Article(id=1322923613556454234, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923490592043032, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.05.026, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339168204, onlineDateStr=2026-10-30, pubDate=1746806400000, pubDateStr=2025-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339168204, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339168204, creator=13701087609, updateTime=1793339168204, updator=13701087609, issue=Issue{id=1322923490592043032, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1746806400000', pubDateStr='2025-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339138887, creator='13701087609', updateTime=1793340572227, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929502539612595, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923490592043032, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929502539612596, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923490592043032, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=129, endPage=138, ext={EN=ArticleExt(id=1322923613757780827, articleId=1322923613556454234, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Renshen（Ginseng Radix et Rhizoma）Regulating Immune System Diseases and Quality Marker Prediction Analysis, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Renshen（Ginseng Radix et Rhizoma）is the dried root and rhizome of plant Renshen（Panax ginseng C. A. Mey.）. The main chemical components include saponins，polysaccharides，polyynols，volatile oils，proteins，peptides，amino acids，etc. In this paper，based on the summary of the chemical composition and pharmacological effects of Renshen（Ginseng Radix et Rhizoma）regulating immune function and the principle of quality marker（Q-Marker），the plant affinity，the effectiveness of chemical components，the specificity and the compatibility of compound formulae were predicted and analyzed. Ginsenosides，polysaccharides，proteins and volatile oils were the Q-Markers of Renshen（Ginseng Radix et Rhizoma）regulating immune function，and ginsenosides Rg1，Re，Rb1，Rg3，Rh1，Rh2，Rd，CK，Ro，Rg5，ginseng D-glucose，galactose，arabinose and ginsekyl can be selected as alternative substances for a single component，which can provide a certain quality control method reference.

, authors=Hui XU¹, Jing RAN¹, Dan WANG², Wei ZHANG¹, Xueyuan BAI¹, authorsList=Hui XU, Jing RAN, Dan WANG, Wei ZHANG, Xueyuan BAI, authorCompany=null, correspAuthors=Wei ZHANG, Xueyuan BAI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322923614751830882, articleId=1322923613556454234, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=人参调节免疫系统疾病研究进展及质量标志物预测分析, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

人参为五加科（Araliaceae）植物人参Panaxginseng C. A. Mey.的干燥根及根茎。主要化学成分包括皂苷、多糖、聚炔醇、挥发油、蛋白质、多肽、氨基酸等。在总结人参调节免疫功能的化学成分和药理作用的基础上，基于质量标志物（Quality marker，Q-Marker）原则从植物亲缘性，化学成分有效性，特有性和复方配伍等方面进行预测分析。大类成分以人参皂苷、多糖、蛋白质、挥发油为人参调节免疫功能的质量标志物，单一成分可选取人参皂苷Rg1、Re、Rb1、Rg3、Rh1、Rh2、Rd、CK、Ro、Rg5、人参D-葡萄糖、半乳糖、阿拉伯糖、人参炔醇作为备选物质，为其提供一定的质量控制方法参考。

, authors=徐慧¹, 冉靖¹, 王丹², 张巍¹, 白雪媛¹, authorsList=徐慧, 冉靖, 王丹, 张巍, 白雪媛, authorCompany=null, correspAuthors=张巍, 白雪媛, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=xjT4TpF9m99rqkOiR9farg==, magXml=RAd/Qutx7tkH6igagDRb+w==, pdfUrl=null, pdf=Zmd3xZyowPkFPLUWU7S7qw==, pdfFileSize=2036590, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=/YikoEH7QPrrU4ln3N+Cvw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=rLGmH4WQs0Lc1GZlXv/FWQ==, mapNumber=null, fund=null)}, authors=[Author(id=1322923617549431659, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322923618354738030, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923617549431659, language=EN, stringName=Hui XU, firstName=Hui, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Northeast Asia Institute of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130021，Jilin，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322923618807722863, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923617549431659, language=CN, stringName=徐慧, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.长春中医药大学东北亚中医药研究院，吉林 长春 130021, bio={"content":"

徐慧（2001-），女，贵州铜仁人，硕士，研究方向：中药有效成分发现、生物转化及健康产品研究与开发。

"}, bioImg=null, bioContent=

徐慧（2001-），女，贵州铜仁人，硕士，研究方向：中药有效成分发现、生物转化及健康产品研究与开发。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322923615464862564, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, xref=1., ext=[AuthorCompanyExt(id=1322923615477445477, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Northeast Asia Institute of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130021，Jilin，China), AuthorCompanyExt(id=1322923615490028390, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.长春中医药大学东北亚中医药研究院，吉林 长春 130021)])]), Author(id=1322923618988077938, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322923619210376052, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923618988077938, language=EN, stringName=Jing RAN, firstName=Jing, middleName=null, lastName=RAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Northeast Asia Institute of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130021，Jilin，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322923619365565302, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923618988077938, language=CN, stringName=冉靖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.长春中医药大学东北亚中医药研究院，吉林 长春 130021, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322923615464862564, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, xref=1., ext=[AuthorCompanyExt(id=1322923615477445477, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Northeast Asia Institute of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130021，Jilin，China), AuthorCompanyExt(id=1322923615490028390, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.长春中医药大学东北亚中医药研究院，吉林 长春 130021)])]), Author(id=1322923620032459641, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322923621483688829, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923620032459641, language=EN, stringName=Dan WANG, firstName=Dan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Changchun Jinsai Pharmaceutical Co.，Ltd，Changchun 130021，Jilin，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322923621819233151, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923620032459641, language=CN, stringName=王丹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.长春金赛药业有限责任公司，吉林 长春 130021, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322923617150972775, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, xref=2., ext=[AuthorCompanyExt(id=1322923617205498728, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923617150972775, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Changchun Jinsai Pharmaceutical Co.，Ltd，Changchun 130021，Jilin，China), AuthorCompanyExt(id=1322923617247441769, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923617150972775, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.长春金赛药业有限责任公司，吉林 长春 130021)])]), Author(id=1322923621907313537, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=545529755@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322923622196720515, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923621907313537, language=EN, stringName=Wei ZHANG, firstName=Wei, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Northeast Asia Institute of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130021，Jilin，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322923622309966725, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923621907313537, language=CN, stringName=张巍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.长春中医药大学东北亚中医药研究院，吉林 长春 130021, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322923615464862564, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, xref=1., ext=[AuthorCompanyExt(id=1322923615477445477, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Northeast Asia Institute of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130021，Jilin，China), AuthorCompanyExt(id=1322923615490028390, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.长春中医药大学东北亚中医药研究院，吉林 长春 130021)])]), Author(id=1322923622976861063, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=23165956@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322923623387902858, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923622976861063, language=EN, stringName=Xueyuan BAI, firstName=Xueyuan, middleName=null, lastName=BAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Northeast Asia Institute of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130021，Jilin，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322923623593423754, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, authorId=1322923622976861063, language=CN, stringName=白雪媛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.长春中医药大学东北亚中医药研究院，吉林 长春 130021, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322923615464862564, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, xref=1., ext=[AuthorCompanyExt(id=1322923615477445477, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Northeast Asia Institute of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130021，Jilin，China), AuthorCompanyExt(id=1322923615490028390, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.长春中医药大学东北亚中医药研究院，吉林 长春 130021)])])], keywords=[Keyword(id=1322923623945745292, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, orderNo=1, keyword=Renshen（Ginseng Radix et Rhizoma）), Keyword(id=1322923624235152269, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, orderNo=2, keyword=immunomodulation), Keyword(id=1322923625933845392, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, orderNo=3, keyword=chemical composition), Keyword(id=1322923626038702994, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, orderNo=4, keyword=pharmacological action), Keyword(id=1322923626328109972, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, orderNo=5, keyword=quality markers), Keyword(id=1322923626420384663, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, orderNo=6, keyword=review), Keyword(id=1322923626751734680, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, orderNo=1, keyword=人参), Keyword(id=1322923626810454937, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, orderNo=2, keyword=免疫调节), Keyword(id=1322923626860786586, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, orderNo=3, keyword=化学成分), Keyword(id=1322923626927895451, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, orderNo=4, keyword=药理作用), Keyword(id=1322923627196330908, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, orderNo=5, keyword=质量标志物), Keyword(id=1322923627276022686, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, orderNo=6, keyword=综述)], refs=[Reference(id=1322923631575184313, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2005, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［1］, rfOrder=0, authorNames=国家药典委员会, journalName=null, refType=null, unstructuredReference=国家药典委员会. 中华人民共和国药典：一部［S］. 北京：化学工业出版社，2005., articleTitle=null, refAbstract=null), Reference(id=1322923631793288123, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=null, issue=5, pageStart=36, pageEnd=38, url=null, language=null, rfNumber=［2］, rfOrder=1, authorNames=丁元, 吴阳, journalName=新长征, refType=null, unstructuredReference=丁元，吴阳. 加速推动人参全产业链高质量发展［J］. 新长征，2023（5）：36-38., articleTitle=加速推动人参全产业链高质量发展, refAbstract=null), Reference(id=1322923631889757116, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=33, issue=5, pageStart=455, pageEnd=460, url=null, language=null, rfNumber=［3］, rfOrder=2, authorNames=张艳, 周淑如, 韩仕阳, journalName=江苏大学学报（医学版）, refType=null, unstructuredReference=张艳，周淑如，韩仕阳，等. 人参皂苷对免疫功能的调节作用及机制［J］. 江苏大学学报（医学版），2023，33（5）：455-460., articleTitle=人参皂苷对免疫功能的调节作用及机制, refAbstract=null), Reference(id=1322923632212718525, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2011, volume=20, issue=11, pageStart=953, pageEnd=958, url=null, language=null, rfNumber=［4］, rfOrder=3, authorNames=张琛, 赵钢, journalName=中国新药杂志, refType=null, unstructuredReference=张琛，赵钢. 人参皂苷Rd的药理作用研究进展［J］. 中国新药杂志，2011，20（11）：953-958., articleTitle=人参皂苷Rd的药理作用研究进展, refAbstract=null), Reference(id=1322923632313381822, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2015, volume=21, issue=6, pageStart=1, pageEnd=4, url=null, language=null, rfNumber=［5］, rfOrder=4, authorNames=徐志立, 陶小军, 黎明, journalName=儿科药学杂志, refType=null, unstructuredReference=徐志立，陶小军，黎明，等. 人参皂苷Re对脾虚小鼠免疫功能及抗应激反应的影响［J］. 儿科药学杂志，2015，21（6）：1-4., articleTitle=人参皂苷Re对脾虚小鼠免疫功能及抗应激反应的影响, refAbstract=null), Reference(id=1322923632380490688, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2015, volume=31, issue=3, pageStart=309, pageEnd=311, url=null, language=null, rfNumber=［6］, rfOrder=5, authorNames=杨逸, 覃筱燕, 郭哲, journalName=中国公共卫生, refType=null, unstructuredReference=杨逸，覃筱燕，郭哲，等. 人参皂苷Rg1对小鼠免疫性肝损伤保护作用［J］. 中国公共卫生，2015，31（3）：309-311., articleTitle=人参皂苷Rg1对小鼠免疫性肝损伤保护作用, refAbstract=null), Reference(id=1322923632623760321, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2012, volume=26, issue=17, pageStart=7, pageEnd=9, url=null, language=null, rfNumber=［7］, rfOrder=6, authorNames=赵刚, 葛信国, journalName=实用中医内科杂志, refType=null, unstructuredReference=赵刚，葛信国. 人参皂甙Rg3对H22荷瘤小鼠免疫微环境的影响［J］. 实用中医内科杂志，2012，26（17）：7-9., articleTitle=人参皂甙Rg3对H22荷瘤小鼠免疫微环境的影响, refAbstract=null), Reference(id=1322923632762172355, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=50, issue=15, pageStart=3729, pageEnd=3734, url=null, language=null, rfNumber=［8］, rfOrder=7, authorNames=王曼, 黄念, 凌昌全, journalName=中草药, refType=null, unstructuredReference=王曼，黄念，凌昌全. 人参皂苷Rg₃对肿瘤的免疫调节作用及其纳米给药体系研究进展［J］. 中草药，2019，50（15）：3729-3734., articleTitle=人参皂苷Rg₃对肿瘤的免疫调节作用及其纳米给药体系研究进展, refAbstract=null), Reference(id=1322923632867029956, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［9］, rfOrder=8, authorNames=唐敏敏, journalName=null, refType=null, unstructuredReference=唐敏敏. 人参皂苷Rb1的抗抑郁作用及其神经免疫机制的研究［D］. 成都：电子科技大学，2017., articleTitle=人参皂苷Rb1的抗抑郁作用及其神经免疫机制的研究, refAbstract=null), Reference(id=1322923632988664773, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2013, volume=48, issue=15, pageStart=1233, pageEnd=1237, url=null, language=null, rfNumber=［10］, rfOrder=9, authorNames=杨秋娅, 李晓宇, 刘皋林, journalName=中国药学杂志, refType=null, unstructuredReference=杨秋娅，李晓宇，刘皋林. 人参皂苷Rb1的药理作用研究进展［J］. 中国药学杂志，2013，48（15）：1233-1237., articleTitle=人参皂苷Rb1的药理作用研究进展, refAbstract=null), Reference(id=1322923633118688199, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=43, issue=3, pageStart=368, pageEnd=371, url=null, language=null, rfNumber=［11］, rfOrder=10, authorNames=牛瑞娟, 马思佳, 唐亮, journalName=国际老年医学杂志, refType=null, unstructuredReference=牛瑞娟，马思佳，唐亮，等. 人参皂苷Rh1免疫调节作用的研究进展［J］. 国际老年医学杂志，2022，43（3）：368-371., articleTitle=人参皂苷Rh1免疫调节作用的研究进展, refAbstract=null), Reference(id=1322923634867712968, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［12］, rfOrder=11, authorNames=杨春媚, journalName=null, refType=null, unstructuredReference=杨春媚. 人参皂苷Rh2干预sMICA相关蛋白酶ERp5促进NK细胞的肿瘤免疫监视［D］. 南京：南京中医药大学，2021., articleTitle=人参皂苷Rh2干预sMICA相关蛋白酶ERp5促进NK细胞的肿瘤免疫监视, refAbstract=null), Reference(id=1322923635257783242, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=35, issue=23, pageStart=2936, pageEnd=2941, url=null, language=null, rfNumber=［13］, rfOrder=12, authorNames=黄容容, 钱颖, 向明, journalName=中国免疫学杂志, refType=null, unstructuredReference=黄容容，钱颖，向明. 人参皂苷Rh2免疫调节作用研究进展［J］. 中国免疫学杂志，2019，35（23）：2936-2941., articleTitle=人参皂苷Rh2免疫调节作用研究进展, refAbstract=null), Reference(id=1322923635589133259, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2018, volume=41, issue=4, pageStart=241, pageEnd=243，258, url=null, language=null, rfNumber=［14］, rfOrder=13, authorNames=王庆华, 商琼琼, 张建民, journalName=滨州医学院学报, refType=null, unstructuredReference=王庆华，商琼琼，张建民，等. 人参皂苷CK对重症急性胰腺炎大鼠肝功能和免疫作用的影响［J］. 滨州医学院学报，2018，41（4）：241-243，258., articleTitle=人参皂苷CK对重症急性胰腺炎大鼠肝功能和免疫作用的影响, refAbstract=null), Reference(id=1322923635752711117, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=35, issue=6, pageStart=478, pageEnd=481，488, url=null, language=null, rfNumber=［15］, rfOrder=14, authorNames=杨伟, 滕林, 丁家望, journalName=心肺血管病杂志, refType=null, unstructuredReference=杨伟，滕林，丁家望，等. 人参皂苷compound K对小鼠心肌梗死后心室重构的保护及免疫机制研究［J］. 心肺血管病杂志，2016，35（6）：478-481，488., articleTitle=人参皂苷compound K对小鼠心肌梗死后心室重构的保护及免疫机制研究, refAbstract=null), Reference(id=1322923636012757966, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=31, issue=4, pageStart=62, pageEnd=65, url=null, language=null, rfNumber=［16］, rfOrder=15, authorNames=浦滇, 李俊, 黄娜娜, journalName=中国民族民间医药, refType=null, unstructuredReference=浦滇，李俊，黄娜娜，等. 人参皂苷CK对肝脏的药理作用研究概况［J］. 中国民族民间医药，2022，31（4）：62-65., articleTitle=人参皂苷CK对肝脏的药理作用研究概况, refAbstract=null), Reference(id=1322923636146975696, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=33, issue=8, pageStart=1170, pageEnd=1176, url=null, language=null, rfNumber=［17］, rfOrder=16, authorNames=李紫薇, 于宁, 朱肖肖, journalName=中国免疫学杂志, refType=null, unstructuredReference=李紫薇，于宁，朱肖肖，等. 人参皂苷Ro促进THP-1细胞向DC分化的作用［J］. 中国免疫学杂志，2017，33（8）：1170-1176., articleTitle=人参皂苷Ro促进THP-1细胞向DC分化的作用, refAbstract=null), Reference(id=1322923636528657361, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=30, issue=11, pageStart=29, pageEnd=32，37, url=null, language=null, rfNumber=［18］, rfOrder=17, authorNames=徐小雪, 张文文, 杨潮, journalName=中国当代医药, refType=null, unstructuredReference=徐小雪，张文文，杨潮. 人参皂苷Rg5的抗癌作用研究进展［J］. 中国当代医药，2023，30（11）：29-32，37., articleTitle=人参皂苷Rg5的抗癌作用研究进展, refAbstract=null), Reference(id=1322923636948087762, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2012, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［19］, rfOrder=18, authorNames=宋利华, journalName=null, refType=null, unstructuredReference=宋利华. 基于免疫调节作用的人参多糖效应部位研究［D］. 南京：南京中医药大学，2012., articleTitle=基于免疫调节作用的人参多糖效应部位研究, refAbstract=null), Reference(id=1322923637229106132, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=35, issue=6, pageStart=143, pageEnd=146，150, url=null, language=null, rfNumber=［20］, rfOrder=19, authorNames=王国明, 徐清华, 谢丽娟, journalName=粮食与油脂, refType=null, unstructuredReference=王国明，徐清华，谢丽娟，等. 人参、西洋参中多糖成分分析及其抗氧化活性研究［J］. 粮食与油脂，2022，35（6）：143-146，150., articleTitle=人参、西洋参中多糖成分分析及其抗氧化活性研究, refAbstract=null), Reference(id=1322923637673702358, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2009, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［21］, rfOrder=20, authorNames=张旭, journalName=null, refType=null, unstructuredReference=张旭. 人参多糖的系统分析及其免疫活性研究［D］. 长春：东北师范大学，2009., articleTitle=人参多糖的系统分析及其免疫活性研究, refAbstract=null), Reference(id=1322923639351423960, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=12, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［22］, rfOrder=21, authorNames=LIU S, LIU F B, WANGT T, journalName=Front Pharmacol, refType=null, unstructuredReference=LIU S，LIU F B，WANGT T，et al. Polysaccharides extracted from Panax ginseng C. A. mey enhance complement component 4 biosynthesis in human hepatocytes［J］. Front Pharmacol，2021，12：734394., articleTitle=Polysaccharides extracted from Panax ginseng C. A. mey enhance complement component 4 biosynthesis in human hepatocytes, refAbstract=null), Reference(id=1322923639456281561, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2020, volume=150, issue=null, pageStart=695, pageEnd=704, url=null, language=null, rfNumber=［23］, rfOrder=22, authorNames=FANG X X, ZHUDF, CHENY H, journalName=Int J Biol Macromol, refType=null, unstructuredReference=FANG X X，ZHUDF，CHENY H，et al. LC-MS/MSanalysis of partial structure of Panax ginseng protein and its distribution in vivo［J］. Int J Biol Macromol，2020，150：695-704., articleTitle=LC-MS/MSanalysis of partial structure of Panax ginseng protein and its distribution in vivo, refAbstract=null), Reference(id=1322923639749882842, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2010, volume=6, issue=1, pageStart=14, pageEnd=16, url=null, language=null, rfNumber=［24］, rfOrder=23, authorNames=李红艳, 赵雨, 孙晓迪, journalName=亚太传统医药, refType=null, unstructuredReference=李红艳，赵雨，孙晓迪，等. 人参蛋白对小鼠免疫功能影响的研究［J］. 亚太传统医药，2010，6（1）：14-16., articleTitle=人参蛋白对小鼠免疫功能影响的研究, refAbstract=null), Reference(id=1322923639879906268, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=28, issue=13, pageStart=1856, pageEnd=1859, url=null, language=null, rfNumber=［25］, rfOrder=24, authorNames=赵岩, 王红, 蔡恩博, journalName=中国药房, refType=null, unstructuredReference=赵岩，王红，蔡恩博，等. 人参挥发油化学成分及其主要活性成分聚乙炔醇类药理作用研究进展［J］. 中国药房，2017，28（13）：1856-1859., articleTitle=人参挥发油化学成分及其主要活性成分聚乙炔醇类药理作用研究进展, refAbstract=null), Reference(id=1322923640228033501, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=左旭, journalName=null, refType=null, unstructuredReference=左旭. 人参挥发油的抗炎活性研究［D］. 长春：吉林大学，2021., articleTitle=人参挥发油的抗炎活性研究, refAbstract=null), Reference(id=1322923640295142367, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2004, volume=39, issue=4, pageStart=261, pageEnd=264, url=null, language=null, rfNumber=［27］, rfOrder=26, authorNames=张仲苗, 江波, 郑筱祥, journalName=中国药学杂志, refType=null, unstructuredReference=张仲苗，江波，郑筱祥. 人参皂苷Rg₃对肿瘤放疗患者外周血淋巴细胞的体外免疫增强作用［J］. 中国药学杂志，2004，39（4）：261-264., articleTitle=人参皂苷Rg₃对肿瘤放疗患者外周血淋巴细胞的体外免疫增强作用, refAbstract=null), Reference(id=1322923640366445536, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2018, volume=39, issue=1, pageStart=101, pageEnd=103, url=null, language=null, rfNumber=［28］, rfOrder=27, authorNames=赵燕, journalName=陕西中医, refType=null, unstructuredReference=赵燕. 人参皂苷Rg3对鼻咽癌Th1/Th2细胞因子表达情况及临床治疗效果分析［J］. 陕西中医，2018，39（1）：101-103., articleTitle=人参皂苷Rg3对鼻咽癌Th1/Th2细胞因子表达情况及临床治疗效果分析, refAbstract=null), Reference(id=1322923640429360097, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=35, issue=1, pageStart=47, pageEnd=51, url=null, language=null, rfNumber=［29］, rfOrder=28, authorNames=缪志伟, 严晶, 顾鸣佳, journalName=中药药理与临床, refType=null, unstructuredReference=缪志伟，严晶，顾鸣佳，等. 人参皂苷Rg3对DSS诱导的溃疡性结肠炎小鼠Th1/Th2失衡的影响［J］. 中药药理与临床，2019，35（1）：47-51., articleTitle=人参皂苷Rg3对DSS诱导的溃疡性结肠炎小鼠Th1/Th2失衡的影响, refAbstract=null), Reference(id=1322923640496468962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=46, issue=5, pageStart=628, pageEnd=635, url=null, language=null, rfNumber=［30］, rfOrder=29, authorNames=ULLAH H M A, SABA E, LEE Y Y, journalName=J Ginseng Res, refType=null, unstructuredReference=ULLAH H M A，SABA E，LEE Y Y，et al. Restorative effects of Rg3-enriched Korean Red Ginseng and Persicaria tinctoria extract on oxazolone-induced ulcerative colitis in mice［J］. J Ginseng Res，2022，46（5）：628-635., articleTitle=Restorative effects of Rg3-enriched Korean Red Ginseng and Persicaria tinctoria extract on oxazolone-induced ulcerative colitis in mice, refAbstract=null), Reference(id=1322923640571966436, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=39, issue=8, pageStart=1430, pageEnd=1437, url=null, language=null, rfNumber=［31］, rfOrder=30, authorNames=赵涵, 邹珏瑶, 何勇, journalName=中国药理学通报, refType=null, unstructuredReference=赵涵，邹珏瑶，何勇，等. 人参皂苷Rg3激活MAPK/ERK信号通路促进T细胞功能的抗肿瘤机制［J］. 中国药理学通报，2023，39（8）：1430-1437., articleTitle=人参皂苷Rg3激活MAPK/ERK信号通路促进T细胞功能的抗肿瘤机制, refAbstract=null), Reference(id=1322923640643269605, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2020, volume=10, issue=1, pageStart=122, pageEnd=null, url=null, language=null, rfNumber=［32］, rfOrder=31, authorNames=PARK Y J, CHO M, CHOI G, journalName=Biomolecules, refType=null, unstructuredReference=PARK Y J，CHO M，CHOI G，et al. A critical regulation of Th17 cell responses and autoimmune neuro-inflammation by ginsenoside Rg₃［J］. Biomolecules，2020，10（1）：122., articleTitle=A critical regulation of Th17 cell responses and autoimmune neuro-inflammation by ginsenoside Rg₃, refAbstract=null), Reference(id=1322923640710378470, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=20, issue=14, pageStart=1464, pageEnd=1467, url=null, language=null, rfNumber=［33］, rfOrder=32, authorNames=马成军, 陈明, 张穹, journalName=临床和实验医学杂志, refType=null, unstructuredReference=马成军，陈明，张穹，等. 人参皂苷RG3对自身免疫性甲状腺炎小鼠甲状腺功能和辅助型T细胞亚群的影响及相关机制［J］. 临床和实验医学杂志，2021，20（14）：1464-1467., articleTitle=人参皂苷RG3对自身免疫性甲状腺炎小鼠甲状腺功能和辅助型T细胞亚群的影响及相关机制, refAbstract=null), Reference(id=1322923640773293031, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2020, volume=31, issue=6, pageStart=894, pageEnd=895, url=null, language=null, rfNumber=［34］, rfOrder=33, authorNames=孙义长, journalName=现代诊断与治疗, refType=null, unstructuredReference=孙义长. 人参皂苷Rg3联合新辅助放化疗对胃癌患者免疫功能及生存率的影响［J］. 现代诊断与治疗，2020，31（6）：894-895., articleTitle=人参皂苷Rg3联合新辅助放化疗对胃癌患者免疫功能及生存率的影响, refAbstract=null), Reference(id=1322923640840401897, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2020, volume=68, issue=17, pageStart=4893, pageEnd=4902, url=null, language=null, rfNumber=［35］, rfOrder=34, authorNames=ZHANG Y, WANG S, SONG S, journalName=J Agric Food Chem, refType=null, unstructuredReference=ZHANG Y，WANG S，SONG S，et al. Ginsenoside Rg3 alleviates complete Freund’s adjuvant-induced rheumatoid arthritis in mice by regulating CD4^＋CD25^＋Foxp3^＋Treg cells［J］. J Agric Food Chem，2020，68（17）：4893-4902., articleTitle=Ginsenoside Rg3 alleviates complete Freund’s adjuvant-induced rheumatoid arthritis in mice by regulating CD4^＋CD25^＋Foxp3^＋Treg cells, refAbstract=null), Reference(id=1322923640903316458, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=96, issue=null, pageStart=378, pageEnd=383, url=null, language=null, rfNumber=［36］, rfOrder=35, authorNames=JIANGZ S, YANGY F, YANGY L, journalName=Biomed Pharmacother, refType=null, unstructuredReference=JIANGZ S，YANGY F，YANGY L，et al. Ginsenoside Rg3 attenuates cisplatin resistance in lung cancer by downregulating PD-L1 and resuming immune［J］. Biomed Pharmacother，2017，96：378-383., articleTitle=Ginsenoside Rg3 attenuates cisplatin resistance in lung cancer by downregulating PD-L1 and resuming immune, refAbstract=null), Reference(id=1322923640966231019, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=33, issue=1, pageStart=20, pageEnd=26, url=null, language=null, rfNumber=［37］, rfOrder=36, authorNames=龙健, 康增平, 钟友宝, journalName=中药新药与临床药理, refType=null, unstructuredReference=龙健，康增平，钟友宝，等. 人参皂苷Rg1对DSS诱导的溃疡性结肠炎小鼠Treg/Th9细胞平衡的调控作用［J］. 中药新药与临床药理，2022，33（1）：20-26., articleTitle=人参皂苷Rg1对DSS诱导的溃疡性结肠炎小鼠Treg/Th9细胞平衡的调控作用, refAbstract=null), Reference(id=1322923641041728492, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2015, volume=762, issue=null, pageStart=333, pageEnd=343, url=null, language=null, rfNumber=［38］, rfOrder=37, authorNames=LEE SY, JEONGJJ, EUNSH, journalName=Eur JPharmacol, refType=null, unstructuredReference=LEE SY，JEONGJJ，EUNSH，et al. Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20（S）-protopanaxatriol in mice with TNBS-induced colitis［J］. Eur JPharmacol，2015，762：333-343., articleTitle=Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20（S）-protopanaxatriol in mice with TNBS-induced colitis, refAbstract=null), Reference(id=1322923641134003182, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=40, issue=1, pageStart=76, pageEnd=81, url=null, language=null, rfNumber=［39］, rfOrder=38, authorNames=徐文, 周妍, 朱国旗, journalName=安徽中医药大学学报, refType=null, unstructuredReference=徐文，周妍，朱国旗. 人参皂苷Rg1抑制小鼠实验性自身免疫性脑脊髓炎的作用及免疫机制［J］. 安徽中医药大学学报，2021，40（1）：76-81., articleTitle=人参皂苷Rg1抑制小鼠实验性自身免疫性脑脊髓炎的作用及免疫机制, refAbstract=null), Reference(id=1322923641217889263, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［40］, rfOrder=39, authorNames=张娜, journalName=null, refType=null, unstructuredReference=张娜. 人参皂苷Rg1对系统性红斑狼疮的免疫调节作用的实验研究［D］. 青岛：青岛大学，2016., articleTitle=人参皂苷Rg1对系统性红斑狼疮的免疫调节作用的实验研究, refAbstract=null), Reference(id=1322923641297581040, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2006, volume=6, issue=9, pageStart=1424, pageEnd=1430, url=null, language=null, rfNumber=［41］, rfOrder=40, authorNames=LEE JH, HAN Y, journalName=Int Immunopharmacol, refType=null, unstructuredReference=LEE JH，HAN Y. Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4^＋T cell［J］. Int Immunopharmacol，2006，6（9）：1424-1430., articleTitle=Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4^＋T cell, refAbstract=null), Reference(id=1322923641360495601, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2012, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［42］, rfOrder=41, authorNames=张亚兴, journalName=null, refType=null, unstructuredReference=张亚兴. 人参皂苷Rg1对CLP诱导的脓毒血症小鼠免疫调节机制研究［D］. 广州：暨南大学，2012., articleTitle=人参皂苷Rg1对CLP诱导的脓毒血症小鼠免疫调节机制研究, refAbstract=null), Reference(id=1322923641456964594, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2020, volume=9, issue=5, pageStart=3436, pageEnd=3446, url=null, language=null, rfNumber=［43］, rfOrder=42, authorNames=HE J, YU Q T, WU C L, journalName=Ann Palliat Med, refType=null, unstructuredReference=HE J，YU Q T，WU C L，et al. Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with chronic fatigue syndrome［J］. Ann Palliat Med，2020，9（5）：3436-3446., articleTitle=Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with chronic fatigue syndrome, refAbstract=null), Reference(id=1322923641540850675, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2013, volume=380, issue=1-2, pageStart=203, pageEnd=210, url=null, language=null, rfNumber=［44］, rfOrder=43, authorNames=CAO L J, ZOU Y, ZHU J L, journalName=Mol Cell Biochem, refType=null, unstructuredReference=CAO L J，ZOU Y，ZHU J L，et al. Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration［J］. Mol Cell Biochem，2013，380（1-2）：203-210., articleTitle=Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration, refAbstract=null), Reference(id=1322923641603765236, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=35, issue=2, pageStart=54, pageEnd=56, url=null, language=null, rfNumber=［45］, rfOrder=44, authorNames=孙睿, 张建文, 梁辉, journalName=四川中医, refType=null, unstructuredReference=孙睿，张建文，梁辉，等. 人参皂苷Rg1对大鼠Ⅲ型前列腺炎血清细胞免疫因子的影响［J］. 四川中医，2017，35（2）：54-56., articleTitle=人参皂苷Rg1对大鼠Ⅲ型前列腺炎血清细胞免疫因子的影响, refAbstract=null), Reference(id=1322923641704428533, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2013, volume=183, issue=2, pageStart=760, pageEnd=766, url=null, language=null, rfNumber=［46］, rfOrder=45, authorNames=ZOU Y, TAO T Z, TIAN Y, journalName=J Surg Res, refType=null, unstructuredReference=ZOU Y，TAO T Z，TIAN Y，et al. Ginsenoside Rg1 improves survival in a murine model of polymicrobial sepsis by suppressing the inflammatory response and apoptosis of lymphocytes［J］. J Surg Res，2013，183（2）：760-766., articleTitle=Ginsenoside Rg1 improves survival in a murine model of polymicrobial sepsis by suppressing the inflammatory response and apoptosis of lymphocytes, refAbstract=null), Reference(id=1322923641771537398, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=85, issue=8, pageStart=1809, pageEnd=1817, url=null, language=null, rfNumber=［47］, rfOrder=46, authorNames=LI Q, ZHAI C M, WANG G D, journalName=Biosci Biotechnol Biochem, refType=null, unstructuredReference=LI Q，ZHAI C M，WANG G D，et al. Ginsenoside Rh1 attenuates ovalbumin-induced asthma by regulating Th1/Th2 cytokines balance［J］. Biosci Biotechnol Biochem，2021，85（8）：1809-1817., articleTitle=Ginsenoside Rh1 attenuates ovalbumin-induced asthma by regulating Th1/Th2 cytokines balance, refAbstract=null), Reference(id=1322923641851229175, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2012, volume=14, issue=4, pageStart=481, pageEnd=486, url=null, language=null, rfNumber=［48］, rfOrder=47, authorNames=KIM J, HAN B J, KIM H, journalName=Int Immunopharmacol, refType=null, unstructuredReference=KIM J，HAN B J，KIM H，et al. Th1 immunity induction by ginsenoside Re involves in protection of mice against disseminated candidiasis due to Candida albicans［J］. Int Immunopharmacol，2012，14（4）：481-486., articleTitle=Th1 immunity induction by ginsenoside Re involves in protection of mice against disseminated candidiasis due to Candida albicans, refAbstract=null), Reference(id=1322923641926726648, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=198, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［49］, rfOrder=48, authorNames=HUANG M Y, CHEN Y C, LYU W Y, journalName=Pharmacol Res, refType=null, unstructuredReference=HUANG M Y，CHEN Y C，LYU W Y，et al. Ginsenoside Rh2 augmented anti-PD-L1 immunotherapy by reinvigorating CD8^＋T cells via increasing intratumoral CXCL10［J］. Pharmacol Res，2023，198：106988., articleTitle=Ginsenoside Rh2 augmented anti-PD-L1 immunotherapy by reinvigorating CD8^＋T cells via increasing intratumoral CXCL10, refAbstract=null), Reference(id=1322923641998029817, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2015, volume=36, issue=3, pageStart=980, pageEnd=987, url=null, language=null, rfNumber=［50］, rfOrder=49, authorNames=ZHOU J, GAO Y L, YI X M, journalName=Cell Physiol Biochem, refType=null, unstructuredReference=ZHOU J，GAO Y L，YI X M，et al. Ginsenoside Rh2 suppresses neovascularization in xenograft psoriasis model［J］. Cell Physiol Biochem，2015，36（3）：980-987., articleTitle=Ginsenoside Rh2 suppresses neovascularization in xenograft psoriasis model, refAbstract=null), Reference(id=1322923643654779898, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=101, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［51］, rfOrder=50, authorNames=WU H C, HU Q R, LUO T, journalName=Int Immunopharmacol, refType=null, unstructuredReference=WU H C，HU Q R，LUO T，et al. The immunomodulatory effects of ginsenoside derivative Rh2-O on splenic lymphocytes in H22 tumor-bearing mice is partially mediated by TLR4［J］. Int Immunopharmacol，2021，101（Pt B）：108316., articleTitle=The immunomodulatory effects of ginsenoside derivative Rh2-O on splenic lymphocytes in H22 tumor-bearing mice is partially mediated by TLR4, refAbstract=null), Reference(id=1322923643956769787, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［52］, rfOrder=51, authorNames=李煜, journalName=null, refType=null, unstructuredReference=李煜. 人参皂苷Rh2抗急性淋巴细胞白血病的作用及其机制研究［D］. 天津：天津科技大学，2021., articleTitle=人参皂苷Rh2抗急性淋巴细胞白血病的作用及其机制研究, refAbstract=null), Reference(id=1322923644057433084, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=31, issue=7, pageStart=2807, pageEnd=2811, url=null, language=null, rfNumber=［53］, rfOrder=52, authorNames=崔勇, 李世明, 金燕, journalName=中华中医药杂志, refType=null, unstructuredReference=崔勇，李世明，金燕，等. 人参皂苷Rh2抗小鼠哮喘模型气道炎性反应的作用研究［J］. 中华中医药杂志，2016，31（7）：2807-2811., articleTitle=人参皂苷Rh2抗小鼠哮喘模型气道炎性反应的作用研究, refAbstract=null), Reference(id=1322923644363617277, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2015, volume=38, issue=5, pageStart=1814, pageEnd=1822, url=null, language=null, rfNumber=［54］, rfOrder=53, authorNames=CHEN T, XIAOL, ZHUL P, journalName=Inflammation, refType=null, unstructuredReference=CHEN T，XIAOL，ZHUL P，et al. Anti-asthmatic effectsof ginsenoside Rb1 in a mouse model of allergic asthma through relegating Th1/Th₂［J］. Inflammation，2015，38（5）：1814-1822., articleTitle=Anti-asthmatic effectsof ginsenoside Rb1 in a mouse model of allergic asthma through relegating Th1/Th₂, refAbstract=null), Reference(id=1322923644443309054, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=220, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［55］, rfOrder=54, authorNames=ALI RAJPUT S, SHAUKAT A, RAJPUT I R, journalName=Ecotoxicol Environ Saf, refType=null, unstructuredReference=ALI RAJPUT S，SHAUKAT A，RAJPUT I R，et al. Ginsenoside Rb1 prevents deoxynivalenol-induced immune injury via alleviating oxidative stress and apoptosis in mice［J］. Ecotoxicol Environ Saf，2021，220：112333., articleTitle=Ginsenoside Rb1 prevents deoxynivalenol-induced immune injury via alleviating oxidative stress and apoptosis in mice, refAbstract=null), Reference(id=1322923644527195135, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=41, issue=null, pageStart=136, pageEnd=143, url=null, language=null, rfNumber=［56］, rfOrder=55, authorNames=CHEN W, MENGQ F, SUIJK, journalName=Int Immunopharmacol, refType=null, unstructuredReference=CHEN W，MENGQ F，SUIJK，et al. Ginsenoside Rb1：The new treatment measure of myasthenia gravis［J］. Int Immunopharmacol，2016，41：136-143., articleTitle=Ginsenoside Rb1：The new treatment measure of myasthenia gravis, refAbstract=null), Reference(id=1322923644787241984, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=24, issue=5, pageStart=418, pageEnd=422, url=null, language=null, rfNumber=［57］, rfOrder=56, authorNames=杨帆, 沈俊逸, 蔡辉, journalName=实用药物与临床, refType=null, unstructuredReference=杨帆，沈俊逸，蔡辉. 人参皂苷Rb1对系统性红斑狼疮患者外周血T淋巴细胞体外活化的影响［J］. 实用药物与临床，2021，24（5）：418-422., articleTitle=人参皂苷Rb1对系统性红斑狼疮患者外周血T淋巴细胞体外活化的影响, refAbstract=null), Reference(id=1322923644871127040, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2014, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［58］, rfOrder=57, authorNames=刘永林, journalName=null, refType=null, unstructuredReference=刘永林. T细胞、MSC、FSH在再生障碍性贫血患者发病中的作用及人参皂苷Rb1治疗再生障碍性贫血的机制研究［D］. 杭州：浙江中医药大学，2014., articleTitle=T细胞、MSC、FSH在再生障碍性贫血患者发病中的作用及人参皂苷Rb1治疗再生障碍性贫血的机制研究, refAbstract=null), Reference(id=1322923644963401729, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2014, volume=92, issue=9, pageStart=1217, pageEnd=1226, url=null, language=null, rfNumber=［59］, rfOrder=58, authorNames=ZHU D L, LIU M, YANG Y W, journalName=J Neurosci Res, refType=null, unstructuredReference=ZHU D L，LIU M，YANG Y W，et al. Ginsenoside Rd ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice［J］. J Neurosci Res，2014，92（9）：1217-1226., articleTitle=Ginsenoside Rd ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice, refAbstract=null), Reference(id=1322923645227642882, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2018, volume=11, issue=15, pageStart=66, pageEnd=68, url=null, language=null, rfNumber=［60］, rfOrder=59, authorNames=杨晓玲, 周强, 郑春华, journalName=临床合理用药杂志, refType=null, unstructuredReference=杨晓玲，周强，郑春华，等. 人参多糖对创伤性脓毒症患者免疫功能和细胞炎性因子的影响［J］. 临床合理用药杂志，2018，11（15）：66-68., articleTitle=人参多糖对创伤性脓毒症患者免疫功能和细胞炎性因子的影响, refAbstract=null), Reference(id=1322923645298946051, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=1995, volume=20, issue=5, pageStart=307, pageEnd=309, url=null, language=null, rfNumber=［61］, rfOrder=60, authorNames=马路, 侯桂霞, 周柱亮, journalName=中国中药杂志, refType=null, unstructuredReference=马路，侯桂霞，周柱亮，等. 人参多糖对慢性肾功能衰竭患者细胞免疫功能影响的体外研究［J］. 中国中药杂志，1995，20（5）：307-309., articleTitle=人参多糖对慢性肾功能衰竭患者细胞免疫功能影响的体外研究, refAbstract=null), Reference(id=1322923645621907460, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2018, volume=36, issue=7, pageStart=1760, pageEnd=1763, url=null, language=null, rfNumber=［62］, rfOrder=61, authorNames=陈华敏, 吴煌福, 黄光钺, journalName=中华中医药学刊, refType=null, unstructuredReference=陈华敏，吴煌福，黄光钺. 人参多糖注射液联合新辅助化疗治疗乳腺癌疗效及对免疫功能的影响［J］. 中华中医药学刊，2018，36（7）：1760-1763., articleTitle=人参多糖注射液联合新辅助化疗治疗乳腺癌疗效及对免疫功能的影响, refAbstract=null), Reference(id=1322923645701599237, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=22, issue=7, pageStart=1352, pageEnd=1356, url=null, language=null, rfNumber=［63］, rfOrder=62, authorNames=王敏, 孔德军, 杨莉, journalName=现代生物医学进展, refType=null, unstructuredReference=王敏，孔德军，杨莉，等. 人参多糖注射液联合TP方案对晚期非小细胞肺癌患者Th1/Th2免疫平衡和血清肿瘤标志物的影响［J］. 现代生物医学进展，2022，22（7）：1352-1356., articleTitle=人参多糖注射液联合TP方案对晚期非小细胞肺癌患者Th1/Th2免疫平衡和血清肿瘤标志物的影响, refAbstract=null), Reference(id=1322923645768708102, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2011, volume=138, issue=2, pageStart=169, pageEnd=178, url=null, language=null, rfNumber=［64］, rfOrder=63, authorNames=HWANG I, AHN G, PARK E, journalName=Immunol Lett, refType=null, unstructuredReference=HWANG I，AHN G，PARK E，et al. An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells［J］. Immunol Lett，2011，138（2）：169-178., articleTitle=An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells, refAbstract=null), Reference(id=1322923645835816967, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2014, volume=34, issue=6, pageStart=641, pageEnd=645, url=null, language=null, rfNumber=［65］, rfOrder=64, authorNames=MA J J, LIU H P, WANG X L, journalName=J Tradit Chin Med, refType=null, unstructuredReference=MA J J，LIU H P，WANG X L. Effect of ginseng polysaccharides and dendritic cells on the balance of Th1/Th2 T helper cells in patients with non-small cell lung cancer［J］. J Tradit Chin Med，2014，34（6）：641-645., articleTitle=Effect of ginseng polysaccharides and dendritic cells on the balance of Th1/Th2 T helper cells in patients with non-small cell lung cancer, refAbstract=null), Reference(id=1322923645907120136, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2007, volume=8, issue=1, pageStart=39, pageEnd=44, url=null, language=null, rfNumber=［66］, rfOrder=65, authorNames=KIM H J, KIM M H, BYON Y Y, journalName=J Vet Sci, refType=null, unstructuredReference=KIM H J，KIM M H，BYON Y Y，et al. Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells［J］. J Vet Sci，2007，8（1）：39-44., articleTitle=Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells, refAbstract=null), Reference(id=1322923645961646089, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=1998, volume=64, issue=2, pageStart=110, pageEnd=115, url=null, language=null, rfNumber=［67］, rfOrder=66, authorNames=KIM K H, LEE Y S, JUNG I S, journalName=Planta Med, refType=null, unstructuredReference=KIM K H，LEE Y S，JUNG I S，et al. Acidic polysaccharide from Panax ginseng，ginsan，induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2［J］. Planta Med，1998，64（2）：110-115., articleTitle=Acidic polysaccharide from Panax ginseng，ginsan，induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2, refAbstract=null), Reference(id=1322923646053920778, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2015, volume=12, issue=3, pageStart=3557, pageEnd=3562, url=null, language=null, rfNumber=［68］, rfOrder=67, authorNames=LUO Y, ZHANG P, ZENG H Q, journalName=Mol Med Rep, refType=null, unstructuredReference=LUO Y，ZHANG P，ZENG H Q，et al. Ginsenoside Rg3 induces apoptosis in human multiple myeloma cells via the activation of Bcl-2-associated X protein［J］. Mol Med Rep，2015，12（3）：3557-3562., articleTitle=Ginsenoside Rg3 induces apoptosis in human multiple myeloma cells via the activation of Bcl-2-associated X protein, refAbstract=null), Reference(id=1322923646142001163, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［69］, rfOrder=68, authorNames=余昕, journalName=null, refType=null, unstructuredReference=余昕. 四种人参皂苷单体对系统性红斑狼疮体液免疫的调节作用［D］. 上海：第二军医大学，2017., articleTitle=四种人参皂苷单体对系统性红斑狼疮体液免疫的调节作用, refAbstract=null), Reference(id=1322923646242664460, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=27, issue=4, pageStart=845, pageEnd=856, url=null, language=null, rfNumber=［70］, rfOrder=69, authorNames=ZHANG M, HU SS, TAOJ, journalName=Inflammopharmacology, refType=null, unstructuredReference=ZHANG M，HU SS，TAOJ，et al. Ginsenoside compound-K inhibits the activity of B cells through inducing IgD-B cell receptor endocytosis in mice with collagen-induced arthritis［J］. Inflammopharmacology，2019，27（4）：845-856., articleTitle=Ginsenoside compound-K inhibits the activity of B cells through inducing IgD-B cell receptor endocytosis in mice with collagen-induced arthritis, refAbstract=null), Reference(id=1322923646305579021, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=1960, issue=null, pageStart=57, pageEnd=62, url=null, language=null, rfNumber=［71］, rfOrder=70, authorNames=RONEY K, journalName=Methods Mol Biol, refType=null, unstructuredReference=RONEY K. Bone marrow-derived dendritic cells［J］. Methods Mol Biol，2019，1960：57-62., articleTitle=Bone marrow-derived dendritic cells, refAbstract=null), Reference(id=1322923646381076494, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2009, volume=24, issue=5, pageStart=35, pageEnd=38, url=null, language=null, rfNumber=［72］, rfOrder=71, authorNames=黑秀明, 黄志华, 高立超, journalName=国医论坛, refType=null, unstructuredReference=黑秀明，黄志华，高立超，等. 人参多糖诱生脐血来源树突状细胞的免疫机制研究［J］. 国医论坛，2009，24（5）：35-38., articleTitle=人参多糖诱生脐血来源树突状细胞的免疫机制研究, refAbstract=null), Reference(id=1322923646502711311, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=20, issue=10, pageStart=1021, pageEnd=1025, url=null, language=null, rfNumber=［73］, rfOrder=72, authorNames=雒宏, 陈雁飞, 钱军, journalName=临床和实验医学杂志, refType=null, unstructuredReference=雒宏，陈雁飞，钱军. 人参皂苷对胶原诱导类风湿关节炎小鼠脾脏树突状细胞亚群的影响［J］. 临床和实验医学杂志，2021，20（10）：1021-1025., articleTitle=人参皂苷对胶原诱导类风湿关节炎小鼠脾脏树突状细胞亚群的影响, refAbstract=null), Reference(id=1322923648142684176, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［74］, rfOrder=73, authorNames=莫婵, journalName=null, refType=null, unstructuredReference=莫婵. 保肝宁和人参皂苷Rg1对肝纤维化小鼠IDO1及树突状细胞的作用机制研究［D］. 广州：南方医科大学，2021., articleTitle=保肝宁和人参皂苷Rg1对肝纤维化小鼠IDO1及树突状细胞的作用机制研究, refAbstract=null), Reference(id=1322923648239153169, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=61, issue=4, pageStart=7, pageEnd=10，23, url=null, language=null, rfNumber=［75］, rfOrder=74, authorNames=黄艳琴, 袁佳蕾, 余艳容, journalName=南昌大学学报（医学版）, refType=null, unstructuredReference=黄艳琴，袁佳蕾，余艳容，等. 人参皂甙Rg3下调树突状细胞IDO杀伤小鼠肾癌细胞的实验研究［J］. 南昌大学学报（医学版），2021，61（4）：7-10，23., articleTitle=人参皂甙Rg3下调树突状细胞IDO杀伤小鼠肾癌细胞的实验研究, refAbstract=null), Reference(id=1322923648331427858, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［76］, rfOrder=75, authorNames=冯辉, journalName=null, refType=null, unstructuredReference=冯辉. 人参皂苷Rb1对免疫介导再生障碍性贫血小鼠造血功能及成熟树突状细胞数量的影响［D］. 杭州：浙江中医药大学，2016., articleTitle=人参皂苷Rb1对免疫介导再生障碍性贫血小鼠造血功能及成熟树突状细胞数量的影响, refAbstract=null), Reference(id=1322923648545337363, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［77］, rfOrder=76, authorNames=李紫薇, journalName=null, refType=null, unstructuredReference=李紫薇. 人参皂苷Ro调控STAT5通路促进白血病细胞向DC定向分化作用与机制研究［D］. 济南：济南大学，2017., articleTitle=人参皂苷Ro调控STAT5通路促进白血病细胞向DC定向分化作用与机制研究, refAbstract=null), Reference(id=1322923648612446228, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=248, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［78］, rfOrder=77, authorNames=LI Q, HE J L, LI SL, journalName=Clin Immunol, refType=null, unstructuredReference=LI Q，HE J L，LI SL，et al. The combination of gemcitabine and ginsenoside Rh2 enhances the immune function of dendritic cells against pancreatic cancer via the CARD9-BCL10-MALT1/NFκB pathway［J］. Clin Immunol，2023，248：109217., articleTitle=The combination of gemcitabine and ginsenoside Rh2 enhances the immune function of dendritic cells against pancreatic cancer via the CARD9-BCL10-MALT1/NFκB pathway, refAbstract=null), Reference(id=1322923648679555093, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2018, volume=5, issue=71, pageStart=197, pageEnd=null, url=null, language=null, rfNumber=［79］, rfOrder=78, authorNames=张浩, 高维实, 高艳伟, journalName=临床医药文献电子杂志, refType=null, unstructuredReference=张浩，高维实，高艳伟. NK细胞识别和杀伤机制研究进展［J］. 临床医药文献电子杂志，2018，5（71）：197., articleTitle=NK细胞识别和杀伤机制研究进展, refAbstract=null), Reference(id=1322923649082208278, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=42, issue=5, pageStart=901, pageEnd=910, url=null, language=null, rfNumber=［80］, rfOrder=79, authorNames=张月洋, 王绮昀, 何小花, journalName=生命的化学, refType=null, unstructuredReference=张月洋，王绮昀，何小花，等. NK细胞免疫治疗在肺癌中的作用［J］. 生命的化学，2022，42（5）：901-910., articleTitle=NK细胞免疫治疗在肺癌中的作用, refAbstract=null), Reference(id=1322923649161900055, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2004, volume=306, issue=5701, pageStart=1517, pageEnd=1519, url=null, language=null, rfNumber=［81］, rfOrder=80, authorNames=VIVIER E, NUNÈS J A, VÉLY F, journalName=Science, refType=null, unstructuredReference=VIVIER E，NUNÈS J A，VÉLY F. Natural killer cell signaling pathways［J］. Science，2004，306（5701）：1517-1519., articleTitle=Natural killer cell signaling pathways, refAbstract=null), Reference(id=1322923649224814616, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2014, volume=31, issue=3, pageStart=293, pageEnd=297, url=null, language=null, rfNumber=［82］, rfOrder=81, authorNames=李红英, 陈红霞, 汪蕾, journalName=中国现代应用药学, refType=null, unstructuredReference=李红英，陈红霞，汪蕾. 人参皂苷Rb1拮抗达沙替尼抑制NK细胞杀伤卵巢癌的研究［J］. 中国现代应用药学，2014，31（3）：293-297., articleTitle=人参皂苷Rb1拮抗达沙替尼抑制NK细胞杀伤卵巢癌的研究, refAbstract=null), Reference(id=1322923649409363993, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2012, volume=21, issue=28, pageStart=3099, pageEnd=3101, url=null, language=null, rfNumber=［83］, rfOrder=82, authorNames=汪蕾, 陈红霞, journalName=现代中西医结合杂志, refType=null, unstructuredReference=汪蕾，陈红霞. 人参皂苷Rb1拮抗肝癌细胞抑制NK细胞免疫功能的研究［J］. 现代中西医结合杂志，2012，21（28）：3099-3101., articleTitle=人参皂苷Rb1拮抗肝癌细胞抑制NK细胞免疫功能的研究, refAbstract=null), Reference(id=1322923649526804506, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=107, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［84］, rfOrder=83, authorNames=LEE Y, PARK A, PARK Y J, journalName=Int Immunopharmacol, refType=null, unstructuredReference=LEE Y，PARK A，PARK Y J，et al. Ginsenoside 20（R）-Rg3 enhances natural killer cell activity by increasing activating receptor expression through the MAPK/ERK signaling pathway［J］. Int Immunopharmacol，2022，107：108618., articleTitle=Ginsenoside 20（R）-Rg3 enhances natural killer cell activity by increasing activating receptor expression through the MAPK/ERK signaling pathway, refAbstract=null), Reference(id=1322923649614884891, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=103, issue=null, pageStart=1327, pageEnd=1333, url=null, language=null, rfNumber=［85］, rfOrder=84, authorNames=SHIN M S, HWANGSH, YOON T J, journalName=Int J Biol Macromol, refType=null, unstructuredReference=SHIN M S，HWANGSH，YOON T J，et al. Polysaccharides from ginseng leaves inhibit tumor metastasis via macrophage and NK cell activation［J］. Int J Biol Macromol，2017，103：1327-1333., articleTitle=Polysaccharides from ginseng leaves inhibit tumor metastasis via macrophage and NK cell activation, refAbstract=null), Reference(id=1322923649816211484, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=25, issue=6, pageStart=153, pageEnd=158, url=null, language=null, rfNumber=［86］, rfOrder=85, authorNames=黄沛沛, 高静东, journalName=辽宁中医药大学学报, refType=null, unstructuredReference=黄沛沛，高静东. 中药多糖通过影响巨噬细胞发挥免疫调节及抗肿瘤作用研究进展［J］. 辽宁中医药大学学报，2023，25（6）：153-158., articleTitle=中药多糖通过影响巨噬细胞发挥免疫调节及抗肿瘤作用研究进展, refAbstract=null), Reference(id=1322923649883320349, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=37, issue=1, pageStart=297, pageEnd=301, url=null, language=null, rfNumber=［87］, rfOrder=86, authorNames=赵益, 徐国良, 刘红宁, journalName=中华中医药杂志, refType=null, unstructuredReference=赵益，徐国良，刘红宁，等. 中药复方调节巨噬细胞极化的研究进展［J］. 中华中医药杂志，2022，37（1）：297-301., articleTitle=中药复方调节巨噬细胞极化的研究进展, refAbstract=null), Reference(id=1322923650009149470, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2020, volume=877, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［88］, rfOrder=87, authorNames=YUNNA C, MENGRU H, LEI W, journalName=Eur J Pharmacol, refType=null, unstructuredReference=YUNNA C，MENGRU H，LEI W，et al. Macrophage M1/M2 polarization［J］. Eur J Pharmacol，2020，877：173090., articleTitle=Macrophage M1/M2 polarization, refAbstract=null), Reference(id=1322923650076258335, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2007, volume=32, issue=5, pageStart=868, pageEnd=872, url=null, language=null, rfNumber=［89］, rfOrder=88, authorNames=周东波, 胡成平, 梁硕, journalName=中南大学学报（医学版）, refType=null, unstructuredReference=周东波，胡成平，梁硕，等. 人参单体皂甙Rh₂对非小细胞肺癌患者肺泡巨噬细胞免疫活性的影响［J］. 中南大学学报（医学版），2007，32（5）：868-872., articleTitle=人参单体皂甙Rh₂对非小细胞肺癌患者肺泡巨噬细胞免疫活性的影响, refAbstract=null), Reference(id=1322923650143367200, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=14, issue=null, pageStart=1789, pageEnd=1806, url=null, language=null, rfNumber=［90］, rfOrder=89, authorNames=WANGSH, CUI Y M, XIONGM Q, journalName=JInflamm Res, refType=null, unstructuredReference=WANGSH，CUI Y M，XIONGM Q，et al. Dual activity of ginsenoside Rb1 in hypertrophic cardiomyocytes and activated macrophages：implications for the therapeutic intervention of cardiac hypertrophy［J］. JInflamm Res，2021，14：1789-1806., articleTitle=Dual activity of ginsenoside Rb1 in hypertrophic cardiomyocytes and activated macrophages：implications for the therapeutic intervention of cardiac hypertrophy, refAbstract=null), Reference(id=1322923650231447585, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=118, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［91］, rfOrder=90, authorNames=LANG Z C, YU SH, HU Y H, journalName=Phytomedicine, refType=null, unstructuredReference=LANG Z C，YU SH，HU Y H，et al. Ginsenoside Rh2 promotes hepatic stellate cell ferroptosis and inactivation via regulation of IRF1 - inhibited SLC7A11 ［J］. Phytomedicine，2023，118：154950., articleTitle=Ginsenoside Rh2 promotes hepatic stellate cell ferroptosis and inactivation via regulation of IRF1 - inhibited SLC7A11, refAbstract=null), Reference(id=1322923650332110882, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2001, volume=15, issue=2, pageStart=83, pageEnd=86, url=null, language=null, rfNumber=［92］, rfOrder=91, authorNames=刘轩, 魏育林, 李波, journalName=中日友好医院学报, refType=null, unstructuredReference=刘轩，魏育林，李波，等. 人参皂甙对脂多糖诱导小鼠肺泡巨噬细胞分泌肿瘤坏死因子的作用及机制探讨［J］. 中日友好医院学报，2001，15（2）：83-86., articleTitle=人参皂甙对脂多糖诱导小鼠肺泡巨噬细胞分泌肿瘤坏死因子的作用及机制探讨, refAbstract=null), Reference(id=1322923650411802659, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［93］, rfOrder=92, authorNames=张雪, journalName=null, refType=null, unstructuredReference=张雪. 人参皂甙Rb1调节巨噬细胞极化稳定动脉粥样硬化斑块及其机制研究［D］. 青岛：青岛大学，2017., articleTitle=人参皂甙Rb1调节巨噬细胞极化稳定动脉粥样硬化斑块及其机制研究, refAbstract=null), Reference(id=1322923650491494436, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2018, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［94］, rfOrder=93, authorNames=李海波, journalName=null, refType=null, unstructuredReference=李海波. 人参皂苷Rg1通过调节巨噬细胞/小胶质细胞的极化促进大鼠脊髓损伤后神经功能的恢复［D］. 南京：南京医科大学，2018., articleTitle=人参皂苷Rg1通过调节巨噬细胞/小胶质细胞的极化促进大鼠脊髓损伤后神经功能的恢复, refAbstract=null), Reference(id=1322923650558603301, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=157, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［95］, rfOrder=94, authorNames=WANG B, DONGJX, XU J, journalName=Microb Pathog, refType=null, unstructuredReference=WANG B，DONGJX，XU J，et al. Ginsenoside CK inhibits obese insulin resistance by activating PPARγto interfere with macrophage activation［J］. Microb Pathog，2021，157：105002., articleTitle=Ginsenoside CK inhibits obese insulin resistance by activating PPARγto interfere with macrophage activation, refAbstract=null), Reference(id=1322923650642489382, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=13, issue=6, pageStart=3561, pageEnd=3571, url=null, language=null, rfNumber=［96］, rfOrder=95, authorNames=XU J, DONG JX, DING H Y, journalName=Food Funct, refType=null, unstructuredReference=XU J，DONG JX，DING H Y，et al. Ginsenoside compound K inhibits obesity-induced insulin resistance by regulation of macrophage recruitment and polarization via activating PPARγ［J］. Food Funct，2022，13（6）：3561-3571., articleTitle=Ginsenoside compound K inhibits obesity-induced insulin resistance by regulation of macrophage recruitment and polarization via activating PPARγ, refAbstract=null), Reference(id=1322923650734764071, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=13, issue=1, pageStart=49, pageEnd=null, url=null, language=null, rfNumber=［97］, rfOrder=96, authorNames=DING L L, GAO Z, WU SL, journalName=Nat Prod Bioprospect, refType=null, unstructuredReference=DING L L，GAO Z，WU SL，et al. Ginsenoside compound-K attenuates OVX -induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress［J］. Nat Prod Bioprospect，2023，13（1）：49., articleTitle=Ginsenoside compound-K attenuates OVX -induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress, refAbstract=null), Reference(id=1322923650818650152, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2017, volume=92, issue=null, pageStart=927, pageEnd=934, url=null, language=null, rfNumber=［98］, rfOrder=97, authorNames=CONG F, LIU J, WANG C M, journalName=Biomed Pharmacother, refType=null, unstructuredReference=CONG F，LIU J，WANG C M，et al. Ginsenoside Rb2 inhibits osteoclast differentiation through nuclear factor-kappaB and signal transducer and activator of transcription protein 3 signaling pathway［J］. Biomed Pharmacother，2017，92：927-934., articleTitle=Ginsenoside Rb2 inhibits osteoclast differentiation through nuclear factor-kappaB and signal transducer and activator of transcription protein 3 signaling pathway, refAbstract=null), Reference(id=1322923650889953321, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=115, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［99］, rfOrder=98, authorNames=WANGR, ZHANG M, HU SS, journalName=Biomed Pharmacother, refType=null, unstructuredReference=WANGR，ZHANG M，HU SS，et al. Ginsenoside metabolite compound-K regulates macrophage function through inhibition ofβarrestin2［J］. Biomed Pharmacother，2019，115：108909., articleTitle=Ginsenoside metabolite compound-K regulates macrophage function through inhibition ofβarrestin2, refAbstract=null), Reference(id=1322923652546703402, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2005, volume=5, issue=7-8, pageStart=1183, pageEnd=1191, url=null, language=null, rfNumber=［100］, rfOrder=99, authorNames=SHIN Y W, BAE E A, KIM SS, journalName=Int Immunopharmacol, refType=null, unstructuredReference=SHIN Y W，BAE E A，KIM SS，et al. Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis［J］. Int Immunopharmacol，2005，5（7-8）：1183-1191., articleTitle=Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis, refAbstract=null), Reference(id=1322923652789973035, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=16, issue=null, pageStart=1793, pageEnd=1809, url=null, language=null, rfNumber=［101］, rfOrder=100, authorNames=LIU JJ, FAN G Q, TAO N N, journalName=Drug Des Devel Ther, refType=null, unstructuredReference=LIU JJ，FAN G Q，TAO N N，et al. Ginsenoside Rb1 alleviates bleomycin-induced pulmonary inflammation and fibrosis by suppressing central nucleotide-binding oligomerization-，leucinerich repeat-，and pyrin domains-containing protein three inflammasome activation and the NF-κB pathway［J］. Drug Des Devel Ther，2022，16：1793-1809., articleTitle=Ginsenoside Rb1 alleviates bleomycin-induced pulmonary inflammation and fibrosis by suppressing central nucleotide-binding oligomerization-，leucinerich repeat-，and pyrin domains-containing protein three inflammasome activation and the NF-κB pathway, refAbstract=null), Reference(id=1322923652882247724, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2014, volume=17, issue=8, pageStart=849, pageEnd=854, url=null, language=null, rfNumber=［102］, rfOrder=101, authorNames=JEONG J J, KIM B, KIM D H, journalName=J Med Food, refType=null, unstructuredReference=JEONG J J，KIM B，KIM D H. Ginsenoside Rb1 eliminates HIV-1（D3）-transduced cytoprotective human macrophages by inhibiting the AKT pathway［J］. J Med Food，2014，17（8）：849-854., articleTitle=Ginsenoside Rb1 eliminates HIV-1（D3）-transduced cytoprotective human macrophages by inhibiting the AKT pathway, refAbstract=null), Reference(id=1322923652953550893, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=40, issue=2, pageStart=196, pageEnd=202, url=null, language=null, rfNumber=［103］, rfOrder=102, authorNames=REN K X, JIN C, MA P F, journalName=J Ginseng Res, refType=null, unstructuredReference=REN K X，JIN C，MA P F，et al. Ginsenoside Rd alleviates mouse acute renal ischemia/reperfusion injury by modulating macrophage phenotype［J］. J Ginseng Res，2016，40（2）：196-202., articleTitle=Ginsenoside Rd alleviates mouse acute renal ischemia/reperfusion injury by modulating macrophage phenotype, refAbstract=null), Reference(id=1322923653012271150, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=16, issue=null, pageStart=2767, pageEnd=2782, url=null, language=null, rfNumber=［104］, rfOrder=103, authorNames=ZHAO T Y, WANG X T, LIU Q, journalName=Drug Des Devel Ther, refType=null, unstructuredReference=ZHAO T Y，WANG X T，LIU Q，et al. Ginsenoside rd promotes cardiac repair after myocardial infarction by modulating monocytes/macrophages subsets conversion［J］. Drug Des Devel Ther，2022，16：2767-2782., articleTitle=Ginsenoside rd promotes cardiac repair after myocardial infarction by modulating monocytes/macrophages subsets conversion, refAbstract=null), Reference(id=1322923653171654703, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=917, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［105］, rfOrder=104, authorNames=LONG J, LIU X K, KANGZ P, journalName=Eur J Pharmacol, refType=null, unstructuredReference=LONG J，LIU X K，KANGZ P，et al. Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1/M2 macrophage polarization and the homeostasis of intestinal flora［J］. Eur J Pharmacol，2022，917：174742., articleTitle=Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1/M2 macrophage polarization and the homeostasis of intestinal flora, refAbstract=null), Reference(id=1322923653234569265, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=11, issue=11, pageStart=3493, pageEnd=3507, url=null, language=null, rfNumber=［106］, rfOrder=105, authorNames=ZHAI K F, DUAN H, WANGW, journalName=Acta Pharm Sin B, refType=null, unstructuredReference=ZHAI K F，DUAN H，WANGW，et al. Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release［J］. Acta Pharm Sin B，2021，11（11）：3493-3507., articleTitle=Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release, refAbstract=null), Reference(id=1322923653293289522, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2024, volume=38, issue=4, pageStart=1745, pageEnd=1760, url=null, language=null, rfNumber=［107］, rfOrder=106, authorNames=ZHEN J, BAIJ, LIUJ, journalName=Phytother Res, refType=null, unstructuredReference=ZHEN J，BAIJ，LIUJ，et al. Ginsenoside RG1-induced mesenchymal stem cells alleviate diabetic cardiomyopathy through secreting exosomal circNOTCH1 to promote macrophage M2 polarization［J］. Phytother Res，2024，38（4）：1745-1760., articleTitle=Ginsenoside RG1-induced mesenchymal stem cells alleviate diabetic cardiomyopathy through secreting exosomal circNOTCH1 to promote macrophage M2 polarization, refAbstract=null), Reference(id=1322923653360398387, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2015, volume=59, issue=9, pageStart=5654, pageEnd=5663, url=null, language=null, rfNumber=［108］, rfOrder=107, authorNames=SU F, XUE Y, WANG Y M, journalName=Antimicrob Agents Chemother, refType=null, unstructuredReference=SU F，XUE Y，WANG Y M，et al. Protective effect of ginsenosides Rg1 and Re on lipopolysaccharide-induced sepsis by competitive binding to Toll-like receptor 4［J］. Antimicrob Agents Chemother，2015，59（9）：5654-5663., articleTitle=Protective effect of ginsenosides Rg1 and Re on lipopolysaccharide-induced sepsis by competitive binding to Toll-like receptor 4, refAbstract=null), Reference(id=1322923653440090164, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2012, volume=12, issue=1, pageStart=110, pageEnd=116, url=null, language=null, rfNumber=［109］, rfOrder=108, authorNames=KIM T W, JOH E H, KIM B, journalName=Int Immunopharmacol, refType=null, unstructuredReference=KIM T W，JOH E H，KIM B，et al. Ginsenoside Rg5 ameliorates lung inflammation in mice by inhibiting the binding of LPSto tolllike receptor-4 on macrophages［J］. Int Immunopharmacol，2012，12（1）：110-116., articleTitle=Ginsenoside Rg5 ameliorates lung inflammation in mice by inhibiting the binding of LPSto tolllike receptor-4 on macrophages, refAbstract=null), Reference(id=1322923653515587637, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=52, issue=3, pageStart=287, pageEnd=295, url=null, language=null, rfNumber=［110］, rfOrder=109, authorNames=AHN S, SIDDIQI M H, ACEITUNO V C, journalName=In Vitro Cell Dev Biol Anim, refType=null, unstructuredReference=AHN S，SIDDIQI M H，ACEITUNO V C，et al. Ginsenoside Rg5：Rk1 attenuates TNF-α/IFN-γ-induced production of Thymus-and activation-regulated chemokine（TARC/CCL17）and LPS-induced NO production via downregulation of NF-κB/p38 MAPK/STAT1 signaling in human keratinocytes and macrophages［J］. In Vitro Cell Dev Biol Anim，2016，52（3）：287-295., articleTitle=Ginsenoside Rg5：Rk1 attenuates TNF-α/IFN-γ-induced production of Thymus-and activation-regulated chemokine（TARC/CCL17）and LPS-induced NO production via downregulation of NF-κB/p38 MAPK/STAT1 signaling in human keratinocytes and macrophages, refAbstract=null), Reference(id=1322923653586890806, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=206, issue=null, pageStart=162, pageEnd=179, url=null, language=null, rfNumber=［111］, rfOrder=110, authorNames=HUANG Y M, LU J, ZHAO L E, journalName=Free Radic Biol Med, refType=null, unstructuredReference=HUANG Y M，LU J，ZHAO L E，et al. Retinal cell-targeted liposomal ginsenoside Rg3 attenuates retinal ischemia-reperfusion injury via alleviating oxidative stress and promoting microglia/macrophage M2 polarization［J］. Free Radic Biol Med，2023，206：162-179., articleTitle=Retinal cell-targeted liposomal ginsenoside Rg3 attenuates retinal ischemia-reperfusion injury via alleviating oxidative stress and promoting microglia/macrophage M2 polarization, refAbstract=null), Reference(id=1322923653683359799, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2006, volume=null, issue=null, pageStart=76, pageEnd=77, url=null, language=null, rfNumber=［112］, rfOrder=111, authorNames=张皖东, 吕诚, 赵宏艳, journalName=null, refType=null, unstructuredReference=张皖东，吕诚，赵宏艳，等. 人参多糖和猪苓多糖对自身免疫性关节炎大鼠肠道粘膜免疫细胞功能的影响［C］//第六届中国中西医结合风湿病学术会议论文汇编. 义乌，2006：76-77., articleTitle=人参多糖和猪苓多糖对自身免疫性关节炎大鼠肠道粘膜免疫细胞功能的影响, refAbstract=null), Reference(id=1322923653750468664, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［113］, rfOrder=112, authorNames=崔庆丽, journalName=null, refType=null, unstructuredReference=崔庆丽. 基于网络药理学探讨人参挥发性成分治疗胃癌的作用机制研究［D］. 南京：南京中医药大学，2022., articleTitle=基于网络药理学探讨人参挥发性成分治疗胃癌的作用机制研究, refAbstract=null), Reference(id=1322923653813383225, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=47, issue=9, pageStart=1443, pageEnd=1457, url=null, language=null, rfNumber=［114］, rfOrder=113, authorNames=刘昌孝, 陈士林, 肖小河, journalName=中草药, refType=null, unstructuredReference=刘昌孝，陈士林，肖小河，等. 中药质量标志物（Q-Marker）：中药产品质量控制的新概念［J］. 中草药，2016，47（9）：1443-1457., articleTitle=中药质量标志物（Q-Marker）：中药产品质量控制的新概念, refAbstract=null), Reference(id=1322923653876297786, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2020, volume=32, issue=6, pageStart=53, pageEnd=58, url=null, language=null, rfNumber=［115］, rfOrder=114, authorNames=李萌萌, 黄鑫, 越皓, journalName=人参研究, refType=null, unstructuredReference=李萌萌，黄鑫，越皓，等. 人参属中药药性评价研究进展［J］. 人参研究，2020，32（6）：53-58., articleTitle=人参属中药药性评价研究进展, refAbstract=null), Reference(id=1322923653947600955, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2012, volume=24, issue=1, pageStart=24, pageEnd=29, url=null, language=null, rfNumber=［116］, rfOrder=115, authorNames=任跃英, journalName=人参研究, refType=null, unstructuredReference=任跃英. 人参育种的种质资源及生物学基础的研究［J］. 人参研究，2012，24（1）：24-29., articleTitle=人参育种的种质资源及生物学基础的研究, refAbstract=null), Reference(id=1322923654014709820, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［117］, rfOrder=116, authorNames=艾显慧, journalName=null, refType=null, unstructuredReference=艾显慧. 历史时期上党人参的使用与灭绝［D］. 郑州：郑州大学，2019., articleTitle=历史时期上党人参的使用与灭绝, refAbstract=null), Reference(id=1322923654106984509, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=42, issue=3, pageStart=394, pageEnd=401, url=null, language=null, rfNumber=［118］, rfOrder=117, authorNames=范馨元, 王添琦, 惠赫童, journalName=药物分析杂志, refType=null, unstructuredReference=范馨元，王添琦，惠赫童，等. 基于EST-SSR标记鉴别人参、西洋参和三七的研究［J］. 药物分析杂志，2022，42（3）：394-401., articleTitle=基于EST-SSR标记鉴别人参、西洋参和三七的研究, refAbstract=null), Reference(id=1322923654165704766, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=54, issue=17, pageStart=1402, pageEnd=1410, url=null, language=null, rfNumber=［119］, rfOrder=118, authorNames=刘永利, 雷蓉, 王晓蕾, journalName=中国药学杂志, refType=null, unstructuredReference=刘永利，雷蓉，王晓蕾，等. 基于中药质量标志物的人参、西洋参、三七及相关中成药质量控制方法研究［J］. 中国药学杂志，2019，54（17）：1402-1410., articleTitle=基于中药质量标志物的人参、西洋参、三七及相关中成药质量控制方法研究, refAbstract=null), Reference(id=1322923654241202239, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=52, issue=23, pageStart=7364, pageEnd=7372, url=null, language=null, rfNumber=［120］, rfOrder=119, authorNames=常虹, 张春红, 张娜, journalName=中草药, refType=null, unstructuredReference=常虹，张春红，张娜，等. 中药药性理论研究方法对蒙古族药药性理论研究的启示与借鉴［J］. 中草药，2021，52（23）：7364-7372., articleTitle=中药药性理论研究方法对蒙古族药药性理论研究的启示与借鉴, refAbstract=null), Reference(id=1322923654312505408, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2018, volume=30, issue=6, pageStart=39, pageEnd=43, url=null, language=null, rfNumber=［121］, rfOrder=120, authorNames=任国庆, 窦德强, journalName=人参研究, refType=null, unstructuredReference=任国庆，窦德强. 人参类中药药性考证［J］. 人参研究，2018，30（6）：39-43., articleTitle=人参类中药药性考证, refAbstract=null), Reference(id=1322923654371225665, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2000, volume=19, issue=S1, pageStart=72, pageEnd=null, url=null, language=null, rfNumber=［122］, rfOrder=121, authorNames=常学辉, 张华军, journalName=内蒙古中医药, refType=null, unstructuredReference=常学辉，张华军. 论中药四气五味的科学性［J］. 内蒙古中医药，2000，19（S1）：72., articleTitle=论中药四气五味的科学性, refAbstract=null), Reference(id=1322923654438334530, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=47, issue=4, pageStart=533, pageEnd=539, url=null, language=null, rfNumber=［123］, rfOrder=122, authorNames=张静雅, 曹煌, 龚苏晓, journalName=中草药, refType=null, unstructuredReference=张静雅，曹煌，龚苏晓，等. 中药甘味的药性表达及在临证配伍中的应用［J］. 中草药，2016，47（4）：533-539., articleTitle=中药甘味的药性表达及在临证配伍中的应用, refAbstract=null), Reference(id=1322923654518026307, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2005, volume=16, issue=1, pageStart=77, pageEnd=78, url=null, language=null, rfNumber=［124］, rfOrder=123, authorNames=于培明, 田智勇, 林桂涛, journalName=时珍国医国药, refType=null, unstructuredReference=于培明，田智勇，林桂涛. 甘味药的药性理论及其配伍探讨［J］. 时珍国医国药，2005，16（1）：77-78., articleTitle=甘味药的药性理论及其配伍探讨, refAbstract=null), Reference(id=1322923654589329476, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=52, issue=2, pageStart=45, pageEnd=48, url=null, language=null, rfNumber=［125］, rfOrder=124, authorNames=汪树理, journalName=吉林林业科技, refType=null, unstructuredReference=汪树理. 人参苦味物质研究进展［J］. 吉林林业科技，2023，52（2）：45-48., articleTitle=人参苦味物质研究进展, refAbstract=null), Reference(id=1322923654648049733, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=1996, volume=6, issue=4, pageStart=43, pageEnd=null, url=null, language=null, rfNumber=［126］, rfOrder=125, authorNames=李新, 李沈, journalName=中西医结合肝病杂志, refType=null, unstructuredReference=李新，李沈. 从仲景肝病用药的五味规律看现代慢性肝炎用药五味现状［J］. 中西医结合肝病杂志，1996，6（4）：43., articleTitle=从仲景肝病用药的五味规律看现代慢性肝炎用药五味现状, refAbstract=null), Reference(id=1322923654715158598, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2018, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［127］, rfOrder=126, authorNames=李峰, journalName=null, refType=null, unstructuredReference=李峰. 人参的四性、归肝经及大补元气功效的中药药理学研究［D］. 长春：吉林农业大学，2018., articleTitle=人参的四性、归肝经及大补元气功效的中药药理学研究, refAbstract=null), Reference(id=1322923654782267463, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=38, issue=9, pageStart=890, pageEnd=892，896, url=null, language=null, rfNumber=［128］, rfOrder=127, authorNames=张佩佩, 申玉芹, 林泓兵, journalName=新乡医学院学报, refType=null, unstructuredReference=张佩佩，申玉芹，林泓兵，等. 人参多糖免疫调节作用研究进展［J］. 新乡医学院学报，2021，38（9）：890-892，896., articleTitle=人参多糖免疫调节作用研究进展, refAbstract=null), Reference(id=1322923654857764936, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=46, issue=1, pageStart=23, pageEnd=32, url=null, language=null, rfNumber=［129］, rfOrder=128, authorNames=HU Y Y, HE Y, NIU ZQ, journalName=J Ginseng Res, refType=null, unstructuredReference=HU Y Y，HE Y，NIU ZQ，et al. A review of the immunomodulatory activities of polysaccharides isolated from Panax species［J］. J Ginseng Res，2022，46（1）：23-32., articleTitle=A review of the immunomodulatory activities of polysaccharides isolated from Panax species, refAbstract=null), Reference(id=1322923654945845321, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2014, volume=65, issue=null, pageStart=229, pageEnd=233, url=null, language=null, rfNumber=［130］, rfOrder=129, authorNames=JIAOL L, ZHANGX Y, LIB, journalName=Int J Biol Macromol, refType=null, unstructuredReference=JIAOL L，ZHANGX Y，LIB，et al. Anti-tumour and immunomodulatory activities of oligosaccharides isolated from Panax ginseng C. A. Meyer［J］. Int J Biol Macromol，2014，65：229-233., articleTitle=Anti-tumour and immunomodulatory activities of oligosaccharides isolated from Panax ginseng C. A. Meyer, refAbstract=null), Reference(id=1322923655004565578, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=47, issue=4, pageStart=823, pageEnd=839, url=null, language=null, rfNumber=［131］, rfOrder=130, authorNames=LEE D Y, PARK C W, LEE S J, journalName=Am J Chin Med, refType=null, unstructuredReference=LEE D Y，PARK C W，LEE S J，et al. Immunostimulating and antimetastatic effects of polysaccharides purified from ginseng berry［J］. Am J Chin Med，2019，47（4）：823-839., articleTitle=Immunostimulating and antimetastatic effects of polysaccharides purified from ginseng berry, refAbstract=null), Reference(id=1322923655067480139, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2016, volume=18, issue=1, pageStart=72, pageEnd=75，81, url=null, language=null, rfNumber=［132］, rfOrder=131, authorNames=李红艳, 张江华, 张惠, journalName=中国现代中药, refType=null, unstructuredReference=李红艳，张江华，张惠，等. 人参总蛋白的酶解及氨基酸含量测定［J］. 中国现代中药，2016，18（1）：72-75，81., articleTitle=人参总蛋白的酶解及氨基酸含量测定, refAbstract=null), Reference(id=1322923655122006092, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［133］, rfOrder=132, authorNames=任雨贺, journalName=null, refType=null, unstructuredReference=任雨贺. 人参蛋白质的提取及其对乳腺癌MCF-7细胞的抗肿瘤作用研究［D］. 长春：长春中医药大学，2019., articleTitle=人参蛋白质的提取及其对乳腺癌MCF-7细胞的抗肿瘤作用研究, refAbstract=null), Reference(id=1322923655193309261, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=29, issue=4, pageStart=287, pageEnd=292, url=null, language=null, rfNumber=［134］, rfOrder=133, authorNames=邵琦, 李佳丽, 周李宁, journalName=江苏大学学报（医学版）, refType=null, unstructuredReference=邵琦，李佳丽，周李宁，等. 人参炔醇重塑巨噬细胞表型调控乳腺癌细胞生物学行为［J］. 江苏大学学报（医学版），2019，29（4）：287-292., articleTitle=人参炔醇重塑巨噬细胞表型调控乳腺癌细胞生物学行为, refAbstract=null), Reference(id=1322923655252029518, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2015, volume=35, issue=5, pageStart=125, pageEnd=126, url=null, language=null, rfNumber=［135］, rfOrder=134, authorNames=乔铁, 马进, 梁可, journalName=现代中医药, refType=null, unstructuredReference=乔铁，马进，梁可，等. 《方剂学》中人参当归配伍规律浅析［J］. 现代中医药，2015，35（5）：125-126., articleTitle=《方剂学》中人参当归配伍规律浅析, refAbstract=null), Reference(id=1322923655327526991, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2012, volume=13, issue=2, pageStart=67, pageEnd=69, url=null, language=null, rfNumber=［136］, rfOrder=135, authorNames=樊东升, 曹学东, 马小娟, journalName=山西中医学院学报, refType=null, unstructuredReference=樊东升，曹学东，马小娟，等. 人参、五灵脂配伍的实验研究进展及展望［J］. 山西中医学院学报，2012，13（2）：67-69., articleTitle=人参、五灵脂配伍的实验研究进展及展望, refAbstract=null), Reference(id=1322923655398830160, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2021, volume=16, issue=7, pageStart=1041, pageEnd=1044, url=null, language=null, rfNumber=［137］, rfOrder=136, authorNames=陈红映, 孙建辉, 于泽玥, journalName=世界中医药, refType=null, unstructuredReference=陈红映，孙建辉，于泽玥，等. 玛咖-人参水煎液对小鼠免疫功能的影响［J］. 世界中医药，2021，16（7）：1041-1044., articleTitle=玛咖-人参水煎液对小鼠免疫功能的影响, refAbstract=null), Reference(id=1322923657026220113, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2013, volume=25, issue=5, pageStart=10, pageEnd=13，20, url=null, language=null, rfNumber=［138］, rfOrder=137, authorNames=李振彬, 张秋媛, 陈晶, journalName=解放军医药杂志, refType=null, unstructuredReference=李振彬，张秋媛，陈晶，等. 雷公藤多苷联合人参皂苷对胶原诱导关节炎大鼠外周血CD4^＋CD25^＋Foxp3＋调节性T细胞和白介素-17的影响［J］. 解放军医药杂志，2013，25（5）：10-13，20., articleTitle=雷公藤多苷联合人参皂苷对胶原诱导关节炎大鼠外周血CD4^＋CD25^＋Foxp3＋调节性T细胞和白介素-17的影响, refAbstract=null), Reference(id=1322923657089134674, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2008, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［139］, rfOrder=138, authorNames=李丹, journalName=null, refType=null, unstructuredReference=李丹. 鸡胚及其人参配伍免疫调节与抗疲劳作用的研究［D］. 泰安：山东农业大学，2008., articleTitle=鸡胚及其人参配伍免疫调节与抗疲劳作用的研究, refAbstract=null), Reference(id=1322923657160437843, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=51, issue=8, pageStart=104, pageEnd=109, url=null, language=null, rfNumber=［140］, rfOrder=139, authorNames=王婉莹, 姜思亮, 柴军红, journalName=中医药学报, refType=null, unstructuredReference=王婉莹，姜思亮，柴军红，等. 黄芪和人参配伍的药理作用及临床应用研究进展［J］. 中医药学报，2023，51（8）：104-109., articleTitle=黄芪和人参配伍的药理作用及临床应用研究进展, refAbstract=null), Reference(id=1322923657223352404, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2010, volume=19, issue=9, pageStart=1559, pageEnd=1561, url=null, language=null, rfNumber=［141］, rfOrder=140, authorNames=周娅红, journalName=中国中医急症, refType=null, unstructuredReference=周娅红. 人参总皂苷对免疫低下小鼠免疫功能的影响［J］. 中国中医急症，2010，19（9）：1559-1561., articleTitle=人参总皂苷对免疫低下小鼠免疫功能的影响, refAbstract=null), Reference(id=1322923657290461269, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2023, volume=45, issue=3, pageStart=163, pageEnd=168, url=null, language=null, rfNumber=［142］, rfOrder=141, authorNames=郭校妍, 张伟东, 张扬, journalName=特产研究, refType=null, unstructuredReference=郭校妍，张伟东，张扬. 人参皂苷治疗骨性关节炎的研究进展［J］. 特产研究，2023，45（3）：163-168., articleTitle=人参皂苷治疗骨性关节炎的研究进展, refAbstract=null), Reference(id=1322923657361764438, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2018, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［143］, rfOrder=142, authorNames=刘俊秋, journalName=null, refType=null, unstructuredReference=刘俊秋. 补气药黄芪、人参及其配伍免疫调节和代谢组学研究［D］. 北京：中国中医科学院，2018., articleTitle=补气药黄芪、人参及其配伍免疫调节和代谢组学研究, refAbstract=null), Reference(id=1322923657420484695, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2022, volume=38, issue=8, pageStart=717, pageEnd=726, url=null, language=null, rfNumber=［144］, rfOrder=143, authorNames=杨葛俊, 邹珏瑶, 赵涵, journalName=南京中医药大学学报, refType=null, unstructuredReference=杨葛俊，邹珏瑶，赵涵，等. 丹参-人参配伍调控MDSCs重塑黑色素瘤免疫微环境的研究［J］. 南京中医药大学学报，2022，38（8）：717-726., articleTitle=丹参-人参配伍调控MDSCs重塑黑色素瘤免疫微环境的研究, refAbstract=null), Reference(id=1322923657475010648, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2012, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［145］, rfOrder=144, authorNames=张秋媛, journalName=null, refType=null, unstructuredReference=张秋媛. 雷公藤多苷联合人参皂苷对胶原诱导关节炎大鼠CD4^＋CD25^＋Foxp3^＋调节性T细胞的影响及骨免疫学机制探讨［D］. 石家庄：河北医科大学，2012., articleTitle=雷公藤多苷联合人参皂苷对胶原诱导关节炎大鼠CD4^＋CD25^＋Foxp3^＋调节性T细胞的影响及骨免疫学机制探讨, refAbstract=null), Reference(id=1322923657563091033, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2010, volume=25, issue=9, pageStart=1448, pageEnd=1451, url=null, language=null, rfNumber=［146］, rfOrder=145, authorNames=黎莲珺, 高铭坚, 梁爱玲, journalName=中华中医药杂志, refType=null, unstructuredReference=黎莲珺，高铭坚，梁爱玲，等. 人参、五灵脂配伍的现代研究进展［J］. 中华中医药杂志，2010，25（9）：1448-1451., articleTitle=人参、五灵脂配伍的现代研究进展, refAbstract=null), Reference(id=1322923657630199898, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2004, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［147］, rfOrder=146, authorNames=李超, journalName=null, refType=null, unstructuredReference=李超. 人参配伍当归对小鼠化学性骨髓抑制、免疫抑制防治作用及其最佳配伍比例初筛的研究［D］. 沈阳：辽宁中医学院，2004., articleTitle=人参配伍当归对小鼠化学性骨髓抑制、免疫抑制防治作用及其最佳配伍比例初筛的研究, refAbstract=null), Reference(id=1322923657697308763, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2024, volume=45, issue=10, pageStart=300, pageEnd=307, url=null, language=null, rfNumber=［148］, rfOrder=147, authorNames=王佳男, 王慧敏, 章宝栗, journalName=食品工业科技, refType=null, unstructuredReference=王佳男，王慧敏，章宝栗，等. 人参与蒲公英根配伍对大鼠“上火”症状的调节作用［J］. 食品工业科技，2024，45（10）：300-307., articleTitle=人参与蒲公英根配伍对大鼠“上火”症状的调节作用, refAbstract=null), Reference(id=1322923657760223324, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2013, volume=24, issue=39, pageStart=3682, pageEnd=3684, url=null, language=null, rfNumber=［149］, rfOrder=148, authorNames=潘爱珍, 易伟民, 余晓娟, journalName=中国药房, refType=null, unstructuredReference=潘爱珍，易伟民，余晓娟，等. 人参总皂苷对脾虚模型大鼠的保护作用研究［J］. 中国药房，2013，24（39）：3682-3684., articleTitle=人参总皂苷对脾虚模型大鼠的保护作用研究, refAbstract=null), Reference(id=1322923657831526493, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, doi=null, pmid=null, pmcid=null, year=2019, volume=25, issue=11, pageStart=8, pageEnd=15, url=null, language=null, rfNumber=［150］, rfOrder=149, authorNames=黄文武, 彭颖, 王梦月, journalName=中国实验方剂学杂志, refType=null, unstructuredReference=黄文武，彭颖，王梦月，等. 四君子汤及其单味药水煎液对脾虚大鼠肠道菌群的调节作用［J］. 中国实验方剂学杂志，2019，25（11）：8-15., articleTitle=四君子汤及其单味药水煎液对脾虚大鼠肠道菌群的调节作用, refAbstract=null)], funds=[Fund(id=1322923631214474168, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, awardId=U19A2013, language=CN, fundingSource=国家自然科学基金联合基金重点支持项目(U19A2013), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322923615464862564, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, xref=1., ext=[AuthorCompanyExt(id=1322923615477445477, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Northeast Asia Institute of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130021，Jilin，China), AuthorCompanyExt(id=1322923615490028390, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923615464862564, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.长春中医药大学东北亚中医药研究院，吉林 长春 130021)]), AuthorCompany(id=1322923617150972775, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, xref=2., ext=[AuthorCompanyExt(id=1322923617205498728, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923617150972775, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Changchun Jinsai Pharmaceutical Co.，Ltd，Changchun 130021，Jilin，China), AuthorCompanyExt(id=1322923617247441769, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, companyId=1322923617150972775, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.长春金赛药业有限责任公司，吉林 长春 130021)])], figs=[ArticleFig(id=1322923627410240415, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=0XRUBnTnBpz1/Iq4sOLg0Q==, figureFileBig=/YikoEH7QPrrU4ln3N+Cvw==, tableContent=null), ArticleFig(id=1322923627586401184, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=图1, caption=人参调节免疫功能的主要皂苷类成分结构, figureFileSmall=0XRUBnTnBpz1/Iq4sOLg0Q==, figureFileBig=/YikoEH7QPrrU4ln3N+Cvw==, tableContent=null), ArticleFig(id=1322923627762561954, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=JG7pOik+7gzCvWk5XfVzOQ==, figureFileBig=g7q4owifBRk161S8M069Jg==, tableContent=null), ArticleFig(id=1322923627833865123, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=图2, caption=人参调节免疫功能的主要多糖类成分结构式, figureFileSmall=JG7pOik+7gzCvWk5XfVzOQ==, figureFileBig=g7q4owifBRk161S8M069Jg==, tableContent=null), ArticleFig(id=1322923627896779684, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

编号	化学成分	分子式	参考文献
1	Rg1	C42H72O14	［6］
2	Rg3	C42H72O13	［7-8］
3	Rb1	C54H92O23	［9-10］
4	Rh1	C36H62O9	［11］
5	Rh2	C36H62O8	［12-13］
6	Re	C48H82O18	［14-15］
7	Rd	C48H82O18	［4］
8	CK	C36H62O8	［16］
9	Ro	C48H76O19	［17］
10	Rg5	C42H70O12	［18］

), ArticleFig(id=1322923627968082853, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=表1, caption=

人参调节免疫功能的主要皂苷类成分

, figureFileSmall=null, figureFileBig=null, tableContent=

编号	化学成分	分子式	参考文献
1	Rg1	C42H72O14	［6］
2	Rg3	C42H72O13	［7-8］
3	Rb1	C54H92O23	［9-10］
4	Rh1	C36H62O9	［11］
5	Rh2	C36H62O8	［12-13］
6	Re	C48H82O18	［14-15］
7	Rd	C48H82O18	［4］
8	CK	C36H62O8	［16］
9	Ro	C48H76O19	［17］
10	Rg5	C42H70O12	［18］

), ArticleFig(id=1322923628060357542, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

编号	化学成分	分子式	参考文献
11	葡萄糖	C6H12O6	［20］
12	阿拉伯糖	C5H10O5	［20］
13	半乳糖	C20H31N3O12	［20］
14	鼠李糖	C6H14O6	［20］
15	半乳糖醛酸	C18H26O19	［20］
16	葡萄糖醛酸	C6H10O7	［20］
17	甘露糖	C6H14O6	［22］

), ArticleFig(id=1322923628140049319, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=表2, caption=

人参调节免疫功能的主要多糖类成分

, figureFileSmall=null, figureFileBig=null, tableContent=

编号	化学成分	分子式	参考文献
11	葡萄糖	C6H12O6	［20］
12	阿拉伯糖	C5H10O5	［20］
13	半乳糖	C20H31N3O12	［20］
14	鼠李糖	C6H14O6	［20］
15	半乳糖醛酸	C18H26O19	［20］
16	葡萄糖醛酸	C6H10O7	［20］
17	甘露糖	C6H14O6	［22］

), ArticleFig(id=1322923628198769576, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rg3	肿瘤化疗	增加人类白细胞抗原DR（Human leukocyte antigen DR，HLA-DR）、人类白细胞抗原ABC（Human leukocyte antigen ABC，HLA-ABC）、CD3-CD56+16等分子表达，使CD4+/CD8+及辅助性T细胞1（T helper cell 1，Th1）/辅助性T细胞2（T helper cell 2，Th2）向免疫增强的方向漂移	［27］
	鼻咽癌	促进Th1/Th2细胞平衡，抑制血管内皮生长因子（Vascular endothelial growth factor，VEGF）产生与表达	［28］
	溃疡性结肠炎	通过调节Th1与Th2细胞因子表达，促进Th1/Th2平衡，抑制核转录因子-kappa B（nuclear factor-kappa B，NF-κB）活化	［29-30］
	黑色素瘤	激活丝裂原激活蛋白激酶（Mitogen-activated protein kinase，MAPK）/细胞外信号调节激酶（Extracellular Signal-Regulated Kinases，ERK）通路促进CD8 T淋巴细胞的杀伤性作用	［31］
	神经炎症	通过负调控CD4 T细胞中维甲酸相关孤儿受体γ t（RetinoicAcid-related Orphangammat，ROR-γ t）的表达，进而阻碍辅助性T细胞17（T helpercell 1，Th17）细胞分化和Th17介导的神经炎症	［32］
	甲状腺炎	调控CD3CD8白介素-4（Interleukin-4，IL-4）和CD3CD8伽马干扰素（Interferon-γ，IFN-γ）辅助T淋巴细胞频率而降低IL-4和IFN-γ的分泌	［33］
	胃癌	使患者体内CD3+、CD4+、T淋巴细胞转化率及CD4+/CD8+值均上升，且CD8+值下降	［34］
	关节炎	调节氧化磷酸化途径和增强CD4（+）CD25（+）叉头翼状螺旋转录因子3（Forkhead box protein 3，FOXP3）（+）调节性T细胞（Regulatory Tcell，Treg）细胞维持类风湿性关节炎（RheumatoidArthritis，RA）小鼠外周免疫耐受的功能	［35］
	肺癌	降低化疗耐药诱导的程序性死亡蛋白配体-1（Programmed death ligand-1，PD-L1）表达，恢复T细胞对癌细胞的细胞毒素	［36］
Rg1	溃疡性结肠炎	发挥程序性细胞死亡蛋白-1（Programmed cell death-1，PD-1）/PD-L1抑制作用，通过调控Treg/辅助性T细胞9（T helper cell 9，Th9）平衡而有效改善实验性小鼠的结肠炎	［37］
	结肠炎	通过抑制脂多糖（Lipopolysaccharides，LPS）与巨噬细胞上Toll样受体4（Toll-like receptor 4，TLR4）的结合并恢复Th17/Treg失衡来改善结肠炎	［38］
	脑脊髓炎	通过抑制Th17、Th1细胞及其分泌的炎症细胞因子而调控Treg细胞失衡，抑制中枢神经系统炎症过度激活	［39］
	系统性红斑狼疮	调节T细胞活化和Th1/Th2平衡	［40］
	抗念珠菌病	通过由Th4显性细胞因子反应导致的CD1+T细胞介导的免疫反应帮助宿主抵抗播散性念珠菌病	［41］
	脓毒血症	显著提高体外淋巴细胞的活性，显著促进刀豆蛋白A（Con A）诱导下淋巴细胞的增殖，T细胞表面活化分子CD69、CD25、CD71的表达及淋巴细胞线粒体膜电势的升高，以及促进淋巴细胞增殖于S期	［42］
	抗疲劳	调节体内T细胞亚群的数量，增强免疫力，对抗疲劳	［43］
	肝炎	通过抑制促炎反应降低肝损伤的发生率，抑制CD4+和CD8+T淋巴细胞向肝脏的募集	［44］
	Ⅲ型前列腺炎	降低Ⅲ型前列腺炎模型中异常增高的IL-4、肿瘤坏死因子-α（Tumor necrosis factor-alpha，TNF-α）水平，减轻前列腺的损伤，通过信号传导通路促进T细胞增殖，进而产生较多细胞因子	［45］
	抗病毒	通过由Th4显性细胞因子反应导致的CD1+T细胞介导免疫反应	［41］
	败血症	增强CD4tT淋巴细胞的活性，保护胸腺和脾脏中的免疫细胞免于凋亡	［46］
Rh1	抗哮喘	调节Th1/Th2细胞因子平衡，减轻小鼠模型中卵白蛋白（Oval albumin，OVA）诱导的哮喘	［47］
Re	抗念珠菌病	通过刺激CD4+T细胞来操纵Th1/Th2分化	［48］
Rh2	抗结肠腺癌	促进T细胞浸润和活化增强了PD-L1阻断的抗癌作用	［49］
	银屑病	通过抑制血管通透性来显著减少T细胞的浸润	［50］
	抗荷瘤	增加肿瘤坏死因子受体相关因子6（Tumour necrosis factor receptor associated factor 6，TRAF6）的表达，抑制Tlr65小鼠核内NF-κBp4水平	［51］
	白血病	抑制磷脂酰肌醇3激酶（Phosphoinositide 3-kinase，PI3K）/蛋白激酶B（Protein kinase B，Akt）/雷帕霉素靶蛋白（Mammalian target of rapamycin，mTOR）信号通路，发挥抗急性淋巴细胞白血病作用	［52］
	抗哮喘	通过抑制磷酸化AKT、p38MAPK和NF-κB信号通路而实现抗哮喘作用	［53］
Rb1	抗哮喘	降级Th1/Th2	［54］
	抗细胞凋亡	显著逆转了脱氧雪腐镰刀菌烯醇诱导的T细胞亚群百分比、细胞因子水平和免疫球蛋白的产生	［55］
	重症肌无力	降低单核细胞（MNCs）中Th17细胞的百分比，增加MNCs中Treg和Th2细胞的数量	［56］
	系统性红斑狼疮	抑制ConA刺激的系统性红斑狼疮患者外周血T淋巴细胞增殖活性，增加CD4CD25T细胞比例，维持Th1/Th2免疫平衡	［57］
	再生障碍性贫血	增加CD4/CD8比例、降低Th1型细胞因子IFN-γ分泌、促进CD34+干细胞生长	［58］
Rd	脑脊髓炎	调节IFN-γ和IL-4的分泌，促进体内（大脑皮层）和体外（脾细胞培养上清液）Th2转移	［59］
人参多糖	创伤性脓毒症	使HLA-DR、CD4+细胞分数、CD4+/CD8+比值、NK百分率升高，CD8+细胞分数降低	［60］
	慢性肾功能衰竭	促进体外T细胞的转化和IL-2（Interleukin-2，IL-2）诱生能力	［61］
	乳腺癌	CD3+、CD4+、CD++1656的比例均出现了下降，而CD8+的比例出现了上升	［62］
	抗肺癌	有效调节Th1/Th2免疫平衡。可能是因为人参多糖注射液可调控多种抗肿瘤细胞因子的释放，发挥免疫调节作用	［63］
	脑脊髓炎	通过抑制自身反应性T细胞的增殖和炎性细胞因子的产生来显著改善该免疫疾病。此外，人参通过激活转录因子Foxp3促进免疫抑制Tregs的产生。	［64］
	非小细胞肺癌	Th1细胞因子（INF-γ、IL-2）表达增加和Th1/Th2比值［INF-γ/IL-4、IL-2/白细胞介素（IL-5）］以及FACT-L评分和Th2细胞因子（IL-4、IL-5）表达降低	［65］
	放射防护	人参处理的骨髓细胞的主要组织相容性复合物Ⅱ（Major histocompatibility complexⅡ，MHC-Ⅱ）类分子的表达增加，同时显示出更高的同种异体CD4+T淋巴细胞增殖水平	［66］
	黑色素瘤	通过内源产生的多种细胞因子从NK和T细胞中产生LAK细胞	［67］

), ArticleFig(id=1322923628278461354, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=表3, caption=

人参调节T淋巴细胞治疗免疫相关疾病及作用机制

, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rg3	肿瘤化疗	增加人类白细胞抗原DR（Human leukocyte antigen DR，HLA-DR）、人类白细胞抗原ABC（Human leukocyte antigen ABC，HLA-ABC）、CD3-CD56+16等分子表达，使CD4+/CD8+及辅助性T细胞1（T helper cell 1，Th1）/辅助性T细胞2（T helper cell 2，Th2）向免疫增强的方向漂移	［27］
	鼻咽癌	促进Th1/Th2细胞平衡，抑制血管内皮生长因子（Vascular endothelial growth factor，VEGF）产生与表达	［28］
	溃疡性结肠炎	通过调节Th1与Th2细胞因子表达，促进Th1/Th2平衡，抑制核转录因子-kappa B（nuclear factor-kappa B，NF-κB）活化	［29-30］
	黑色素瘤	激活丝裂原激活蛋白激酶（Mitogen-activated protein kinase，MAPK）/细胞外信号调节激酶（Extracellular Signal-Regulated Kinases，ERK）通路促进CD8 T淋巴细胞的杀伤性作用	［31］
	神经炎症	通过负调控CD4 T细胞中维甲酸相关孤儿受体γ t（RetinoicAcid-related Orphangammat，ROR-γ t）的表达，进而阻碍辅助性T细胞17（T helpercell 1，Th17）细胞分化和Th17介导的神经炎症	［32］
	甲状腺炎	调控CD3CD8白介素-4（Interleukin-4，IL-4）和CD3CD8伽马干扰素（Interferon-γ，IFN-γ）辅助T淋巴细胞频率而降低IL-4和IFN-γ的分泌	［33］
	胃癌	使患者体内CD3+、CD4+、T淋巴细胞转化率及CD4+/CD8+值均上升，且CD8+值下降	［34］
	关节炎	调节氧化磷酸化途径和增强CD4（+）CD25（+）叉头翼状螺旋转录因子3（Forkhead box protein 3，FOXP3）（+）调节性T细胞（Regulatory Tcell，Treg）细胞维持类风湿性关节炎（RheumatoidArthritis，RA）小鼠外周免疫耐受的功能	［35］
	肺癌	降低化疗耐药诱导的程序性死亡蛋白配体-1（Programmed death ligand-1，PD-L1）表达，恢复T细胞对癌细胞的细胞毒素	［36］
Rg1	溃疡性结肠炎	发挥程序性细胞死亡蛋白-1（Programmed cell death-1，PD-1）/PD-L1抑制作用，通过调控Treg/辅助性T细胞9（T helper cell 9，Th9）平衡而有效改善实验性小鼠的结肠炎	［37］
	结肠炎	通过抑制脂多糖（Lipopolysaccharides，LPS）与巨噬细胞上Toll样受体4（Toll-like receptor 4，TLR4）的结合并恢复Th17/Treg失衡来改善结肠炎	［38］
	脑脊髓炎	通过抑制Th17、Th1细胞及其分泌的炎症细胞因子而调控Treg细胞失衡，抑制中枢神经系统炎症过度激活	［39］
	系统性红斑狼疮	调节T细胞活化和Th1/Th2平衡	［40］
	抗念珠菌病	通过由Th4显性细胞因子反应导致的CD1+T细胞介导的免疫反应帮助宿主抵抗播散性念珠菌病	［41］
	脓毒血症	显著提高体外淋巴细胞的活性，显著促进刀豆蛋白A（Con A）诱导下淋巴细胞的增殖，T细胞表面活化分子CD69、CD25、CD71的表达及淋巴细胞线粒体膜电势的升高，以及促进淋巴细胞增殖于S期	［42］
	抗疲劳	调节体内T细胞亚群的数量，增强免疫力，对抗疲劳	［43］
	肝炎	通过抑制促炎反应降低肝损伤的发生率，抑制CD4+和CD8+T淋巴细胞向肝脏的募集	［44］
	Ⅲ型前列腺炎	降低Ⅲ型前列腺炎模型中异常增高的IL-4、肿瘤坏死因子-α（Tumor necrosis factor-alpha，TNF-α）水平，减轻前列腺的损伤，通过信号传导通路促进T细胞增殖，进而产生较多细胞因子	［45］
	抗病毒	通过由Th4显性细胞因子反应导致的CD1+T细胞介导免疫反应	［41］
	败血症	增强CD4tT淋巴细胞的活性，保护胸腺和脾脏中的免疫细胞免于凋亡	［46］
Rh1	抗哮喘	调节Th1/Th2细胞因子平衡，减轻小鼠模型中卵白蛋白（Oval albumin，OVA）诱导的哮喘	［47］
Re	抗念珠菌病	通过刺激CD4+T细胞来操纵Th1/Th2分化	［48］
Rh2	抗结肠腺癌	促进T细胞浸润和活化增强了PD-L1阻断的抗癌作用	［49］
	银屑病	通过抑制血管通透性来显著减少T细胞的浸润	［50］
	抗荷瘤	增加肿瘤坏死因子受体相关因子6（Tumour necrosis factor receptor associated factor 6，TRAF6）的表达，抑制Tlr65小鼠核内NF-κBp4水平	［51］
	白血病	抑制磷脂酰肌醇3激酶（Phosphoinositide 3-kinase，PI3K）/蛋白激酶B（Protein kinase B，Akt）/雷帕霉素靶蛋白（Mammalian target of rapamycin，mTOR）信号通路，发挥抗急性淋巴细胞白血病作用	［52］
	抗哮喘	通过抑制磷酸化AKT、p38MAPK和NF-κB信号通路而实现抗哮喘作用	［53］
Rb1	抗哮喘	降级Th1/Th2	［54］
	抗细胞凋亡	显著逆转了脱氧雪腐镰刀菌烯醇诱导的T细胞亚群百分比、细胞因子水平和免疫球蛋白的产生	［55］
	重症肌无力	降低单核细胞（MNCs）中Th17细胞的百分比，增加MNCs中Treg和Th2细胞的数量	［56］
	系统性红斑狼疮	抑制ConA刺激的系统性红斑狼疮患者外周血T淋巴细胞增殖活性，增加CD4CD25T细胞比例，维持Th1/Th2免疫平衡	［57］
	再生障碍性贫血	增加CD4/CD8比例、降低Th1型细胞因子IFN-γ分泌、促进CD34+干细胞生长	［58］
Rd	脑脊髓炎	调节IFN-γ和IL-4的分泌，促进体内（大脑皮层）和体外（脾细胞培养上清液）Th2转移	［59］
人参多糖	创伤性脓毒症	使HLA-DR、CD4+细胞分数、CD4+/CD8+比值、NK百分率升高，CD8+细胞分数降低	［60］
	慢性肾功能衰竭	促进体外T细胞的转化和IL-2（Interleukin-2，IL-2）诱生能力	［61］
	乳腺癌	CD3+、CD4+、CD++1656的比例均出现了下降，而CD8+的比例出现了上升	［62］
	抗肺癌	有效调节Th1/Th2免疫平衡。可能是因为人参多糖注射液可调控多种抗肿瘤细胞因子的释放，发挥免疫调节作用	［63］
	脑脊髓炎	通过抑制自身反应性T细胞的增殖和炎性细胞因子的产生来显著改善该免疫疾病。此外，人参通过激活转录因子Foxp3促进免疫抑制Tregs的产生。	［64］
	非小细胞肺癌	Th1细胞因子（INF-γ、IL-2）表达增加和Th1/Th2比值［INF-γ/IL-4、IL-2/白细胞介素（IL-5）］以及FACT-L评分和Th2细胞因子（IL-4、IL-5）表达降低	［65］
	放射防护	人参处理的骨髓细胞的主要组织相容性复合物Ⅱ（Major histocompatibility complexⅡ，MHC-Ⅱ）类分子的表达增加，同时显示出更高的同种异体CD4+T淋巴细胞增殖水平	［66］
	黑色素瘤	通过内源产生的多种细胞因子从NK和T细胞中产生LAK细胞	［67］

), ArticleFig(id=1322923628370736043, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rg3	骨髓癌	上调B细胞淋巴瘤-2相关X蛋白（Bax）的表达，诱导多发性骨髓瘤细胞凋亡	［68］
	系统性红斑狼疮	抑制B细胞增殖，减少B细胞分泌物免疫球蛋白G（Immunoglobulin G，IgG）和免疫球蛋白M（Immunoglobulin M，IgM）的分泌，提升B细胞凋亡相关蛋白和抑制B细胞相关因子的表达	［69］
Rh1	系统性红斑狼疮	抑制B细胞增殖，减少B细胞分泌物IgG和IgM的分泌，提升B细胞凋亡相关蛋白和抑制B细胞相关因子的表达	［69］
Rg1	系统性红斑狼疮	抑制B细胞增殖，减少B细胞分泌物IgG和IgM的分泌，提升B细胞凋亡相关蛋白和抑制B细胞相关因子的表达	［69］
Rb1	系统性红斑狼疮	抑制B细胞增殖，减少B细胞分泌物IgG和IgM的分泌，提升B细胞凋亡相关蛋白和抑制B细胞相关因子的表达	［69］
CK	关节炎	以β抑制因子1（β-arrestin1）-AP2依赖性方式触发免疫球蛋白D（MmunoglobulinD，Ig D）-B细胞受体（B cell receptor，BCR）内化来抑制B细胞活化	［70］

), ArticleFig(id=1322923628458816428, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=表4, caption=

人参调节B淋巴细胞治疗免疫相关疾病及作用机制

, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rg3	骨髓癌	上调B细胞淋巴瘤-2相关X蛋白（Bax）的表达，诱导多发性骨髓瘤细胞凋亡	［68］
	系统性红斑狼疮	抑制B细胞增殖，减少B细胞分泌物免疫球蛋白G（Immunoglobulin G，IgG）和免疫球蛋白M（Immunoglobulin M，IgM）的分泌，提升B细胞凋亡相关蛋白和抑制B细胞相关因子的表达	［69］
Rh1	系统性红斑狼疮	抑制B细胞增殖，减少B细胞分泌物IgG和IgM的分泌，提升B细胞凋亡相关蛋白和抑制B细胞相关因子的表达	［69］
Rg1	系统性红斑狼疮	抑制B细胞增殖，减少B细胞分泌物IgG和IgM的分泌，提升B细胞凋亡相关蛋白和抑制B细胞相关因子的表达	［69］
Rb1	系统性红斑狼疮	抑制B细胞增殖，减少B细胞分泌物IgG和IgM的分泌，提升B细胞凋亡相关蛋白和抑制B细胞相关因子的表达	［69］
CK	关节炎	以β抑制因子1（β-arrestin1）-AP2依赖性方式触发免疫球蛋白D（MmunoglobulinD，Ig D）-B细胞受体（B cell receptor，BCR）内化来抑制B细胞活化	［70］

), ArticleFig(id=1322923628530119597, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rg1	肺纤维化	降低肝纤维化小鼠肝脏中的吲哚胺-2，3-双加氧酶1（Indoleamine-2，3-dioxygenase1，IDO1）蛋白表达水平，提高肝纤维化小鼠肝脏中DDCs免疫表型的成熟	［74］
Rg3	肾癌	Rg3促进DC分化，MHC-Ⅱ的增强使DC获得更强的抗原摄取能力，刺激细胞毒性T淋巴细胞的免疫反应	［75］
Rb1	再生障碍性贫血	抑制树突状细胞的成熟，调节CD4+T细胞/CD8+T细胞比例	［76］
Ro	白血病	转录活化子5（Signaltrans-ducer and activators of transcription 5，STAT5）信号通路可能是人参皂苷Ro促进白血病源DC的关键机制之一	［77］
Rh2	胰腺癌	吉西他滨（GEM）-Rh2可能通过增强肿瘤免疫原性和降低免疫抑制因子水平，通过胱天蛋白酶募集域蛋白9（Caspase recruitment domain-containing protein 9，CARD9）-B细胞淋巴瘤因子10（B cell lymphoma/leukemia 10，BCL10）-泪腺黏膜相关淋巴组织淋巴瘤1（Mucosa-associated Lymphoid Tissue Lymphoma，MALT1）/NF-κB通路重新激活DC细胞	［78］

), ArticleFig(id=1322923628614005679, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=表5, caption=

人参调节树突状细胞治疗免疫相关疾病及作用机制

, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rg1	肺纤维化	降低肝纤维化小鼠肝脏中的吲哚胺-2，3-双加氧酶1（Indoleamine-2，3-dioxygenase1，IDO1）蛋白表达水平，提高肝纤维化小鼠肝脏中DDCs免疫表型的成熟	［74］
Rg3	肾癌	Rg3促进DC分化，MHC-Ⅱ的增强使DC获得更强的抗原摄取能力，刺激细胞毒性T淋巴细胞的免疫反应	［75］
Rb1	再生障碍性贫血	抑制树突状细胞的成熟，调节CD4+T细胞/CD8+T细胞比例	［76］
Ro	白血病	转录活化子5（Signaltrans-ducer and activators of transcription 5，STAT5）信号通路可能是人参皂苷Ro促进白血病源DC的关键机制之一	［77］
Rh2	胰腺癌	吉西他滨（GEM）-Rh2可能通过增强肿瘤免疫原性和降低免疫抑制因子水平，通过胱天蛋白酶募集域蛋白9（Caspase recruitment domain-containing protein 9，CARD9）-B细胞淋巴瘤因子10（B cell lymphoma/leukemia 10，BCL10）-泪腺黏膜相关淋巴组织淋巴瘤1（Mucosa-associated Lymphoid Tissue Lymphoma，MALT1）/NF-κB通路重新激活DC细胞	［78］

), ArticleFig(id=1322923628672725936, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rb1	卵巢癌	人参皂苷Rb1不能直接活化NK细胞，但是能拮抗达沙替尼通过NK细胞对卵巢癌细胞抑制效应	［82］
	抗肝癌	人参皂苷Rb1通过拮抗人肝癌细胞（Human hepatocellular carcinomas，HepG2）对NK细胞的免疫抑制	［83］
Rg3	宫颈癌	20（R）-Rg3通过激活MAPK/ERK通路促进NK细胞活性	［84］
	前列腺癌	20（R）-Rg3通过激活MAPK/ERK通路促进NK细胞活性	［84］
	肺癌	20（R）-Rg3通过激活MAPK/ERK通路促进NK细胞活性	［84］
	胰腺癌	20（R）-Rg3通过激活MAPK/ERK通路促进NK细胞活性	［84］
Rh2	乳腺癌	Rh2通过抑制内质网蛋白5（Endoplasmic reticulum protein 5，ERp5）表达，减少主要MHCI.类链相关分子（MHC classI chain-related molecule A，MICA）的脱落，从而干预乳腺癌的免疫逃逸，增强NK细胞的细胞毒作用，促进NK细胞对乳腺癌的免疫监视功能	［12］
人参多糖	抑制肿瘤转移	白介素-12（Interleukin-12，IL-12）在动物模型中显示出强大的抗肿瘤和抗转移活性，并通过激活效应细胞来诱导。IL-12的作用很可能是由IFN-γ介导的，主要在NK细胞中	［85］

), ArticleFig(id=1322923630384001970, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=表6, caption=

人参调节NK细胞的免疫相关疾病及作用机制

, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rb1	卵巢癌	人参皂苷Rb1不能直接活化NK细胞，但是能拮抗达沙替尼通过NK细胞对卵巢癌细胞抑制效应	［82］
	抗肝癌	人参皂苷Rb1通过拮抗人肝癌细胞（Human hepatocellular carcinomas，HepG2）对NK细胞的免疫抑制	［83］
Rg3	宫颈癌	20（R）-Rg3通过激活MAPK/ERK通路促进NK细胞活性	［84］
	前列腺癌	20（R）-Rg3通过激活MAPK/ERK通路促进NK细胞活性	［84］
	肺癌	20（R）-Rg3通过激活MAPK/ERK通路促进NK细胞活性	［84］
	胰腺癌	20（R）-Rg3通过激活MAPK/ERK通路促进NK细胞活性	［84］
Rh2	乳腺癌	Rh2通过抑制内质网蛋白5（Endoplasmic reticulum protein 5，ERp5）表达，减少主要MHCI.类链相关分子（MHC classI chain-related molecule A，MICA）的脱落，从而干预乳腺癌的免疫逃逸，增强NK细胞的细胞毒作用，促进NK细胞对乳腺癌的免疫监视功能	［12］
人参多糖	抑制肿瘤转移	白介素-12（Interleukin-12，IL-12）在动物模型中显示出强大的抗肿瘤和抗转移活性，并通过激活效应细胞来诱导。IL-12的作用很可能是由IFN-γ介导的，主要在NK细胞中	［85］

), ArticleFig(id=1322923630597911476, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rh2	肺癌	IFN与G-Rh2作为第一启动信号在第二信号（如脂多糖）的协同下，诱导MHC-Ⅱ类抗原及Fc受体表达，调节TNF-α，NO和IL-1等活性物质的生成	［89］
	抗炎	抑制LPS刺激的巨噬细胞中的炎症反应	［90］
	肝纤维化	Rh2通过调节炎症相关基因来抑制巨噬细胞募集从而抑制肝纤维化。	［91］
Rb1	抗炎	阻断LPS与肺泡巨噬细胞膜的结合，抑制LPS诱导的细胞内核转录因子抑制蛋白（IκB）低表达，从而使TNFα分泌水平下降	［92］
	动脉粥样硬化	Rb1通过促进IL-4/白介素-13（Interleukin-13，IL-13）分泌诱导M2巨噬细胞极化，也可通过诱导M2巨噬细胞极化增加动脉粥样硬化斑块的稳定性	［93］
	脊髓损伤	通过调节巨噬细胞/小胶质细胞的极化、减轻炎症反应而促进大鼠脊髓损伤后神经功能的恢复。	［94］
	心脏肥大	降低丝裂原活化蛋白激酶（MAPKs）和丝裂原活化蛋白激酶1/2（Mitogen kinase 1and 2，MEK1/2）的磷酸化，并减少炎症介质的产生，抑制LPS或血管紧张素Ⅱ（Angiotensin-Ⅱ，Ang-Ⅱ）刺激的巨噬细胞中促肥厚microRNA-155（miR-155）的表达	［90］
CK	抗炎	诱导单核细胞趋化因子-1（Monocyte chemokine-1，MCP-1）和TNF-α升高，促进白介素-10（Interleukin-10，IL-10）表达，抑制炎性巨噬细胞活化，增加抗炎巨噬细胞表达	［95］
	抗肥胖	通过激活过氧化物酶体增殖物激活受体γ（Peroxisome proliferatoractivated receptorγ，PPARγ），调节巨噬细胞募集和极化	［96］
	骨质疏松症	通过抑制NF-κB信号通路，降低破骨细胞生成并防止去卵巢骨质疏松模型大鼠诱导的骨流失	［97-98］
	关节炎	抑制巨噬细胞吞噬，降低M1比例。降低胶原诱导性关节炎（Collagen-induced arthritis，CIA）小鼠巨噬细胞中过表达的β-arrestin2、抑制型G蛋白α（Gαi）、TLR4和NF-κB，同时增加激动型G蛋白α（Gαs）的表达。此外，CK通过巨噬细胞中的β-arrestin2调节，促进TLR4-Gαs偶联并抑制TLR4-Gαi偶联	［99］
	耳皮炎	调节巨噬细胞产生的环氧合酶-2（Cyclooxygenase，COX-2）和Th细胞诱导的干扰素-γ和IL-4。	［100］
Rb1	肺纤维化	巨噬细胞中NOD样受体热蛋白结构域相关蛋白3（NOD-like receptor thermal protein domain associated protein 3，NLRP3）炎症小体激活后分泌的白细胞介素-1β（Interleukin-1β，IL-1β），促进成纤维细胞分化。Rb1抑制脂多糖和三磷酸腺苷诱导的巨噬细胞中NLRP3炎症小体活化，并干扰巨噬细胞和成纤维细胞之间的串扰	［101］
	抗病毒	抑制脂多糖/环己酰亚胺诱导的D3转导巨噬细胞中的AKT和糖原合酶激酶-3β磷酸化，但不抑制磷酸肌醇依赖性蛋白激酶1（Phosphoinositide dependent protein kinase 1，PDK-1）和磷酸肌醇-3-激酶（Phosphoinositide 3-kinase，PI3K）的磷酸化	［102］
Rd	肾缺血再灌注损伤	通过下调M1巨噬细胞极化，对肾缺血/再灌注损伤具有保护功能	［103］
	心肌梗死	人参皂苷Rd促进Ly6C的转化高MOS/MPS为Ly6C低心肌梗死后小鼠的Mos/Mps，通过激活AKT/mTOR信号通路，抑制心功能障碍，促进心脏修复	［104］
Rg1	结肠炎	人参皂苷Rg1通过调节M1/M2巨噬细胞极化和微生物群组成来改善结肠炎，通过抑制Nogo-B/RhoA信号通路完成	［105］
	创伤性脑损伤	Rg1降低IL-1β诱导的巨噬细胞（IIM）-Exos-miR-21（RIIM-Exos）中miR-21-5p的含量。Rg1可以抑制外周血流向脑Exos-miR-21的释放，增强基质金属蛋白酶组织抑制剂（Tissue inhibitors of matrix metalloproteinases，TIMPs）表达、基质金属蛋白酶（Matrix metalloproteinases，MMPs）水解，限制致结蛋白降解，从而保护神经炎症和血脑屏障的完整性	［106］
	糖尿病性心肌病	RG1诱导的间充质干细胞分泌的外泌体circNOTCH1可以通过激活NOTCH信号通路，诱导巨噬细胞M2极化来缓解糖尿病性心肌病（Diabetic cardiomyopathy，DCM）	［107］
	脓毒症	抑制mRNA表达和促炎介质的产生，包括肿瘤坏死因子α、白细胞介素-1β、白细胞介素-6、cox-2和LPS刺激的巨噬细胞诱导的一氧化氮合酶	［108］
Rg5	肺部炎症	抑制LPS与巨噬细胞上的toll样受体-4的结合	［109］
	特应性皮炎	下调人角质形成细胞和巨噬细胞中NF-κB/p38MAPK/STAT1信号传导，减弱TNF-α/IFN-γ诱导的胸腺活化调节趋化因子（Thymus andactivation regulated chemokine，TARC）/CCL17的产生和LPS诱导的NO产生	［110］
Rg3	视网膜缺血再灌注	缓解氧化应激和促进小胶质细胞/巨噬细胞M2极化	［111］
人参多糖	关节炎	使Peyer＇s结淋巴细胞（Lymphocytes of Peyer＇s patch，PPL）分泌TNF-α，使IFN-γ的分泌增加，而上皮内淋巴细胞（Intraepithelial lymphocytes，IELs）和固有层淋巴细胞（Lamina propria lymphocytes，LPLs）所分泌的TNF-α和IFN-γ的水平均有不同程度地降低	［112］
人参挥发油	抗炎	抑制巨噬细胞的TNF-α、IL-6和IL-1β蛋白质分泌量及IImRNA的表达水平	［26］
	胃癌	通过作用表皮生长因子受体（Epidermal growth factor receptor，EGFR）、MAPK1、MAPK3和IL-6这几个靶点来实现治疗胃癌作用	［113］

), ArticleFig(id=1322923630698574773, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=表7, caption=

人参调节巨噬细胞的免疫相关疾病及作用机制

, figureFileSmall=null, figureFileBig=null, tableContent=

化学成分	相关疾病	作用机制	参考文献
Rh2	肺癌	IFN与G-Rh2作为第一启动信号在第二信号（如脂多糖）的协同下，诱导MHC-Ⅱ类抗原及Fc受体表达，调节TNF-α，NO和IL-1等活性物质的生成	［89］
	抗炎	抑制LPS刺激的巨噬细胞中的炎症反应	［90］
	肝纤维化	Rh2通过调节炎症相关基因来抑制巨噬细胞募集从而抑制肝纤维化。	［91］
Rb1	抗炎	阻断LPS与肺泡巨噬细胞膜的结合，抑制LPS诱导的细胞内核转录因子抑制蛋白（IκB）低表达，从而使TNFα分泌水平下降	［92］
	动脉粥样硬化	Rb1通过促进IL-4/白介素-13（Interleukin-13，IL-13）分泌诱导M2巨噬细胞极化，也可通过诱导M2巨噬细胞极化增加动脉粥样硬化斑块的稳定性	［93］
	脊髓损伤	通过调节巨噬细胞/小胶质细胞的极化、减轻炎症反应而促进大鼠脊髓损伤后神经功能的恢复。	［94］
	心脏肥大	降低丝裂原活化蛋白激酶（MAPKs）和丝裂原活化蛋白激酶1/2（Mitogen kinase 1and 2，MEK1/2）的磷酸化，并减少炎症介质的产生，抑制LPS或血管紧张素Ⅱ（Angiotensin-Ⅱ，Ang-Ⅱ）刺激的巨噬细胞中促肥厚microRNA-155（miR-155）的表达	［90］
CK	抗炎	诱导单核细胞趋化因子-1（Monocyte chemokine-1，MCP-1）和TNF-α升高，促进白介素-10（Interleukin-10，IL-10）表达，抑制炎性巨噬细胞活化，增加抗炎巨噬细胞表达	［95］
	抗肥胖	通过激活过氧化物酶体增殖物激活受体γ（Peroxisome proliferatoractivated receptorγ，PPARγ），调节巨噬细胞募集和极化	［96］
	骨质疏松症	通过抑制NF-κB信号通路，降低破骨细胞生成并防止去卵巢骨质疏松模型大鼠诱导的骨流失	［97-98］
	关节炎	抑制巨噬细胞吞噬，降低M1比例。降低胶原诱导性关节炎（Collagen-induced arthritis，CIA）小鼠巨噬细胞中过表达的β-arrestin2、抑制型G蛋白α（Gαi）、TLR4和NF-κB，同时增加激动型G蛋白α（Gαs）的表达。此外，CK通过巨噬细胞中的β-arrestin2调节，促进TLR4-Gαs偶联并抑制TLR4-Gαi偶联	［99］
	耳皮炎	调节巨噬细胞产生的环氧合酶-2（Cyclooxygenase，COX-2）和Th细胞诱导的干扰素-γ和IL-4。	［100］
Rb1	肺纤维化	巨噬细胞中NOD样受体热蛋白结构域相关蛋白3（NOD-like receptor thermal protein domain associated protein 3，NLRP3）炎症小体激活后分泌的白细胞介素-1β（Interleukin-1β，IL-1β），促进成纤维细胞分化。Rb1抑制脂多糖和三磷酸腺苷诱导的巨噬细胞中NLRP3炎症小体活化，并干扰巨噬细胞和成纤维细胞之间的串扰	［101］
	抗病毒	抑制脂多糖/环己酰亚胺诱导的D3转导巨噬细胞中的AKT和糖原合酶激酶-3β磷酸化，但不抑制磷酸肌醇依赖性蛋白激酶1（Phosphoinositide dependent protein kinase 1，PDK-1）和磷酸肌醇-3-激酶（Phosphoinositide 3-kinase，PI3K）的磷酸化	［102］
Rd	肾缺血再灌注损伤	通过下调M1巨噬细胞极化，对肾缺血/再灌注损伤具有保护功能	［103］
	心肌梗死	人参皂苷Rd促进Ly6C的转化高MOS/MPS为Ly6C低心肌梗死后小鼠的Mos/Mps，通过激活AKT/mTOR信号通路，抑制心功能障碍，促进心脏修复	［104］
Rg1	结肠炎	人参皂苷Rg1通过调节M1/M2巨噬细胞极化和微生物群组成来改善结肠炎，通过抑制Nogo-B/RhoA信号通路完成	［105］
	创伤性脑损伤	Rg1降低IL-1β诱导的巨噬细胞（IIM）-Exos-miR-21（RIIM-Exos）中miR-21-5p的含量。Rg1可以抑制外周血流向脑Exos-miR-21的释放，增强基质金属蛋白酶组织抑制剂（Tissue inhibitors of matrix metalloproteinases，TIMPs）表达、基质金属蛋白酶（Matrix metalloproteinases，MMPs）水解，限制致结蛋白降解，从而保护神经炎症和血脑屏障的完整性	［106］
	糖尿病性心肌病	RG1诱导的间充质干细胞分泌的外泌体circNOTCH1可以通过激活NOTCH信号通路，诱导巨噬细胞M2极化来缓解糖尿病性心肌病（Diabetic cardiomyopathy，DCM）	［107］
	脓毒症	抑制mRNA表达和促炎介质的产生，包括肿瘤坏死因子α、白细胞介素-1β、白细胞介素-6、cox-2和LPS刺激的巨噬细胞诱导的一氧化氮合酶	［108］
Rg5	肺部炎症	抑制LPS与巨噬细胞上的toll样受体-4的结合	［109］
	特应性皮炎	下调人角质形成细胞和巨噬细胞中NF-κB/p38MAPK/STAT1信号传导，减弱TNF-α/IFN-γ诱导的胸腺活化调节趋化因子（Thymus andactivation regulated chemokine，TARC）/CCL17的产生和LPS诱导的NO产生	［110］
Rg3	视网膜缺血再灌注	缓解氧化应激和促进小胶质细胞/巨噬细胞M2极化	［111］
人参多糖	关节炎	使Peyer＇s结淋巴细胞（Lymphocytes of Peyer＇s patch，PPL）分泌TNF-α，使IFN-γ的分泌增加，而上皮内淋巴细胞（Intraepithelial lymphocytes，IELs）和固有层淋巴细胞（Lamina propria lymphocytes，LPLs）所分泌的TNF-α和IFN-γ的水平均有不同程度地降低	［112］
人参挥发油	抗炎	抑制巨噬细胞的TNF-α、IL-6和IL-1β蛋白质分泌量及IImRNA的表达水平	［26］
	胃癌	通过作用表皮生长因子受体（Epidermal growth factor receptor，EGFR）、MAPK1、MAPK3和IL-6这几个靶点来实现治疗胃癌作用	［113］

), ArticleFig(id=1322923631017341878, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

编号	药对	作用机制	参考文献
1	人参-黄芪	增加小鼠特异性免疫（脾脏淋巴细胞增殖转化率）和非特异性免疫（NK细胞杀伤活性）	［143］
2	人参-丹参	增强T淋巴细胞对肿瘤细胞体外的杀伤能力	［144］
3	人参-鸡胚	通过氧化低密度脂蛋白（ox-LDL）和H2O2诱导脐静脉内皮细胞（Human Umbilical Vein Endothelial Cells，HUVECs）抑制巨噬细胞存活率	［139］
4	人参-雷公藤	调节Treg/Th17之间的平衡	［145］
5	人参-玛咖	提高小鼠单核-巨噬细胞功能、细胞免疫功能和体液免疫功能	［137］
6	人参-五灵脂	增加血中红细胞、白细胞数及免疫器官胸腺、脾脏、肾上腺的重量	［146］
7	人参-当归	对环磷酞胺引起的小鼠骨髓抑制和免疫抑制均有较好的改善作用，而当参、归为1∶2的配伍比例时，促进造血功能、改善免疫功能的效果最好	［147］
8	人参-蒲公英	人参-蒲公英配伍后可以改善免疫系统（IL-2、IL-6、TNF-α降低）相关指标的分泌	［148］

), ArticleFig(id=1322923631101227959, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923613556454234, language=CN, label=表8, caption=

人参在不同药对环境中的表达

, figureFileSmall=null, figureFileBig=null, tableContent=

编号	药对	作用机制	参考文献
1	人参-黄芪	增加小鼠特异性免疫（脾脏淋巴细胞增殖转化率）和非特异性免疫（NK细胞杀伤活性）	［143］
2	人参-丹参	增强T淋巴细胞对肿瘤细胞体外的杀伤能力	［144］
3	人参-鸡胚	通过氧化低密度脂蛋白（ox-LDL）和H2O2诱导脐静脉内皮细胞（Human Umbilical Vein Endothelial Cells，HUVECs）抑制巨噬细胞存活率	［139］
4	人参-雷公藤	调节Treg/Th17之间的平衡	［145］
5	人参-玛咖	提高小鼠单核-巨噬细胞功能、细胞免疫功能和体液免疫功能	［137］
6	人参-五灵脂	增加血中红细胞、白细胞数及免疫器官胸腺、脾脏、肾上腺的重量	［146］
7	人参-当归	对环磷酞胺引起的小鼠骨髓抑制和免疫抑制均有较好的改善作用，而当参、归为1∶2的配伍比例时，促进造血功能、改善免疫功能的效果最好	［147］
8	人参-蒲公英	人参-蒲公英配伍后可以改善免疫系统（IL-2、IL-6、TNF-α降低）相关指标的分泌	［148］

)], attaches=null, journal=Journal(id=1255846881855815682, delFlag=0, nameCn=中华中医药学刊, nameEn=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, issn=1673-7717, eissn=null, cn=21-1546/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=v4T+dd+NLAnioIpGAbkcEQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Archives of Traditional Chinese Medicine, journalRemark=null, publicationField=null, createdTime=1777346829146, updatedTime=1788949222391, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=v4T+dd+NLAnioIpGAbkcEQ==, picEn=RAy5vuC40hwJB+Y0pEARug==, jcr=null, cjcr=null, exts=[JournalExt(id=1304510846391050374, language=CN, name=中华中医药学刊, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222419, updatedTime=1788949222419, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304510846449770631, language=EN, name=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222433, updatedTime=1788949222433, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1255847919539208197, websiteList=[Website(id=1255847989868900719, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN, language=CN, createTime=1777347093312, createBy=18614031015, updateTime=1777347427646, updateBy=18614031015, name=中华中医药学刊-中文, tplId=1146099689490845704, title=中华中医药学刊, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849512594170105, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=articleTextType, value=kx, createTime=1777347456358, updateTime=1777347456358, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512564809974, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=banner, value=null, createTime=1777347456352, updateTime=1777347456352, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512631918844, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=grayFlag, value=0, createTime=1777347456367, updateTime=1777347456367, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512552227061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347456348, updateTime=1777347456348, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512657084670, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=minRunFlag, value=0, createTime=1777347456373, updateTime=1777347456373, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512589975800, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic, createTime=1777347456357, updateTime=1777347456357, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512648696061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=silenceFlag, value=0, createTime=1777347456371, updateTime=1777347456371, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512581587191, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1777347456355, updateTime=1777347456355, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512619335930, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeColor, value=null, createTime=1777347456364, updateTime=1777347456364, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512627724539, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeStyle, value=null, createTime=1777347456366, updateTime=1777347456366, creator=18614031015, updator=18614031015)]), Website(id=1255847989944398211, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN, language=EN, createTime=1777347093330, createBy=18614031015, updateTime=1777347417860, updateBy=18614031015, name=中华中医药学刊-英文, tplId=1146101810881728533, title=Chinese Archives of Traditional Chinese Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849538993119491, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=articleTextType, value=kx, createTime=1777347462652, updateTime=1777347462652, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538972147968, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=banner, value=null, createTime=1777347462647, updateTime=1777347462647, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539047645446, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=grayFlag, value=0, createTime=1777347462665, updateTime=1777347462665, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538930204927, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347462637, updateTime=1777347462637, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539064422664, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=minRunFlag, value=0, createTime=1777347462669, updateTime=1777347462669, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538988925186, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic, createTime=1777347462651, updateTime=1777347462651, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539060228359, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=silenceFlag, value=0, createTime=1777347462668, updateTime=1777347462668, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538980536577, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1777347462649, updateTime=1777347462649, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539001508100, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeColor, value=null, createTime=1777347462654, updateTime=1777347462654, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539039256837, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeStyle, value=null, createTime=1777347462663, updateTime=1777347462663, creator=18614031015, updator=18614031015)])], journalTitle=中华中医药学刊, weixinUrl=null, journalUrl=https://castjournals.cast.org.cn/zhzyyxk, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Archives of Traditional Chinese Medicine, journalPhotoCn=v4T+dd+NLAnioIpGAbkcEQ==, journalPhotoEn=RAy5vuC40hwJB+Y0pEARug==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2025.05.026, detailUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2025.05.026, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/PDF/10.13193/j.issn.1673-7717.2025.05.026, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/PDF/10.13193/j.issn.1673-7717.2025.05.026, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1746806400000, fullTextJson=null, articleText=null, reference=null)