Article(id=1322923898844619349, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.06.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339236221, onlineDateStr=2026-10-30, pubDate=1749484800000, pubDateStr=2025-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339236221, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339236221, creator=13701087609, updateTime=1793339236221, updator=13701087609, issue=Issue{id=1322923782029062261, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1749484800000', pubDateStr='2025-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339208371, creator='13701087609', updateTime=1793340556755, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929437859258468, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929437859258469, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=104, endPage=107, ext={EN=ArticleExt(id=1322923899427627606, articleId=1322923898844619349, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Observation on Treatment of Epistaxis in Little's Area with Modified Xiaoji Yinzi（小蓟饮子加减）Combined with Compound Mufurong Nasal Ointment（复方木芙蓉涂鼻软膏）, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the clinical value of Modified Xiaoji Yinzi（小蓟饮子加减）combined with Compound Mufurong Nasal Ointment（复方木芙蓉涂鼻软膏）in treating epistaxis in Little's area.
Methods Seventy children with epistaxis in Little's area admitted to the hospital from January 2022 to May 2022 were randomly divided into a combined group and a control group，with 35 cases in each group.The two groups were treated with nasal irrigation with normal saline，erythromycin eye ointment and Compound Mufurong Nasal Ointment，while the combined group was treated with Modified Xiaoji Yinzi.The therapeutic effects，symptoms and changes of blood routine test results of the two groups were compared，and the clinical value of the two treatment schemes was analyzed.
Results After 7 days of treatment，the symptoms of epistaxis，nasal cavity ulcer and nasal cavity erosion in the two groups were significantly improved compared with those before treatment.After 7 days of treatment，the incidence of epistaxis，nasal cavity ulcer and nasal cavity erosion in the combined group was lower than that in the control group，with statistical significance（P<0.05）.After 7 days of combined treatment，the total clinical effective rate of group A was 100.00%，which was higher than that of the control group（82.86%）with statistical significance（P<0.05）.After 7 days of treatment，the levels of white blood cells（WBC）and C-reaction protein（CRP）in both groups decreased compared with those before treatment.After 7 days of treatment，the levels of WBC and CRP in the combined group were lower than those in the control group with statistical significance（P<0.05）.There was no recurrence in the two-month follow-up of the effective group，but there were 5 cases in the control group，with a recurrence rate of 17.24%（5/29），and the difference between the two groups was statistically significant（P=0.037）.
Conclusion On the basis of Compound Mufurong Nasal Ointment，the clinical effect of treating epistaxis in Little's area by combined application of Modified Xiaoji Yinzi is more significant，and there are obvious advantages in improving children's symptoms，alleviating inflammatory reaction，preventing anemia and reducing the risk of recurrence.
, authors=Xiaoyan WANG, Li ZHAO, Jiangang LYU, Lingxia KONG, Yafeng YANG, Chenyang JING, authorsList=Xiaoyan WANG, Li ZHAO, Jiangang LYU, Lingxia KONG, Yafeng YANG, Chenyang JING, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322923903496102503, articleId=1322923898844619349, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=小蓟饮子加减联合复方木芙蓉涂鼻软膏治疗Little氏区鼻衄临床观察, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 分析小蓟饮子加减联合复方木芙蓉涂鼻软膏治疗Little氏区鼻衄临床价值。
方法 纳入医院2022年1月—2022年5月收治的70例Little氏区鼻衄患儿，随机分为联合组、对照组，各35例。两组给予0.9%氯化钠溶液鼻腔冲洗、红霉素眼膏、复方木芙蓉涂鼻软膏涂抹治疗，联合组加用小蓟饮子加减。对比两组治疗效果及症状、血常规检测结果变化，分析两种治疗方案的临床价值。
结果 两组治疗7 d后鼻出血、鼻腔内溃疡或糜烂症状均较治疗前显著好转，联合组治疗7 d后鼻出血、鼻腔内溃疡或糜烂症状发生率均低于对照组，差异有统计学意义（P<0.05）。联合组治疗7 d后临床总有效率为100.00%，较对照组的82.86%更高，差异有统计学意义（P<0.05）。两组治疗7 d后白细胞（white blood cell，WBC）、C反应蛋白（C-reactive protein，CRP）均较治疗前下降；联合组治疗7 d后WBC、CRP均低于对照组，差异有统计学意义（P<0.05）。联合组治疗有效者随访2个月期间未见复发，对照组治疗有效者复发5例，复发率为17.24%（5/29），组间比较差异有统计学意义（P=0.037）。
结论 在复方木芙蓉涂鼻软膏的基础上，联合应用小蓟饮子加减治疗Little氏区鼻衄的临床疗效更为显著，且在改善患儿症状、减轻炎症反应、预防贫血、降低复发风险方面均存在明显优势。
, authors=王晓燕, 赵丽, 吕建刚, 孔令霞, 杨亚峰, 荆晨阳, authorsList=王晓燕, 赵丽, 吕建刚, 孔令霞, 杨亚峰, 荆晨阳, authorCompany=null, correspAuthors=null, authorNote=
王晓燕（1963-），女，河南陕县人，主任医师，学士，研究方向：中医药防治小儿呼吸系统疾病。
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王晓燕（1963-），女，河南陕县人，主任医师，学士，研究方向：中医药防治小儿呼吸系统疾病。
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王晓燕（1963-），女，河南陕县人，主任医师，学士，研究方向：中医药防治小儿呼吸系统疾病。
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38（18）：3573-3575., articleTitle=瓜蒌瞿麦汤对糖尿病肾病糖脂代谢及血管内皮损伤的影响, refAbstract=null), Reference(id=1322923912333501109, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923898844619349, doi=null, pmid=null, pmcid=null, year=2023, volume=45, issue=6, pageStart=1929, pageEnd=1936, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=陈瑞鑫, 梁淞婷, 戴忠华, journalName=中成药, refType=null, unstructuredReference=陈瑞鑫，梁淞婷，戴忠华，
等. 萹蓄化学成分及药理活性研究进展［J］.
中成药，
2023，
45（6）：1929-1936., articleTitle=萹蓄化学成分及药理活性研究进展, refAbstract=null)], funds=[Fund(id=1322923908621542041, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923898844619349, awardId=国中医药人教函〔2022〕1号, language=CN, fundingSource=国家中医药管理局第五批全国中医临床优秀人才研修项目(国中医药人教函〔2022〕1号), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322923903785509480, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923898844619349, xref=null, ext=[AuthorCompanyExt(id=1322923903798092393, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923898844619349, companyId=1322923903785509480, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Zhengzhou Traditional Chinese Medicine Hospital，Zhengzhou 450007，Henan，China), AuthorCompanyExt(id=1322923903810675306, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923898844619349, companyId=1322923903785509480, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=郑州市中医院，河南 郑州 450007)])], figs=[ArticleFig(id=1322923907602326161, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923898844619349, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 年龄/（岁， ±s） | 病程/（d， ±s）  | 性别/［例（%）］ | 诱因/［例（%）］ |
|---|
| 男女 | 无诱因 | 外感 | 其他 |
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| 联合组 | 35 | 7.61±1.85 | 4.23±0.91 | 24（68.57）11（31.43） | 17（48.57） | 8（22.86） | 10（28.57） |
| 对照组 | 35 | 7.22±2.03 | 4.11±0.88 | 22（62.86）13（37.14） | 19（54.29） | 10（28.57） | 6（17.14） |
| t/χ2值 | | 0.840 | 0.561 | 0.254 | 1.333 |
| P值 | | 0.404 | 0.577 | 0.615 | 0.513 |
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两组鼻衄患儿一般临床资料比较（
±s）
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| 组别 | 例数 | 年龄/（岁，±s） | 病程/（d，±s） | 性别/［例（%）］ | 诱因/［例（%）］ |
|---|
| 男女 | 无诱因 | 外感 | 其他 |
|---|
| 联合组 | 35 | 7.61±1.85 | 4.23±0.91 | 24（68.57）11（31.43） | 17（48.57） | 8（22.86） | 10（28.57） |
| 对照组 | 35 | 7.22±2.03 | 4.11±0.88 | 22（62.86）13（37.14） | 19（54.29） | 10（28.57） | 6（17.14） |
| t/χ2值 | | 0.840 | 0.561 | 0.254 | 1.333 |
| P值 | | 0.404 | 0.577 | 0.615 | 0.513 |
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| 组别 | 例数 | 鼻出血 | 鼻腔内溃疡或糜烂 |
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| 治疗前 | 治疗7 d后 | 治疗前 | 治疗7 d后 |
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| 联合组 | 35 | 35（100.00） | 1（2.86）* | 21（60.00） | 0* |
| 对照组 | 35 | 35（100.00） | 8（22.86）* | 19（54.29） | 6（17.14）* |
| χ2值 | | | 4.590 | 0.233 | 4.557 |
| P值 | | | 0.037 | 0.629 | 0.033 |
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两组鼻衄患儿治疗前后临床症状变化比较
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| 组别 | 例数 | 鼻出血 | 鼻腔内溃疡或糜烂 |
|---|
| 治疗前 | 治疗7 d后 | 治疗前 | 治疗7 d后 |
|---|
| 联合组 | 35 | 35（100.00） | 1（2.86）* | 21（60.00） | 0* |
| 对照组 | 35 | 35（100.00） | 8（22.86）* | 19（54.29） | 6（17.14）* |
| χ2值 | | | 4.590 | 0.233 | 4.557 |
| P值 | | | 0.037 | 0.629 | 0.033 |
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| 组别 | 例数 | 治愈 | 好转 | 无效 | 总有效 |
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| 联合组 | 35 | 22（62.86） | 13（37.14） | 0 | 35（100.00） |
| 对照组 | 35 | 9（25.71） | 20（57.14） | 6（17.14） | 29（82.86） |
| χ2值 | | | | | 4.558 |
| P值 | | | | | 0.033 |
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两组鼻衄患儿治疗7 d后临床疗效比较
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| 组别 | 例数 | 治愈 | 好转 | 无效 | 总有效 |
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| 联合组 | 35 | 22（62.86） | 13（37.14） | 0 | 35（100.00） |
| 对照组 | 35 | 9（25.71） | 20（57.14） | 6（17.14） | 29（82.86） |
| χ2值 | | | | | 4.558 |
| P值 | | | | | 0.033 |
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| 组别 | 例数 | WBC（×109/L） | CRP/（mg/L） |
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| 治疗前 | 治疗7 d后 | 治疗前 | 治疗7 d后 |
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| 联合组 | 35 | 9.24±1.33 | 7.35±0.99* | 10.19±2.24 | 2.37±0.52* |
| 对照组 | 35 | 9.35±1.28 | 7.86±0.75* | 10.24±1.95 | 3.88±0.89* |
| t值 | | 0.353 | 2.429 | 0.100 | 8.667 |
| P值 | | 0.726 | 0.018 | 0.921 | <0.001 |
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| 组别 | 例数 | WBC（×109/L） | CRP/（mg/L） |
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| 治疗前 | 治疗7 d后 | 治疗前 | 治疗7 d后 |
|---|
| 联合组 | 35 | 9.24±1.33 | 7.35±0.99* | 10.19±2.24 | 2.37±0.52* |
| 对照组 | 35 | 9.35±1.28 | 7.86±0.75* | 10.24±1.95 | 3.88±0.89* |
| t值 | | 0.353 | 2.429 | 0.100 | 8.667 |
| P值 | | 0.726 | 0.018 | 0.921 | <0.001 |
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