via downregulating fatty acid oxidation to prevent colitis-associated cancer［J］.
Cancer Lett，
2020，
491：162-179., articleTitle=Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages
via downregulating fatty acid oxidation to prevent colitis-associated cancer, refAbstract=null), Reference(id=1322927809273921866, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=217, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［15］, rfOrder=14, authorNames=RAMOS-TOVAR E, MURIEL P, journalName=Biochem Pharmacol, refType=null, unstructuredReference=RAMOS-TOVAR E，MURIEL P. NLRP3 inflammasome in hepatic diseases：a pharmacological target［J］.
Biochem Pharmacol，
2023，
217：115861., articleTitle=NLRP3 inflammasome in hepatic diseases：a pharmacological target, refAbstract=null), Reference(id=1322927809345225035, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=14, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［16］, rfOrder=15, authorNames=LIU Y R, WANG J Q, LI J, journalName=Front Immunol, refType=null, unstructuredReference=LIU Y R，WANG J Q，LI J. Role of NLRP3 in the pathogenesis and treatment of gout arthritis［J］.
Front Immunol，
2023，
14：1137822., articleTitle=Role of NLRP3 in the pathogenesis and treatment of gout arthritis, refAbstract=null), Reference(id=1322927809412333900, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=174, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［17］, rfOrder=16, authorNames=ZHANG W J, LIK Y, LAN Y, journalName=Food Chem Toxicol, refType=null, unstructuredReference=ZHANG W J，LIK Y，LAN Y，
et al. NLRP3 Inflammasome：a key contributor to the inflammation formation［J］.
Food Chem Toxicol，
2023，
174：113683., articleTitle=NLRP3 Inflammasome：a key contributor to the inflammation formation, refAbstract=null), Reference(id=1322927809471054157, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=257, issue=2, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［18］, rfOrder=17, authorNames=LEU SY, TSANGY L, HO L C, journalName=JEndocrinol, refType=null, unstructuredReference=LEU SY，TSANGY L，HO L C，
et al. NLRP3 inflammasomeactivation，metabolic danger signals，and protein binding partners［J］.
JEndocrinol，
2023，
257（2）：e220184., articleTitle=NLRP3 inflammasomeactivation，metabolic danger signals，and protein binding partners, refAbstract=null), Reference(id=1322927809689157966, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=75, issue=3, pageStart=487, pageEnd=520, url=null, language=null, rfNumber=［19］, rfOrder=18, authorNames=MA Q, journalName=Pharmacol Rev, refType=null, unstructuredReference=MA Q. Pharmacological inhibition of the NLRP3 inflammasome：structure，molecular activation，and inhibitor-NLRP3 interaction［J］.
Pharmacol Rev，
2023，
75（3）：487-520., articleTitle=Pharmacological inhibition of the NLRP3 inflammasome：structure，molecular activation，and inhibitor-NLRP3 interaction, refAbstract=null), Reference(id=1322927809752072528, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=41, issue=null, pageStart=301, pageEnd=316, url=null, language=null, rfNumber=［20］, rfOrder=19, authorNames=FU JN, WU H, journalName=Annu Rev Immunol, refType=null, unstructuredReference=FU JN，WU H. Structural mechanisms of NLRP3 inflammasome assembly and activation［J］.
Annu Rev Immunol，
2023，
41：301-316., articleTitle=Structural mechanisms of NLRP3 inflammasome assembly and activation, refAbstract=null), Reference(id=1322927809819181393, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=13, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［21］, rfOrder=20, authorNames=ZHAN X Y, LI Q, XU G, journalName=Front Immunol, refType=null, unstructuredReference=ZHAN X Y，LI Q，XU G，
et al. The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors［J］.
Front Immunol，
2023，
13：1109938., articleTitle=The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors, refAbstract=null), Reference(id=1322927809882095954, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=187, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［22］, rfOrder=21, authorNames=XIA C Y, GUO Y X, LIAN W W, journalName=Pharmacol Res, refType=null, unstructuredReference=XIA C Y，GUO Y X，LIAN W W，
et al. The NLRP3 inflammasome in depression：potential mechanisms and therapies［J］.
Pharmacol Res，
2023，
187：106625., articleTitle=The NLRP3 inflammasome in depression：potential mechanisms and therapies, refAbstract=null), Reference(id=1322927810112782675, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2023, volume=28, issue=11, pageStart=4512, pageEnd=4527, url=null, language=null, rfNumber=［23］, rfOrder=22, authorNames=YAO J, WANG Z, SONGW H, journalName=Mol Psychiatry, refType=null, unstructuredReference=YAO J，WANG Z，SONGW H，
et al. Targeting NLRP3 inflammasome for neurodegenerative disorders［J］.
Mol Psychiatry，
2023，
28（11）：4512-4527., articleTitle=Targeting NLRP3 inflammasome for neurodegenerative disorders, refAbstract=null), Reference(id=1322927810205057364, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2024, volume=21, issue=4, pageStart=219, pageEnd=237, url=null, language=null, rfNumber=［24］, rfOrder=23, authorNames=TOLDO S, ABBATE A, journalName=Nat Rev Cardiol, refType=null, unstructuredReference=TOLDO S，ABBATE A. The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases［J］.
Nat Rev Cardiol，
2024，
21（4）：219-237., articleTitle=The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases, refAbstract=null), Reference(id=1322927810272166229, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2018, volume=17, issue=7, pageStart=694, pageEnd=702, url=null, language=null, rfNumber=［25］, rfOrder=24, authorNames=SHEN H H, YANG Y X, MENG X, journalName=Autoimmun Rev, refType=null, unstructuredReference=SHEN H H，YANG Y X，MENG X，
et al. NLRP3：a promising therapeutic target for autoimmune diseases［J］.
Autoimmun Rev，
2018，
17（7）：694-702., articleTitle=NLRP3：a promising therapeutic target for autoimmune diseases, refAbstract=null), Reference(id=1322927810544795991, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, doi=null, pmid=null, pmcid=null, year=2022, volume=44, issue=1, pageStart=120, pageEnd=128, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=张东玥, 郑国光, journalName=中国细胞生物学学报, refType=null, unstructuredReference=张东玥，郑国光. 巨噬细胞的固有免疫记忆研究进展［J］.
中国细胞生物学学报，
2022，
44（1）：120-128., articleTitle=巨噬细胞的固有免疫记忆研究进展, refAbstract=null)], funds=[Fund(id=1322927806157553977, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, awardId=82174189, language=CN, fundingSource=国家自然科学基金面上项目(82174189), fundOrder=null, country=null), Fund(id=1322927806212079930, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, awardId=PWzy2020-07, language=CN, fundingSource=上海市浦东新区重点亚专科建设项目(PWzy2020-07), fundOrder=null, country=null), Fund(id=1322927806274994491, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, awardId=PDZY-2022-0701, language=CN, fundingSource=上海市浦东新区中医高端人才引入工程项目(PDZY-2022-0701), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322927801371853059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, xref=null, ext=[AuthorCompanyExt(id=1322927801380241668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai200137，China), AuthorCompanyExt(id=1322927801388630277, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, companyId=1322927801371853059, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=上海中医药大学附属第七人民医院，上海 200137)])], figs=[ArticleFig(id=1322927805117366572, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, label=null, caption=null, figureFileSmall=NJLcciYNNYK3fSJ20goJ9w==, figureFileBig=0Nqxey3cQfMPh/ajsst3Ig==, tableContent=null), ArticleFig(id=1322927805176086829, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, label=图1, caption=
不同浓度牛蒡子苷元对RAW264.7细胞活力的影响, figureFileSmall=NJLcciYNNYK3fSJ20goJ9w==, figureFileBig=0Nqxey3cQfMPh/ajsst3Ig==, tableContent=null), ArticleFig(id=1322927805364830510, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, label=null, caption=null, figureFileSmall=OWJHRFLaV5iH7erOHhXepQ==, figureFileBig=VZsvASmfw3So6Zkp/xkdrw==, tableContent=null), ArticleFig(id=1322927805494853935, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, label=图2, caption=
牛蒡子苷元对LPS联合ATP诱导的RAW264.7细胞活力的影响注：****与对照组相比，P<0.000 1；＃与模型组相比，P<0.05；＃＃与模型组相比，P<0.01；＃＃＃＃与模型组相比，P<0.000 1。
, figureFileSmall=OWJHRFLaV5iH7erOHhXepQ==, figureFileBig=VZsvASmfw3So6Zkp/xkdrw==, tableContent=null), ArticleFig(id=1322927805549379888, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, label=null, caption=null, figureFileSmall=Mw21pJdrdpT+ot7n8oKjLg==, figureFileBig=cQQ7esUXfU5VrhQnWzflUw==, tableContent=null), ArticleFig(id=1322927805612294449, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, label=图3, caption=
牛蒡子苷元对RAW264.7细胞焦亡模型LDH释放量的影响注：****与对照组相比，P<0.000 1；＃＃＃与模型组相比，P<0.001；＃＃＃＃与模型组相比，P<0.000 1。
, figureFileSmall=Mw21pJdrdpT+ot7n8oKjLg==, figureFileBig=cQQ7esUXfU5VrhQnWzflUw==, tableContent=null), ArticleFig(id=1322927805683597618, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, label=null, caption=null, figureFileSmall=+aPpm/FUphOsTEh0TZ7TCA==, figureFileBig=zGXpnfHyegph83qwa5yEqQ==, tableContent=null), ArticleFig(id=1322927805763289395, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, label=图4, caption=
牛蒡子苷元对RAW264.7细胞焦亡模型TNF-α、IL-6、IL-1β释放量的影响注：****与对照组相比，P<0.000 1；＃＃＃＃与模型组相比，P<0.000 1。
, figureFileSmall=+aPpm/FUphOsTEh0TZ7TCA==, figureFileBig=zGXpnfHyegph83qwa5yEqQ==, tableContent=null), ArticleFig(id=1322927805834592564, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, label=null, caption=null, figureFileSmall=LufNvQ+hJ1df6XTwB2dcjg==, figureFileBig=02lFNsO6jXOOFslyXRVr3Q==, tableContent=null), ArticleFig(id=1322927805914284341, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, label=图5, caption=
牛蒡子苷元对RAW264.7细胞焦亡相关蛋白水平的影响注：****与对照组相比，P<0.000 1；＃与模型组相比，P<0.05；＃＃与模型组相比，P<0.01；＃＃＃＃与模型组相比，P<0.000 1。
, figureFileSmall=LufNvQ+hJ1df6XTwB2dcjg==, figureFileBig=02lFNsO6jXOOFslyXRVr3Q==, tableContent=null), ArticleFig(id=1322927805977198902, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=EN, label=null, caption=null, figureFileSmall=pQiotsflF2i739jOnktD7w==, figureFileBig=+O/qUB0SRBM/K0b4CiBSWQ==, tableContent=null), ArticleFig(id=1322927806048502071, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927796032504049, language=CN, label=图6, caption=
牛蒡子苷元抑制LPS+ATP诱导的RAW264.7细胞焦亡（×20）注：****与对照组相比，P<0.000 1；＃＃＃与模型组相比，P<0.001；＃＃＃＃与模型组相比，P<0.000 1。
, figureFileSmall=pQiotsflF2i739jOnktD7w==, figureFileBig=+O/qUB0SRBM/K0b4CiBSWQ==, tableContent=null)], attaches=null, journal=Journal(id=1255846881855815682, delFlag=0, nameCn=中华中医药学刊, nameEn=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, issn=1673-7717, eissn=null, cn=21-1546/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=v4T+dd+NLAnioIpGAbkcEQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Archives of Traditional Chinese Medicine, journalRemark=null, publicationField=null, createdTime=1777346829146, updatedTime=1788949222391, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=v4T+dd+NLAnioIpGAbkcEQ==, picEn=RAy5vuC40hwJB+Y0pEARug==, jcr=null, cjcr=null, exts=[JournalExt(id=1304510846391050374, language=CN, name=中华中医药学刊, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222419, updatedTime=1788949222419, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304510846449770631, language=EN, name=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222433, updatedTime=1788949222433, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1255847919539208197, websiteList=[Website(id=1255847989868900719, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN, language=CN, createTime=1777347093312, createBy=18614031015, updateTime=1777347427646, updateBy=18614031015, name=中华中医药学刊-中文, tplId=1146099689490845704, title=中华中医药学刊, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849512594170105, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=articleTextType, value=kx, createTime=1777347456358, updateTime=1777347456358, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512564809974, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=banner, value=null, createTime=1777347456352, updateTime=1777347456352, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512631918844, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=grayFlag, value=0, createTime=1777347456367, updateTime=1777347456367, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512552227061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347456348, updateTime=1777347456348, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512657084670, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=minRunFlag, value=0, createTime=1777347456373, updateTime=1777347456373, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512589975800, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic, createTime=1777347456357, updateTime=1777347456357, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512648696061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=silenceFlag, value=0, createTime=1777347456371, updateTime=1777347456371, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512581587191, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1777347456355, updateTime=1777347456355, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512619335930, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeColor, value=null, createTime=1777347456364, updateTime=1777347456364, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512627724539, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeStyle, value=null, createTime=1777347456366, updateTime=1777347456366, creator=18614031015, updator=18614031015)]), Website(id=1255847989944398211, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN, language=EN, createTime=1777347093330, createBy=18614031015, updateTime=1777347417860, updateBy=18614031015, name=中华中医药学刊-英文, tplId=1146101810881728533, title=Chinese Archives of Traditional Chinese Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849538993119491, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=articleTextType, value=kx, createTime=1777347462652, updateTime=1777347462652, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538972147968, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=banner, value=null, createTime=1777347462647, updateTime=1777347462647, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539047645446, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=grayFlag, value=0, createTime=1777347462665, updateTime=1777347462665, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538930204927, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347462637, updateTime=1777347462637, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539064422664, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=minRunFlag, value=0, createTime=1777347462669, updateTime=1777347462669, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538988925186, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic, createTime=1777347462651, updateTime=1777347462651, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539060228359, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=silenceFlag, value=0, createTime=1777347462668, updateTime=1777347462668, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538980536577, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1777347462649, updateTime=1777347462649, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539001508100, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeColor, value=null, createTime=1777347462654, updateTime=1777347462654, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539039256837, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeStyle, value=null, createTime=1777347462663, updateTime=1777347462663, creator=18614031015, updator=18614031015)])], journalTitle=中华中医药学刊, weixinUrl=null, journalUrl=https://castjournals.cast.org.cn/zhzyyxk, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Archives of Traditional Chinese Medicine, journalPhotoCn=v4T+dd+NLAnioIpGAbkcEQ==, journalPhotoEn=RAy5vuC40hwJB+Y0pEARug==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2025.08.024, detailUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2025.08.024, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/PDF/10.13193/j.issn.1673-7717.2025.08.024, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/PDF/10.13193/j.issn.1673-7717.2025.08.024, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1754755200000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
22
7
关闭全屏
北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
