Article(id=1322926012182438090, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.07.025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339740081, onlineDateStr=2026-10-30, pubDate=1752076800000, pubDateStr=2025-07-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339740081, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339740081, creator=13701087609, updateTime=1793339740081, updator=13701087609, issue=Issue{id=1322925862630339452, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='7', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1752076800000', pubDateStr='2025-07-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339704424, creator='13701087609', updateTime=1793340532184, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929334587105328, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929334587105329, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=114, endPage=120, ext={EN=ArticleExt(id=1322926012379570379, articleId=1322926012182438090, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Pharmacological Action and Mechanism of Cangzhu（Atractylodis Rhizoma）, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Cangzhu（Atractylodis Rhizoma）is a major traditional Chinese medicine commonly used in TCM clinical practice and has a long history of medicinal use. It has the effect of drying dampness and strengthening spleen，dispelling wind and dispelling cold，and brightening eyes. It is widely used in gastrointestinal diseases and rheumatic diseases，the clinical effect is remarkable. The main active ingredients are volatile oils，including atractyloketone，atractylotin，β-phylloalcohol and citronol. Atractylotin is one of the main efficacy components of Cangzhu（Atractylodis Rhizoma）. It is also an important index component for quality control of Cangzhu（Atractylodis Rhizoma）. Modern pharmacological studies have shown that atractylotin has anti-inflammatory，gastric emptying，anti-tumor，positive muscle strength，antibacterial，liver protection，heart protection，antioxidant activities. It has a wide range of anti-inflammatory effects and therapeutic effects on intestinal inflammation，arthritis，airway inflammation，pneumonia，etc. It can improve gastrointestinal function to strengthen spleen，inhibit the proliferation of bile duct cancer，liver cancer，breast cancer and lung cancer cells，and has significant antibacterial effect. The liver protection effect may be related to its antioxidant and anti-inflammatory activities，and it also has protective effects on the heart and nervous system. Atractylotin has a wide range of pharmacological effects and great potential for development and application. With further research，more and more pharmacological mechanisms will be elucidated，which will play an important role in promoting the development and utilization of atractylotin. The pharmacological action and mechanism of atractylotin were summarized in order to provide reference for its clinical application and new drug development.
, authors=Ping YANG, Xixiang LI, Wei SONG, Xuemei WANG, authorsList=Ping YANG, Xixiang LI, Wei SONG, Xuemei WANG, authorCompany=null, correspAuthors=Xixiang LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322926017362403554, articleId=1322926012182438090, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=苍术素药理作用及机制的研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
苍术为中医临床常用的大宗中药，药用历史悠久，具有燥湿健脾、祛风散寒、明目的功效，在胃肠道疾病、风湿性疾病中应用广泛，临床疗效显著。主要活性成分为挥发油类，包括苍术酮、苍术素、β-桉叶醇和茅术醇等。苍术素是苍术的主要药效成分之一，也是苍术药材质量控制的重要指标性成分。现代研究表明苍术素具有抗炎、促进胃排空、抗肿瘤、正性肌力、抗菌、保肝、心脏保护、抗氧化等多种药理活性。其抗炎作用广泛，对于肠道炎症、关节炎、气道炎症、肺炎等均有治疗作用，可改善胃肠功能以健脾，抑制胆管癌、肝癌、乳腺癌、肺癌细胞增殖，抑菌作用显著，保肝作用可能与其抗氧化和抗炎活性有关，对于心脏和神经系统也具有保护作用。因此，苍术素药理作用广泛，具有较大的开发应用潜力，随着对其进一步深入研究，越来越多的药理作用机制将会被阐明，对于苍术素的开发利用具有重要促进作用。通过对苍术素的药理作用及机制进行归纳总结，以期为其临床应用及新药开发提供参考。
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杨萍（1989-），女，甘肃白银人，主管中药师，硕士，研究方向：中药复方及配伍药效机制。
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杨萍（1989-），女，甘肃白银人，主管中药师，硕士，研究方向：中药复方及配伍药效机制。
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| 药理作用 | 剂量 | 实验对象 | 作用机制 | 文献 |
|---|
| 抗炎 | 50 μmol/L | HCT116细胞 | 抑制炎症因子表达及炎症相关信号通路 | ［7-8，10-11，14，17，19-21］ |
| 40 mg/kg | 小鼠 | |
| 20、40 μmol/L | RAW264.7细胞 | |
| 20 mg/kg | 小鼠 | | |
| 14 mg/kg | 小鼠 | | |
| 10 mg/kg | 大鼠 | | |
| 10、50、100 mg/kg | 人OA软骨细胞 | | |
| 20、40 mg/kg | 小鼠 | | |
| 40、80 mg/kg | 小鼠 | | |
| 100 μmol/L | A549细胞 | | |
| 30、90 mg/kg | 小鼠 | | |
| 10、20、50、100、200 μmol/L | NIH3T3细胞 | | |
| 促进胃排空 | 1、10、50 μmol/L | HGSMC细胞 | 激活GHSR促进胃排空，提高小肠推进比，调节胃肠动力起搏细胞表达改善胃肠运动 | ［23-25］ |
| 0.1、1、10 mg/kg | 小鼠 | |
| 0.1~0.3 mg/kg | 大鼠 | |
| 1.5、3、6 g/kg | 大鼠 | | |
| 抗肿瘤 | 50、250、500 μmol/L | CL-6细胞 | 调节肿瘤细胞中凋亡及自噬相关蛋白表达，抑制肿瘤细胞增殖、迁移和侵袭，调节细胞周期，诱导细胞凋亡及自噬 | ［28-30，32，36-38］ |
| 1.95~250 μg/mL | HuCCT-1细胞 |
| 20、40、80、160、320、640、1280 μmol/L | HuCCT1细胞 | |
| 5、10、20 μmol/L | Huh7，Hccm细胞 | | |
| 20、40、60、80、100 μmol/L | A549细胞 | | |
| 10、20、40 μmol/L | HCC827细胞 | | |
| 10、20、40、80 mg/L | A549细胞 | | |
| 正性肌力作用 | 3 mg/kg | 大鼠 | 作用于心肌中ghrelin受体，增强SERCA2a活性及肌浆网Ca2+含量促进SR Ca2+瞬时振幅 | ［40-41］ |
| 0.1、1、5、10 μmol/L | 大鼠 | |
| 3 mg/kg | 大鼠 | |
| 0.1、1、10 μmol/L | 大鼠左心室肌细胞 | | |
| 抗菌 | 30、60 mg/kg | 小鼠 | 通过上调Nrf2通路和抑制NLRP3炎性体激活阻断细菌生物膜形成及在宿主细胞中复制 | ［43］ |
| 4、8 μg/mL | 小鼠巨噬细胞样细胞系J774A.1 | |
| 保肝 | 20、40、80 mg/kg | 小鼠 | 通过调控nrf2介导的铁下垂抑制肝脏中炎症因子表达，调节血清氧化酶含量，减少肝脏氧化损伤，改善肝脏病理性损害 | ［46-47］ |
| 10、20、40 μmol/L | HepG2细胞 | |
| 40、80 mg/kg | 小鼠 | |
| 10~40 μmol/L | HepG2细胞 | | |
| 对心脏的保护作用 | 1000 mg/kg | 小鼠 | 激活GHSR-Sirt1通路调节SIRT1、IκB、p53蛋白表达，拮抗AngⅡ诱导的房颤易感性增强，保护心肌细胞及肌纤维 | ［49-50］ |
| 1 mg/kg | 小鼠 | |
| 抗氧化 | 20、40、80 μmol/L | 人足细胞 | 调控CAT、ROS、SOD等氧化酶的水平，减少细胞氧化应激损伤 | ［52-53］ |
| 20、40、80 μmol/L | 大鼠肾小球足细胞 | |
| 其他 | 100 μg/mL | 星形胶质细胞 | 增加嗅觉中NGF的表达来促进嗅觉神经元的再生；抑制脂肪酶生成；激活TRPA1通道产生镇痛作用 | ［54-56］ |
| 250、500 mg/kg | 小鼠 | |
| 5 μmol/L | HEK293细胞 | |
| 5 mg/kg | 大鼠 | | |
), ArticleFig(id=1322926029756571933, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926012182438090, language=CN, label=表1, caption=
苍术素的药理作用及机制
, figureFileSmall=null, figureFileBig=null, tableContent=
| 药理作用 | 剂量 | 实验对象 | 作用机制 | 文献 |
|---|
| 抗炎 | 50 μmol/L | HCT116细胞 | 抑制炎症因子表达及炎症相关信号通路 | ［7-8，10-11，14，17，19-21］ |
| 40 mg/kg | 小鼠 | |
| 20、40 μmol/L | RAW264.7细胞 | |
| 20 mg/kg | 小鼠 | | |
| 14 mg/kg | 小鼠 | | |
| 10 mg/kg | 大鼠 | | |
| 10、50、100 mg/kg | 人OA软骨细胞 | | |
| 20、40 mg/kg | 小鼠 | | |
| 40、80 mg/kg | 小鼠 | | |
| 100 μmol/L | A549细胞 | | |
| 30、90 mg/kg | 小鼠 | | |
| 10、20、50、100、200 μmol/L | NIH3T3细胞 | | |
| 促进胃排空 | 1、10、50 μmol/L | HGSMC细胞 | 激活GHSR促进胃排空，提高小肠推进比，调节胃肠动力起搏细胞表达改善胃肠运动 | ［23-25］ |
| 0.1、1、10 mg/kg | 小鼠 | |
| 0.1~0.3 mg/kg | 大鼠 | |
| 1.5、3、6 g/kg | 大鼠 | | |
| 抗肿瘤 | 50、250、500 μmol/L | CL-6细胞 | 调节肿瘤细胞中凋亡及自噬相关蛋白表达，抑制肿瘤细胞增殖、迁移和侵袭，调节细胞周期，诱导细胞凋亡及自噬 | ［28-30，32，36-38］ |
| 1.95~250 μg/mL | HuCCT-1细胞 |
| 20、40、80、160、320、640、1280 μmol/L | HuCCT1细胞 | |
| 5、10、20 μmol/L | Huh7，Hccm细胞 | | |
| 20、40、60、80、100 μmol/L | A549细胞 | | |
| 10、20、40 μmol/L | HCC827细胞 | | |
| 10、20、40、80 mg/L | A549细胞 | | |
| 正性肌力作用 | 3 mg/kg | 大鼠 | 作用于心肌中ghrelin受体，增强SERCA2a活性及肌浆网Ca2+含量促进SR Ca2+瞬时振幅 | ［40-41］ |
| 0.1、1、5、10 μmol/L | 大鼠 | |
| 3 mg/kg | 大鼠 | |
| 0.1、1、10 μmol/L | 大鼠左心室肌细胞 | | |
| 抗菌 | 30、60 mg/kg | 小鼠 | 通过上调Nrf2通路和抑制NLRP3炎性体激活阻断细菌生物膜形成及在宿主细胞中复制 | ［43］ |
| 4、8 μg/mL | 小鼠巨噬细胞样细胞系J774A.1 | |
| 保肝 | 20、40、80 mg/kg | 小鼠 | 通过调控nrf2介导的铁下垂抑制肝脏中炎症因子表达，调节血清氧化酶含量，减少肝脏氧化损伤，改善肝脏病理性损害 | ［46-47］ |
| 10、20、40 μmol/L | HepG2细胞 | |
| 40、80 mg/kg | 小鼠 | |
| 10~40 μmol/L | HepG2细胞 | | |
| 对心脏的保护作用 | 1000 mg/kg | 小鼠 | 激活GHSR-Sirt1通路调节SIRT1、IκB、p53蛋白表达，拮抗AngⅡ诱导的房颤易感性增强，保护心肌细胞及肌纤维 | ［49-50］ |
| 1 mg/kg | 小鼠 | |
| 抗氧化 | 20、40、80 μmol/L | 人足细胞 | 调控CAT、ROS、SOD等氧化酶的水平，减少细胞氧化应激损伤 | ［52-53］ |
| 20、40、80 μmol/L | 大鼠肾小球足细胞 | |
| 其他 | 100 μg/mL | 星形胶质细胞 | 增加嗅觉中NGF的表达来促进嗅觉神经元的再生；抑制脂肪酶生成；激活TRPA1通道产生镇痛作用 | ［54-56］ |
| 250、500 mg/kg | 小鼠 | |
| 5 μmol/L | HEK293细胞 | |
| 5 mg/kg | 大鼠 | | |
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