Article(id=1322923753033839519, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923490592043032, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.05.046, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339201457, onlineDateStr=2026-10-30, pubDate=1746806400000, pubDateStr=2025-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339201457, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339201456, creator=13701087609, updateTime=1793339201456, updator=13701087609, issue=Issue{id=1322923490592043032, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1746806400000', pubDateStr='2025-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339138887, creator='13701087609', updateTime=1793340572227, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929502539612595, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923490592043032, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929502539612596, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923490592043032, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=243, endPage=246, ext={EN=ArticleExt(id=1322923753264526240, articleId=1322923753033839519, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Exploring Effect of Yishen Paidu Formula（益肾排毒方）Combined with Sanqi（Notoginseng Radix et Rhizoma）on Serum Leptin, Lipids, Oxidative Stress and Endothelial Function in Renal Failure Based on Theory of “Intestine-Kidney Axis”, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effects of Yishen Paidu Formula（益肾排毒方）combined with Sanqi（Notoginseng Radix et Rhizoma）on serum leptin，blood lipids，oxidative stress and endothelial function in renal failure based on the theory of“intestine-kidney axis”.
Method A total of 60 cases of renal failure admitted to the traditional Chinese medicine and nephrology department of the hospital from June 2020 to June 2022 were selected as the research subjects. The patients in the control group received levocarnitine injection combined with compoundα-ketonic acid tablets，and those in the experimental group combined Yishen Paidu Formula combined with Sanqi（Notoginseng Radix et Rhizoma）on this basis. The clinical efficacy，blood glucose，blood lipids，leptin，vascular endothelial function，oxidative stress indicators，inflammation indicators and safety were compared between the two groups.
Result Compared with the control group，the experimental group had a higher overall effective rate（P<0.05）. After treatment，the levels of serum fasting plasma glucose（FPG），total cholesterol（TC），triglyceride（TG），leptin，soluble intercellular adhesion molecule-1（sICAM-1），endothelin-1（ET-1），malondialdehyde（MDA），C-reactive protein（CRP），tumor crossing factor alpha（TNF-α）and interleukin-6（IL-6）were measured in the experimental and control groups decreased compared to those before treatment，while the levels of superoxide dismutase（SOD）increased compared to those before treatment（P<0.05）. The experimental group had the levels of serum FPG，TC，TG，leptin，sICAM-1，ET-1，MDA，CRP，TNF-αand IL-6 were lower than those of the control group（P<0.05），and the level of SOD was higher than that of the control group（P<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups of drugs（P>0.05）.
Conclusion Yishen Paidu Formula combined with Sanqi（Notoginseng Radix et Rhizoma）exert good therapeutic effects on renal failure，and the improvement of its therapeutic effect may be closely related to the improvement of endothelial and oxidative stress functions.
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目的 基于“肠-肾轴”理论探究益肾排毒方加三七对肾衰竭血清瘦素、血脂、氧化应激及内皮功能的影响。
方法 选择肾衰竭患者共计60例作为研究对象。对照组30例予以注射用左卡尼汀联合复方α-酮酸片，试验组30例在对照组基础上联用益肾排毒方加三七。对比两组临床疗效、血糖、血脂、瘦素、血管内皮功能、氧化应激指标、炎症指标及安全性。
结果 与对照组相比，试验组总有效率较高（P<0.05）。治疗后，两组血清空腹血糖（fasting plasma glucose，FPG）、总胆固醇（total Cholesterol，TC）、三酰甘油（triglyceride，TG）、瘦素、可溶性细胞间黏附分子-1（soluble intercellular adhesion molecule-1，sICAM-1）、内皮素-1（endothelin，ET-1）、丙二醛（malondialdehyde，MDA）、C反应蛋白（C-reactive，CRP）、肿瘤坏死因子-α（tumor necrosis factor alpha，TNF-α）、白细胞介素-6（interleukin-6，IL-6）水平均较治疗前降低，超氧化物歧化酶（superoxide dismutase，SOD）水平较治疗前升高（P<0.05），试验组血清FPG、TC、TG、瘦素、血清sICAM-1、ET-1、MDA、CRP、TNF-α、IL-6水平低于对照组（P<0.05），SOD水平高于对照组（P<0.05）。两组药物不良反应发生率比较差异无统计学意义（P>0.05）。
结论 益肾排毒方加三七应用于肾衰竭能够发挥较好疗效，其治疗效果提升可能与改善内皮、氧化应激功能具有密切相关性。
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胡溪（1987-），女，湖北武汉人，主治医师，硕士，研究方向：中西医防治肾脏病。
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胡溪（1987-），女，湖北武汉人，主治医师，硕士，研究方向：中西医防治肾脏病。
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胡溪（1987-），女，湖北武汉人，主治医师，硕士，研究方向：中西医防治肾脏病。
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中国临床药理学杂志，
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陕西中医，
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河北中医，
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中国中医基础医学杂志，
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中国现代医生，
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黑龙江医学，
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当代医药论丛，
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中国临床药理学杂志，
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世界科学技术-中医药现代化，
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中国中医基础医学杂志，
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中华中医药学刊，
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中国中药杂志，
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食品科学，
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世界科学技术-中医药现代化，
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世界科学技术-中医药现代化，
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中国药房，
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中国骨质疏松杂志，
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中国老年学杂志，
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| 组别 | 例数 | 显效 | 有效 | 稳定 | 无效 | 总有效 |
|---|
| 试验组 | 30 | 4（13.33） | 16（53.33） | 7（23.34） | 3（10.00） | 27（90.00）# |
| 对照组 | 30 | 1（3.33） | 11（36.67） | 8（26.67） | 10（33.33） | 20（66.67） |
), ArticleFig(id=1322923758549349331, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923753033839519, language=CN, label=表1, caption=
两组肾衰竭患者患者临床疗效比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 显效 | 有效 | 稳定 | 无效 | 总有效 |
|---|
| 试验组 | 30 | 4（13.33） | 16（53.33） | 7（23.34） | 3（10.00） | 27（90.00）# |
| 对照组 | 30 | 1（3.33） | 11（36.67） | 8（26.67） | 10（33.33） | 20（66.67） |
), ArticleFig(id=1322923758637429716, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923753033839519, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间点 | FPG/（mmol·L-1） | TC/（mmol·L-1） | TG/（mmol·L-1） | 瘦素/（μg·L-1） |
|---|
| 试验组 | 30 | 治疗前 | 9.32±1.02 | 6.24±0.72 | 2.77±0.35 | 18.43±2.43 |
| | 治疗后 | 6.53±0.79*# | 3.55±0.42*# | 1.02±0.17*# | 10.22±1.54*# |
| 对照组 | 30 | 治疗前 | 9.53±1.01 | 6.30±0.73 | 2.80±0.41 | 19.50±2.46 |
| | 治疗后 | 7.32±0.92* | 4.50±0.56* | 1.89±0.22* | 14.23±1.72* |
), ArticleFig(id=1322923758691955669, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923753033839519, language=CN, label=表2, caption=
两组肾衰竭患者患者治疗前后血糖、血脂和瘦素水平比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间点 | FPG/（mmol·L-1） | TC/（mmol·L-1） | TG/（mmol·L-1） | 瘦素/（μg·L-1） |
|---|
| 试验组 | 30 | 治疗前 | 9.32±1.02 | 6.24±0.72 | 2.77±0.35 | 18.43±2.43 |
| | 治疗后 | 6.53±0.79*# | 3.55±0.42*# | 1.02±0.17*# | 10.22±1.54*# |
| 对照组 | 30 | 治疗前 | 9.53±1.01 | 6.30±0.73 | 2.80±0.41 | 19.50±2.46 |
| | 治疗后 | 7.32±0.92* | 4.50±0.56* | 1.89±0.22* | 14.23±1.72* |
), ArticleFig(id=1322923758754870230, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923753033839519, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间点 | sICAM-1/（μg·L-1） | ET-1/（mg·L-1） |
|---|
| 试验组 | 30 | 治疗前 | 545.32±67.24 | 265.24±30.44 |
| | 治疗后 | 443.24±50.36*# | 164.96±17.14*# |
| 对照组 | 30 | 治疗前 | 540.92±66.83 | 260.74±30.57 |
| | 治疗后 | 485.22±55.40* | 192.32±22.31* |
), ArticleFig(id=1322923758821979095, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923753033839519, language=CN, label=表3, caption=
两组肾衰竭患者治疗前后血管内皮比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间点 | sICAM-1/（μg·L-1） | ET-1/（mg·L-1） |
|---|
| 试验组 | 30 | 治疗前 | 545.32±67.24 | 265.24±30.44 |
| | 治疗后 | 443.24±50.36*# | 164.96±17.14*# |
| 对照组 | 30 | 治疗前 | 540.92±66.83 | 260.74±30.57 |
| | 治疗后 | 485.22±55.40* | 192.32±22.31* |
), ArticleFig(id=1322923758893282264, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923753033839519, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间点 | SOD/（U·mL-1） | MDA/（U·mL-1） |
|---|
| 试验组 | 30 | 治疗前 | 174.33±20.44 | 62.34±6.99 |
| | 治疗后 | 243.24±30.55*# | 54.83±5.93*# |
| 对照组 | 30 | 治疗前 | 174.03±20.63 | 63.04±7.02 |
| | 治疗后 | 201.32±25.45* | 58.92±6.45* |
), ArticleFig(id=1322923758964585433, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923753033839519, language=CN, label=表4, caption=
两组肾衰竭患者治疗前后氧化应激指标比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间点 | SOD/（U·mL-1） | MDA/（U·mL-1） |
|---|
| 试验组 | 30 | 治疗前 | 174.33±20.44 | 62.34±6.99 |
| | 治疗后 | 243.24±30.55*# | 54.83±5.93*# |
| 对照组 | 30 | 治疗前 | 174.03±20.63 | 63.04±7.02 |
| | 治疗后 | 201.32±25.45* | 58.92±6.45* |
), ArticleFig(id=1322923759040082906, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923753033839519, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间点 | CRP/（mg·L-1） | TNF-α/（pg·mL-1） | IL-6/（pg·mL-1） |
|---|
| 试验组 | 30 | 治疗前 | 7.32±0.88 | 43.33±4.62 | 41.22±4.92 |
| | 治疗后 | 5.24±0.59*# | 20.82±2.11*# | 15.79±1.93*# |
| 对照组 | 30 | 治疗前 | 7.60±0.90 | 43.18±4.72 | 42.20±4.87 |
| | 治疗后 | 6.33±0.72* | 25.82±2.81* | 25.92±2.82* |
), ArticleFig(id=1322923759115580379, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923753033839519, language=CN, label=表5, caption=
两组肾衰竭患者治疗前后血清炎症因子水平比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间点 | CRP/（mg·L-1） | TNF-α/（pg·mL-1） | IL-6/（pg·mL-1） |
|---|
| 试验组 | 30 | 治疗前 | 7.32±0.88 | 43.33±4.62 | 41.22±4.92 |
| | 治疗后 | 5.24±0.59*# | 20.82±2.11*# | 15.79±1.93*# |
| 对照组 | 30 | 治疗前 | 7.60±0.90 | 43.18±4.72 | 42.20±4.87 |
| | 治疗后 | 6.33±0.72* | 25.82±2.81* | 25.92±2.82* |
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