Article(id=1322924175182143883, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.06.037, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339302105, onlineDateStr=2026-10-30, pubDate=1749484800000, pubDateStr=2025-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339302105, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339302105, creator=13701087609, updateTime=1793339302105, updator=13701087609, issue=Issue{id=1322923782029062261, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1749484800000', pubDateStr='2025-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339208371, creator='13701087609', updateTime=1793340556755, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929437859258468, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929437859258469, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=183, endPage=188, ext={EN=ArticleExt(id=1322924175366693260, articleId=1322924175182143883, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Exploring Mechanism of Intestinal Inflammation in Rats with Spleen Deficiency Treated with Acupuncture Based on LncRNA（UCA1）Regulation of miRNA-331/BRD4 Axis, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective The aim of this study is to investigate the regulatory mechanism of LncRNA（UCA1）on the miRNA-331-3p/bromine domain protein 4（BRD4）axis through acupuncture，in order to ameliorate colonic inflammation in rats with spleen deficiency.Additionally，this study seeks to explore the contemporary mechanism of“strengthening spleen and benefiting Qi”acupuncture therapy in improving symptoms of spleen deficiency and loose stools.
Methods Sixty male SD rats were randomly assigned to four groups：normal group，model group，non-meridian non-acupuncture group and acupuncture group，with 15 rats in each group.With the exception of the normal group，the remaining three groups were utilized to establish a rat model of spleen deficiency through the compound method of overwork and irregular diet.Following successful modeling，the acupuncture group re-ceived electro-acupuncture at“Zusanli（ST36）”and“Pishu（BL20）”，while the non-meridian non-acupuncture group was treated with electro-acupuncture at the tail tip as a control.The treatment was administered once daily for 20 minutes over a period of 14 days.After treatment，serum and colonic tissues were collected from the rats.The expressions of LncRNA（UCA1）and miRNA-331-3p/BRD4 axis-related genes in rat colon tissue were detected by qPCR.The contents of interleukin-1β（IL-1β）and interleukin-6（IL-6）in rat serum were detected by ELISA.The pathological morphological changes of rat colon tissue were observed by HE staining.The staining of BRD4 in colon was observed by immunohistochemistry method.The immunoactivities of IL-1β，IL-6，tumor necrosis factor-α（TNF-α）and NFκB p65 expression levels were detected by immunofluorescence histochemistry.The apoptosis in colon tissues of each group was detected by TUNEL staining.
Results Compared with those of the normal group，the expression levels of miRNA-331-3p in colon tissues of rats in the model group and non-meridian non-acupuncture group were significantly decreased（P<0.05），and the mRNA expression levels of LncRNA（UCA1），BRD4，nuclear factor kappa-B（NF-κB）p65，IL-1β，IL-6，IL-8 and TNF-αwere increased（P<0.05）.Compared with those of the model group，the expression levels of miRNA-331-3p in the colon tissue of rats were significantly increased（P<0.05）in the acupuncture group，and the mRNA expression levels of LncRNA（UCA1），BRD4，NF-κB p65，IL-1β，IL-6，IL-8 and TNF-αwere decreased（P<0.05）.Compared with those of the normal group，the expression levels of IL-1βand IL-6 in the serum of rats in the model group were significantly increased（P<0.05），and the expression levels of IL-1βand IL-6 in the colon tissue of rats in the acupuncture group were decreased（P<0.05）compared with those in the model group.Immunohistochemical results showed that the expression of BRD4 in the colon tissue of rats in the model group was increased compared with that in the normal group（P<0.05）.Compared with that in the model group，the expression of BRD4 in the acupuncture group was decreased（P<0.05）.The immunofluorescence histochemistry results showed that the mean absorbance values of IL-1β，IL-6，TNF-αand NF-κB p65 immunofluorescence in colon tissues of the model group and non-meridian non-acupuncture group were increased compared with those of the normal group（P<0.05）.Compared with those of the model group，the mean absorbance values of IL-1β，IL-6，TNF-αand NF-κB p65 immunofluorescence in colon tissues of rats in the acupuncture group were decreased（P<0.05）.In addition，HE staining results showed that acupuncture could effectively reduce inflammatory cell infiltration and loss of cupped cells in colonic mucosal tissues.TUNEL staining results showed that acupuncture could improve colonic inflammation and inhibit apoptosis of colonic mucosal cells in spleen deficiency rats.
Conclusion Electro-acupuncture at“Zusanli（ST36）”and“Pishu（BL20）”can interfere with the LncRNA（UCA1）regulating miRNA-331-3p/BRD4 axis，inhibit the expressions of intestinal inflammation and pro-inflammatory mediators，and then inhibit the apoptosis of colonic mucosal cells and improve the immunity of the body，thus improving the symptoms of spleen deficiency and loose stools.
, authors=Jidong LIU
1, 2, Jiahao ZANG
1, Jianbo WANG
1, 2, Yi QU
1, 2, Yanan XUE
1, 2, authorsList=Jidong LIU, Jiahao ZANG, Jianbo WANG, Yi QU, Yanan XUE, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322924178768273823, articleId=1322924175182143883, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=从LncRNA-UCA1探讨针刺调节miRNA-331-3p/BRD4轴改善脾虚大鼠肠道炎症作用机制, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 从长链非编码RNA尿路上皮癌相关基因1（LncRNA-UCA1）探讨针刺调节miRNA-331-3p/溴结构域蛋白4（BRD4）轴改善脾虚大鼠肠道炎症作用机制，探讨“健益脾气”针刺疗法改善脾虚便溏症状现代作用机制。
方法 将60只SD雄性大鼠以随机数字表法分为正常组、模型组、非经非穴组、针刺组，每组15只。除正常组外，其余3组采用劳倦过度和不规律饮食复合方法建立脾虚证大鼠模型。造模成功后，针刺组电针“足三里”穴及“脾俞”穴干预治疗，非经非穴组给予电针尾尖作为对照干预，每日1次/20 min，共治疗14 d。治疗结束后，取大鼠血清及结肠组织。qPCR法检测大鼠结肠组织LncRNA-UCA1、miRNA-331-3p/BRD4轴相关基因的表达；ELISA法检测大鼠血清中白介素-1β（IL-1β）、白细胞介素-6（IL-6）的含量；HE染色法观察大鼠结肠组织病理形态变化；免疫组化法观察结肠中BRD4、白细胞介素-8（IL-8）的表达情况；免疫荧光法观察IL-1β、IL-6、肿瘤坏死因子-α（TNF-α）及核因子-κBp65（NFκBp65）的表达水平；TUNEL染色法观察各组结肠组织凋亡情况。
结果 与正常组比较，模型组、非经非穴组大鼠结肠组织miRNA-331-3p的表达水平明显下降（P<0.05），LncRNA-UCA1、BRD4、NF-κB p65、IL-1β、IL-6、IL-8、TNF-α的mRNA表达水平有所升高（P<0.05）；与模型组比较，针刺组大鼠结肠组织miRNA-331-3p的表达水平明显升高（P<0.05），LncRNA-UCA1、BRD4、NF-κB p65、IL-1β、IL-6、IL-8、TNF-α的mRNA表达水平有所降低（P<0.05）。与正常组比较，模型组大鼠血清中促炎因子IL-1β、IL-6表达水平明显升高（P<0.05），与模型组比较，针刺组大鼠结肠组织中促炎因子IL-1β、IL-6的表达水平有所降低（P<0.05）。免疫组化法结果显示与正常组比较，模型组大鼠结肠组织BRD4、IL-8表达有所升高（P<0.05）；与模型组比较，针刺组的BRD4表达有所降低（P<0.05）。免疫荧光结果显示与正常组比较，模型组、非经非穴组结肠组织IL-1β、IL-6、TNF-α、NF-κB p65免疫荧光平均吸光度值升高（P<0.05）；与模型组比较，针刺组大鼠结肠组织中IL-1β、IL-6、TNF-α、NF-κB p65免疫荧光平均吸光度值降低（P<0.05）。另外HE染色结果显示，针刺治疗可有效减轻结肠黏膜组织中炎症细胞浸润和杯状细胞的损失；TUNEL染色结果显示，针刺治疗可以改善脾虚大鼠结肠炎症，抑制结肠黏膜细胞凋亡。
结论 电针“足三里”“脾俞”穴可以干预LncRNA-UCA1调节miRNA-331-3p/BRD4轴，抑制肠道炎症和促炎症介质的表达，进而抑制结肠黏膜细胞凋亡，提高机体免疫力，从而改善脾虚便溏症状。
, authors=刘继东
1, 2, 张家豪
1, 王建波
1, 2, 曲怡
1, 2, 薛亚楠
1, 2, authorsList=刘继东, 张家豪, 王建波, 曲怡, 薛亚楠, authorCompany=null, correspAuthors=null, authorNote=
刘继东（1976-），男（锡伯族），辽宁沈阳人，副教授，博士，研究方向：针灸作用机制。
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1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China
2.Key Laboratory of The Theory and Application of Viscera in Chinese Medicine，Ministry of Education，Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322924179586163115, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, authorId=1322924179418390951, language=CN, stringName=刘继东, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1.辽宁中医药大学，辽宁 沈阳 110847
2.辽宁中医药大学中医脏象理论及应用教育部重点实验室，辽宁 沈阳 110847, bio={"content":"
刘继东（1976-），男（锡伯族），辽宁沈阳人，副教授，博士，研究方向：针灸作用机制。
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刘继东（1976-），男（锡伯族），辽宁沈阳人，副教授，博士，研究方向：针灸作用机制。
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1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China
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1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China
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36（6）：54-57., articleTitle=淫羊藿及其活性成分防治骨质疏松症的研究进展, refAbstract=null)], funds=[Fund(id=1322924184627716584, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, awardId=LJKZ0886, language=CN, fundingSource=辽宁省教育厅高等学校基本科研项目(LJKZ0886), fundOrder=null, country=null), Fund(id=1322924184699019753, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, awardId=2021-MS-248, language=CN, fundingSource=辽宁省科学技术计划项目(2021-MS-248), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322924179233841568, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, xref=1., ext=[AuthorCompanyExt(id=1322924179242230177, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, companyId=1322924179233841568, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2.辽宁中医药大学中医脏象理论及应用教育部重点实验室，辽宁 沈阳 110847)])], figs=[ArticleFig(id=1322924182719308240, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=aFl25nWArN34dMlok2uuAQ==, figureFileBig=eGysvTSksHtzhRvl2dU/XQ==, tableContent=null), ArticleFig(id=1322924182790611409, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=图1, caption=
针刺对脾虚大鼠相关因子影响注：A.IL-1β表达水平；B.IL-6表达水平。*与正常组比较，P<0.05；＃与模型组比较，P<0.05。
, figureFileSmall=aFl25nWArN34dMlok2uuAQ==, figureFileBig=eGysvTSksHtzhRvl2dU/XQ==, tableContent=null), ArticleFig(id=1322924182991938002, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=02coWT6e0M/+KyY+VShhyQ==, figureFileBig=UDqVK7ITtvElcrp/waDDbw==, tableContent=null), ArticleFig(id=1322924183054852563, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=图2, caption=
各组大鼠肠黏膜组织病理观察（HE）, figureFileSmall=02coWT6e0M/+KyY+VShhyQ==, figureFileBig=UDqVK7ITtvElcrp/waDDbw==, tableContent=null), ArticleFig(id=1322924183126155732, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=SV3FAGAe264jjKYiMvgkGw==, figureFileBig=EJete70ImCf7xqs1+Z1bcA==, tableContent=null), ArticleFig(id=1322924183197458901, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=图3, caption=
各组大鼠结肠组织BRD4、IL-8的表达（400×）注：*与正常组比较，P<0.05；＃与模型组比较，P<0.05。
, figureFileSmall=SV3FAGAe264jjKYiMvgkGw==, figureFileBig=EJete70ImCf7xqs1+Z1bcA==, tableContent=null), ArticleFig(id=1322924183277150678, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=0QUBiU/CXEbbTKzvNCOiiw==, figureFileBig=A6F5Ym+yRnBOCQ6jJJHrFw==, tableContent=null), ArticleFig(id=1322924183352648151, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=图4, caption=
各组大鼠结肠组织IL-6、IL-1β免疫荧光染色图, figureFileSmall=0QUBiU/CXEbbTKzvNCOiiw==, figureFileBig=A6F5Ym+yRnBOCQ6jJJHrFw==, tableContent=null), ArticleFig(id=1322924183419757016, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=gEQhxUUsq3wYSsC9BveXCw==, figureFileBig=FnKgDccp3sjuLXp5PBTlHQ==, tableContent=null), ArticleFig(id=1322924183474282969, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=图5, caption=
各组大鼠结肠组织TNF-α、NF-κB p65免疫荧光染色图, figureFileSmall=gEQhxUUsq3wYSsC9BveXCw==, figureFileBig=FnKgDccp3sjuLXp5PBTlHQ==, tableContent=null), ArticleFig(id=1322924183537197530, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=Ki/NPceewz6Z4qzE1AJKFw==, figureFileBig=dncYEmn7wk15F4+xVaWT8A==, tableContent=null), ArticleFig(id=1322924183604306395, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=图6, caption=
各组大鼠结肠上皮黏膜细胞凋亡情况（200×）, figureFileSmall=Ki/NPceewz6Z4qzE1AJKFw==, figureFileBig=dncYEmn7wk15F4+xVaWT8A==, tableContent=null), ArticleFig(id=1322924183683998172, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 基因 | 引物序列（5′→3′） | 产物长度/bp |
|---|
| miRNA-331-3p | 上游：UCAUUUUACCCUCCACCAGGGGG | （加尾法） |
| LncRNA-UCA1 | 上游：GAGCCCTGTCCTTTGATG | 279 |
| 下游：GATAGACTGTGACCCGATA | |
| BRD4 | 上游：GAGGAAAGAAACAGGGACA | 77 |
| 下游：TCTGCGGAGAAGTTGATG | |
| NFκBp65 | 上游：ACAACTATGAGATGAACTCCGGG | 114 |
| 下游：GATAGCAGTGGGCTGTCTCC | |
| IL-6 | 上游：ATCAAGAGTCAACTGGCTCAACTCA | 142 |
| 下游：TGTTGGGCGCACATAGCTTATC | |
| IL-8 | 上游：CCCCCATGGTTCAGAAGATTG | 125 |
| 下游：TTGTCAGAAGCCAGCGTTCAC | |
| TNFα | 上游：CCACGCTCTTCTGTCTACTG | 145 |
| 下游：GCTACGGGCTTGTCACTC | |
| IL-1β | 上游：TGTGATGTTCCCATTAGAC | 131 |
| 下游：AATACCACTTGTTGGCTTA | |
| β-actin | 上游：CCTCTATGCCAACACAGT | 155 |
| 下游：AGCCACCAATCCACACAG | |
), ArticleFig(id=1322924183751107037, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=表1, caption=
引物序列
, figureFileSmall=null, figureFileBig=null, tableContent=
| 基因 | 引物序列（5′→3′） | 产物长度/bp |
|---|
| miRNA-331-3p | 上游：UCAUUUUACCCUCCACCAGGGGG | （加尾法） |
| LncRNA-UCA1 | 上游：GAGCCCTGTCCTTTGATG | 279 |
| 下游：GATAGACTGTGACCCGATA | |
| BRD4 | 上游：GAGGAAAGAAACAGGGACA | 77 |
| 下游：TCTGCGGAGAAGTTGATG | |
| NFκBp65 | 上游：ACAACTATGAGATGAACTCCGGG | 114 |
| 下游：GATAGCAGTGGGCTGTCTCC | |
| IL-6 | 上游：ATCAAGAGTCAACTGGCTCAACTCA | 142 |
| 下游：TGTTGGGCGCACATAGCTTATC | |
| IL-8 | 上游：CCCCCATGGTTCAGAAGATTG | 125 |
| 下游：TTGTCAGAAGCCAGCGTTCAC | |
| TNFα | 上游：CCACGCTCTTCTGTCTACTG | 145 |
| 下游：GCTACGGGCTTGTCACTC | |
| IL-1β | 上游：TGTGATGTTCCCATTAGAC | 131 |
| 下游：AATACCACTTGTTGGCTTA | |
| β-actin | 上游：CCTCTATGCCAACACAGT | 155 |
| 下游：AGCCACCAATCCACACAG | |
), ArticleFig(id=1322924183830798814, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 造模前体质量 | 治疗前体质量 | 治疗后体质量 |
|---|
| 正常组 | 15 | 215.40±6.69 | 402.20±17.76 | 483.40±29.62 |
| 模型组 | 15 | 212.40±6.77 | 181.80±5.26* | 223.00±12.53* |
| 非经非穴组 | 15 | 217.20±4.77 | 185.20±13.77* | 236.60±9.99* |
| 针刺组 | 15 | 211.60±7.77 | 194.40±13.24* | 284.00±10.93*# |
), ArticleFig(id=1322924183902101983, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=表2, caption=
各组大鼠体质量比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 造模前体质量 | 治疗前体质量 | 治疗后体质量 |
|---|
| 正常组 | 15 | 215.40±6.69 | 402.20±17.76 | 483.40±29.62 |
| 模型组 | 15 | 212.40±6.77 | 181.80±5.26* | 223.00±12.53* |
| 非经非穴组 | 15 | 217.20±4.77 | 185.20±13.77* | 236.60±9.99* |
| 针刺组 | 15 | 211.60±7.77 | 194.40±13.24* | 284.00±10.93*# |
), ArticleFig(id=1322924183985988064, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 造模前抓力/（N） | 治疗前抓力/（N） | 治疗后抓力/（N） | 结肠长度/（cm） |
|---|
| 正常组 | 15 | 887.40±27.37 | 1020.10±68.12 | 1278.00±22.31 | 8.88±0.34* |
| 模型组 | 15 | 874.00±19.65 | 798.20±23.91* | 807.00±54.14* | 7.30±0.42* |
| 非经非穴组 | 15 | 891.80±25.58 | 775.40±45.32* | 785.40±26.47* | 7.43±0.57*# |
| 针刺组 | 15 | 893.40±16.89 | 803.40±36.86* | 869.40±23.45*# | 8.08±0.15 |
), ArticleFig(id=1322924184061485537, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=表3, caption=
各组大鼠抓力及结肠长度比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 造模前抓力/（N） | 治疗前抓力/（N） | 治疗后抓力/（N） | 结肠长度/（cm） |
|---|
| 正常组 | 15 | 887.40±27.37 | 1020.10±68.12 | 1278.00±22.31 | 8.88±0.34* |
| 模型组 | 15 | 874.00±19.65 | 798.20±23.91* | 807.00±54.14* | 7.30±0.42* |
| 非经非穴组 | 15 | 891.80±25.58 | 775.40±45.32* | 785.40±26.47* | 7.43±0.57*# |
| 针刺组 | 15 | 893.40±16.89 | 803.40±36.86* | 869.40±23.45*# | 8.08±0.15 |
), ArticleFig(id=1322924184136983010, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | miRNA-331-3p | UCA1 | BRD4 | NFκB P65 |
|---|
| 正常组 | 15 | 1.00±0.00 | 1.00±0.00 | 1.00±0.00 | 1.00±0.00 |
| 模型组 | 15 | 0.68±0.32* | 1.80±0.12* | 2.02±0.38* | 1.97±0.25* |
| 非经非穴组 | 15 | 0.70±0.59* | 1.88±0.11* | 2.13±0.49* | 1.97±0.24* |
| 针刺组 | 15 | 0.87±0.95*# | 1.30±0.11*# | 1.41±0.80# | 1.37±0.19# |
), ArticleFig(id=1322924184220869091, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=表4, caption=
针刺对脾虚大鼠UCA1及miRNA-331-3p/BRD4轴mRNA表达影响
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | miRNA-331-3p | UCA1 | BRD4 | NFκB P65 |
|---|
| 正常组 | 15 | 1.00±0.00 | 1.00±0.00 | 1.00±0.00 | 1.00±0.00 |
| 模型组 | 15 | 0.68±0.32* | 1.80±0.12* | 2.02±0.38* | 1.97±0.25* |
| 非经非穴组 | 15 | 0.70±0.59* | 1.88±0.11* | 2.13±0.49* | 1.97±0.24* |
| 针刺组 | 15 | 0.87±0.95*# | 1.30±0.11*# | 1.41±0.80# | 1.37±0.19# |
), ArticleFig(id=1322924184308949476, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | IL-1β mRNA | IL-6 mRNA | IL-8 mRNA | TNF-αmRNA |
|---|
| 正常组 | 15 | 1.00±0.00 | 1.00±0.00 | 1.00±0.00 | 1.00±0.00 |
| 模型组 | 15 | 2.22±0.54* | 1.39±0.22* | 2.10±0.55* | 1.88±0.23* |
| 非经非穴组 | 15 | 1.81±0.25* | 1.34±0.16* | 1.86±0.10* | 1.43±0.20*# |
| 针刺组 | 15 | 1.42±0.19# | 0.97±0.16# | 1.19±0.30# | 1.14±0.27# |
), ArticleFig(id=1322924184376058341, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=表5, caption=
针刺对脾虚大鼠IL-1β、IL-6、IL-8、TNF-α的mRNA表达影响（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | IL-1β mRNA | IL-6 mRNA | IL-8 mRNA | TNF-αmRNA |
|---|
| 正常组 | 15 | 1.00±0.00 | 1.00±0.00 | 1.00±0.00 | 1.00±0.00 |
| 模型组 | 15 | 2.22±0.54* | 1.39±0.22* | 2.10±0.55* | 1.88±0.23* |
| 非经非穴组 | 15 | 1.81±0.25* | 1.34±0.16* | 1.86±0.10* | 1.43±0.20*# |
| 针刺组 | 15 | 1.42±0.19# | 0.97±0.16# | 1.19±0.30# | 1.14±0.27# |
), ArticleFig(id=1322924184443167206, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | IL-1β | IL-6 | TNF-α | NFκB P65 |
|---|
| 正常组 | 15 | 102.90±2.52 | 98.34±4.80 | 105.44±2.14 | 87.58±3.05 |
| 模型组 | 15 | 131.89±6.14* | 146.54±3.66* | 135.30±2.38* | 120.96±4.54* |
| 非经非穴组 | 15 | 128.25±9.64* | 148.83±6.58* | 131.57±2.56* | 111.51±2.80*# |
| 针刺组 | 15 | 113.54±3.76# | 124.41±3.78*# | 115.86±2.60*# | 98.42±4.28*# |
), ArticleFig(id=1322924184514470375, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322924175182143883, language=CN, label=表6, caption=
各组大鼠中IL-1β、IL-6、TNF-α及NF-κB p65平均荧光强度比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | IL-1β | IL-6 | TNF-α | NFκB P65 |
|---|
| 正常组 | 15 | 102.90±2.52 | 98.34±4.80 | 105.44±2.14 | 87.58±3.05 |
| 模型组 | 15 | 131.89±6.14* | 146.54±3.66* | 135.30±2.38* | 120.96±4.54* |
| 非经非穴组 | 15 | 128.25±9.64* | 148.83±6.58* | 131.57±2.56* | 111.51±2.80*# |
| 针刺组 | 15 | 113.54±3.76# | 124.41±3.78*# | 115.86±2.60*# | 98.42±4.28*# |
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