Article(id=1322926027613274518, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.06.035, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339743760, onlineDateStr=2026-10-30, pubDate=1749484800000, pubDateStr=2025-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339743760, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339743760, creator=13701087609, updateTime=1793339743760, updator=13701087609, issue=Issue{id=1322923782029062261, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1749484800000', pubDateStr='2025-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339208371, creator='13701087609', updateTime=1793340556755, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929437859258468, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929437859258469, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=175, endPage=178, ext={EN=ArticleExt(id=1322926029240664472, articleId=1322926027613274518, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of TCM Syndrome Differentiation on Nasosinusitis Induced by Radiotherapy in Nasopharyngeal Carcinoma and Its Effect on hs-CRP，IL-17 and TNF-α, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To study the therapeutic effect of traditional Chinese medicine（TCM）on nasosinusitis induced by radiotherapy of nasopharyngeal carcinoma（NPC）and its effect on the indexes of hypersensitive C-reactive protein（hs-CRP），interleukin-17（IL-17）and tumor necrosis factor-α（TNF-α）.
Methods From December 2019 to November 2022，108 patients with nasosinusitis caused by radiotherapy of spleen-stomach deficiency，dampness-heat invading the upper syndrome and lung-stomach Yin deficiency and evil toxin retention syndrome were selected and divided into two groups according to different treatment methods.The patients in the routine treatment group were treated with saline rinse and roxithromycin orally.The TCM syndrome differentiation group was combined with TCM syndrome differentiation treatment on the basis of routine treatment and analyzed the clinical curative effect of the two groups after treatment.
Results The total effective rate was 96.30%（52/54）in the TCM syndrome differentiation group and 85.19% （46/54）in the routine treatment group.The total effective rate of the patients in the TCM syndrome differentiation group was higher than that in the routine treatment group（P<0.05）.The levels of hs-CRP，IL-17 and TNF-αin the two groups before treatment were compared between the two groups.The difference was not statistically significant（P>0.05）.After treatment，the levels of hs-CRP，IL-17 and TNF-αin TCM syndrome differentiation group were lower than those in the routine treatment group（P<0.05）.There was no significant difference in cilia transmission rate，Lund-Mackay score or pain score between two groups before treatment（P>0.05）.After treatment，the cilia transmission rate in the TCM syndrome differentiation group was（4.58±0.61）mm/min，higher than that in the routine treatment group.The Lund-Mackay score［（3.89±0.54）points］and the pain score［（1.14±0.75）points］in the TCM syndrome differentiation group were lower than those in the routine treatment group（P<0.05）.
Conclusion The treatment of nasosinusitis caused by radiotherapy of NPCby TCM syndrome differentiation can inhibit the expressions of inflammatory factors，improve the cilia transmission rate，alleviate the pain degree of patients and improve the therapeutic effect.
, authors=Yan LI, Hongyan WANG, Jun JIANG, Mei ZHANG, authorsList=Yan LI, Hongyan WANG, Jun JIANG, Mei ZHANG, authorCompany=null, correspAuthors=Mei ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322926037100790183, articleId=1322926027613274518, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=中医辨证治疗鼻咽癌放疗所致鼻窦炎疗效及对hs-CRP、IL-17、TNF-α指标的影响研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 研究中医辨证治疗鼻咽癌放疗所致鼻窦炎疗效及对超敏C反应蛋白（hypersensitivity C-reactive protein，hs-CRP）、白细胞介素-17（interleukin-17，IL-17）、肿瘤坏死因子-α（tumor Necrosis Factor-α，TNF-α）指标的影响。
方法 选取2019年12月—2022年11月收治的脾胃虚弱、湿热上犯型和肺胃阴虚、邪毒滞留型的鼻咽癌放疗所致鼻窦炎患者108例，根据治疗方法不同分为两组。常规治疗组54例给予生理盐水冲洗，口服罗红霉素治疗，中药辨证组54例在常规治疗组基础上联合中医辨证治疗，分析两组患者治疗后的临床疗效。
结果 中药辨证组总有效率为96.30%（52/54），常规治疗组为85.19%（46/54），中药辨证组患者总有效率高于常规治疗组（P<0.05）。两组治疗前hs-CRP、IL-17、TNF-α水平组间比较，差异无统计学意义（P>0.05）。中药辨证组治疗后hs-CRP、IL-17、TNF-α水平低于常规治疗组（P<0.05）。两组治疗前纤毛传输速率、Lund-Mackay评分、疼痛评分组间比较，差异无统计学意义（P>0.05）。中药辨证组治疗后纤毛传输速率（4.58±0.61）mm/min高于常规治疗组，Lund-Mackay评分（3.89±0.54）分、疼痛评分（1.14±0.75）分低于常规治疗组（P<0.05）。
结论 中医辨证治疗鼻咽癌放疗所致鼻窦炎可抑制炎症因子的表达，改善纤毛传输速率，减轻患者疼痛程度，提高治疗效果。
, authors=李俨, 汪红艳, 蒋俊, 张梅, authorsList=李俨, 汪红艳, 蒋俊, 张梅, authorCompany=null, correspAuthors=张梅, authorNote=
李俨（1988-），女，安徽合肥人，主治医师，博士，研究方向：头颈部肿瘤的放射治疗及相关不良反应的防治。
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李俨（1988-），女，安徽合肥人，主治医师，博士，研究方向：头颈部肿瘤的放射治疗及相关不良反应的防治。
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李俨（1988-），女，安徽合肥人，主治医师，博士，研究方向：头颈部肿瘤的放射治疗及相关不良反应的防治。
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| 组别 | 例数 | 痊愈 | 有效 | 无效 | 总有效 |
|---|
| 常规治疗组 | 54 | 31（57.41） | 15（27.78） | 8（14.81） | 46（85.19） |
| 中药辨证组 | 54 | 43（79.63） | 9（16.67） | 2（3.70） | 52（96.30） |
| χ2值 | | | | | 3.967 |
| P值 | | | | | 0.046 |
), ArticleFig(id=1322926046500225494, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926027613274518, language=CN, label=表1, caption=
两组鼻咽癌放疗所致鼻窦炎患者疗效比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 痊愈 | 有效 | 无效 | 总有效 |
|---|
| 常规治疗组 | 54 | 31（57.41） | 15（27.78） | 8（14.81） | 46（85.19） |
| 中药辨证组 | 54 | 43（79.63） | 9（16.67） | 2（3.70） | 52（96.30） |
| χ2值 | | | | | 3.967 |
| P值 | | | | | 0.046 |
), ArticleFig(id=1322926048454771160, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926027613274518, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | hs-CRP/（mg/L） | IL-17/（mg/L） | TNF-α/（pg/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 常规治疗组 | 54 | 16.21±3.85 | 10.56±3.11 | 14.55±2.88 | 5.28±1.21 | 192.33±36.85 | 120.67±25.11 |
| 中药辨证组 | 54 | 16.18±3.94 | 6.42±1.14 | 14.50±3.02 | 2.82±0.98 | 189.63±40.11 | 91.84±11.75 |
| t值 | | 0.040 | 9.185 | 0.088 | 11.610 | 0.364 | 7.642 |
| P值 | | 0.484 | 0.000 | 0.465 | 0.000 | 0.358 | 0.000 |
), ArticleFig(id=1322926048538657241, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926027613274518, language=CN, label=表2, caption=
两组鼻咽癌放疗所致鼻窦炎患者hs-CRP、IL-17、TNF-α水平比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | hs-CRP/（mg/L） | IL-17/（mg/L） | TNF-α/（pg/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 常规治疗组 | 54 | 16.21±3.85 | 10.56±3.11 | 14.55±2.88 | 5.28±1.21 | 192.33±36.85 | 120.67±25.11 |
| 中药辨证组 | 54 | 16.18±3.94 | 6.42±1.14 | 14.50±3.02 | 2.82±0.98 | 189.63±40.11 | 91.84±11.75 |
| t值 | | 0.040 | 9.185 | 0.088 | 11.610 | 0.364 | 7.642 |
| P值 | | 0.484 | 0.000 | 0.465 | 0.000 | 0.358 | 0.000 |
), ArticleFig(id=1322926048643514842, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926027613274518, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗前 | 治疗后 |
|---|
| 常规治疗组 | 54 | 2.80±0.40 | 3.89±0.47 |
| 中药辨证组 | 54 | 2.78±0.42 | 4.58±0.61 |
| t值 | | 0.253 | 6.584 |
| P值 | | 0.400 | 0.000 |
), ArticleFig(id=1322926048706429403, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926027613274518, language=CN, label=表3, caption=
两组鼻咽癌放疗所致鼻窦炎患者纤毛传输速率比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗前 | 治疗后 |
|---|
| 常规治疗组 | 54 | 2.80±0.40 | 3.89±0.47 |
| 中药辨证组 | 54 | 2.78±0.42 | 4.58±0.61 |
| t值 | | 0.253 | 6.584 |
| P值 | | 0.400 | 0.000 |
), ArticleFig(id=1322926050367373788, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926027613274518, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | Lund-Mackay评分 | 疼痛评分 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 常规治疗组 | 54 | 10.52±2.63 | 5.12±0.63 | 7.95±2.14 | 3.46±0.89 |
| 中药辨证组 | 54 | 10.55±2.59 | 3.89±0.54 | 8.02±2.06 | 1.14±0.75 |
| t值 | | 0.060 | 10.893 | 0.173 | 14.648 |
| P值 | | 0.476 | 0.000 | 0.431 | 0.000 |
), ArticleFig(id=1322926050610643421, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926027613274518, language=CN, label=表4, caption=
两组鼻咽癌放疗所致鼻窦炎患者Lund-Mackay评分、疼痛评分比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | Lund-Mackay评分 | 疼痛评分 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 常规治疗组 | 54 | 10.52±2.63 | 5.12±0.63 | 7.95±2.14 | 3.46±0.89 |
| 中药辨证组 | 54 | 10.55±2.59 | 3.89±0.54 | 8.02±2.06 | 1.14±0.75 |
| t值 | | 0.060 | 10.893 | 0.173 | 14.648 |
| P值 | | 0.476 | 0.000 | 0.431 | 0.000 |
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