Article(id=1322927281815040810, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926985957221241, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.11.040, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793340042785, onlineDateStr=2026-10-30, pubDate=1762704000000, pubDateStr=2025-11-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793340042785, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793340042785, creator=13701087609, updateTime=1793340042785, updator=13701087609, issue=Issue{id=1322926985957221241, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='11', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1762704000000', pubDateStr='2025-11-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339972247, creator='13701087609', updateTime=1793340743335, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322930220201804556, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926985957221241, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322930220201804557, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926985957221241, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=200, endPage=203, ext={EN=ArticleExt(id=1322927282238665515, articleId=1322927281815040810, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Efficacy and Safety Observation on Treatment of Insomnia of Heart-Kidney Yang Deficiency Type by Combining Fuzi Decoction（附子汤）and Guizhi Gancao Longgu Muli Decoction（桂枝甘草龙骨牡蛎汤）, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of the treatment of insomnia of heart-kidney Yang deficiency type with Fuzi Decoction（附子汤）combined with Guizhi Gancao Longgu Muli Decoction（桂枝甘草龙骨牡蛎汤）.
Methods A total of 114 patients with insomnia due to deficiency of heart and kidney yang were enrolled from January 2022 to December 2023. Simple randomization was performed using a random number table. The Western medicine group（n＝57）received zopiclone treatment，while the pattern differentiation group（n＝57）received Fuzi Tang combined with Guizhi Gancao Longgu Muli Tang. Both groups underwent continuous treatment for 4 weeks. The following parameters were assessed：Hamilton Anxiety Scale（HAMA）scores，5-hydroxytryptamine（5-HT），glutamate，gamma-aminobutyric acid（GABA），melatonin，Pittsburgh Sleep Quality Index（PSQI）scores，sleep architecture，TCM syndrome scores，and Hamilton Depression Scale（HAMD）scores. Efficacy and safety were statistically analyzed between groups.
Results Following treatment，both groups exhibited reduced HAMD scores，PSQI scores，TCM syndrome scores，and HAMA scores compared to pre-treatment levels，with the patterndifferentiation group showing lower scores than the Western medicine group（P<0.05）. The pattern-differentiation group achieved a total effective rate of 92.98% （53/57 cases），surpassing the Western medicine group's rate of 78.95% （45/57 cases）（P<0.05）. Post-treatment levels of serotonin and glutamate decreased in both groups compared to pre-treatment levels，with the pattern-differentiation group showing a greater reduction than the Western medicine group（P<0.05）. Post-treatment levels of gamma-aminobutyric acid（GABA）and melatonin increased in both groups compared to pre-treatment levels，with the pattern-differentiation group showing a greater increase than the Western medicine group（P<0.05）. After treatment，both groups showed reduced sleep latency（SOL）and wake-up time（WASO）compared to pre-treatment levels，with the pattern-differentiation group exhibiting a greater reduction than the Western medicine group（P<0.05）. Following treatment，both groups exhibited increased total sleep time（TST）and sleep efficiency（SE）compared to pre-treatment levels，with the pattern-differentiation group showing greater improvement than the Western medicine group（P<0.05）. The overall adverse reaction rate in the pattern-differentiation group was 5.26% （3/57 cases），compared to 7.02% （4/57 cases）in the Western medicine group，with no statistically significant difference（P>0.05）.
Conclusion The treatment of heart-kidney Yang deficiency type of insomnia by Fuzi Decoction combined with Guizhi Gancao Longgu Muli Decoction can regulate the neurotransmitters，improve the sleep structure and enhance the clinical efficacy.
, authors=Xiaojun ZHU, Hualong ZENG, Shuqing ZHU, Birong ZHENG, authorsList=Xiaojun ZHU, Hualong ZENG, Shuqing ZHU, Birong ZHENG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322927286000956214, articleId=1322927281815040810, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=附子汤合桂枝甘草龙骨牡蛎汤治疗心肾阳虚型失眠临床疗效观察, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 观察附子汤合桂枝甘草龙骨牡蛎汤治疗心肾阳虚型失眠的临床疗效与安全性。
方法 选取2022年1月—2023年12月收治的心肾阳虚型失眠患者114例，采用随机数字表法进行简单随机分组。西药组57例给予右佐匹克隆治疗，辨证组57例给予附子汤合桂枝甘草龙骨牡蛎汤治疗，连续用药4周。评估两组汉密尔顿焦虑量表（Hamilton anxiety scale，HAMA）评分、5-羟色胺、谷氨酸、γ-氨基丁酸、褪黑素、匹兹堡睡眠质量指数（Pittsburgh sleep quality index，PSQI）评分、睡眠结构、中医证候评分和汉密尔顿抑郁量表（Hamilton depression scale，HAMD）评分变化，统计两组疗效和安全性。
结果 治疗后两组HAMD评分、PSQI评分、中医证候评分、HAMA评分均较治疗前降低，辨证组较西药组更低（P<0.05）。辨证组总有效率为92.98%（53/57），高于西药组的78.95%（45/57）（P<0.05）。治疗后两组5-羟色胺、谷氨酸均较治疗前降低，辨证组较西药组更低（P<0.05）；治疗后两组γ-氨基丁酸、褪黑素均较治疗前升高，辨证组较西药组更高（P<0.05）。治疗后两组睡眠潜伏期（Sleep latency，SOL）、觉醒时间（Wake-up time，WASO）均较治疗前降低，辨证组较西药组更低（P<0.05）；治疗后两组总睡眠时间（Total sleep time，TST）、睡眠效率（Sleep efficiency，SE）均较治疗前升高，辨证组较西药组更高（P<0.05）。辨证组总不良反应率5.26%（3/57），与西药组7.02%（4/57）比较，差异无统计学意义（P>0.05）。
结论 附子汤合桂枝甘草龙骨牡蛎汤治疗心肾阳虚型失眠可调节神经递质，改善睡眠结构，提高临床疗效。
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朱晓军（1979-），女，福建永安人，副主任中医师，硕士，研究方向：中医内科。
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等. 基于真实世界诊疗数据的失眠症状群分类方法研究［J］.
世界中医药，
2022，
17（5）：635-644., articleTitle=基于真实世界诊疗数据的失眠症状群分类方法研究, refAbstract=null), Reference(id=1322927292405658471, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2023, volume=48, issue=4, pageStart=454, pageEnd=460, url=null, language=null, rfNumber=［2］, rfOrder=1, authorNames=明泽艳, 蔡鹏, 赵雪, journalName=贵州医科大学学报, refType=null, unstructuredReference=明泽艳，蔡鹏，赵雪，
等. 门诊老年失眠患者安全使用镇静催眠药物相关知识和行为及其影响因素［J］.
贵州医科大学学报，
2023，
48（4）：454-460., articleTitle=门诊老年失眠患者安全使用镇静催眠药物相关知识和行为及其影响因素, refAbstract=null), Reference(id=1322927292476961640, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2020, volume=41, issue=5, pageStart=670, pageEnd=672, url=null, language=null, rfNumber=［3］, rfOrder=2, authorNames=任鑫睿, 刘莎, 王昕, journalName=陕西中医, refType=null, unstructuredReference=任鑫睿，刘莎，王昕，
等. 杨志宏教授治疗失眠经验采撷［J］.
陕西中医，
2020，
41（5）：670-672., articleTitle=杨志宏教授治疗失眠经验采撷, refAbstract=null), Reference(id=1322927292548264809, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2023, volume=16, issue=9, pageStart=1852, pageEnd=1854, url=null, language=null, rfNumber=［4］, rfOrder=3, authorNames=刘璐瑶, 刘敏, journalName=环球中医药, refType=null, unstructuredReference=刘璐瑶，刘敏. 略论附子汤证属少阴表证［J］.
环球中医药，
2023，
16（9）：1852-1854., articleTitle=略论附子汤证属少阴表证, refAbstract=null), Reference(id=1322927292636345195, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2016, volume=48, issue=7, pageStart=45, pageEnd=46, url=null, language=null, rfNumber=［5］, rfOrder=4, authorNames=吴林胜, 苏思敏, journalName=新中医, refType=null, unstructuredReference=吴林胜，苏思敏. 加味桂枝甘草龙骨牡蛎汤治疗老年人失眠疗效观察［J］.
新中医，
2016，
48（7）：45-46., articleTitle=加味桂枝甘草龙骨牡蛎汤治疗老年人失眠疗效观察, refAbstract=null), Reference(id=1322927292728619884, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2001, volume=null, issue=null, pageStart=112, pageEnd=116, url=null, language=null, rfNumber=［6］, rfOrder=5, authorNames=中华医学会精神科分会, journalName=CCMD-3中国精神障碍分类与诊断标准, refType=null, unstructuredReference=中华医学会精神科分会.
CCMD-3中国精神障碍分类与诊断标准［M］. 3版. 济南：山东科学技术出版社，
2001：112-116., articleTitle=null, refAbstract=null), Reference(id=1322927292976083821, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2012, volume=null, issue=null, pageStart=24, pageEnd=null, url=null, language=null, rfNumber=［7］, rfOrder=6, authorNames=国家中医药管理局, journalName=null, refType=null, unstructuredReference=国家中医药管理局. 中医病证诊断疗效标准［S］. 北京：中国医药科技出版社，
2012：24., articleTitle=null, refAbstract=null), Reference(id=1322927293076747118, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2014, volume=43, issue=3, pageStart=260, pageEnd=263, url=null, language=null, rfNumber=［8］, rfOrder=7, authorNames=路桃影, 李艳, 夏萍, journalName=重庆医学, refType=null, unstructuredReference=路桃影，李艳，夏萍，
等. 匹兹堡睡眠质量指数的信度及效度分析［J］.
重庆医学，
2014，
43（3）：260-263., articleTitle=匹兹堡睡眠质量指数的信度及效度分析, refAbstract=null), Reference(id=1322927293156438895, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2019, volume=17, issue=2, pageStart=140, pageEnd=142, url=null, language=null, rfNumber=［9］, rfOrder=8, authorNames=侍成栋, 潘永良, journalName=全科护理, refType=null, unstructuredReference=侍成栋，潘永良. 汉密尔顿抑郁及焦虑量表与正性负性情绪量表的相关性研究［J］.
全科护理，
2019，
17（2）：140-142., articleTitle=汉密尔顿抑郁及焦虑量表与正性负性情绪量表的相关性研究, refAbstract=null), Reference(id=1322927293215159152, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2022, volume=52, issue=1, pageStart=39, pageEnd=46, url=null, language=null, rfNumber=［10］, rfOrder=9, authorNames=UENO T, ICHIKAWA D, SHIMIZU Y, journalName=Jpn J Clin Oncol, refType=null, unstructuredReference=UENO T，ICHIKAWA D，SHIMIZU Y，
et al. Comorbid insomnia among breast cancer survivors and its prediction using machine learning：a nationwide study in Japan［J］.
Jpn J Clin Oncol，
2022，
52（1）：39-46., articleTitle=Comorbid insomnia among breast cancer survivors and its prediction using machine learning：a nationwide study in Japan, refAbstract=null), Reference(id=1322927294863520625, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2022, volume=18, issue=3, pageStart=779, pageEnd=787, url=null, language=null, rfNumber=［11］, rfOrder=10, authorNames=FRØJD L A, PAPAGEORGIOU C, MUNKHAUGEN J, journalName=J Clin Sleep Med, refType=null, unstructuredReference=FRØJD L A，PAPAGEORGIOU C，MUNKHAUGEN J，
et al. Worry and rumination predict insomnia in patients with coronary heart disease：a cross-sectional study with long-term follow-up［J］.
J Clin Sleep Med，
2022，
18（3）：779-787., articleTitle=Worry and rumination predict insomnia in patients with coronary heart disease：a cross-sectional study with long-term follow-up, refAbstract=null), Reference(id=1322927294968378226, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2023, volume=51, issue=11, pageStart=1227, pageEnd=1231, url=null, language=null, rfNumber=［12］, rfOrder=11, authorNames=张璐, 张卫, 袁长红, journalName=天津医药, refType=null, unstructuredReference=张璐，张卫，袁长红，
等. 经颅直流电刺激联合右佐匹克隆治疗慢性失眠患者的临床研究［J］.
天津医药，
2023，
51（11）：1227-1231., articleTitle=经颅直流电刺激联合右佐匹克隆治疗慢性失眠患者的临床研究, refAbstract=null), Reference(id=1322927295048070003, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2020, volume=32, issue=11, pageStart=2079, pageEnd=2081, url=null, language=null, rfNumber=［13］, rfOrder=12, authorNames=金珊, 方向, 杨文明, journalName=中医药临床杂志, refType=null, unstructuredReference=金珊，方向，杨文明. 杨文明从肾论治老年性失眠经验［J］.
中医药临床杂志，
2020，
32（11）：2079-2081., articleTitle=杨文明从肾论治老年性失眠经验, refAbstract=null), Reference(id=1322927295131956084, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2020, volume=35, issue=12, pageStart=1902, pageEnd=1905, url=null, language=null, rfNumber=［14］, rfOrder=13, authorNames=文世虹, 王杰, 李孝波, journalName=光明中医, refType=null, unstructuredReference=文世虹，王杰，李孝波，
等. 基于功能衰微态辨证以附子汤加干姜治疗慢性失眠障碍［J］.
光明中医，
2020，
35（12）：1902-1905., articleTitle=基于功能衰微态辨证以附子汤加干姜治疗慢性失眠障碍, refAbstract=null), Reference(id=1322927295211647861, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2021, volume=30, issue=3, pageStart=161, pageEnd=166, url=null, language=null, rfNumber=［15］, rfOrder=14, authorNames=张可兴, 张博, 朱姗姗, journalName=中国药物依赖性杂志, refType=null, unstructuredReference=张可兴，张博，朱姗姗，
等. 柴胡加龙骨牡蛎汤治疗失眠的研究进展［J］.
中国药物依赖性杂志，
2021，
30（3）：161-166., articleTitle=柴胡加龙骨牡蛎汤治疗失眠的研究进展, refAbstract=null), Reference(id=1322927295287145334, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2021, volume=46, issue=3, pageStart=785, pageEnd=795, url=null, language=null, rfNumber=［16］, rfOrder=15, authorNames=冉思邈, 谭爱华, 石和元, journalName=广西大学学报（自然科学版）, refType=null, unstructuredReference=冉思邈，谭爱华，石和元，
等. 基于网络药理学探讨人参治疗失眠的潜在分子机制与实验研究［J］.
广西大学学报（自然科学版），
2021，
46（3）：785-795., articleTitle=基于网络药理学探讨人参治疗失眠的潜在分子机制与实验研究, refAbstract=null), Reference(id=1322927295362642807, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2023, volume=25, issue=1, pageStart=115, pageEnd=121, url=null, language=null, rfNumber=［17］, rfOrder=16, authorNames=胡云飞, 王玺, 刘晴, journalName=辽宁中医药大学学报, refType=null, unstructuredReference=胡云飞，王玺，刘晴，
等. 中药茯神相关研究进展［J］.
辽宁中医药大学学报，
2023，
25（1）：115-121., articleTitle=中药茯神相关研究进展, refAbstract=null), Reference(id=1322927295442334584, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2023, volume=25, issue=7, pageStart=2465, pageEnd=2478, url=null, language=null, rfNumber=［18］, rfOrder=17, authorNames=张洪雄, 高太祥, 赵峰, journalName=世界科学技术-中医药现代化, refType=null, unstructuredReference=张洪雄，高太祥，赵峰，
等. 药效学结合网络药理学研究酸枣仁汤对不同疾病模型的干预作用及其作用机制［J］.
世界科学技术-中医药现代化，
2023，
25（7）：2465-2478., articleTitle=药效学结合网络药理学研究酸枣仁汤对不同疾病模型的干预作用及其作用机制, refAbstract=null), Reference(id=1322927295509443449, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2023, volume=51, issue=2, pageStart=109, pageEnd=112, url=null, language=null, rfNumber=［19］, rfOrder=18, authorNames=李力恒, 陈丽萍, 胡晓阳, journalName=中医药学报, refType=null, unstructuredReference=李力恒，陈丽萍，胡晓阳，
等. 柴胡的化学成分及药理作用研究进展［J］.
中医药学报，
2023，
51（2）：109-112., articleTitle=柴胡的化学成分及药理作用研究进展, refAbstract=null), Reference(id=1322927295589135226, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2013, volume=19, issue=2, pageStart=108, pageEnd=110, url=null, language=null, rfNumber=［20］, rfOrder=19, authorNames=姚秋菊, 韩旭, journalName=中医药导报, refType=null, unstructuredReference=姚秋菊，韩旭. 5-羟色胺与失眠的相关性及中医辨证治疗的研究进展［J］.
中医药导报，
2013，
19（2）：108-110., articleTitle=5-羟色胺与失眠的相关性及中医辨证治疗的研究进展, refAbstract=null), Reference(id=1322927295668827003, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2021, volume=38, issue=5, pageStart=407, pageEnd=410, url=null, language=null, rfNumber=［21］, rfOrder=20, authorNames=苏婷, 高威, 李华欣, journalName=中风与神经疾病杂志, refType=null, unstructuredReference=苏婷，高威，李华欣，
等. 失眠患者血清钙调蛋白及GABA/Glu水平检测及其意义［J］.
中风与神经疾病杂志，
2021，
38（5）：407-410., articleTitle=失眠患者血清钙调蛋白及GABA/Glu水平检测及其意义, refAbstract=null), Reference(id=1322927295744324476, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2022, volume=49, issue=4, pageStart=609, pageEnd=611, url=null, language=null, rfNumber=［22］, rfOrder=21, authorNames=颜瑞, journalName=国际精神病学杂志, refType=null, unstructuredReference=颜瑞. 抑郁症患者血清谷氨酸、γ-氨基丁酸的水平及其临床意义［J］.
国际精神病学杂志，
2022，
49（4）：609-611., articleTitle=抑郁症患者血清谷氨酸、γ-氨基丁酸的水平及其临床意义, refAbstract=null), Reference(id=1322927295849182077, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2023, volume=39, issue=1, pageStart=42, pageEnd=47, url=null, language=null, rfNumber=［23］, rfOrder=22, authorNames=段晓晔, 郭立新, journalName=中华内分泌代谢杂志, refType=null, unstructuredReference=段晓晔，郭立新. 补充褪黑素对急性睡眠剥夺的生长期大鼠骨转换状态的影响［J］.
中华内分泌代谢杂志，
2023，
39（1）：42-47., articleTitle=补充褪黑素对急性睡眠剥夺的生长期大鼠骨转换状态的影响, refAbstract=null), Reference(id=1322927295924679550, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2022, volume=25, issue=2, pageStart=37, pageEnd=40, url=null, language=null, rfNumber=［24］, rfOrder=23, authorNames=全伟, journalName=广西中医药大学学报, refType=null, unstructuredReference=全伟. 柴胡加龙骨牡蛎汤联合睡眠限制疗法治疗围绝经期失眠疗效观察［J］.
广西中医药大学学报，
2022，
25（2）：37-40., articleTitle=柴胡加龙骨牡蛎汤联合睡眠限制疗法治疗围绝经期失眠疗效观察, refAbstract=null), Reference(id=1322927296000177023, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2024, volume=22, issue=10, pageStart=1802, pageEnd=1809, url=null, language=null, rfNumber=［25］, rfOrder=24, authorNames=刘庆阳, 王振涛, journalName=中西医结合心脑血管病杂志, refType=null, unstructuredReference=刘庆阳，王振涛. 柴胡加龙骨牡蛎汤治疗双心疾病的研究进展［J］.
中西医结合心脑血管病杂志，
2024，
22（10）：1802-1809., articleTitle=柴胡加龙骨牡蛎汤治疗双心疾病的研究进展, refAbstract=null), Reference(id=1322927296063091584, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2023, volume=33, issue=1, pageStart=59, pageEnd=61, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=葛旭峰, 马长林, 张莉, journalName=临床精神医学杂志, refType=null, unstructuredReference=葛旭峰，马长林，张莉，
等. 失眠症患者多导睡眠图的临床研究［J］.
临床精神医学杂志，
2023，
33（1）：59-61., articleTitle=失眠症患者多导睡眠图的临床研究, refAbstract=null), Reference(id=1322927296142783361, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2023, volume=43, issue=3, pageStart=249, pageEnd=253, url=null, language=null, rfNumber=［27］, rfOrder=26, authorNames=曹家桢, 莽靖, 徐忠信, journalName=吉林中医药, refType=null, unstructuredReference=曹家桢，莽靖，徐忠信，
等. 针刺单穴与配伍腧穴对原发性失眠患者多导睡眠图睡眠参数的影响差异研究［J］.
吉林中医药，
2023，
43（3）：249-253., articleTitle=针刺单穴与配伍腧穴对原发性失眠患者多导睡眠图睡眠参数的影响差异研究, refAbstract=null), Reference(id=1322927296209892226, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2022, volume=38, issue=7, pageStart=53, pageEnd=55, url=null, language=null, rfNumber=［28］, rfOrder=27, authorNames=姜新媛, 张海啸, journalName=中国社区医师, refType=null, unstructuredReference=姜新媛，张海啸. 加味桂枝甘草龙骨牡蛎汤联合艾司唑仑片治疗心胆气虚型失眠的临床研究［J］.
中国社区医师，
2022，
38（7）：53-55., articleTitle=加味桂枝甘草龙骨牡蛎汤联合艾司唑仑片治疗心胆气虚型失眠的临床研究, refAbstract=null), Reference(id=1322927296268612483, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2019, volume=43, issue=8, pageStart=817, pageEnd=819, url=null, language=null, rfNumber=［29］, rfOrder=28, authorNames=杨营, 丁泽琳, 王海霞, journalName=浙江中医药大学学报, refType=null, unstructuredReference=杨营，丁泽琳，王海霞. 从“阳虚阴不内守”论桂枝加龙骨牡蛎汤的临床应用［J］.
浙江中医药大学学报，
2019，
43（8）：817-819., articleTitle=从“阳虚阴不内守”论桂枝加龙骨牡蛎汤的临床应用, refAbstract=null), Reference(id=1322927296331527044, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, doi=null, pmid=null, pmcid=null, year=2022, volume=42, issue=5, pageStart=131, pageEnd=132, url=null, language=null, rfNumber=［30］, rfOrder=29, authorNames=平慧强, journalName=哈尔滨医药, refType=null, unstructuredReference=平慧强. 桂枝甘草龙骨牡蛎汤加减联合针灸治疗更年期失眠的临床研究［J］.
哈尔滨医药，
2022，
42（5）：131-132., articleTitle=桂枝甘草龙骨牡蛎汤加减联合针灸治疗更年期失眠的临床研究, refAbstract=null)], funds=[Fund(id=1322927292246274917, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, awardId=2019174, language=CN, fundingSource=福建省卫生健康青年科研项目(2019174), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322927286227448631, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, xref=null, ext=[AuthorCompanyExt(id=1322927286235837240, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, companyId=1322927286227448631, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Traditional Chinese Medicine Department，Sanming First Hospital，Sanming 365000，Fujian，China), AuthorCompanyExt(id=1322927286244225849, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, companyId=1322927286227448631, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=三明市第一医院，福建 三明 365000)])], figs=[ArticleFig(id=1322927290883126106, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | PSQI评分 | 中医证候评分 | HAMD评分 | HAMA评分 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 西药组 | 57 | 14.12±2.98 | 9.25±1.45* | 24.85±2.04 | 12.74±1.56* | 12.94±2.21 | 8.87±1.68* | 11.76±1.82 | 7.96±1.27* |
| 辨证组 | 57 | 13.97±3.02 | 7.07±1.88* | 24.37±2.15 | 8.56±1.44* | 13.01±2.14 | 6.24±1.33* | 11.84±1.79 | 5.34±1.03* |
| t值 | | 0.267 | 6.932 | 1.223 | 14.865 | 0.172 | 9.267 | 0.237 | 12.097 |
| P值 | | 0.790 | 0.000 | 0.224 | 0.000 | 0.864 | 0.000 | 0.813 | 0.000 |
), ArticleFig(id=1322927290971206491, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=CN, label=表1, caption=
两组心肾阳虚型失眠患者相关评分比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | PSQI评分 | 中医证候评分 | HAMD评分 | HAMA评分 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 西药组 | 57 | 14.12±2.98 | 9.25±1.45* | 24.85±2.04 | 12.74±1.56* | 12.94±2.21 | 8.87±1.68* | 11.76±1.82 | 7.96±1.27* |
| 辨证组 | 57 | 13.97±3.02 | 7.07±1.88* | 24.37±2.15 | 8.56±1.44* | 13.01±2.14 | 6.24±1.33* | 11.84±1.79 | 5.34±1.03* |
| t值 | | 0.267 | 6.932 | 1.223 | 14.865 | 0.172 | 9.267 | 0.237 | 12.097 |
| P值 | | 0.790 | 0.000 | 0.224 | 0.000 | 0.864 | 0.000 | 0.813 | 0.000 |
), ArticleFig(id=1322927291042509660, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 临床治愈 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 西药组 | 57 | 15（26.32） | 17（29.82） | 13（22.81） | 12（21.05） | 45（78.95） |
| 辨证组 | 57 | 26（45.61） | 18（31.58） | 9（15.79） | 4（7.02） | 53（92.98） |
| χ2值 | | | | | | 4.653 |
| P值 | | | | | | 0.031 |
), ArticleFig(id=1322927291134784349, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=CN, label=表2, caption=
两组心肾阳虚型失眠患者疗效比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 临床治愈 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 西药组 | 57 | 15（26.32） | 17（29.82） | 13（22.81） | 12（21.05） | 45（78.95） |
| 辨证组 | 57 | 26（45.61） | 18（31.58） | 9（15.79） | 4（7.02） | 53（92.98） |
| χ2值 | | | | | | 4.653 |
| P值 | | | | | | 0.031 |
), ArticleFig(id=1322927291310945118, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 5-羟色胺/（μmol/L） | 谷氨酸/（μmol/L） | γ-氨基丁酸/（mg/mL） | 褪黑素/（pg/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 西药组 | 57 | 0.55±0.21 | 0.27±0.10* | 71.43±21.43 | 51.14±15.63* | 6.58±2.11 | 9.05±1.76* | 40.14±6.77 | 47.98±5.78* |
| 辨证组 | 57 | 0.54±0.23 | 0.21±0.08* | 70.54±24.36 | 44.72±12.57* | 6.47±2.08 | 11.41±2.08* | 39.75±7.05 | 56.71±6.82* |
| t值 | | 0.242 | 3.537 | 0.207 | 2.417 | 0.280 | 6.539 | 0.301 | 7.373 |
| P值 | | 0.809 | 0.001 | 0.836 | 0.017 | 0.780 | 0.000 | 0.764 | 0.000 |
), ArticleFig(id=1322927291407414112, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=CN, label=表3, caption=
两组心肾阳虚型失眠患者5-羟色胺、谷氨酸、γ-氨基丁酸、褪黑素比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 5-羟色胺/（μmol/L） | 谷氨酸/（μmol/L） | γ-氨基丁酸/（mg/mL） | 褪黑素/（pg/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 西药组 | 57 | 0.55±0.21 | 0.27±0.10* | 71.43±21.43 | 51.14±15.63* | 6.58±2.11 | 9.05±1.76* | 40.14±6.77 | 47.98±5.78* |
| 辨证组 | 57 | 0.54±0.23 | 0.21±0.08* | 70.54±24.36 | 44.72±12.57* | 6.47±2.08 | 11.41±2.08* | 39.75±7.05 | 56.71±6.82* |
| t值 | | 0.242 | 3.537 | 0.207 | 2.417 | 0.280 | 6.539 | 0.301 | 7.373 |
| P值 | | 0.809 | 0.001 | 0.836 | 0.017 | 0.780 | 0.000 | 0.764 | 0.000 |
), ArticleFig(id=1322927291491300193, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | TST/（min） | SOL/（min） | WASO/（min） | SE/（%） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 西药组 | 57 | 352.23±41.58 | 405.52±43.36* | 38.95±15.63 | 24.25±10.34* | 75.56±18.41 | 26.86±9.11* | 75.53±12.65 | 79.45±14.47* |
| 辨证组 | 57 | 348.96±45.17 | 434.74±48.01* | 39.11±13.74 | 20.08±8.17* | 74.19±20.27 | 20.01±7.74* | 74.91±14.08 | 88.52±16.35* |
| t值 | | 0.402 | 3.410 | 0.058 | 2.389 | 0.378 | 4.326 | 0.247 | 3.136 |
| P值 | | 0.688 | 0.001 | 0.954 | 0.019 | 0.706 | 0.000 | 0.805 | 0.002 |
), ArticleFig(id=1322927291818455906, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=CN, label=表4, caption=
两组心肾阳虚型失眠患者睡眠结构比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | TST/（min） | SOL/（min） | WASO/（min） | SE/（%） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 西药组 | 57 | 352.23±41.58 | 405.52±43.36* | 38.95±15.63 | 24.25±10.34* | 75.56±18.41 | 26.86±9.11* | 75.53±12.65 | 79.45±14.47* |
| 辨证组 | 57 | 348.96±45.17 | 434.74±48.01* | 39.11±13.74 | 20.08±8.17* | 74.19±20.27 | 20.01±7.74* | 74.91±14.08 | 88.52±16.35* |
| t值 | | 0.402 | 3.410 | 0.058 | 2.389 | 0.378 | 4.326 | 0.247 | 3.136 |
| P值 | | 0.688 | 0.001 | 0.954 | 0.019 | 0.706 | 0.000 | 0.805 | 0.002 |
), ArticleFig(id=1322927291914924899, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 胃肠道不适 | 口苦 | 乏力 | 嗜睡 | 总不良反应 |
|---|
| 西药组 | 57 | 0（0.00） | 1（17.54） | 1（17.54） | 2（3.51） | 4（7.02） |
| 辨证组 | 57 | 2（3.51） | 1（17.54） | 0（0.00） | 0（0.00） | 3（5.26） |
| 矫正统计值 | | | | | | 0.000 |
| P值 | | | | | | 1.000 |
), ArticleFig(id=1322927292145611620, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927281815040810, language=CN, label=表5, caption=
两组心肾阳虚型失眠患者安全性比较
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| 组别 | 例数 | 胃肠道不适 | 口苦 | 乏力 | 嗜睡 | 总不良反应 |
|---|
| 西药组 | 57 | 0（0.00） | 1（17.54） | 1（17.54） | 2（3.51） | 4（7.02） |
| 辨证组 | 57 | 2（3.51） | 1（17.54） | 0（0.00） | 0（0.00） | 3（5.26） |
| 矫正统计值 | | | | | | 0.000 |
| P值 | | | | | | 1.000 |
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