Article(id=1322927707113259727, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.08.044, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793340144183, onlineDateStr=2026-10-30, pubDate=1754755200000, pubDateStr=2025-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793340144183, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793340144183, creator=13701087609, updateTime=1793340144183, updator=13701087609, issue=Issue{id=1322926217711726961, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1754755200000', pubDateStr='2025-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339789083, creator='13701087609', updateTime=1793340517761, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929274071679978, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929274071679979, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=224, endPage=227, ext={EN=ArticleExt(id=1322927707482358480, articleId=1322927707113259727, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Consciousness-Restoring and Orifice-Opening Acupuncture Combined with Brain-Computer Interface Therapy on Upper Limb Function in Patients with Spastic Upper Limb Hemiplegia after Cerebral Infarction, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the effect of consciousness-restoring and orifice-opening acupuncture combined with brain-computer interface therapy on upper limb function in patients with spastic upper limb hemiplegia after cerebral infarction.
Methods 63 patients with upper limb spastic hemiplegia after cerebral infarction were divided into the control group（32 cases）and the combined group（31 cases）by random number table method.The control group was treated with brain-computer interface，and the combined group was treated with brain-computer interface combined with consciousness-restoring and orifice-opening acupuncture.Both groups were treated for 3 weeks.The neurological function deficit，activities of daily living，upper limb function，electrophysiology，vascular endothelial function of two groups before and after 3 weeks of treatment and the safety during treatment were compared.
Results Compared with those before treatment，after 3 weeks of treatment，the National institutes of health stroke scale（NIHSS）score，the serum levels of C-reactive protein（CRP）and endothelin（ET）in the two groups decreased，and the scores and levels were lower than those in the combined group（P<0.05）. Compared with those before treatment，after 3 weeks of treatment，the scores of Barthel index（BI），Fugl-meyer Motor function（FMA），Action research arm test（ARAT），WOLF motor function evaluation scale（WMFT）and serum nitric oxide（NO）levels increased in both groups，and those were higher in the combined group（P<0.05）. Compared with those before treatment，the motor evoked potential latency（MEP）and central motor conduction time（CMCT）of the two groups were shortened after 3 weeks of treatment，and the time of the combined group was shorter（P<0.05）.During treatment，the adverse reactions did not affect the course of treatment in both groups，and the incidence of adverse reactions was similar［16.13%（5/31）vs 9.38%（3/32），P>0.05］.
Conclusion consciousness-restoring and orifice-opening acupuncture combined with brain-computer interface therapy could improve the upper limb function，reduce the nerve function defect and improve the ability of daily living in patients with upper limb spastic hemiplegia after cerebral infarction，which was analyzed that it is related to the regulation of electrophysiology and vascular endothelial function，and had good safety.
, authors=Xiaohong MA, Xiaojuan CHEN, Huilin ZHOU, authorsList=Xiaohong MA, Xiaojuan CHEN, Huilin ZHOU, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322927710644863707, articleId=1322927707113259727, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=醒脑开窍针刺法联合脑机接口治疗对脑梗死后上肢痉挛性偏瘫患者上肢功能的影响, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 分析醒脑开窍针刺法联合脑机接口治疗对脑梗死后上肢痉挛性偏瘫患者上肢功能的影响。
方法 选取脑梗死后上肢痉挛性偏瘫患者63例，随机分为对照组32例与联合组31例。对照组予以脑机接口治疗，联合组采用脑机接口联合醒脑开窍针刺法治疗，均治疗3周。比较两组治疗3周后疗效，治疗前、治疗3周后神经功能缺损、日常生活活动能力、上肢功能、电生理、血管内皮功能，治疗期间安全性情况。
结果 与治疗前比较，治疗3周后，两组美国国立卫生研究院卒中量表（National institutes of health stroke scale，NIHSS）评分，血清C反应蛋白（C-reactive protein，CRP）、内皮素（Endothelin，ET）水平降低，相较而言联合组下降更为明显（P<0.05）。与治疗前比较，治疗3周后，两组Barthel指数（Barthel index，BI）、Fugl-meyer运动功能评分（Fugl-meyer motor function，FMA）、手臂动作调查测试表（Action Research arm test，ARAT）、WOLF运动功能评价量表（WOLF motor function evaluation scale，WMFT）评分，血清一氧化氮（Nitric oxide，NO）水平升高，相较而言联合组升高更为明显（P<0.05）。与治疗前比较，治疗3周后两组脑区运动诱发电位潜伏期（Motor evoked potential latency，MEP）、中枢运动传导时间（Central motor conduction time，CMCT）缩短，且组间比较联合组更短（P<0.05）。治疗期间，两组产生的不良反应均未影响治疗的进行，不良反应发生率接近［16.13%（5/31）vs 9.38%（3/32），P>0.05］。
结论 醒脑开窍针刺法联合脑机接口治疗可改善脑梗死后上肢痉挛性偏瘫患者上肢功能，降低神经功能缺损，改善日常生活活动能力，分析与其调节电生理、血管内皮功能有关，安全性良好。
, authors=马晓红, 陈晓娟, 周辉林, authorsList=马晓红, 陈晓娟, 周辉林, authorCompany=null, correspAuthors=null, authorNote=
马晓红（1989-），女，青海海东人，主管治疗师，学士，研究方向：脑机接口与手功能。
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| 时间 | 组别 | 例数 | NIHSS | BI |
|---|
| 治疗前 | 联合组 | 31 | 15.95±2.73 | 31.19±3.65 |
| 对照组 | 32 | 16.02±2.88 | 30.74±3.63 |
| 治疗3周后 | 联合组 | 31 | 7.63±1.61*# | 77.02±5.75*# |
| 对照组 | 32 | 9.62±2.56* | 54.94±7.81* |
), ArticleFig(id=1322927714344239870, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927707113259727, language=CN, label=表1, caption=
两组脑梗死后上肢痉挛性偏瘫患者治疗前后神经功能缺损及日常生活活动能力比较（
）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 时间 | 组别 | 例数 | NIHSS | BI |
|---|
| 治疗前 | 联合组 | 31 | 15.95±2.73 | 31.19±3.65 |
| 对照组 | 32 | 16.02±2.88 | 30.74±3.63 |
| 治疗3周后 | 联合组 | 31 | 7.63±1.61*# | 77.02±5.75*# |
| 对照组 | 32 | 9.62±2.56* | 54.94±7.81* |
), ArticleFig(id=1322927714415543039, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927707113259727, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 时间 | 组别 | 例数 | FMA | ARAT | WMFT |
|---|
| 治疗前 | 联合组 | 31 | 13.77±1.89 | 22.56±3.57 | 32.79±5.68 |
| 对照组 | 32 | 14.01±1.95 | 23.03±3.46 | 33.13±5.26 |
| 治疗3周后 | 联合组 | 31 | 26.07±3.01*# | 33.57±3.15*# | 54.26±4.36*# |
| 对照组 | 32 | 23.43±3.23* | 29.96±3.19* | 43.09±5.57* |
), ArticleFig(id=1322927714491040512, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927707113259727, language=CN, label=表2, caption=
两组脑梗死后上肢痉挛性偏瘫患者治疗前后上肢功能比较（
）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 时间 | 组别 | 例数 | FMA | ARAT | WMFT |
|---|
| 治疗前 | 联合组 | 31 | 13.77±1.89 | 22.56±3.57 | 32.79±5.68 |
| 对照组 | 32 | 14.01±1.95 | 23.03±3.46 | 33.13±5.26 |
| 治疗3周后 | 联合组 | 31 | 26.07±3.01*# | 33.57±3.15*# | 54.26±4.36*# |
| 对照组 | 32 | 23.43±3.23* | 29.96±3.19* | 43.09±5.57* |
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| 时间 | 组别 | 例数 | MEP | CMCT |
|---|
| 治疗前 | 联合组 | 31 | 25.11±2.31 | 10.82±1.15 |
| 对照组 | 32 | 24.95±2.37 | 10.75±1.16 |
| 治疗3周后 | 联合组 | 31 | 20.07±2.02*# | 7.41±1.13*# |
| 对照组 | 32 | 22.92±2.09* | 8.57±1.06* |
), ArticleFig(id=1322927714629452546, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927707113259727, language=CN, label=表3, caption=
两组脑梗死后上肢痉挛性偏瘫患者治疗前后电生理比较（
）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 时间 | 组别 | 例数 | MEP | CMCT |
|---|
| 治疗前 | 联合组 | 31 | 25.11±2.31 | 10.82±1.15 |
| 对照组 | 32 | 24.95±2.37 | 10.75±1.16 |
| 治疗3周后 | 联合组 | 31 | 20.07±2.02*# | 7.41±1.13*# |
| 对照组 | 32 | 22.92±2.09* | 8.57±1.06* |
), ArticleFig(id=1322927714717532931, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927707113259727, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 时间 | 组别 | 例数 | CRP/（μmol/L） | ET/（ng/L） | NO/（μmol/L） |
|---|
| 治疗前 | 联合组 | 31 | 19.87±2.83 | 81.73±7.54 | 51.33±3.17 |
| 对照组 | 32 | 20.11±3.92 | 82.04±8.22 | 52.89±4.08 |
| 治疗3周后 | 联合组 | 31 | 8.13±1.75*# | 64.36±7.11*# | 66.20±5.19*# |
| 对照组 | 32 | 12.84±2.82* | 73.84±8.26* | 57.39±5.18* |
), ArticleFig(id=1322927714797224708, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927707113259727, language=CN, label=表4, caption=
两组脑梗死后上肢痉挛性偏瘫患者治疗前后血管内皮功能比较（
）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 时间 | 组别 | 例数 | CRP/（μmol/L） | ET/（ng/L） | NO/（μmol/L） |
|---|
| 治疗前 | 联合组 | 31 | 19.87±2.83 | 81.73±7.54 | 51.33±3.17 |
| 对照组 | 32 | 20.11±3.92 | 82.04±8.22 | 52.89±4.08 |
| 治疗3周后 | 联合组 | 31 | 8.13±1.75*# | 64.36±7.11*# | 66.20±5.19*# |
| 对照组 | 32 | 12.84±2.82* | 73.84±8.26* | 57.39±5.18* |
), ArticleFig(id=1322927714872722181, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927707113259727, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 胸闷 | 皮疹 | 心悸 | 总计 |
|---|
| 联合组 | 31 | 3（9.68） | 1（3.23） | 1（3.23） | 5（16.13） |
| 对照组 | 32 | 1（3.13） | 1（3.13） | 1（3.13） | 3（9.38） |
| 校正χ2 | | | | | 0.182 |
| P值 | | | | | 0.670 |
), ArticleFig(id=1322927714956608262, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927707113259727, language=CN, label=表5, caption=
两组脑梗死后上肢痉挛性偏瘫患者治疗期间安全性比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 胸闷 | 皮疹 | 心悸 | 总计 |
|---|
| 联合组 | 31 | 3（9.68） | 1（3.23） | 1（3.23） | 5（16.13） |
| 对照组 | 32 | 1（3.13） | 1（3.13） | 1（3.13） | 3（9.38） |
| 校正χ2 | | | | | 0.182 |
| P值 | | | | | 0.670 |
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