Article(id=1322926366609514958, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.08.046, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339824582, onlineDateStr=2026-10-30, pubDate=1754755200000, pubDateStr=2025-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339824582, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339824582, creator=13701087609, updateTime=1793339824582, updator=13701087609, issue=Issue{id=1322926217711726961, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1754755200000', pubDateStr='2025-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339789083, creator='13701087609', updateTime=1793340517761, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929274071679978, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929274071679979, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=232, endPage=235, ext={EN=ArticleExt(id=1322926366798258639, articleId=1322926366609514958, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effects of Xiaoqinglong Decoction(小青龙汤)Combined with Glucocorticoid on Pulmonary Function and Levels of Serum TGF-β1 and Smad3 in Treatment of Bronchial Asthma, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the effects of Xiaoqinglong Decoction(小青龙汤)combined with glucocorticoids on pulmonary function and serum indexes in patients with bronchial asthma.

Methods

A total of 108 patients with bronchial asthma were selected and divided into two groups according to random number table method.The study group(54 cases)was treated with Xiaoqinglong Decoction combined with glucocorticoid,and the control group(54 cases)was treated with glucocorticoid.The clinical efficacy,TCM syndrome scores,lung function indexes[forced expiratory volume in first second(FEV1),forced vital capacity(FVC),forced expiratory flow at 50% of FVC exhaled(FEF50%),peak expiratory flow rate(PEF)],laboratory indexes[C-reactive protein(CRP),serum transforming growth faction-β1(TGF-β1),Cellular signal transduction molecules-3(Smad-3)]and adverse reactions of the two groups were compared.

Results

The total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the scores of cough,wheezing,sputum and headache in both groups were decreased(P<0.05),and the scores in the study group were lower than those in the control group(P<0.05).After treatment,the values of FEV1,FVC,FEF50% and PEF of the study group were increased(P<0.05),and the values of the study group were higher than those of the control group(P<0.05).After treatment,the levels of CRP,TGF-β1 and SAMad-3 in both groups were decreased(P<0.05),and the levels of in the study group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).

Conclusion

Xiaoqinglong Decoction combined with glucocorticoid therapy in patients with bronchial asthma can improve lung function indexes andreduce the levels of TGF-β1 and SAMAD-3,with good efficacy and safety.

, authors=Na REN, Jun WANG, Hong YU, Yongxin WANG, authorsList=Na REN, Jun WANG, Hong YU, Yongxin WANG, authorCompany=null, correspAuthors=Yongxin WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322926369398727128, articleId=1322926366609514958, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=小青龙汤联合糖皮质激素治疗支气管哮喘对肺功能及血清TGF-β1、Smad3水平的影响, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的

探讨小青龙汤联合糖皮质激素对支气管哮喘患者肺功能、血清指标的影响。

方法

选取支气管哮喘患者108例,按照随机数字表法分为两组,对照组54例采用糖皮质激素治疗,研究组54例采用小青龙汤联合糖皮质激素治疗,对比两组临床疗效、中医证候积分、肺功能指标[1秒呼吸容积(forced expiratory volume in first second,FEV1)、用力肺活量(forced vital capacity,FVC)、用力呼出一半肺活量的气流量(forced expiratory flow at 50% of FVC ex haled,FEF50%)、呼气时峰流量(peak expiratory flow,PEF)]、实验室指标[C反应蛋白(C-reactiveprotein,CRP)、血清转化生长因子-β1(transforming growth factor-β1,TGF-β1)、细胞信号转导分子3(cellular signal transduction molecules-3,Smad-3)]及不良反应。

结果

研究组总有效率高于对照组(P<0.05);治疗后两组咳嗽、喘息、咳痰、头痛评分均降低(P<0.05),且研究组咳嗽、喘息、咳痰、头痛评分均低于对照组(P<0.05);治疗后研究组FEV1、FVC、FEF50%、PEF均升高(P<0.05),且研究组FEV1、FVC、FEF50%、PEF均高于对照组(P<0.05);治疗后两组CRP、TGF-β1、Smad-3均降低(P<0.05),且研究组CRP、TGF-β1、Smad-3均低于对照组(P<0.05);两组不良反应发生率对比差异无统计学意义(P>0.05)。

结论

在支气管哮喘患者中应用小青龙汤联合糖皮质激素治疗能够改善肺功能指标,降低TGF-β1、Smad-3水平,具有良好疗效及安全性。

, authors=任娜, 王俊, 于红, 王永鑫, authorsList=任娜, 王俊, 于红, 王永鑫, authorCompany=null, correspAuthors=王永鑫, authorNote=

任娜(1982-),女,山东烟台人,主治医师,硕士,研究方向:心血管内科。

, correspAuthorsNote=
王永鑫(1984-),男,山东青岛人,副主任医师,学士,研究方向:急救医学。E-mail:。
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任娜(1982-),女,山东烟台人,主治医师,硕士,研究方向:心血管内科。

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任娜(1982-),女,山东烟台人,主治医师,硕士,研究方向:心血管内科。

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组别例数显效有效无效总有效
研究组5432(59.26)18(33.33)4(7.41)50(92.59)
对照组5417(31.48)25(46.30)12(22.22)42(77.78)
χ2值4.696
P值0.030
), ArticleFig(id=1322926371730760185, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926366609514958, language=CN, label=表1, caption=

两组支气管哮喘患者临床疗效对比

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组别例数显效有效无效总有效
研究组5432(59.26)18(33.33)4(7.41)50(92.59)
对照组5417(31.48)25(46.30)12(22.22)42(77.78)
χ2值4.696
P值0.030
), ArticleFig(id=1322926371810451962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926366609514958, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数咳嗽喘息咳痰头痛
治疗前治疗后治疗前治疗后治疗前治疗后治疗前治疗后
研究组544.58±0.251.35±0.16*4.28±0.321.28±0.28*4.03±0.511.04±0.30*3.56±0.520.85±0.23*
对照组544.49±0.301.90±0.22*4.35±0.281.68±0.23*4.10±0.451.58±0.35*3.50±0.461.24±0.27*
t值1.69414.8571.2108.1120.7568.6080.6358.080
P值0.0930.0000.2290.0000.4510.0000.5270.000
), ArticleFig(id=1322926371906920955, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926366609514958, language=CN, label=表2, caption=

两组支气管哮喘患者中医证候积分对比()

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组别例数咳嗽喘息咳痰头痛
治疗前治疗后治疗前治疗后治疗前治疗后治疗前治疗后
研究组544.58±0.251.35±0.16*4.28±0.321.28±0.28*4.03±0.511.04±0.30*3.56±0.520.85±0.23*
对照组544.49±0.301.90±0.22*4.35±0.281.68±0.23*4.10±0.451.58±0.35*3.50±0.461.24±0.27*
t值1.69414.8571.2108.1120.7568.6080.6358.080
P值0.0930.0000.2290.0000.4510.0000.5270.000
), ArticleFig(id=1322926372007584252, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926366609514958, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数FEV1/(L/s)FVC/(L)FEF50%/(%)PEF/(L/s)
治疗前治疗后治疗前治疗后治疗前治疗后治疗前治疗后
研究组540.82±0.261.72±0.52*1.02±0.201.79±0.36*2.15±0.293.52±0.47*1.68±0.363.50±0.63*
对照组540.80±0.231.40±0.38*1.06±0.191.56±0.27*2.20±0.313.02±0.31*1.70±0.322.96±0.46*
t值0.4233.6511.0663.7560.8666.5260.3055.087
P值0.6730.0000.2890.0000.3890.0000.7610.000
), ArticleFig(id=1322926373668528637, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926366609514958, language=CN, label=表3, caption=

两组支气管哮喘患者肺功能指标对比()

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组别例数FEV1/(L/s)FVC/(L)FEF50%/(%)PEF/(L/s)
治疗前治疗后治疗前治疗后治疗前治疗后治疗前治疗后
研究组540.82±0.261.72±0.52*1.02±0.201.79±0.36*2.15±0.293.52±0.47*1.68±0.363.50±0.63*
对照组540.80±0.231.40±0.38*1.06±0.191.56±0.27*2.20±0.313.02±0.31*1.70±0.322.96±0.46*
t值0.4233.6511.0663.7560.8666.5260.3055.087
P值0.6730.0000.2890.0000.3890.0000.7610.000
), ArticleFig(id=1322926373756609022, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926366609514958, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数CRP/(mg/L)TGF-β1/(μg/L)Smad-3/(μg/L)
治疗前治疗后治疗前治疗后治疗前治疗后
研究组5413.48±2.325.16±0.75*50.16±3.2322.12±1.57*235.42±7.58158.54±5.12*
对照组5413.19±2.108.25±0.83*50.30±3.0630.21±1.30*233.15±7.24169.35±5.29*
t值0.68120.2980.23129.1651.59110.790
P值0.4970.0000.8180.0000.1150.000
), ArticleFig(id=1322926373836300799, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926366609514958, language=CN, label=表4, caption=

两组支气管哮喘患者实验室指标对比()

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组别例数CRP/(mg/L)TGF-β1/(μg/L)Smad-3/(μg/L)
治疗前治疗后治疗前治疗后治疗前治疗后
研究组5413.48±2.325.16±0.75*50.16±3.2322.12±1.57*235.42±7.58158.54±5.12*
对照组5413.19±2.108.25±0.83*50.30±3.0630.21±1.30*233.15±7.24169.35±5.29*
t值0.68120.2980.23129.1651.59110.790
P值0.4970.0000.8180.0000.1150.000
), ArticleFig(id=1322926373895021056, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926366609514958, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数胃肠道反应肥胖低血钾总发生
研究组543(5.56)1(1.85)0(0.00)4(7.41)
对照组542(3.70)1(1.85)2(3.70)5(9.26)
χ2值0.121
P值0.728
), ArticleFig(id=1322926373962129921, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926366609514958, language=CN, label=表5, caption=

两组支气管哮喘患者不良反应对比

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组别例数胃肠道反应肥胖低血钾总发生
研究组543(5.56)1(1.85)0(0.00)4(7.41)
对照组542(3.70)1(1.85)2(3.70)5(9.26)
χ2值0.121
P值0.728
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小青龙汤联合糖皮质激素治疗支气管哮喘对肺功能及血清TGF-β1、Smad3水平的影响
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任娜 , 王俊 , 于红 , 王永鑫
中华中医药学刊 | 省级项目平台 2025,43(8): 232-235
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中华中医药学刊 |省级项目平台 2025 , 43 (8) : 232 -235
小青龙汤联合糖皮质激素治疗支气管哮喘对肺功能及血清TGF-β1、Smad3水平的影响
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任娜, 王俊, 于红, 王永鑫
作者信息
  • 青岛市中医医院,青岛市海慈医院,山东 青岛 266011
通讯作者:
王永鑫(1984-),男,山东青岛人,副主任医师,学士,研究方向:急救医学。E-mail:。
作者简介:

任娜(1982-),女,山东烟台人,主治医师,硕士,研究方向:心血管内科。

Effects of Xiaoqinglong Decoction(小青龙汤)Combined with Glucocorticoid on Pulmonary Function and Levels of Serum TGF-β1 and Smad3 in Treatment of Bronchial Asthma
Na REN, Jun WANG, Hong YU, Yongxin WANG
Affiliations
  • Qingdao Traditional Chinese Medicine Hospital(Qingdao Haici Hospital),Qingdao 266011,Shandong,China
出版时间: 2025-08-10 doi: 10.13193/j.issn.1673-7717.2025.08.046
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目的

探讨小青龙汤联合糖皮质激素对支气管哮喘患者肺功能、血清指标的影响。

方法

选取支气管哮喘患者108例,按照随机数字表法分为两组,对照组54例采用糖皮质激素治疗,研究组54例采用小青龙汤联合糖皮质激素治疗,对比两组临床疗效、中医证候积分、肺功能指标[1秒呼吸容积(forced expiratory volume in first second,FEV1)、用力肺活量(forced vital capacity,FVC)、用力呼出一半肺活量的气流量(forced expiratory flow at 50% of FVC ex haled,FEF50%)、呼气时峰流量(peak expiratory flow,PEF)]、实验室指标[C反应蛋白(C-reactiveprotein,CRP)、血清转化生长因子-β1(transforming growth factor-β1,TGF-β1)、细胞信号转导分子3(cellular signal transduction molecules-3,Smad-3)]及不良反应。

结果

研究组总有效率高于对照组(P<0.05);治疗后两组咳嗽、喘息、咳痰、头痛评分均降低(P<0.05),且研究组咳嗽、喘息、咳痰、头痛评分均低于对照组(P<0.05);治疗后研究组FEV1、FVC、FEF50%、PEF均升高(P<0.05),且研究组FEV1、FVC、FEF50%、PEF均高于对照组(P<0.05);治疗后两组CRP、TGF-β1、Smad-3均降低(P<0.05),且研究组CRP、TGF-β1、Smad-3均低于对照组(P<0.05);两组不良反应发生率对比差异无统计学意义(P>0.05)。

结论

在支气管哮喘患者中应用小青龙汤联合糖皮质激素治疗能够改善肺功能指标,降低TGF-β1、Smad-3水平,具有良好疗效及安全性。

支气管哮喘  /  小青龙汤  /  糖皮质激素  /  肺功能指标
Objective

To investigate the effects of Xiaoqinglong Decoction(小青龙汤)combined with glucocorticoids on pulmonary function and serum indexes in patients with bronchial asthma.

Methods

A total of 108 patients with bronchial asthma were selected and divided into two groups according to random number table method.The study group(54 cases)was treated with Xiaoqinglong Decoction combined with glucocorticoid,and the control group(54 cases)was treated with glucocorticoid.The clinical efficacy,TCM syndrome scores,lung function indexes[forced expiratory volume in first second(FEV1),forced vital capacity(FVC),forced expiratory flow at 50% of FVC exhaled(FEF50%),peak expiratory flow rate(PEF)],laboratory indexes[C-reactive protein(CRP),serum transforming growth faction-β1(TGF-β1),Cellular signal transduction molecules-3(Smad-3)]and adverse reactions of the two groups were compared.

Results

The total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the scores of cough,wheezing,sputum and headache in both groups were decreased(P<0.05),and the scores in the study group were lower than those in the control group(P<0.05).After treatment,the values of FEV1,FVC,FEF50% and PEF of the study group were increased(P<0.05),and the values of the study group were higher than those of the control group(P<0.05).After treatment,the levels of CRP,TGF-β1 and SAMad-3 in both groups were decreased(P<0.05),and the levels of in the study group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).

Conclusion

Xiaoqinglong Decoction combined with glucocorticoid therapy in patients with bronchial asthma can improve lung function indexes andreduce the levels of TGF-β1 and SAMAD-3,with good efficacy and safety.

bronchial asthma  /  Xiaoqinglong Decoction(小青龙汤)  /  glucocorticoid  /  pulmonary function index
任娜, 王俊, 于红, 王永鑫. 小青龙汤联合糖皮质激素治疗支气管哮喘对肺功能及血清TGF-β1、Smad3水平的影响. 中华中医药学刊, 2025 , 43 (8) : 232 -235 . DOI: 10.13193/j.issn.1673-7717.2025.08.046
Na REN, Jun WANG, Hong YU, Yongxin WANG. Effects of Xiaoqinglong Decoction(小青龙汤)Combined with Glucocorticoid on Pulmonary Function and Levels of Serum TGF-β1 and Smad3 in Treatment of Bronchial Asthma[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (8) : 232 -235 . DOI: 10.13193/j.issn.1673-7717.2025.08.046
支气管哮喘是以可逆气流受限为特征的慢性抑制性气道疾病,其发病基础在于炎症浸润的气道环境,可由多种因子相互影响作用,形成气道慢性炎症。中医认为本病病机在于外感风寒失于表散,凝而成寒痰,或由于饮食不当,内酿痰热,上感于肺,此外先天禀赋不足、久病成虚等也可致病,导致脏腑失调,变生痰浊[1-2]。在治疗上,西医常给予糖皮质激素以抗炎、抗过敏,且能够缓解气道高反应性,从而改善临床症状。中医则可给予中药对症治疗,标本兼治,祛痰理气,温化宣肺,以改善肺部功能[3]。小青龙汤为中医解表药方,具有辛温解表、温肺化饮之效,其组方中有效成分在哮喘相关疾病中能够发挥不同的作用,临床应用广泛[4]。本研究为了探讨小青龙汤联合糖皮质激素在支气管哮喘患者中的应用效果,于本院收治的108例患者中开展对照试验,具体内容如下。
在我院2022年1月—2023年1月收治的支气管哮喘患者中选取108例,样本量估计:结合既往报道,预估本次研究中观察组比对照组疗效好10%~15%,α=0.08,β=0.2,按照公式计算样本量:N=Z2×[P×(1-P)]÷E2,计算样本量108例。
纳入标准:(1)西医诊断符合《支气管哮喘防治指南》[5]中对支气管哮喘的诊断标准;(2)中医符合《中医内科常见病诊疗指南》[6]中肺气虚弱型,主症:哮喘声高气粗、呼吸深长、呼出为快,次证:咳嗽喘息、咳痰稀薄、形寒无汗、头痛、静脉怒张、口唇紫绀,舌脉:苔薄白、脉浮紧;(3)年龄>18岁;(4)对本研究知情并同意参与。
排除标准:(1)合并肝肾等脏器功能障碍;(2)合并免疫或凝血功能障碍;(2)对本研究用药有禁忌证;(4)近期使用激素或免疫制剂治疗;(5)精神异常。
入选患者按照随机数字表法分为两组,研究组54例,男28例,女26例,年龄25~60岁,平均(43.15±4.02)岁,病程1~8月,平均(5.21±1.14)月。对照组54例,男26例,女28例,年龄25~61岁,平均(43.54±4.13)岁,病程1~8月,平均(5.15±1.20)月。两组一般资料对比差异无统计学意义(P>0.05)。研究经院伦理委员会审核批准(批号〔2021〕伦审〔科〕第〔115〕号)。
两组均给予抗感染、吸氧、镇静、平衡酸碱等基础治疗,对照组给予布地奈德福莫特罗粉吸入剂[AstraZeneca AB(瑞典);国药准字H20140459;(80μg+4.5μg)×60吸],2吸/次,2次/d。研究组在对照组基础上给予小青龙汤,组方:炙麻黄12 g,桂枝12 g,炒白芍10 g,炙甘草6 g,细辛3 g,干姜6 g,姜半夏10 g,五味子6 g。饮片由上海药材公司提供,制作成浓度为1.6 g生药/mL的水煎液,1包/次,1次/d。两组均治疗2周。
(1)临床疗效。显效:咳嗽、喘息等症状及体征显著缓解,中医证候积分减少90%以上;有效:咳嗽、喘息等症状及体征改善,中医证候积分减少60%~90%;无效:症状、体征均无显著变化,未达上述标准。总有效率=显效率+有效率。(2)中医证候积分。按照《中药新药临床研究指导原则》[7]中证候评价标准进行评分,对咳嗽、喘息、咳痰、头痛几项进行评分,每项0~6分,得分越高,证候越严重。(3)肺功能指标。治疗前后采用肺功能检查仪(捷斯特肺功能测试仪;HI-801)测定患者1秒呼吸容积(forced expiratory volume in first second,FEV1)、用力呼出一半肺活量的气流量(forced expiratory flow at 50% of FVC ex haled,FEF50%)、呼气时峰流量(peak expiratory flow,PEF)、用力肺活量(forced vital capacity,FVC)。(4)实验室指标。治疗前后采集患者晨起空腹静脉血5 mL,离心取上清(3000 r/min,10 min),以酶联免疫吸附法检测C反应蛋白(C-reactiveprotein,CRP)、血清转化生长因子-β1(transforming growth factor-β1,TGF-β1)、细胞信号转导分子3(cellular signal transduction molecules-3,Smad-3)水平。(5)不良反应。观察两组治疗期间出现胃肠道反应、肥胖、低血钾的情况。
应用SPSS 22.0统计软件进行数据分析,计数资料以例(%)表示,组间比较行χ2检验;计量资料以均数±标准差()表示,组间比较采用t检验,P<0.05为差异有统计学意义。
研究组总有效率高于对照组(P<0.05),提示联合小青龙汤可增强疗效。见表1。
两组治疗前咳嗽、喘息、咳痰、头痛评分对比差异无统计学意义(P>0.05),治疗后两组咳嗽、喘息、咳痰、头痛评分均降低(P<0.05),且研究组咳嗽、喘息、咳痰、头痛评分均低于对照组(P<0.05),提示联合小青龙汤后,患者各项症状的改善情况更加显著。见表2。
两组治疗前FEV1、FVC、FEF50%、PEF对比差异无统计学意义(P>0.05),治疗后研究组FEV1、FVC、FEF50%、PEF均升高(P<0.05),且研究组FEV1、FVC、FEF50%、PEF均高于对照组(P<0.05),提示联合小青龙汤后,患者肺功能指标改善更为显著。见表3。
两组治疗前CRP、TGF-β1、Smad-3对比差异无统计学意义(P>0.05),治疗后两组CRP、TGFβ1、Smad-3均降低(P<0.05),且研究组CRP、TGF-β1、Smad-3均低于对照组(P<0.05),提示联合小青龙汤后患者相关血清学指标改善。见表4。
两组不良反应发生率对比差异无统计学意义(P>0.05),提示联合小青龙汤并未显著增加不良反应发生风险,总体安全可控。见表5。
支气管哮喘是临床常见呼吸道疾病,中医认为其发病与外部因素与内部因素皆有关,外部因素主要是气候、饮食、环境等,如寒温失调、烟尘、花粉等,内部因素包括体质、遗传、情志等[8]。本病患者病情一般迁延难愈,痰浊久留,正气衰弱,年轻患者病多在肺部,以实证为主,老年患者病多由肺转肾,由实证转为虚证,近年来研究发现,支气管哮喘除了痰饮内伏,还可与气郁、血瘀互为因果,导致经络不畅、血行不畅等,促进脏腑失调。对于本病的治疗,中医注重“急则治其标,缓则治其本”,从气、痰、瘀入手,给予利气、祛痰、化瘀,同时进行温肺、扶脾等[9-12]。小青龙汤是治疗外感风寒、寒饮内停喘咳的常用方,适用于支气管炎、支气管哮喘等呼吸道疾病。
本研究结果显示,研究组总有效率高于对照组,治疗后两组咳嗽、喘息、咳痰、头痛评分均降低,且研究组咳嗽、喘息、咳痰、头痛评分均低于对照组,提示糖皮质激素合并小青龙汤能够改善临床证候,疗效较好。糖皮质激素主要作用在于抗炎、免疫抑制、抗过敏,能够缓解气道炎症,从而缓解气道受到的刺激,改善相关症状[13]。小青龙汤组方中炙麻黄可发汗散寒、宣肺平喘、利水消肿;桂枝能够发表解肌、温经通脉、助阳化气;炒白芍养血调经、敛阴止汗;炙甘草补脾和胃、益气复脉;细辛祛风散寒、通窍止痛、温肺祛痰;干姜温中散寒、回阳通脉、燥湿消痰;姜半夏燥湿化痰、降逆止呕;五味子收敛固涩、益气生津、补肾宁心,全方共奏祛痰止咳、温肺解表之效,因此有助于显著改善患者临床证候[14-16]。
治疗后研究组FEV1、FVC、FEF50%、PEF均升高,且研究组FEV1、FVC、FEF50%、PEF均高于对照组,提示联合小青龙汤治疗有助于改善肺功能。临床经验显示,小青龙汤组方中的成分可通过不同途径发挥临床作用,药理研究证明炙麻黄对呼吸系统有平喘、镇咳、祛痰作用,提取出的麻黄碱能够刺激交感神经系统,能抑制组胺H1受体和释放缓释细胞的炎症介质,发挥镇痛、抗过敏、止咳等作用,有效保护肺部功能,促进病情恢复[17-19]。干姜能够增强心脏和肺功能,提高气体交换能力,从而改善喘气、气短等症状,提高肺功能[20]。
治疗后两组CRP、TGF-β1、Smad-3均降低,且研究组CRP、TGF-β1、Smad-3均低于对照组,提示小青龙汤有利于调节血清因子,降低炎症因子、细胞调节因子的水平。细辛能够增强脂质代谢,调节机体平滑肌功能,并且具有消炎镇痛、解热、抗组胺和抗变态反应的作用[21-22]。半夏中提取的多糖具有较强的网状内皮系统激活活性,能增强网状内皮系统吞噬功能和分泌作用,从而增强体内杀伤细胞活性,降低细胞病变能力[23-25]。两组不良反应发生率对比差异无统计学意义,提示联合小青龙汤具有良好的用药安全性。中药内服极少产生明显的不良反应,极少数患者可能表现为胃肠道反应,原因可能与自身胃肠功能有关,在临床应用中可严格控制用药禁忌及剂量,以避免严重的不良反应。
综上所述,在支气管哮喘患者中应用糖皮质激素联合小青龙汤治疗,能够改善肺功能,调节血清指标,临床疗效较好,安全性高,为支气管哮喘的治疗提供更多依据,后续应继续扩大样本量,并延长观察周期及增加观察项目,开展横纵向研究,从而获得更为可靠的结论。
  • 山东省中医药科技项目(Z-2023105)
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doi: 10.13193/j.issn.1673-7717.2025.08.046
  • 首发时间:2026-10-30
  • 出版时间:2025-08-10
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山东省中医药科技项目(Z-2023105)
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    青岛市中医医院,青岛市海慈医院,山东 青岛 266011

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王永鑫(1984-),男,山东青岛人,副主任医师,学士,研究方向:急救医学。E-mail:。
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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