Article(id=1322926397894828731, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.08.035, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339832042, onlineDateStr=2026-10-30, pubDate=1754755200000, pubDateStr=2025-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339832042, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339832042, creator=13701087609, updateTime=1793339832042, updator=13701087609, issue=Issue{id=1322926217711726961, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1754755200000', pubDateStr='2025-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339789083, creator='13701087609', updateTime=1793340517761, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929274071679978, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929274071679979, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=185, endPage=188, ext={EN=ArticleExt(id=1322926398104543932, articleId=1322926397894828731, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Shugan Jieyu Xiaopi Prescription（疏肝解郁消痞方）in Treatment of Functional Dyspepsia of Liver-Stomach Disharmony Syndrome Combined with Insomnia, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the clinical effect of Shugan Jieyu Xiaopi Prescription（疏肝解郁消痞方）in the treatment of functional dyspepsia（FD）of liver-stomach disharmony syndrome complicated with insomnia.
Methods A total of 96 patients with FD of liver-stomach disharmony syndrome combined with insomnia admitted to the hospital from August 2021 to August 2023 were selected and divided into observation group（48 cases）and control group（48 cases）according to random number table method.The control group was given routine intervention，the observation group combined Shugan Jieyu Xiaopi Prescription.The course of treatment in both groups was 1 month.The clinical effect of the two groups was compared.Before treatment and 1 month after treatment，traditional Chinese medicine（TCM）syndrome scores，Nipin dyspepsia Symptom Index（NDSI），Nipin dyspepsia Life Quality Index（NDLQI），Pittsburgh Sleep Quality Index（PSQI），gastrointestinal hormones［motilin（MLT），gastrin（GAS），ghrelin］，neurotransmitters［5-hydroxytryptamine（5-HT），norepinephrine（NE）γ-aminobutyric acid（GABA）］and inflammatory factors［interleukin-6（IL-6），tumor necrosis factor-α（TNF-α）］were recorded and compared between the two groups.The occurrence of adverse reactions in the two groups was recorded.
Results The total effective rate of observation group was significantly higher than that of control group（P<0.05）.After treatment，the TCM syndrome scores of both groups were significantly decreased（P<0.05），and the score of the observation group was significantly lower than that of the control group（P<0.05）.After treatment，NDSI and PSQI scores of both groups were significantly decreased，and the scores of the observation group were significantly lower than those of the control group（P<0.05）.NDLQI scores of both groups were increased，and the score of the observation group was significantly higher than that of the control group（P<0.05）.After treatment，the levels of MLT and GASwere significantly decreased in both groups，and the levels of the observation group were significantly lower than those of the control group（P<0.05），the levels of ghrelin were increased in both groups，and the level of the observation group was significantly higher than that of the control group（P<0.05）.After treatment，the levels of NE in both groups were significantly decreased，and the level of the observation group was significantly lower than that of the control group（P<0.05）.The levels of 5-HT and GABA in both groups were increased，and the levels of the observation group were significantly higher than those of the control group（P<0.05）.After treatment，the levels of IL-6 and TNF-αwere significantly decreased in both groups，and the levels of the observation group were significantly lower than those of the control group（P<0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（P>0.05）.
Conclusions Shugan Jieyu Xiaopi Prescription has a high efficacy in FD of liver-stomach disharmony syndrome complicated with insomnia.It can reduce the symptoms of patients，improve their sleep quality，gastrointestinal hormone and neurotransmitter levels，inhibit inflammation，and have a high safety.
, authors=Ruixing YUAN
1, Dingpeng HUANG
2, Peishan WENG
1, Peidong LYU
1, Xiaomin LU
1, authorsList=Ruixing YUAN, Dingpeng HUANG, Peishan WENG, Peidong LYU, Xiaomin LU, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322926400956670665, articleId=1322926397894828731, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=疏肝解郁消痞方在肝胃不和型功能性消化不良合并失眠治疗中的作用观察, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 探讨疏肝解郁消痞方治疗肝胃不和型功能性消化不良（Functional dyspepsia，FD）合并失眠患者的临床疗效。
方法 选择肝胃不和型FD合并失眠患者96例，按随机数字表法分为观察组与对照组，每组48例。对照组给予常规干预，观察组给予疏肝解郁消痞方联合治疗，两组疗程均为1个月。比较两组临床疗效；治疗前及治疗1个月后，记录比较两组中医证候评分、尼平消化不良症状指数（Nipin dyspepsia symptom index，NDSI）、尼平消化不良生活质量指数（Nipin dyspepsia life quality index，NDLQI）、匹兹堡睡眠质量指数（Pittsburgh Sleep Quality Index，PSQI）、胃肠激素［胃动素（Motilin，MLT）、胃泌素（Gastrin，GAS）、胃饥饿素（Ghrelin）］、神经递质［5-羟色胺（5-hydroxytryptamine，5-HT）、去甲肾上腺素（Norepinephrine，NE）、γ-氨基丁酸（γ-aminobutyric acid，GABA）］、炎症因子［白细胞介素-6（Interleukin-6，IL-6）、肿瘤坏死因子-α（Tumor necrosis factor-alpha，TNF-α）］；记录两组不良反应发生情况。
结果 观察组总有效率显著高于对照组（P<0.05）。治疗后，两组各中医证候评分均显著降低（P<0.05），且观察组显著低于对照组（P<0.05）。治疗后，两组NDSI、PSQI评分均显著降低，且观察组显著低于对照组（P<0.05），两组NDLQI评分均升高，且观察组显著高于对照组（P<0.05）。治疗后，两组MLT、GAS均显著降低，且观察组显著低于对照组（P<0.05），两组Ghrelin均升高，且观察组显著高于对照组（P<0.05）。治疗后，两组NE显著降低，且观察组显著低于对照组（P<0.05），两组5-HT、GABA均升高，且观察组显著高于对照组（P<0.05）。治疗后，两组IL-6、TNF-α显著降低，且观察组显著低于对照组（P<0.05）。两组不良反应总发生率比较差异无统计学意义（P>0.05）。
结论 疏肝解郁消痞方治疗肝胃不和型FD合并失眠有较好疗效，可减轻患者症状，改善其睡眠质量及胃肠激素、神经递质水平，抑制炎症，同时具有较高安全性。
, authors=袁瑞兴
1, 黄定鹏
2, 翁佩珊
1, 吕沛东
1, 卢晓敏
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袁瑞兴（1980-），女，广东东莞人，主任医师，硕士，研究方向：中医脾胃病。
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袁瑞兴（1980-），女，广东东莞人，主任医师，硕士，研究方向：中医脾胃病。
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中国药学杂志，
2019，
54（23）：1951-1957., articleTitle=沉香精油通过抑制p-STAT3和IL-1β/IL-6产生抗炎作用, refAbstract=null)], funds=[Fund(id=1322926404681212671, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, awardId=20222244, language=CN, fundingSource=广东省中医药局科研项目(20222244), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322926401216717514, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, xref=1., ext=[AuthorCompanyExt(id=1322926401225106123, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, companyId=1322926401216717514, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Dongguan Hospital of Guangzhou University of Chinese Medicine，Dongguan 523000，Guangdong，China), AuthorCompanyExt(id=1322926401246077644, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, companyId=1322926401216717514, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.东莞市中医院，广东 东莞 523000)]), AuthorCompany(id=1322926401325769421, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, xref=2., ext=[AuthorCompanyExt(id=1322926401329963726, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, companyId=1322926401325769421, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.General Hospital of Southern Theater Command，Guangzhou 510000，Guangdong，China), AuthorCompanyExt(id=1322926401342546639, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, companyId=1322926401325769421, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.南部战区总医院，广东 广州 510000)])], figs=[ArticleFig(id=1322926403397755633, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 痊愈 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 观察组 | 48 | 25（52.08） | 12（25.00） | 7（14.58） | 4（8.33） | 44（91.67） |
| 对照组 | 48 | 21（43.75） | 8（16.67） | 8（16.67） | 11（22.92） | 37（77.08） |
| χ2值 | | | | | | 3.872 |
| P值 | | | | | | 0.049 |
), ArticleFig(id=1322926403494224626, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=CN, label=表1, caption=
两组肝胃不和型功能性消化性不良合并失眠患者临床疗效比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 痊愈 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 观察组 | 48 | 25（52.08） | 12（25.00） | 7（14.58） | 4（8.33） | 44（91.67） |
| 对照组 | 48 | 21（43.75） | 8（16.67） | 8（16.67） | 11（22.92） | 37（77.08） |
| χ2值 | | | | | | 3.872 |
| P值 | | | | | | 0.049 |
), ArticleFig(id=1322926403561333491, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 胃脘痞满 | 喜太息 | 胁肋窜痛 | 食欲不振 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 4.91±1.25 | 1.74±0.54* | 4.75±1.31 | 1.53±0.49* | 2.52±0.85 | 0.86±0.26* | 2.73±0.72 | 0.95±0.31* |
| 对照组 | 48 | 5.02±1.32 | 2.16±0.67* | 4.89±1.37 | 1.98±0.62* | 2.64±0.87 | 1.24±0.38* | 2.81±0.83 | 1.37±0.44* |
| t值 | | 0.419 | 3.381 | 0.512 | 3.945 | 0.684 | 5.718 | 0.504 | 5.406 |
| P值 | | 0.676 | 0.001 | 0.610 | 0.000 | 0.496 | 0.000 | 0.615 | 0.000 |
), ArticleFig(id=1322926403641025268, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=CN, label=表2, caption=
两组肝胃不和型功能性消化性不良合并失眠患者治疗前后中医证候评分比较（
）
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| 组别 | 例数 | 胃脘痞满 | 喜太息 | 胁肋窜痛 | 食欲不振 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 4.91±1.25 | 1.74±0.54* | 4.75±1.31 | 1.53±0.49* | 2.52±0.85 | 0.86±0.26* | 2.73±0.72 | 0.95±0.31* |
| 对照组 | 48 | 5.02±1.32 | 2.16±0.67* | 4.89±1.37 | 1.98±0.62* | 2.64±0.87 | 1.24±0.38* | 2.81±0.83 | 1.37±0.44* |
| t值 | | 0.419 | 3.381 | 0.512 | 3.945 | 0.684 | 5.718 | 0.504 | 5.406 |
| P值 | | 0.676 | 0.001 | 0.610 | 0.000 | 0.496 | 0.000 | 0.615 | 0.000 |
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| 组别 | 例数 | NDSI | NDLQI | PSQI |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 49.42±13.85 | 23.71±6.22* | 59.06±6.45 | 81.65±3.07* | 13.17±1.34 | 7.49±1.03* |
| 对照组 | 48 | 50.08±15.07 | 28.92±8.54* | 60.11±7.16 | 76.04±5.33* | 13.46±1.23 | 9.74±1.12* |
| t值 | | 0.223 | 3.417 | 0.755 | 6.319 | 1.105 | 10.245 |
| P值 | | 0.824 | 0.001 | 0.452 | 0.000 | 0.272 | 0.000 |
), ArticleFig(id=1322926403796214518, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=CN, label=表3, caption=
两组肝胃不和型功能性消化性不良合并失眠患者治疗前后NDI、PSQI比较（
）
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| 组别 | 例数 | NDSI | NDLQI | PSQI |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 49.42±13.85 | 23.71±6.22* | 59.06±6.45 | 81.65±3.07* | 13.17±1.34 | 7.49±1.03* |
| 对照组 | 48 | 50.08±15.07 | 28.92±8.54* | 60.11±7.16 | 76.04±5.33* | 13.46±1.23 | 9.74±1.12* |
| t值 | | 0.223 | 3.417 | 0.755 | 6.319 | 1.105 | 10.245 |
| P值 | | 0.824 | 0.001 | 0.452 | 0.000 | 0.272 | 0.000 |
), ArticleFig(id=1322926403880100599, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | MTL/（μg/L） | GAS/（μg/L） | Ghrelin/（pg/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 9.91±2.31 | 5.58±1.74* | 9.65±2.46 | 5.76±1.81* | 84.26±4.82 | 107.85±3.64* |
| 对照组 | 48 | 9.83±2.35 | 7.62±2.14* | 9.76±2.51 | 7.87±2.25* | 83.11±4.07 | 96.91±2.81* |
| t值 | | 0.168 | 5.124 | 0.217 | 5.062 | 1.263 | 16.483 |
| P值 | | 0.867 | 0.000 | 0.829 | 0.000 | 0.210 | 0.000 |
), ArticleFig(id=1322926403997541112, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=CN, label=表4, caption=
两组肝胃不和型功能性消化性不良合并失眠患者治疗前后胃肠激素比较（
）
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| 组别 | 例数 | MTL/（μg/L） | GAS/（μg/L） | Ghrelin/（pg/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 9.91±2.31 | 5.58±1.74* | 9.65±2.46 | 5.76±1.81* | 84.26±4.82 | 107.85±3.64* |
| 对照组 | 48 | 9.83±2.35 | 7.62±2.14* | 9.76±2.51 | 7.87±2.25* | 83.11±4.07 | 96.91±2.81* |
| t值 | | 0.168 | 5.124 | 0.217 | 5.062 | 1.263 | 16.483 |
| P值 | | 0.867 | 0.000 | 0.829 | 0.000 | 0.210 | 0.000 |
), ArticleFig(id=1322926404085621497, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 5-HT/（ng/mL） | NE/（μg/L） | GABA/（ng/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 97.51±15.82 | 133.85±21.06* | 51.26±6.46 | 26.99±4.05* | 6.71±2.03 | 23.81±5.74* |
| 对照组 | 48 | 96.79±16.03 | 116.80±19.53* | 52.16±6.08 | 35.03±5.14* | 6.88±1.94 | 19.57±4.93* |
| t值 | | 0.221 | 4.113 | 0.703 | 8.512 | 0.419 | 3.882 |
| P值 | | 0.825 | 0.000 | 0.484 | 0.000 | 0.676 | 0.000 |
), ArticleFig(id=1322926404152730362, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=CN, label=表5, caption=
两组肝胃不和型功能性消化性不良合并失眠患者治疗前后神经递质比较（
）
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| 组别 | 例数 | 5-HT/（ng/mL） | NE/（μg/L） | GABA/（ng/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 97.51±15.82 | 133.85±21.06* | 51.26±6.46 | 26.99±4.05* | 6.71±2.03 | 23.81±5.74* |
| 对照组 | 48 | 96.79±16.03 | 116.80±19.53* | 52.16±6.08 | 35.03±5.14* | 6.88±1.94 | 19.57±4.93* |
| t值 | | 0.221 | 4.113 | 0.703 | 8.512 | 0.419 | 3.882 |
| P值 | | 0.825 | 0.000 | 0.484 | 0.000 | 0.676 | 0.000 |
), ArticleFig(id=1322926404232422139, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | IL-6 | TNF-α |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 96.49±6.51 | 61.15±4.37 | 85.52±7.99 | 47.65±4.43 |
| 对照组 | 48 | 97.23±6.77 | 75.81±5.62 | 86.38±8.14 | 67.12±6.95 |
| t值 | | 0.546 | 14.267 | 0.522 | 16.367 |
| P值 | | 0.587 | 0.000 | 0.603 | 0.000 |
), ArticleFig(id=1322926404337279740, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=CN, label=表6, caption=
两组肝胃不和型功能性消化性不良合并失眠患者治疗前后炎症因子比较（
）
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| 组别 | 例数 | IL-6 | TNF-α |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 48 | 96.49±6.51 | 61.15±4.37 | 85.52±7.99 | 47.65±4.43 |
| 对照组 | 48 | 97.23±6.77 | 75.81±5.62 | 86.38±8.14 | 67.12±6.95 |
| t值 | | 0.546 | 14.267 | 0.522 | 16.367 |
| P值 | | 0.587 | 0.000 | 0.603 | 0.000 |
), ArticleFig(id=1322926404500857597, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 恶心呕吐 | 头晕 | 口干 | 耳廓胀痛 | 总发生 |
|---|
| 观察组 | 48 | 3（6.25） | 1（2.08） | 1（2.08） | 2（4.17） | 7（14.58） |
| 对照组 | 48 | 0（0.00） | 1（2.08） | 0（0.00） | 2（4.17） | 3（6.25） |
| χ2值 | | | | | | 1.786 |
| P值 | | | | | | 0.181 |
), ArticleFig(id=1322926404567966462, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926397894828731, language=CN, label=表7, caption=
两组肝胃不和型功能性消化性不良合并失眠患者不良反应比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 恶心呕吐 | 头晕 | 口干 | 耳廓胀痛 | 总发生 |
|---|
| 观察组 | 48 | 3（6.25） | 1（2.08） | 1（2.08） | 2（4.17） | 7（14.58） |
| 对照组 | 48 | 0（0.00） | 1（2.08） | 0（0.00） | 2（4.17） | 3（6.25） |
| χ2值 | | | | | | 1.786 |
| P值 | | | | | | 0.181 |
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