Article(id=1322925890174332972, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.07.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339710991, onlineDateStr=2026-10-30, pubDate=1752076800000, pubDateStr=2025-07-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339710991, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339710991, creator=13701087609, updateTime=1793339710991, updator=13701087609, issue=Issue{id=1322925862630339452, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='7', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1752076800000', pubDateStr='2025-07-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339704424, creator='13701087609', updateTime=1793340532184, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929334587105328, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929334587105329, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=26, endPage=28, ext={EN=ArticleExt(id=1322925890514071597, articleId=1322925890174332972, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Obesity Induced by High-Fat Diet on Reproductive Ability of Male Rats, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effect of high-fat diet induced obesity on the reproductive ability of male rats.
Method A high-fat diet was used to establish an obese rat model，and changes in sperm concentration，sperm motility，sperm morphology，sperm DNA fragmentation index（DNA fragmentation index，DFI）and testicular tissue pathology were observed in obese rats.
Result Compared with those of the blank group，the sperm motility，sperm morphology and DFI of the modeling group significantly decreased（P<0.05）. Compared with those of the blank group，there was no significant change in sperm concentration in the modeling group（P>0.05）. In the modeling group，there was interstitial edema and fewer interstitial cells compared to the blank group. The interstitial space between the seminiferous tubules widened，and the distance between spermatogonial cells increased. There was a significant decrease in various levels of spermatogenic cells and supporting cells，as well as a significant decrease in sperm cells in the lumen.
Conclusion The obesity induced by high fat diet can reduce the reproductive ability of male rats，especially in terms of sperm motility，sperm morphology，DFI and testicular tissue pathology.
, authors=Zhanmin LI, Zhi SUN, Tiejun LIU, Shilong HU, Yao XIAO, authorsList=Zhanmin LI, Zhi SUN, Tiejun LIU, Shilong HU, Yao XIAO, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322925895954083897, articleId=1322925890174332972, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=高脂饮食诱导肥胖对雄性大鼠生殖能力影响的研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探讨高脂饮食诱导肥胖对雄性大鼠生殖能力的影响。
方法 高脂饮食建立肥胖大鼠模型，观察肥胖大鼠精子浓度、精子活力、精子形态、精子碎片率指数（DFI）及睾丸组织病理学的变化。
结果 与空白组相比，造模组的精子活力、精子形态及精子碎片率指数显著下降，差异具有统计学意义（P<0.05）；与空白组相比，造模组的精子浓度无明显变化，差异无统计学意义（P>0.05）；病理学变化：造模组较空白组间质水肿、间质细胞减少，生精小管间隔增宽，精原细胞间距增大，各级生精细胞和支持细胞大量减少，管腔内精子细胞大量减少。
结论 高脂饮食诱导肥胖可降低雄性大鼠的生殖能力，尤其对精子活力、精子形态、精子碎片率指数及睾丸组织病理学等方面具有显著影响。
, authors=李湛民, 孙智, 刘铁军, 胡世隆, 肖尧, authorsList=李湛民, 孙智, 刘铁军, 胡世隆, 肖尧, authorCompany=null, correspAuthors=null, authorNote=
李湛民（1963-），男，辽宁沈阳人，主任医师、教授，博士，研究方向：中医药治疗男性不育症。
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李湛民（1963-），男，辽宁沈阳人，主任医师、教授，博士，研究方向：中医药治疗男性不育症。
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两组大鼠睾丸组织病理（HE染色）, figureFileSmall=IIu16T8Eg98RSMATl7Fv8A==, figureFileBig=WuvfSL+lmq8jGraYtJO8rg==, tableContent=null), ArticleFig(id=1322925903101177958, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925890174332972, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 浓度/（×106/mL） | 活力/（%） | 异常形态/（%） | DFI/（%） |
|---|
| 空白组 | 10 | 56.40±3.39 | 31.11±2.83 | 8.42±0.76 | 21.70±4.43 |
| 造模组 | 10 | 55.94±2.69 | 19.30±2.29 | 21.05±2.26 | 34.85±5.37 |
| t值 | | 0.335 | 10.260 | -16.742 | -5.975 |
| P值 | | >0.05 | <0.05 | <0.05 | <0.05 |
), ArticleFig(id=1322925903201841255, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925890174332972, language=CN, label=表1, caption=
两组大鼠精子浓度、精子活力、精子异常形态率、碎片率指数DFI比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 浓度/（×106/mL） | 活力/（%） | 异常形态/（%） | DFI/（%） |
|---|
| 空白组 | 10 | 56.40±3.39 | 31.11±2.83 | 8.42±0.76 | 21.70±4.43 |
| 造模组 | 10 | 55.94±2.69 | 19.30±2.29 | 21.05±2.26 | 34.85±5.37 |
| t值 | | 0.335 | 10.260 | -16.742 | -5.975 |
| P值 | | >0.05 | <0.05 | <0.05 | <0.05 |
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