Article(id=1322912263203598627, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322912162913596032, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.01.033, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793336462068, onlineDateStr=2026-10-30, pubDate=1736438400000, pubDateStr=2025-01-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793336462068, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793336462068, creator=13701087609, updateTime=1793336462068, updator=13701087609, issue=Issue{id=1322912162913596032, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='1', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1736438400000', pubDateStr='2025-01-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793336438157, creator='13701087609', updateTime=1793340633627, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929760048906989, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322912162913596032, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929760048906990, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322912162913596032, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=191, endPage=195, ext={EN=ArticleExt(id=1322912263413313828, articleId=1322912263203598627, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Compositional Differences and Anti-Tumor Effect Mechanism of Nobiletin, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
With the continuous development of naturalmedicinal chemistry，natural products with good activity in plants are gradually attracting attention，butmost of them are restricted from further development due to their low content，etc. How to increase the content and ensure the quality of natural sources has become an urgent issue. Nobiletin is a natural polymethoxyflavonoid，mainly exists in Citrus aurantium，family Rutaceae，with awide range of biologicalactivities such as anti-tumor，anti-inflammatory，protection and improvement of the nervous system，etc. Ithas gradually become a hotspot for the development of new anti-tumor drugs for its broad spectrum anti-cancer effects againsta variety of cancer cells through multiple pathways. Through reviewing the literature，summarizing the research on nobiletin at home and abroad in recent years，and outlining the current status of research，this paper summed up the factors influencing the content of nobiletin and its antitumormechanism of action from different sources，origins，storage and concoction，and clarified the quality control methods of natural sources，aiming to provide new ideas for further research and development of nobiletin and new antitumor drugs.
, authors=Li XIN, Wenhui GONG, Jingying GUO, Yuqing ZHENG, Beibei ZHAO, Shihao YAN, Wen ZHANG, Jinlian ZHANG, authorsList=Li XIN, Wenhui GONG, Jingying GUO, Yuqing ZHENG, Beibei ZHAO, Shihao YAN, Wen ZHANG, Jinlian ZHANG, authorCompany=null, correspAuthors=Jinlian ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322912265535631655, articleId=1322912263203598627, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=天然产物川陈皮素的成分差异及抗肿瘤作用机制研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
随着天然药物化学不断地发展，植物中具有良好活性的天然产物逐渐受到人们的关注，但大多由于含量较低等限制了进一步开发，如何提高含量，确保天然来源的质量，成为了迫在眉睫的问题。川陈皮素是一种天然的多甲氧基黄酮类成分，主要存在于芸香科柑橘属植物中，具有抗肿瘤、抗炎、保护及改善神经系统等广泛的生物活性，因其可通过多途径抗多种癌细胞的广谱抗癌作用，逐渐成为抗肿瘤新药开发的热点。通过查阅文献，总结近年来国内外对于川陈皮素的研究，概括研究现状，从不同来源、产地、贮藏、炮制等方面对川陈皮素含量的影响因素及其抗肿瘤作用机制进行总结归纳，明确天然来源的质量控制方法，旨在为川陈皮素的进一步研究开发及抗肿瘤新药研发提供参考。
, authors=辛力, 龚文慧, 郭静英, 郑郁清, 赵蓓蓓, 严世豪, 张文, 张金莲, authorsList=辛力, 龚文慧, 郭静英, 郑郁清, 赵蓓蓓, 严世豪, 张文, 张金莲, authorCompany=null, correspAuthors=张金莲, authorNote=
辛力（2000-），男，江西宜春人，硕士在读，研究方向：中药炮制。
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辛力（2000-），男，江西宜春人，硕士在读，研究方向：中药炮制。
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辛力（2000-），男，江西宜春人，硕士在读，研究方向：中药炮制。
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432：137227., articleTitle=Metabolism and release of characteristic components and their enzymatic mechanisms in Pericarpium Citri Reticulatae co-fermentation, refAbstract=null)], funds=[Fund(id=1322912615172813122, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, awardId=82060724; 81560651, language=CN, fundingSource=国家自然科学基金项目(82060724; 81560651), fundOrder=null, country=null), Fund(id=1322912615248310596, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, awardId=2021B01; 2021B02, language=CN, fundingSource=江西省中医药标准委员会第二批标准化项目(2021B01; 2021B02), fundOrder=null, country=null), Fund(id=1322912615319613765, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, awardId=202310412027; S202310412061; 202210412288, language=CN, fundingSource=江西中医药大学大学生创新创业训练计划项目(202310412027; S202310412061; 202210412288), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322912609497919746, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, xref=null, ext=[AuthorCompanyExt(id=1322912609506308355, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, companyId=1322912609497919746, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi, China), AuthorCompanyExt(id=1322912609514696964, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, companyId=1322912609497919746, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=江西中医药大学，江西 南昌 330004)])], figs=[ArticleFig(id=1322912614103265590, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=EN, label=null, caption=null, figureFileSmall=awqIQCSn55iXF2x7PD63Tw==, figureFileBig=3qSiZxML9gpsc0u1bYZe+Q==, tableContent=null), ArticleFig(id=1322912614178763063, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=CN, label=图1, caption=
川陈皮素分子结构, figureFileSmall=awqIQCSn55iXF2x7PD63Tw==, figureFileBig=3qSiZxML9gpsc0u1bYZe+Q==, tableContent=null), ArticleFig(id=1322912614279426360, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 药材 | 种名 | 含量 | 参考文献 |
|---|
| 枳壳 | 香橙 | 0.058～0.090 | [10] |
| 臭橙 | 0.041～0.081 | [10] |
| 枳橙 | 0.016～0.211 | [10] |
| 代代花 | 0.051～0.054 | [10] |
| 陈皮 | 茶枝柑 | 0.048～0.420 | [7] |
| 温州蜜柑 | 0.031～0.769 | [7] |
| 大红袍 | 0.301～1.048 | [7] |
| 福橘 | 0.026～0.895 | [7] |
| 新会柑仔胎 | 新会柑 | 0.600 | [8] |
), ArticleFig(id=1322912614363312441, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=CN, label=表1, caption=
不同植物来源川陈皮素含量
, figureFileSmall=null, figureFileBig=null, tableContent=
| 药材 | 种名 | 含量 | 参考文献 |
|---|
| 枳壳 | 香橙 | 0.058～0.090 | [10] |
| 臭橙 | 0.041～0.081 | [10] |
| 枳橙 | 0.016～0.211 | [10] |
| 代代花 | 0.051～0.054 | [10] |
| 陈皮 | 茶枝柑 | 0.048～0.420 | [7] |
| 温州蜜柑 | 0.031～0.769 | [7] |
| 大红袍 | 0.301～1.048 | [7] |
| 福橘 | 0.026～0.895 | [7] |
| 新会柑仔胎 | 新会柑 | 0.600 | [8] |
), ArticleFig(id=1322912614443004218, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 药材 | 品种 | 含量 | 参考文献 |
|---|
| 广东新会 | 茶枝柑 | 0.102～1.401 | [11] |
| 江西南昌 | 九月黄 | 0.033～0.034 | [12] |
| 蜜柑 | 0.769 | [9] |
| 湖南常德石门 | 九月黄 | 0.027～0.191 | [13] |
| 江西赣州 | 红橘 | 0.031～0.055 | [12] |
| 四川安岳 | 红橘 | 0.630～0.968 | [12] |
| 浙江温州/金华 | 蜜柑/温州蜜柑 | 0.034～0.080 | [7，12] |
| 广西桂林 | 温州蜜柑 | 0.040 | [13] |
| 江西新干 | 大红袍 | 0.394～1.048 | [7，12] |
| 重庆 | 大红袍 | 0.721～0.968 | [7] |
| 福建 | 福橘 | 0.026～0.895 | [7] |
), ArticleFig(id=1322912614526890299, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=CN, label=表2, caption=
不同产地陈皮中川陈皮素含量
, figureFileSmall=null, figureFileBig=null, tableContent=
| 药材 | 品种 | 含量 | 参考文献 |
|---|
| 广东新会 | 茶枝柑 | 0.102～1.401 | [11] |
| 江西南昌 | 九月黄 | 0.033～0.034 | [12] |
| 蜜柑 | 0.769 | [9] |
| 湖南常德石门 | 九月黄 | 0.027～0.191 | [13] |
| 江西赣州 | 红橘 | 0.031～0.055 | [12] |
| 四川安岳 | 红橘 | 0.630～0.968 | [12] |
| 浙江温州/金华 | 蜜柑/温州蜜柑 | 0.034～0.080 | [7，12] |
| 广西桂林 | 温州蜜柑 | 0.040 | [13] |
| 江西新干 | 大红袍 | 0.394～1.048 | [7，12] |
| 重庆 | 大红袍 | 0.721～0.968 | [7] |
| 福建 | 福橘 | 0.026～0.895 | [7] |
), ArticleFig(id=1322912614631747900, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 品种 | 含量 |
|---|
| 陈皮生品 | 6.810 |
| 四制陈皮 | 6.771 |
| 蒸陈皮 | 7.399 |
| 炒陈皮 | 6.795 |
| 麸炒陈皮 | 6.246 |
| 土炒陈皮 | 6.426 |
| 蜜陈皮 | 5.797 |
| 盐陈皮 | 6.208 |
| 醋陈皮 | 6.909 |
| 黑曲霉发酵陈皮 | 10.500 |
| 枳壳生品 | 0.530 |
| 药典法枳壳 | 0.430 |
| 樟帮生品枳壳 | 0.850 |
| 樟帮法枳壳 | 0.320 |
| 建昌帮法枳壳 | 0.260 |
), ArticleFig(id=1322912614698856765, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=CN, label=表3, caption=
陈皮及枳壳不同炮制品中川陈皮素含量
, figureFileSmall=null, figureFileBig=null, tableContent=
| 品种 | 含量 |
|---|
| 陈皮生品 | 6.810 |
| 四制陈皮 | 6.771 |
| 蒸陈皮 | 7.399 |
| 炒陈皮 | 6.795 |
| 麸炒陈皮 | 6.246 |
| 土炒陈皮 | 6.426 |
| 蜜陈皮 | 5.797 |
| 盐陈皮 | 6.208 |
| 醋陈皮 | 6.909 |
| 黑曲霉发酵陈皮 | 10.500 |
| 枳壳生品 | 0.530 |
| 药典法枳壳 | 0.430 |
| 樟帮生品枳壳 | 0.850 |
| 樟帮法枳壳 | 0.320 |
| 建昌帮法枳壳 | 0.260 |
), ArticleFig(id=1322912614816297278, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 贮藏年限/（年） | 含量/（mg/g） |
|---|
| 1 | 5.264 |
| 2 | 6.511 |
| 3 | 7.634 |
), ArticleFig(id=1322912614879211839, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=CN, label=表4, caption=
不同贮藏年限陈皮中川陈皮素含量
, figureFileSmall=null, figureFileBig=null, tableContent=
| 贮藏年限/（年） | 含量/（mg/g） |
|---|
| 1 | 5.264 |
| 2 | 6.511 |
| 3 | 7.634 |
), ArticleFig(id=1322912614950515008, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 抗肿瘤机制 | 肿瘤细胞类型 | 参考文献 |
|---|
| 抑制肿瘤细胞的生长和增殖 | 肺癌细胞（A549）、结肠癌细胞（HT29、HCT116） | [36] |
| 舌鳞癌细胞（Cal-27） | [37] |
| 胃癌细胞（SGC-7901） | [38] |
| 肝癌细胞 | [39] |
| 诱导肿瘤细胞凋亡 | 非小细胞肺癌A549细胞 | [40] |
| 卵巢癌SKOV3/税细胞 | [41] |
| 人卵巢癌细胞（HO8910） | [42] |
| 胃癌SUN-16细胞 | [43] |
| 宫颈癌HeLa细胞、肝癌HepG2细胞 | [44] |
| 抑制肿瘤细胞的迁移和侵袭 | 非小细胞肺癌NCI-H460细胞 | [45] |
| 舌鳞癌细胞Cal-27 | [46] |
| 骨肉瘤U2OS和HOS细胞 | [47] |
| 纤维肉瘤HT-1080细胞 | [48] |
| 调节癌细胞周期和蛋白表达 | 乳腺癌MCF7和MDA—MB-468细胞 | [49-51] |
| 肝癌HepG2细胞 | [52-53] |
| 结肠癌细胞 | [54] |
), ArticleFig(id=1322912615021818177, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912263203598627, language=CN, label=表5, caption=
川陈皮素抗肿瘤机制
, figureFileSmall=null, figureFileBig=null, tableContent=
| 抗肿瘤机制 | 肿瘤细胞类型 | 参考文献 |
|---|
| 抑制肿瘤细胞的生长和增殖 | 肺癌细胞（A549）、结肠癌细胞（HT29、HCT116） | [36] |
| 舌鳞癌细胞（Cal-27） | [37] |
| 胃癌细胞（SGC-7901） | [38] |
| 肝癌细胞 | [39] |
| 诱导肿瘤细胞凋亡 | 非小细胞肺癌A549细胞 | [40] |
| 卵巢癌SKOV3/税细胞 | [41] |
| 人卵巢癌细胞（HO8910） | [42] |
| 胃癌SUN-16细胞 | [43] |
| 宫颈癌HeLa细胞、肝癌HepG2细胞 | [44] |
| 抑制肿瘤细胞的迁移和侵袭 | 非小细胞肺癌NCI-H460细胞 | [45] |
| 舌鳞癌细胞Cal-27 | [46] |
| 骨肉瘤U2OS和HOS细胞 | [47] |
| 纤维肉瘤HT-1080细胞 | [48] |
| 调节癌细胞周期和蛋白表达 | 乳腺癌MCF7和MDA—MB-468细胞 | [49-51] |
| 肝癌HepG2细胞 | [52-53] |
| 结肠癌细胞 | [54] |
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