Article(id=1322923961163591891, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.06.040, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339251079, onlineDateStr=2026-10-30, pubDate=1749484800000, pubDateStr=2025-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339251079, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339251079, creator=13701087609, updateTime=1793339251079, updator=13701087609, issue=Issue{id=1322923782029062261, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1749484800000', pubDateStr='2025-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339208371, creator='13701087609', updateTime=1793340556755, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929437859258468, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929437859258469, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=196, endPage=199, ext={EN=ArticleExt(id=1322923961360724180, articleId=1322923961163591891, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Modified Dachaihu Decoction（大柴胡汤加味）Combined with Pioglitazone on Improving Vascular Endothelial Function in Patients with Type 2 Diabetes Mellitus, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the clinical effect of Modified Dachaihu Decoction（大柴胡汤加味）combined with pioglitazone in the treatment of type 2 diabetes mellitus and its influence on vascular endothelial function.
Methods A total of 114 patients with type 2 diabetes mellitus admitted from January 2022 to June 2023 were included in the study.The patients were divided into single drug group and combined traditional Chinese medicine group by random number table method，with 57 cases in each group.The patients in the single drug group were treated with pioglitazone，while those in the combined traditional Chinese medicine group were treated with pioglitazone combined with Modified Dachaihu Decoction.One case fell off in the combined traditional Chinese medicine group，and the data of each group was compared，including efficacy，blood glucose indexes such as glycosylated hemoglobin（HbAlc），fasting blood glucose（FPG）and 2 hours postprandial blood glucose（2 h PG）before and after treatment，changes in TCM syndrome scores，oxidative stress indexes such as malonaldehyde（MDA），superoxide dismutase（SOD），glutathione peroxidase（GSH-Px）and hemodynamic indexes such as early reverse diastolic blood flow peak velocity（PRV），systolic peak velocity（PSV），end-diastolic blood flow velocity（EDV）and arterial pulse index（PI），and adverse reactions.
Results The therapeutic effect of combined traditional Chinese medicine group was better than that of single drug group（P<0.05）.The levels of HbAlc，FPG and 2 h PG，TCM syndrome scores，the levels of MDA，SOD and GSH-Px，the values of PRV，PSV，EDV and PI and other indexes were not significant in two groups before treatment（P>0.05）.After treatment，The levels of HbAlc，FPG and 2 h PG，TCM syndrome scores，the levels of MDA，SOD and GSH-Px，the values of PRV，PSV，EDV and PI and other indexes were improved in both groups.The levels of HbAlc，FPG and 2 h PG，TCM syndrome scores，the levels of MDA，SOD and GSH-Px，and the values of PRV，PSV，EDV and PIin the combined traditional Chinese medicine group were better than those in the single drug group（P<0.05）.The adverse reaction rate of the combined traditional Chinese medicine group and single drug group was lower（P>0.05）.
Conclusion Modified Dachaihu Decoction combined with pioglitazone has significant clinical effect in the treatment of type2 diabetes mellitus，which can effectively reduce the blood sugar level of patients and improve clinical symptoms and hemodynamics of patients，and the treatment has fewer adverse reactions，which is relatively safe.
, authors=Xin ZHOU, Quan WEN, Jingjing HU, Jing ZHAO, authorsList=Xin ZHOU, Quan WEN, Jingjing HU, Jing ZHAO, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322923964007330013, articleId=1322923961163591891, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=大柴胡汤加味联合吡格列酮在改善2型糖尿病患者血管内皮功能指标的作用研究, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 探讨大柴胡汤加味联合吡格列酮治疗2型糖尿病的临床效果以及对患者血管内皮功能等指标的影响。
方法 研究总计纳入2型糖尿病患者114例（2022年1月—2023年6月收治），以随机数字表法将患者分为单药组与联合中药组，各组57例，单药组患者采取吡格列酮治疗，联合中药组患者采取吡格列酮结合大柴胡汤加味治疗，研究过程中单药组脱落2例，联合中药组脱落1例，比较各组患者数据：疗效、治疗前后糖化血红蛋白（glycosylated hemoglobin，HbAlc）、空腹血糖（fasting blood glucose，FPG）与餐后2 h血糖（2 hours postprandial blood glucose，2 h PG）等血糖指标变化及中医证候积分变化、丙二醛（malonaldehyde，MDA）及超氧化物歧化酶（superoxide dismutase，SOD）、谷胱甘肽过氧化物酶（glutathione peroxidase，GSH-Px）等氧化应激指标与舒张早期反向血流峰值速度（PRV）、收缩期峰值流速（PSV）、舒张末期血流速度（EDV）、动脉搏动指数（PI）等血流动力学指标变化、不良反应。
结果 联合中药组治疗效果优于单药组，P<0.05；治疗前各组患者HbAlc、FPG、2 h PG、中医证候积分、MDA、SOD、GSH-Px、PRV、PSV、EDV、PI等指标比较，P>0.05，治疗后各组患者HbAlc、FPG、2 h PG、中医证候积分、MDA、SOD、GSH-Px、PRV、PSV、EDV、PI等指标均改善，而联合中药组治疗后HbAlc、FPG、2 h PG、中医症候积分、MDA、SOD、GSH-Px、PRV、PSV、EDV、PI等指标均优于单药组，P<0.05；联合中药组与单药组不良反应率均较低，P>0.05。
结论 大柴胡汤加味联合吡格列酮治疗2型糖尿病的临床效果显著，可较好降低患者血糖水平，改善患者临床症状、血流动力学情况，且治疗不良反应少，较为安全。
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周鑫（1984-），女，安徽肥西人，副主任中医师，硕士，研究方向：中医内科。
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世界科学技术-中医药现代化，
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25（2）：813-819., articleTitle=2型糖尿病患者中医主证脉诊客观参数分析, refAbstract=null), Reference(id=1322923969384427794, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=41, issue=3, pageStart=138, pageEnd=141, url=null, language=null, rfNumber=［5］, rfOrder=4, authorNames=董丽仙, 尹爱武, 李灿委, journalName=中华中医药学刊, refType=null, unstructuredReference=董丽仙，尹爱武，李灿委，
等. 肠道菌群与2型糖尿病及中医药干预研究进展［J］.
中华中医药学刊，
2023，
41（3）：138-141., articleTitle=肠道菌群与2型糖尿病及中医药干预研究进展, refAbstract=null), Reference(id=1322923969464119571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=37, issue=2, pageStart=28, pageEnd=34, url=null, language=null, rfNumber=［6］, rfOrder=5, authorNames=陶乐维, 张一乐, 陆灏, journalName=上海中医药大学学报, refType=null, unstructuredReference=陶乐维，张一乐，陆灏，
等. 2型糖尿病合并新型冠状病毒奥密克戎变异株感染轻症患者出院时的中医症状特征及荆银固表方干预疗效［J］.
上海中医药大学学报，
2023，
37（2）：28-34., articleTitle=2型糖尿病合并新型冠状病毒奥密克戎变异株感染轻症患者出院时的中医症状特征及荆银固表方干预疗效, refAbstract=null), Reference(id=1322923969531228436, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=43, issue=2, pageStart=227, pageEnd=231, url=null, language=null, rfNumber=［7］, rfOrder=6, authorNames=夏城东, journalName=中国中西医结合杂志, refType=null, unstructuredReference=夏城东. 中医药治疗2型糖尿病临床疗效评价方法的思考［J］.
中国中西医结合杂志，
2023，
43（2）：227-231., articleTitle=中医药治疗2型糖尿病临床疗效评价方法的思考, refAbstract=null), Reference(id=1322923969598337301, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=43, issue=2, pageStart=137, pageEnd=142, url=null, language=null, rfNumber=［8］, rfOrder=7, authorNames=刘藜, 丁小燕, 刘晓林, journalName=中国中西医结合杂志, refType=null, unstructuredReference=刘藜，丁小燕，刘晓林，
等. 2型糖尿病患者中医证型与血清代谢学指标相关性研究［J］.
中国中西医结合杂志，
2023，
43（2）：137-142., articleTitle=2型糖尿病患者中医证型与血清代谢学指标相关性研究, refAbstract=null), Reference(id=1322923969657057558, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=25, issue=3, pageStart=58, pageEnd=65, url=null, language=null, rfNumber=［9］, rfOrder=8, authorNames=陈弘东, 王耀献, 刘伟敬, journalName=辽宁中医药大学学报, refType=null, unstructuredReference=陈弘东，王耀献，刘伟敬，
等. 2型糖尿病合并肥胖中医证素特点研究［J］.
辽宁中医药大学学报，
2023，
25（3）：58-65., articleTitle=2型糖尿病合并肥胖中医证素特点研究, refAbstract=null), Reference(id=1322923969715777815, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=18, issue=5, pageStart=739, pageEnd=null, url=null, language=null, rfNumber=［10］, rfOrder=9, authorNames=李思, 吴梅芳, 王军锋, journalName=世界中医药, refType=null, unstructuredReference=李思，吴梅芳，王军锋，
等. 中西医结合治疗2型糖尿病合并代谢综合征的临床价值分析——评《代谢综合征中医诊断与治疗》［J］.
世界中医药，
2023，
18（5）：739., articleTitle=中西医结合治疗2型糖尿病合并代谢综合征的临床价值分析——评《代谢综合征中医诊断与治疗》, refAbstract=null), Reference(id=1322923969778692376, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=37, issue=2, pageStart=116, pageEnd=118，127, url=null, language=null, rfNumber=［11］, rfOrder=10, authorNames=缪卫红, journalName=实用老年医学, refType=null, unstructuredReference=缪卫红. 2型糖尿病的中医治疗研究进展［J］.
实用老年医学，
2023，
37（2）：116-118，127., articleTitle=2型糖尿病的中医治疗研究进展, refAbstract=null), Reference(id=1322923969854189849, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=25, issue=2, pageStart=201, pageEnd=204, url=null, language=null, rfNumber=［12］, rfOrder=11, authorNames=王博谊, 杨宇峰, 石岩, journalName=辽宁中医药大学学报, refType=null, unstructuredReference=王博谊，杨宇峰，石岩. 巨噬细胞极化在2型糖尿病的作用及中医药应用［J］.
辽宁中医药大学学报，
2023，
25（2）：201-204., articleTitle=巨噬细胞极化在2型糖尿病的作用及中医药应用, refAbstract=null), Reference(id=1322923969925493018, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=30, issue=1, pageStart=16, pageEnd=19, url=null, language=null, rfNumber=［13］, rfOrder=12, authorNames=闫子惠, 陈清光, 陆灏, journalName=中国中医药信息杂志, refType=null, unstructuredReference=闫子惠，陈清光，陆灏. 基于肠道免疫探讨2型糖尿病从脾论治作用机制［J］.
中国中医药信息杂志，
2023，
30（1）：16-19., articleTitle=基于肠道免疫探讨2型糖尿病从脾论治作用机制, refAbstract=null), Reference(id=1322923969988407579, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=18, issue=5, pageStart=692, pageEnd=698，703, url=null, language=null, rfNumber=［14］, rfOrder=13, authorNames=华姞安, 孟靓, 孟智睿, journalName=世界中医药, refType=null, unstructuredReference=华姞安，孟靓，孟智睿，
等. 中成药治疗2型糖尿病用药规律及作用靶点分析［J］.
世界中医药，
2023，
18（5）：692-698，703., articleTitle=中成药治疗2型糖尿病用药规律及作用靶点分析, refAbstract=null), Reference(id=1322923970068099356, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=17, issue=19, pageStart=2824, pageEnd=2828, url=null, language=null, rfNumber=［15］, rfOrder=14, authorNames=徐媛颖, 王琪, 陈琳, journalName=世界中医药, refType=null, unstructuredReference=徐媛颖，王琪，陈琳，
等. 中医药治疗2型糖尿病合并肥胖的研究进展［J］.
世界中医药，
2022，
17（19）：2824-2828., articleTitle=中医药治疗2型糖尿病合并肥胖的研究进展, refAbstract=null), Reference(id=1322923970135208221, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=42, issue=15, pageStart=3635, pageEnd=3637, url=null, language=null, rfNumber=［16］, rfOrder=15, authorNames=胡月婷, journalName=中 国老年学杂 志, refType=null, unstructuredReference=胡月婷. 老年原发性高血压合并2型糖尿病患者中医证型分布及其影响 因素［J］.
中 国老年学杂 志，
2022，
42（15）：3635-3637., articleTitle=老年原发性高血压合并2型糖尿病患者中医证型分布及其影响 因素, refAbstract=null), Reference(id=1322923970206511390, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=43, issue=4, pageStart=613, pageEnd=620, url=null, language=null, rfNumber=［17］, rfOrder=16, authorNames=张汀滢, 刘桃丽, 胡建国, journalName=中山大学学报（医学科学版）, refType=null, unstructuredReference=张汀滢，刘桃丽，胡建国，
等. 中医禁食疗法对超重/肥胖2型糖尿病患者的临床疗效［J］.
中山大学学报（医学科学版），
2022，
43（4）：613-620., articleTitle=中医禁食疗法对超重/肥胖2型糖尿病患者的临床疗效, refAbstract=null), Reference(id=1322923970273620255, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=19, issue=18, pageStart=102, pageEnd=105，118, url=null, language=null, rfNumber=［18］, rfOrder=17, authorNames=倪琳琳, 徐云生, 周洪雷, journalName=中国医药导报, refType=null, unstructuredReference=倪琳琳，徐云生，周洪雷. 基于数据挖掘的冯建华名老中医治疗2型糖尿病用药规律分析［J］.
中国医药导报，
2022，
19（18）：102-105，118., articleTitle=基于数据挖掘的冯建华名老中医治疗2型糖尿病用药规律分析, refAbstract=null), Reference(id=1322923970340729120, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=19, issue=31, pageStart=61, pageEnd=64, url=null, language=null, rfNumber=［19］, rfOrder=18, authorNames=魏乐, 国凤琴, 魏玉锁, journalName=中国医药导报, refType=null, unstructuredReference=魏乐，国凤琴，魏玉锁，
等. 中医医疗技术治疗2型糖尿病的研究进展［J］.
中国医药导报，
2022，
19（31）：61-64., articleTitle=中医医疗技术治疗2型糖尿病的研究进展, refAbstract=null), Reference(id=1322923970412032289, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=54, issue=11, pageStart=47, pageEnd=49, url=null, language=null, rfNumber=［20］, rfOrder=19, authorNames=刘伟, 黄菲, 陆而立, journalName=江苏中医药, refType=null, unstructuredReference=刘伟，黄菲，陆而立，
等. 基于中医“清下法”探讨2型糖尿病早期的防治［J］.
江苏中医药，
2022，
54（11）：47-49., articleTitle=基于中医“清下法”探讨2型糖尿病早期的防治, refAbstract=null), Reference(id=1322923970504306978, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=46, issue=1, pageStart=129, pageEnd=136, url=null, language=null, rfNumber=［21］, rfOrder=20, authorNames=王琪, 雷涛, 徐媛颖, journalName=山东中医药大学学报, refType=null, unstructuredReference=王琪，雷涛，徐媛颖，
等. 2型糖尿病合并肌少症发病机制及中医药治疗进展［J］.
山东中医药大学学报，
2022，
46（1）：129-136., articleTitle=2型糖尿病合并肌少症发病机制及中医药治疗进展, refAbstract=null), Reference(id=1322923970588193059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=46, issue=2, pageStart=242, pageEnd=251, url=null, language=null, rfNumber=［22］, rfOrder=21, authorNames=冯慧, 朱晓云, 付守强, journalName=山东中医药大学学报, refType=null, unstructuredReference=冯慧，朱晓云，付守强，
等. 2型糖尿病肾病小鼠的中医证候演变分析［J］.
山东中医药大学学报，
2022，
46（2）：242-251., articleTitle=2型糖尿病肾病小鼠的中医证候演变分析, refAbstract=null), Reference(id=1322923970659496228, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=22, issue=20, pageStart=3922, pageEnd=3926, url=null, language=null, rfNumber=［23］, rfOrder=22, authorNames=徐娇, 唐苗, 陈艳玲, journalName=现代生物医学进展, refType=null, unstructuredReference=徐娇，唐苗，陈艳玲，
等. 清热利湿化痰方对痰湿瘀热型2型糖尿病患者中医症候积分、血糖代谢及血清MCP-1、IL-1β，HMGB1水平的影响［J］.
现代生物医学进展，
2022，
22（20）：3922-3926., articleTitle=清热利湿化痰方对痰湿瘀热型2型糖尿病患者中医症候积分、血糖代谢及血清MCP-1、IL-1β，HMGB1水平的影响, refAbstract=null), Reference(id=1322923970726605093, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=35, issue=12, pageStart=133, pageEnd=136, url=null, language=null, rfNumber=［24］, rfOrder=23, authorNames=陈远瑾, 李双蕾, 陈文辉, journalName=西部中医药, refType=null, unstructuredReference=陈远瑾，李双蕾，陈文辉，
等. 中医理气化痰活血法联合胰岛素强化治疗诱导初发2型糖尿病“蜜月期”［J］.
西部中医药，
2022，
35（12）：133-136., articleTitle=中医理气化痰活血法联合胰岛素强化治疗诱导初发2型糖尿病“蜜月期”, refAbstract=null), Reference(id=1322923970797908262, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=49, issue=8, pageStart=1521, pageEnd=1528, url=null, language=null, rfNumber=［25］, rfOrder=24, authorNames=王子园, 孙璞, 郭成根, journalName=现代预防医学, refType=null, unstructuredReference=王子园，孙璞，郭成根，
等. 中医传统功法对2型糖尿病患者疗效的Meta分析［J］.
现代预防医学，
2022，
49（8）：1521-1528., articleTitle=中医传统功法对2型糖尿病患者疗效的Meta分析, refAbstract=null), Reference(id=1322923970860822823, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2022, volume=33, issue=8, pageStart=1137, pageEnd=1142, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=曹士炜, 王乐旬, 荣向路, journalName=中药新药与临床药理, refType=null, unstructuredReference=曹士炜，王乐旬，荣向路. 中医药治疗2型糖尿病湿热证的用药规律研究［J］.
中药新药与临床药理，
2022，
33（8）：1137-1142., articleTitle=中医药治疗2型糖尿病湿热证的用药规律研究, refAbstract=null), Reference(id=1322923970932125992, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=40, issue=1, pageStart=57, pageEnd=62, url=null, language=null, rfNumber=［27］, rfOrder=26, authorNames=王丹蕾, 季昭臣, 胡海殷, journalName=天津中医药, refType=null, unstructuredReference=王丹蕾，季昭臣，胡海殷，
等. 中成药治疗2型糖尿病的临床研究总结及评价［J］.
天津中医药，
2023，
40（1）：57-62., articleTitle=中成药治疗2型糖尿病的临床研究总结及评价, refAbstract=null), Reference(id=1322923970995040553, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=42, issue=3, pageStart=286, pageEnd=291, url=null, language=null, rfNumber=［28］, rfOrder=27, authorNames=赵进东, 余婵娟, 程若东, journalName=天津中医药大学学报, refType=null, unstructuredReference=赵进东，余婵娟，程若东，
等. 从肾阴虚论治2型糖尿病［J］.
天津中医药大学学报，
2023，
42（3）：286-291., articleTitle=从肾阴虚论治2型糖尿病, refAbstract=null), Reference(id=1322923971053760810, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=39, issue=7, pageStart=763, pageEnd=767, url=null, language=null, rfNumber=［29］, rfOrder=28, authorNames=杨真, 哈团结, 陈秀芝, journalName=长春中医药大学学报, refType=null, unstructuredReference=杨真，哈团结，陈秀芝，
等. 生脉散合六味地黄丸治疗2型糖尿病效果分析［J］.
长春中医药大学学报，
2023，
39（7）：763-767., articleTitle=生脉散合六味地黄丸治疗2型糖尿病效果分析, refAbstract=null), Reference(id=1322923971141841195, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=25, issue=3, pageStart=928, pageEnd=935, url=null, language=null, rfNumber=［30］, rfOrder=29, authorNames=杨骋骏, 罗艳群, 刘翠华, journalName=世界科学技术-中医药现代化, refType=null, unstructuredReference=杨骋骏，罗艳群，刘翠华，
等. 中药制剂治疗2型糖尿病的系统评价再评价［J］.
世界科学技术-中医药现代化，
2023，
25（3）：928-935., articleTitle=中药制剂治疗2型糖尿病的系统评价再评价, refAbstract=null), Reference(id=1322923971217338668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=18, issue=5, pageStart=600, pageEnd=605, url=null, language=null, rfNumber=［31］, rfOrder=30, authorNames=徐晓敏, 房城, 卢芳, journalName=世界中医药, refType=null, unstructuredReference=徐晓敏，房城，卢芳. 基于代谢组学技术的黄芩-白芍对2型糖尿病模型小鼠的作用机制［J］.
世界中医药，
2023，
18（5）：600-605., articleTitle=基于代谢组学技术的黄芩-白芍对2型糖尿病模型小鼠的作用机制, refAbstract=null), Reference(id=1322923971292836141, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=49, issue=3, pageStart=608, pageEnd=616, url=null, language=null, rfNumber=［32］, rfOrder=31, authorNames=关敬, 哈森, 袁颢, journalName=吉林大学学报（医学版）, refType=null, unstructuredReference=关敬，哈森，袁颢，
等. 小陷胸汤加味方对2型糖尿病大鼠肝损伤的保护作用及其机制［J］.
吉林大学学报（医学版），
2023，
49（3）：608-616., articleTitle=小陷胸汤加味方对2型糖尿病大鼠肝损伤的保护作用及其机制, refAbstract=null), Reference(id=1322923971359945006, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, doi=null, pmid=null, pmcid=null, year=2023, volume=41, issue=3, pageStart=46, pageEnd=51, url=null, language=null, rfNumber=［33］, rfOrder=32, authorNames=韩雪莹, 单国顺, 窦德强, journalName=中华中医药学刊, refType=null, unstructuredReference=韩雪莹，单国顺，窦德强，
等. 基于肠道产丁酸菌代谢探讨益糖康防治2型糖尿病的作用机制［J］.
中华中医药学刊，
2023，
41（3）：46-51., articleTitle=基于肠道产丁酸菌代谢探讨益糖康防治2型糖尿病的作用机制, refAbstract=null)], funds=[Fund(id=1322923968927248653, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, awardId=AHWJ2022C037, language=CN, fundingSource=安徽省卫生健康委员会科研项目(AHWJ2022C037), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322923964246405342, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, xref=null, ext=[AuthorCompanyExt(id=1322923964254793951, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, companyId=1322923964246405342, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Lu’an Hospital of Traditional Chinese Medicine，Lu'an 237006，Anhui，China), AuthorCompanyExt(id=1322923964263182560, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, companyId=1322923964246405342, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=六安市中医院，安徽 六安 237006)])], figs=[ArticleFig(id=1322923966398083329, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 单药组 | 55 | 27（49.09） | 20（36.36） | 8（14.55） | 47（85.45） |
| 联合中药组 | 56 | 41（73.21） | 13（23.21） | 2（3.57） | 54（96.43） |
| χ2值 | - | - | - | - | 4.076 5 |
| P值 | - | - | - | - | 0.043 5 |
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单药组及联合中药组患者临床疗效比较
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| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 单药组 | 55 | 27（49.09） | 20（36.36） | 8（14.55） | 47（85.45） |
| 联合中药组 | 56 | 41（73.21） | 13（23.21） | 2（3.57） | 54（96.43） |
| χ2值 | - | - | - | - | 4.076 5 |
| P值 | - | - | - | - | 0.043 5 |
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| 组别 | 例数 | 时间 | HbAlc/（%） | FPG/（mmol/L） | 2 h PG/（mmol/L） |
|---|
| 单药组 | 55 | 治疗前 | 9.84±0.84 | 10.36±0.98 | 13.89±0.76 |
| | 治疗后 | 7.84±0.47a | 8.05±0.64a | 11.63±0.66a |
| 联合中药组 | 56 | 治疗前 | 9.85±0.79 | 10.34±0.86 | 13.91±0.75 |
| | 治疗后 | 7.45±0.43ab | 7.15±0.58ab | 11.06±0.58ab |
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单药组及联合中药组患者治疗前后血糖指标变化（
±s）
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| 组别 | 例数 | 时间 | HbAlc/（%） | FPG/（mmol/L） | 2 h PG/（mmol/L） |
|---|
| 单药组 | 55 | 治疗前 | 9.84±0.84 | 10.36±0.98 | 13.89±0.76 |
| | 治疗后 | 7.84±0.47a | 8.05±0.64a | 11.63±0.66a |
| 联合中药组 | 56 | 治疗前 | 9.85±0.79 | 10.34±0.86 | 13.91±0.75 |
| | 治疗后 | 7.45±0.43ab | 7.15±0.58ab | 11.06±0.58ab |
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| 组别 | 例数 | 时间 | 口干口苦 | 胃脘胀满 | 胸胁胀闷 | 烦躁易怒 | 大便秘结 |
|---|
| 单药组 | 55 | 治疗前 | 2.14±0.26 | 2.36±0.21 | 2.25±0.19 | 2.11±0.30 | 2.01±0.20 |
| | 治疗后 | 0.60±0.07a | 0.65±0.10a | 0.63±0.09a | 0.59±0.05a | 0.56±0.07a |
| 联合中药组 | 56 | 治疗前 | 2.11±0.23 | 2.34±0.22 | 2.27±0.20 | 2.08±0.29 | 2.00±0.18 |
| | 治疗后 | 0.18±0.06ab | 0.23±0.04ab | 0.20±0.05ab | 0.17±0.04ab | 0.16±0.04ab |
), ArticleFig(id=1322923966788153606, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, language=CN, label=表3, caption=
单药组及联合中药组患者治疗前后中医证候积分变化（
±s）
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| 组别 | 例数 | 时间 | 口干口苦 | 胃脘胀满 | 胸胁胀闷 | 烦躁易怒 | 大便秘结 |
|---|
| 单药组 | 55 | 治疗前 | 2.14±0.26 | 2.36±0.21 | 2.25±0.19 | 2.11±0.30 | 2.01±0.20 |
| | 治疗后 | 0.60±0.07a | 0.65±0.10a | 0.63±0.09a | 0.59±0.05a | 0.56±0.07a |
| 联合中药组 | 56 | 治疗前 | 2.11±0.23 | 2.34±0.22 | 2.27±0.20 | 2.08±0.29 | 2.00±0.18 |
| | 治疗后 | 0.18±0.06ab | 0.23±0.04ab | 0.20±0.05ab | 0.17±0.04ab | 0.16±0.04ab |
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| 组别 | 例数 | 时间 | MDA/（mmo/L） | SOD/（U/mL） | GSH-Px/（pg/mL） |
|---|
| 单药组 | 55 | 治疗前 | 4.35±0.67 | 73.26±4.95 | 58.37±3.68 |
| | 治疗后 | 3.50±0.48a | 82.16±6.23a | 104.37±7.62a |
| 联合中药组 | 56 | 治疗前 | 4.37±0.65 | 73.24±4.97 | 58.35±3.70 |
| | 治疗后 | 2.83±0.46ab | 94.26±5.23ab | 142.37±3.79ab |
), ArticleFig(id=1322923968507818248, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, language=CN, label=表4, caption=
单药组及联合中药组患者治疗前后氧化应激指标变化（
±s）
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| 组别 | 例数 | 时间 | MDA/（mmo/L） | SOD/（U/mL） | GSH-Px/（pg/mL） |
|---|
| 单药组 | 55 | 治疗前 | 4.35±0.67 | 73.26±4.95 | 58.37±3.68 |
| | 治疗后 | 3.50±0.48a | 82.16±6.23a | 104.37±7.62a |
| 联合中药组 | 56 | 治疗前 | 4.37±0.65 | 73.24±4.97 | 58.35±3.70 |
| | 治疗后 | 2.83±0.46ab | 94.26±5.23ab | 142.37±3.79ab |
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| 组别 | 例数 | 时间 | PRV/（cm/s） | PSV/（cm/s） | EDV/（cm/s） | PI/（%） |
|---|
| 单药组 | 55 | 治疗前 | 55.43±6.23 | 13.77±2.58 | 12.74±3.85 | 5.59±0.68 |
| | 治疗后 | 62.35±4.72a | 18.50±2.88a | 16.78±2.45a | 7.65±0.83a |
| 联合中药组 | 56 | 治疗前 | 55.45±6.18 | 13.79±2.60 | 12.78±3.90 | 5.60±0.70 |
| | 治疗后 | 68.73±5.23ab | 21.49±2.49ab | 20.14±3.16ab | 9.56±0.68ab |
), ArticleFig(id=1322923968646230282, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, language=CN, label=表5, caption=
单药组及联合中药组患者治疗前后血流动力学指标变化（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | PRV/（cm/s） | PSV/（cm/s） | EDV/（cm/s） | PI/（%） |
|---|
| 单药组 | 55 | 治疗前 | 55.43±6.23 | 13.77±2.58 | 12.74±3.85 | 5.59±0.68 |
| | 治疗后 | 62.35±4.72a | 18.50±2.88a | 16.78±2.45a | 7.65±0.83a |
| 联合中药组 | 56 | 治疗前 | 55.45±6.18 | 13.79±2.60 | 12.78±3.90 | 5.60±0.70 |
| | 治疗后 | 68.73±5.23ab | 21.49±2.49ab | 20.14±3.16ab | 9.56±0.68ab |
), ArticleFig(id=1322923968725922059, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923961163591891, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 腹泻 | 低血糖 | 皮疹 | 总不良反应 |
|---|
| 单药组 | 55 | 1（1.82） | 1（1.82） | 1（1.82） | 3（5.45） |
| 联合中药组 | 56 | 1（1.79） | 1（1.79） | 0（0.00） | 2（3.57） |
| χ2值 | - | - | - | - | 0.228 7 |
| P值 | - | - | - | - | 0.632 5 |
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单药组及联合中药组患者不良反应比较
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| 组别 | 例数 | 腹泻 | 低血糖 | 皮疹 | 总不良反应 |
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| 单药组 | 55 | 1（1.82） | 1（1.82） | 1（1.82） | 3（5.45） |
| 联合中药组 | 56 | 1（1.79） | 1（1.79） | 0（0.00） | 2（3.57） |
| χ2值 | - | - | - | - | 0.228 7 |
| P值 | - | - | - | - | 0.632 5 |
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