Article(id=1322912384360251796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322912162913596032, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.01.044, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793336490954, onlineDateStr=2026-10-30, pubDate=1736438400000, pubDateStr=2025-01-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793336490954, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793336490954, creator=13701087609, updateTime=1793336490954, updator=13701087609, issue=Issue{id=1322912162913596032, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='1', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1736438400000', pubDateStr='2025-01-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793336438157, creator='13701087609', updateTime=1793340633627, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929760048906989, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322912162913596032, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929760048906990, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322912162913596032, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=247, endPage=252, ext={EN=ArticleExt(id=1322912384590938517, articleId=1322912384360251796, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Acute Toxicity and Hepatorenal Toxicity of Aqueous Extracts of Zhizi（Gardeniae Fructus）from Different Degrees of Processing in Zebrafish Model, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To study the acute toxicity and liver and kidney toxicity of raw Zhizi（Gardeniae Fructus）and six water extractswith different processing degrees using zebrafish model and explore the effect of processing degree on Zhizi（Gardeniae Fructus）toxicity.
Methods Acute toxicity studieswere carried outon AB series zebrafish with normal development 3 days（3 dpf）after fertilization，and 6 different dose concentrationswere set for raw products（sp）and sixwater extractswith different degrees of preparation（pz1，pz2，pz3，pz4，pz5，pz6）. Themortality rate of zebrafish at72 h was statistically calculated. Quantitation-toxicity curveswere created using GraphPad Prism 9.0 software to calculate half lethal concentration（LC50）and 10% lethal concentration（LC10）. Liver and kidney injury studies were conducted on gz15Tg/+（AB）liver fluorescent protein transgenic zebrafish with normal development4 days（4 dpf）after fertilization. Three dose concentration groups were set up as low（LC0），medium（LC10）and high（LC20）groups，and the acetaminophen group was setup，with embryonic water as the blank group. After72 h of administration，zebrafish livermorphology and fluorescence area changes were observed，and the activities of alanine aminotransferase（ALT）and aspartate aminotransferase（AST），creatinine（Cr）and urea nitrogen（BUN）were detected.
Results The results of acute toxicity experiments showed that the values of LC50 of the raw productand six water extractswith different processing degreeswere 0.042，0.049，0.053，0.064，0.050，0.058 g·L-1 respectively. The values of LC10 were 0.024，0.025，0.033，0.038，0.036，0.036，0.039 g·L-1 respectively. The results of liver and kidney injury showed that compared with those in the blank group，the livermorphological deformation and fluorescence area of zebrafish in the acetaminophen group decreased（P<0.01）and the activities of ALT and AST increased（P<0.01），indicating that acetaminophen was hepatotoxic to zebrafish. The livermorphological changes and fluorescence area of zebrafish in the low，medium and high groups of sp decreased（P<0.01），the activities of ALT and AST increased（P<0.01，P<0.05）and the activities of BUN and Cr rised（P<0.05），indicating the raw product had hepatic and renal toxicity to zebrafish. Livermorphology and fluorescence area of zebrafish decreased in themedium and high dose groups of pz 1，pz 2 and pz 3（P<0.01），the activities of ALT and AST in pz1 group increased（P<0.01），the activities of BUN and Cr elevated（P<0.01，P<0.05），the activity of ALT in the low，medium and high dose groups of pz2 and pz3 rised（P<0.05，P<0.01），and the activities of AST in themedium and high dose groups increased（P<0.05，P<0.01）. There were no significant changes of livermorphology or fluorescence area in the low and medium dose groups of pz4，pz5 and pz6，and there were changes in the high dose group（P<0.05）. The results showed that the low and medium dose groups of pz4，pz5 and pz6 had no significant effect on the liver of zebrafish，and there was liver damage in the high dose group. ALT and AST were elevated in themedium and high dose groups of pz4（P<0.05，P<0.01）. There was no significant effect on the decrease in the activity of ALT of pz5 and pz6 and there was liver injury in the AST high dose group（P<0.01，P<0.05）. The activities of BUN and Cr were increased in the high dose groups of pz3 and pz5（P<0.01，P<0.05），and the activitieswere elevated in the high dose group of pz4（P<0.01）. The results showed that sp and pz1～pz5 had different degrees of damage to the liver and kidney of zebrafish with different degrees of preparation and different doses. There was no liver or kidney injury neither in the three dose concentration groups of pz6 nor in the ALT，BUN，Cr and AST low and medium dose groups of zebrafish.
Conclusion The liver and kidney injury of Zhizi（Gardeniae Fructus）is related to the degree of processing and dosage. But raw and different processing degrees products showed certain liver and kidney damage to varying degrees. Standardizing the processing conditionsmay be an importantmeasure to realize themedication safety of gardenia.
, authors=Shiya YUAN, Chenying YE, Yiting CHEN, Ting HE, Min WANG, Guilong NONG, Gailian ZHOU, authorsList=Shiya YUAN, Chenying YE, Yiting CHEN, Ting HE, Min WANG, Guilong NONG, Gailian ZHOU, authorCompany=null, correspAuthors=Gailian ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322912386142831010, articleId=1322912384360251796, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=不同炮制程度栀子水提物对斑马鱼模型的急性毒性及肝肾损伤, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 用斑马鱼模型对生栀子及6种不同炮制程度栀子水提物进行急性毒性及肝肾毒性研究，探索炮制程度对栀子毒性的影响。
方法 以受精后3 d（3 dpf）发育正常的AB系斑马鱼为对象进行急性毒性研究，对生品（sp）及6种不同炮制程度栀子水提物（pz1、pz2、pz3、pz4、pz5、pz6）分别设置6个不同剂量浓度，统计斑马鱼72 h死亡率。用Graph-Pad Prism 9.0软件制作量-毒曲线，计算半数致死浓度（LC50）和10%致死浓度（LC10）。以受精后4 d（4 dpf）发育正常的gz15Tg/+（AB）肝脏荧光蛋白转基因斑马鱼为对象进行肝损伤研究。分别设置低（LC0）、中（LC10）、高（LC20）3个剂量浓度组，设对乙酰氨基酚组，以胚胎水为空白组。给药72 h后观察斑马鱼肝脏形态和荧光面积变化，检测丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、肌酐（Cr）和尿素氮（BUN）活性。
结果 急性毒性实验结果显示，生品及6种不同炮制程度栀子水提物LC50分别为0.042、0.049、0.053、0.064、0.050、0.058、0.058 g·L-1；LC10分别为0.024、0.025、0.033、0.038、0.036、0.036、0.039 g·L-1。肝肾损伤实验结果表明，与空白组比较，对乙酰氨基酚组的斑马鱼肝脏形态变形和荧光面积减小（P<0.01），ALT和AST活性升高（P<0.01），表明对乙酰氨基酚对斑马鱼有肝毒性。sp低、中、高剂量组斑马鱼肝脏形态变化和荧光面积减少（P<0.01），ALT和AST活性升高（P<0.01，P<0.05），BUN和Cr活性升高（P<0.05），表明生品对斑马鱼有肝肾毒性。pz1、pz2、pz3中、高剂量浓度组斑马鱼肝脏形态变化和荧光面积减少（P<0.01），pz1的ALT和AST活性升高（P<0.01），BUN和Cr活性升高（P<0.01，P<0.05），pz2、pz3的ALT低、中、高剂量组活性升高（P<0.05，P<0.01），AST中、高剂量组活性升高（P<0.05，P<0.01）。pz4、pz5、pz6低、中剂量组斑马鱼肝脏形态变化和荧光面积无明显变化，高剂量组有变化（P<0.05）。表明pz4、pz5、pz6低、中剂量组对斑马鱼肝脏无明显影响，高剂量组有肝损伤。pz4中、高剂量组ALT、AST升高（P<0.05，P<0.01）；pz5、pz6的ALT活性降低无显著影响，AST高剂量组有肝损伤（P<0.01，P<0.05）。pz3、pz5高剂量组BUN和Cr活性升高（P<0.01，P<0.05），pz4高剂量组BUN和Cr活性升高（P<0.01）。表明sp及pz1～pz5不同炮制程度不同剂量浓度对斑马鱼肝脏及肾脏均有不同程度的损伤。pz6的3个剂量浓度组斑马鱼ALT、BUN、Cr及AST低、中剂量组均无肝肾损伤。
结论 栀子肝肾损伤与炮制程度和给药剂量有关。生品与不同炮制程度栀子均不同程度地表现出一定的肝肾损伤，规范炮制条件可能是实现栀子用药安全的重要措施。
, authors=袁士雅, 叶晨英, 陈亿婷, 何婷, 王敏, 农桂龙, 周改莲, authorsList=袁士雅, 叶晨英, 陈亿婷, 何婷, 王敏, 农桂龙, 周改莲, authorCompany=null, correspAuthors=周改莲, authorNote=
袁士雅（1998-），女，四川成都人，硕士，研究方向：中药饮片质量标准与炮制机理。
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周改莲（1981-），女，河南商水人，教授，硕士研究生导师，博士，研究方向：中药饮片质量标准与炮制机理。E-mail：
zhgllhw@126.com。
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袁士雅（1998-），女，四川成都人，硕士，研究方向：中药饮片质量标准与炮制机理。
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袁士雅（1998-），女，四川成都人，硕士，研究方向：中药饮片质量标准与炮制机理。
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不同炮制程度栀子水提物对斑马鱼的量-毒曲线（n＝3，
±s）, figureFileSmall=FnreoXnfb+ElktoZFXaopA==, figureFileBig=Fi6I0uOxen2YRMiRF2ISWA==, tableContent=null), ArticleFig(id=1322912771192521509, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912384360251796, language=EN, label=null, caption=null, figureFileSmall=fUdlEtwoJZm8D4leG6HBvg==, figureFileBig=ECqNvSX7iNd/3CNaUEuUsA==, tableContent=null), ArticleFig(id=1322912771284796198, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912384360251796, language=CN, label=图2, caption=
不同炮制程度栀子水提物对斑马鱼肝脏荧光面积的影响注：A.空白组；B.对乙酰氨基酚组；C1～C3.sp低、中、高剂量组（0.012、0.024、0.030 g·L-1）；D1～D3.pz1低、中、高剂量组（0.014、0.025、0.033 g·L-1）；E1～E3.pz2低、中、高剂量组（0.015、0.033、0.040 g·L-1）；F1～F3.pz3低、中、高剂量组（0.016、0.038、0.047 g·L-1）；G1～G3.pz4低、中、高剂量组（0.024、0.036、0.041 g·L-1）；H1～H3.pz5低、中、高剂量组（0.024、0.036、0.043 g·L-1）；I1～I3.pz6低、中、高剂量组（0.025、0.039、0.046 g·L-1）。
, figureFileSmall=fUdlEtwoJZm8D4leG6HBvg==, figureFileBig=ECqNvSX7iNd/3CNaUEuUsA==, tableContent=null), ArticleFig(id=1322912771356099367, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912384360251796, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 质量浓度/（g·L-1） | 肝脏荧光面积/
（μm2） |
|---|
| 空白组 | 10 | | 8 413.7±1 517.1 |
| 对乙酰氨基酚组 | 10 | 0.250 | 5 807.5±773.12） |
| sp低剂量组 | 10 | 0.012 | 5 863.1±662.82） |
| sp中剂量组 | 10 | 0.024 | 5 543.8±473.42） |
| sp高剂量组 | 10 | 0.030 | 4 330.8±886.82） |
| pz1低剂量组 | 10 | 0.014 | 7 135.3±454.91） |
| pz1中剂量组 | 10 | 0.025 | 5 543.7±778.22） |
| pz1高剂量组 | 10 | 0.033 | 5 026.3±625.62） |
| pz2低剂量组 | 10 | 0.015 | 7 118.1±1 101.11） |
| pz2中剂量组 | 10 | 0.033 | 5 383.6±566.22） |
| pz2高剂量组 | 10 | 0.040 | 5 582.2±1 394.72） |
| pz3低剂量组 | 10 | 0.016 | 7 321.0±1 160.1 |
| pz3中剂量组 | 10 | 0.038 | 5 890.9±801.72） |
| pz3高剂量组 | 10 | 0.047 | 5 174.6±621.22） |
| pz4低剂量组 | 10 | 0.024 | 8 973.7±588.2 |
| pz4中剂量组 | 10 | 0.036 | 7 526.4±946.6 |
| pz4高剂量组 | 10 | 0.041 | 6 570.4±1 688.01） |
| pz5低剂量组 | 10 | 0.024 | 8 710.9±1 856.1 |
| pz5中剂量组 | 10 | 0.036 | 8 091.9±2 594.1 |
| pz5高剂量组 | 10 | 0.043 | 6 990.3±1 446.11） |
| pz6低剂量组 | 10 | 0.025 | 8 064.8±1 051.6 |
| pz6中剂量组 | 10 | 0.039 | 7 267.9±884.0 |
| pz6高剂量组 | 10 | 0.046 | 6 786.6±1 253.01） |
), ArticleFig(id=1322912773012849448, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912384360251796, language=CN, label=表1, caption=
不同炮制程度栀子水提物对斑马鱼肝脏荧光面积的影响（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 质量浓度/（g·L-1） | 肝脏荧光面积/
（μm2） |
|---|
| 空白组 | 10 | | 8 413.7±1 517.1 |
| 对乙酰氨基酚组 | 10 | 0.250 | 5 807.5±773.12） |
| sp低剂量组 | 10 | 0.012 | 5 863.1±662.82） |
| sp中剂量组 | 10 | 0.024 | 5 543.8±473.42） |
| sp高剂量组 | 10 | 0.030 | 4 330.8±886.82） |
| pz1低剂量组 | 10 | 0.014 | 7 135.3±454.91） |
| pz1中剂量组 | 10 | 0.025 | 5 543.7±778.22） |
| pz1高剂量组 | 10 | 0.033 | 5 026.3±625.62） |
| pz2低剂量组 | 10 | 0.015 | 7 118.1±1 101.11） |
| pz2中剂量组 | 10 | 0.033 | 5 383.6±566.22） |
| pz2高剂量组 | 10 | 0.040 | 5 582.2±1 394.72） |
| pz3低剂量组 | 10 | 0.016 | 7 321.0±1 160.1 |
| pz3中剂量组 | 10 | 0.038 | 5 890.9±801.72） |
| pz3高剂量组 | 10 | 0.047 | 5 174.6±621.22） |
| pz4低剂量组 | 10 | 0.024 | 8 973.7±588.2 |
| pz4中剂量组 | 10 | 0.036 | 7 526.4±946.6 |
| pz4高剂量组 | 10 | 0.041 | 6 570.4±1 688.01） |
| pz5低剂量组 | 10 | 0.024 | 8 710.9±1 856.1 |
| pz5中剂量组 | 10 | 0.036 | 8 091.9±2 594.1 |
| pz5高剂量组 | 10 | 0.043 | 6 990.3±1 446.11） |
| pz6低剂量组 | 10 | 0.025 | 8 064.8±1 051.6 |
| pz6中剂量组 | 10 | 0.039 | 7 267.9±884.0 |
| pz6高剂量组 | 10 | 0.046 | 6 786.6±1 253.01） |
), ArticleFig(id=1322912773130289961, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912384360251796, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 质量浓度/（g·L-1） | ALT/（U·g-1） | AST/（U·g-1） | BUN/（mmol·L-1） | Cr/（μmol·L-1） |
|---|
| 空白组 | 3 | | 33.327±1.445 | 35.033±0.905 | 3.009±0.331 | 6.295±3.426 |
| 对乙酰氨基酚组 | 3 | 0.250 | 45.056±1.5912） | 51.131±1.4532） | 10.949±0.2002） | 20.005±1.1152） |
| sp低剂量组 | 3 | 0.012 | 56.190±1.6702） | 63.690±5.8422） | 3.715±0.2111） | 15.560±4.4571） |
| sp中剂量组 | 3 | 0.024 | 63.443±0.9402） | 63.824±1.0992） | 3.741±0.1441） | 17.238±2.6191） |
| sp高剂量组 | 3 | 0.030 | 66.606±4.4422） | 69.185±12.9791） | 3.869±0.501 | 19.699±6.1141） |
| pz1低剂量组 | 3 | 0.014 | 47.817±1.5382） | 45.565±4.497 | 3.923±0.2621） | 15.860±4.3741） |
| pz1中剂量组 | 3 | 0.025 | 48.591±1.9162） | 51.985±3.3242） | 4.182±0.3201） | 17.411±1.7322） |
| pz1高剂量组 | 3 | 0.033 | 50.698±1.7822） | 55.809±1.6692） | 4.233±0.1782） | 18.146±5.0171） |
| pz2低剂量组 | 3 | 0.015 | 40.610±2.6321） | 34.888±1.640 | 3.319±0.248 | 11.196±5.936 |
| pz2中剂量组 | 3 | 0.033 | 42.070±2.0382） | 37.036±0.7891） | 3.743±0.029 | 14.307±3.918 |
| pz2高剂量组 | 3 | 0.040 | 47.281±1.3402） | 44.784±9.755 | 4.445±0.881 | 19.295±5.5761） |
| pz3低剂量组 | 3 | 0.016 | 38.038±1.4691） | 40.646±2.1731） | 2.652±0.549 | 11.865±2.475 |
| pz3中剂量组 | 3 | 0.038 | 39.073±0.9062） | 41.421±0.4492） | 3.476±0.456 | 11.969±8.351 |
| pz3高剂量组 | 3 | 0.047 | 40.987±1.0472） | 41.683±4.839 | 4.556±0.0101） | 26.011±5.6342） |
| pz4低剂量组 | 3 | 0.024 | 33.241±0.905 | 40.260±12.081 | 3.421±0.331 | 7.995±2.699 |
| pz4中剂量组 | 3 | 0.036 | 38.126±1.6171） | 40.346±1.8971） | 3.667±0.250 | 20.966±4.5591） |
| pz4高剂量组 | 3 | 0.041 | 40.746±2.0352） | 45.600±1.1932） | 4.625±0.1272） | 25.033±4.5922） |
| pz5低剂量组 | 3 | 0.024 | 33.586±1.492 | 34.318±2.7281） | 3.176±0.078 | 8.795±6.581 |
| pz5中剂量组 | 3 | 0.036 | 34.630±1.765 | 36.530±5.060 | 3.697±0.1901） | 12.729±10.533 |
| pz5高剂量组 | 3 | 0.043 | 34.754±2.716 | 38.055±2.2042） | 3.818±0.0591） | 25.477±12.5542） |
| pz6低剂量组 | 3 | 0.025 | 31.909±2.603 | 36.293±2.318 | 3.368±0.916 | 5.747±1.675 |
| pz6中剂量组 | 3 | 0.039 | 32.843±1.808 | 36.412±0.304 | 3.587±0.439 | 10.389±6.707 |
| pz6高剂量组 | 3 | 0.046 | 33.058±3.112 | 37.078±0.2031） | 4.579±2.169 | 13.543±3.8766 |
), ArticleFig(id=1322912773201593130, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912384360251796, language=CN, label=表2, caption=
不同炮制程度栀子水提物对斑马鱼ALT、AST、BUN、Cr活性的影响（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | n | 质量浓度/（g·L-1） | ALT/（U·g-1） | AST/（U·g-1） | BUN/（mmol·L-1） | Cr/（μmol·L-1） |
|---|
| 空白组 | 3 | | 33.327±1.445 | 35.033±0.905 | 3.009±0.331 | 6.295±3.426 |
| 对乙酰氨基酚组 | 3 | 0.250 | 45.056±1.5912） | 51.131±1.4532） | 10.949±0.2002） | 20.005±1.1152） |
| sp低剂量组 | 3 | 0.012 | 56.190±1.6702） | 63.690±5.8422） | 3.715±0.2111） | 15.560±4.4571） |
| sp中剂量组 | 3 | 0.024 | 63.443±0.9402） | 63.824±1.0992） | 3.741±0.1441） | 17.238±2.6191） |
| sp高剂量组 | 3 | 0.030 | 66.606±4.4422） | 69.185±12.9791） | 3.869±0.501 | 19.699±6.1141） |
| pz1低剂量组 | 3 | 0.014 | 47.817±1.5382） | 45.565±4.497 | 3.923±0.2621） | 15.860±4.3741） |
| pz1中剂量组 | 3 | 0.025 | 48.591±1.9162） | 51.985±3.3242） | 4.182±0.3201） | 17.411±1.7322） |
| pz1高剂量组 | 3 | 0.033 | 50.698±1.7822） | 55.809±1.6692） | 4.233±0.1782） | 18.146±5.0171） |
| pz2低剂量组 | 3 | 0.015 | 40.610±2.6321） | 34.888±1.640 | 3.319±0.248 | 11.196±5.936 |
| pz2中剂量组 | 3 | 0.033 | 42.070±2.0382） | 37.036±0.7891） | 3.743±0.029 | 14.307±3.918 |
| pz2高剂量组 | 3 | 0.040 | 47.281±1.3402） | 44.784±9.755 | 4.445±0.881 | 19.295±5.5761） |
| pz3低剂量组 | 3 | 0.016 | 38.038±1.4691） | 40.646±2.1731） | 2.652±0.549 | 11.865±2.475 |
| pz3中剂量组 | 3 | 0.038 | 39.073±0.9062） | 41.421±0.4492） | 3.476±0.456 | 11.969±8.351 |
| pz3高剂量组 | 3 | 0.047 | 40.987±1.0472） | 41.683±4.839 | 4.556±0.0101） | 26.011±5.6342） |
| pz4低剂量组 | 3 | 0.024 | 33.241±0.905 | 40.260±12.081 | 3.421±0.331 | 7.995±2.699 |
| pz4中剂量组 | 3 | 0.036 | 38.126±1.6171） | 40.346±1.8971） | 3.667±0.250 | 20.966±4.5591） |
| pz4高剂量组 | 3 | 0.041 | 40.746±2.0352） | 45.600±1.1932） | 4.625±0.1272） | 25.033±4.5922） |
| pz5低剂量组 | 3 | 0.024 | 33.586±1.492 | 34.318±2.7281） | 3.176±0.078 | 8.795±6.581 |
| pz5中剂量组 | 3 | 0.036 | 34.630±1.765 | 36.530±5.060 | 3.697±0.1901） | 12.729±10.533 |
| pz5高剂量组 | 3 | 0.043 | 34.754±2.716 | 38.055±2.2042） | 3.818±0.0591） | 25.477±12.5542） |
| pz6低剂量组 | 3 | 0.025 | 31.909±2.603 | 36.293±2.318 | 3.368±0.916 | 5.747±1.675 |
| pz6中剂量组 | 3 | 0.039 | 32.843±1.808 | 36.412±0.304 | 3.587±0.439 | 10.389±6.707 |
| pz6高剂量组 | 3 | 0.046 | 33.058±3.112 | 37.078±0.2031） | 4.579±2.169 | 13.543±3.8766 |
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