中华中医药学刊

卵磷脂片联合麝香保心丸对高血脂合并颈动脉粥样硬化的影响

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张敏 , 吴海浪 , 熊语嫣

中华中医药学刊 | 省级项目平台 2026,44(7): 219-221

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中华中医药学刊 |省级项目平台 2026 , 44 (7) : 219 -221

卵磷脂片联合麝香保心丸对高血脂合并颈动脉粥样硬化的影响

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张敏, 吴海浪, 熊语嫣

作者信息

华中科技大学同济医学院附属协和医院，湖北　武汉　430022

作者简介:

张敏（1982-），男，湖南湘潭人，副主任医师，博士，研究方向：炎症在病理性心脏重构中的作用。

Effect of Lecithin Tablets Combined with Shexiang Baoxin Pills (麝香保心丸) in Patients with Carotid Atherosclerosis

Min ZHANG, Hailang WU, Yuyan XIONG

Affiliations

Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, Hubei, China

出版时间: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.038

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摘要

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目的

探讨卵磷脂片联合麝香保心丸对高血脂合并颈动脉粥样硬化患者血脂代谢、颈动脉影像学及肝功能的影响。

方法

选取2023年1月—2023年12月医院收治的108例高血脂合并颈动脉粥样硬化患者，按随机数字表法分为两组。对照组采用普伐他汀常规治疗，观察组在此基础上联合卵磷脂片与麝香保心丸进行治疗。对比两组患者的血脂水平、肝功能及颈动脉影像学变化。

结果

观察组的血脂水平均明显优于对照组，差异有统计学意义（P<0.05）。干预后观察组斑块总数、软斑块总数低于对照组，差异有统计学意义（P<0.05）。干预后观察组肝功能指标优于对照组，差异有统计学意义（P<0.05）。

结论

卵磷脂片联合麝香保心丸可显著改善高血脂合并颈动脉粥样硬化患者的血脂水平、颈动脉病变及肝功能，且药物不良反应较少，值得推广。

关键词

卵磷脂片 / 高血脂 / 麝香保心丸 / 颈动脉粥样硬化 / 颈动脉影像学 / 肝功能

Abstract

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Objective

To investigate the effects of lecithin tablets combined with Shexiang Baoxin Pills (麝香保心丸) on lipid metabolism, carotid imaging and liver function in the patients with hyperlipemia complicated with carotid atherosclerosis.

Methods

A total of 108 patients with hyperlipidemia combined with carotid atherosclerosis admitted to the hospital from January 2023 to December 2023 were selected and divided into two groups according to random number table method. The control group was treated with pravastatin, and the observation group was treated with lecithin tablets and Shexiang Baoxin Pills. The changes of blood lipid levels, liver function and carotid artery imaging were compared between the two groups.

Results

The blood lipid levels of the observation group were significantly better than those of the control group with significant differences (P<0.05). After the intervention, the total number of plaques and soft plaques in the observation group was lower than that in the control group, and the difference was significant (P<0.05). After the intervention, the liver function indicators of the observation group were better than those of the control group with a significant difference (P<0.05).

Conclusion

Lecithin tablets combined with Shexiang Baoxin Pills can significantly improve the blood lipid levels, carotid artery disease and liver function in the patients with hyperlipidemia complicated with carotid atherosclerosis with fewer adverse drug reactions, which is worthy of popularizing.

Key words

lecithin tablets / Shexiang Baoxin Pills (麝香保心丸) / high lipidemia / carotid atherosclerosis / carotid artery imaging / liver function

引用本文

张敏, 吴海浪, 熊语嫣. 卵磷脂片联合麝香保心丸对高血脂合并颈动脉粥样硬化的影响. 中华中医药学刊, 2026 , 44 (7) : 219 -221 . DOI: 10.13193/j.issn.1673-7717.2026.07.038

Min ZHANG, Hailang WU, Yuyan XIONG. Effect of Lecithin Tablets Combined with Shexiang Baoxin Pills (麝香保心丸) in Patients with Carotid Atherosclerosis[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 219 -221 . DOI: 10.13193/j.issn.1673-7717.2026.07.038

基金

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上海市医学专科重点课题计划项目(ZK2019C08)

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排序方式：

[1]

MIURA Y, SUZUKI H. Hypertriglyceridemia and atherosclerotic carotid artery stenosis[J]. Int J Mol Sci, 2022, 23(24): 16224.

[2]

ALLOUBANI A, NIMER R, SAMARA R. Relationship between hyperlipidemia, cardiovascular disease and stroke: a systematic review[J]. Curr Cardiol Rev, 2021, 17(6): e051121189015.

[3]

KWON R J, CHO Y H, PARK E J, et al. Effect of combination therapy with ezetimibe and statins versus statin monotherapy on carotid intima-media thickness: a systematic review and meta-analysis of randomized controlled trials[J]. Medicina, 2023, 59(11): 1980.

[4]

RIVA A, RONCHI M, PETRANGOLINI G, et al. Improved oral absorption of quercetin from quercetin phytosome?, a new delivery system based on food grade lecithin[J]. Eur J Drug Metab Pharmacokinet, 2019, 44(2): 169-177.

[5]

席爱萍, 李欣, 刘可心, 等. 围绝经期女性baPWV、ABI及血清Hcy、Lp(a)与心血管事件的相关性分析[J]. 中国实验诊断学, 2022, 26(6): 799-803.

[6]

张彩霞, 马媛媛, 崔二平, 等. 基于高分辨MRI的颈动脉粥样硬化患者发生缺血性脑卒中风险预警模型的构建[J]. 中国医疗设备, 2022, 37(11): 151-155.

[7]

CAHALANE R, AKYILDIZ A, KAVOUSI M, et al. Cross-sectional validation of a novel computed tomography-based carotid mean calcium density measurement[J]. J Am Heart Assoc, 2023, 12(13): e027866.

[8]

MICHIKURA M, OGURA M, HORI M, et al. Association between A-chilles tendon softness and atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia[J]. J Atheroscler Thromb, 2022, 29(11): 1603-1612.

[9]

王焕, 崔凯, 尤冠巧, 等. 2型糖尿病肾病患者发生颈动脉粥样硬化危险因素分析[J]. 新乡医学院学报, 2021, 38(6): 531-533, 539.

[10]

PERETTI N, VIMONT A, MAS E, et al. Factors predicting statin initiation during childhood in familial hypercholesterolemia: importance of genetic diagnosis[J]. J Pediatr, 2023, 253: 18-24.

[11]

NING S L, WANG C C, ZHAO L, et al. Lecithin/chitosan nanoparticle drug carrier improves anti-tumor efficacy of Monascus pigment rubropunctatin[J]. Int J Biol Macromol, 2023, 242: 125058.

[12]

AMÉZQUETA S, FERNÁNDEZ-PUMAREGA A, FARRÉS, et al. Lecithin liposomes and microemulsions as new chromatographic phases[J]. J Chromatogr A, 2020, 1611: 460596.

[13]

YANG H, GAO Y R, SUN S Y, et al. Formation, characterization, and antigenicity of lecithin-β-conglycinin complexes[J]. Food Chem, 2023, 407: 135178.

[14]

WANG M C, PHILLIPS T D. Lecithin-amended montmorillonite clays enhance the antibacterial effect of barrier creams[J]. Colloids Surf B Biointerfaces, 2023, 229: 113450.

[15]

GU R, WANG H, WANG C L, et al. Gene variants and clinical characteristics of children with sitosterolemia[J]. Lipds Health Dis, 2024, 23(1): 83.

[16]

刘华, 曹菲菲. 卵磷脂辅助治疗青少年脂肪肝的效果及对外周血瘦素、抵抗素水平影响[J]. 糖尿病天地, 2023(1): 113-114.

[17]

LU S X, WU T W, CHOU C L, et al. Combined effects of hypertension, hyperlipidemia, and diabetes mellitus on the presence and severity of carotid atherosclerosis in community-dwelling elders: a community-based study[J]. J Chin Med Assoc, 2023, 86(2): 220-226.

[18]

尹承华, 陈壮, 刘英, 等. 麝香保心丸对慢性心力衰竭患者的生物学标志物影响[J]. 中医临床研究, 2021, 13(20): 47-50.

[19]

王竞, 邢玉, 孙联平, 等. 麝香保心丸联合普罗布考对老年冠心病合并糖尿病患者血脂代谢及血管内皮功能的影响[J]. 临床和实验医学杂志, 2024, 23(15): 1597-1602.

[20]

王智聪, 谢彬, 袁星, 等. 基于网络药理学探讨麝香保心丸治疗动脉粥样硬化作用机制[J]. 药学实践与服务, 2023, 41(5): 296-301.

[21]

赵倩, 任艳琴, 杨晶, 等. 麝香保心丸对冠心病病人PCI术后心功能及生活质量的影响[J]. 中西医结合心脑血管病杂志, 2023, 21(7): 1271-1274.

[22]

魏娜, 李思源, 高苑, 等. 麝香保心丸对缺氧复氧心肌细胞的保护作用及凋亡的影响[J]. 天津医药, 2023, 51(5): 460-463.

[23]

高健, 李军. 麝香保心丸治疗不宜进行血运重建的气滞血瘀型冠心病的随机双盲对照研究[J]. 中西医结合心脑血管病杂志, 2023, 21(1): 15-20.

[24]

周英. 麝香保心丸对碘克沙醇诱导的对比剂急性肾损伤高危人群的作用研究[D]. 衡阳: 南华大学, 2022.

[25]

王卫平, 侯雨蒙, 陈旸, 等. 麝香保心丸联合缬沙坦氨氯地平片治疗冠心病心绞痛临床疗效及对患者血清C反应蛋白、胱抑素C的影响[J]. 河北中医, 2023, 45(5): 756-759, 764.

[26]

魏芹, 赵晓鹏, 陈树泉. 麝香保心丸对糖尿病性心脏病心功能及血清IL-6、TNF-α、TGF-β1、Hcy的影响[J]. 中华中医药学刊, 2023, 41(8): 231-234.

[27]

汪春华. 麝香保心丸联合美托洛尔缓释片治疗急性心肌梗死临床观察[J]. 实用中医药杂志, 2024, 40(3): 538-540.

2026年第44卷第7期

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doi: 10.13193/j.issn.1673-7717.2026.07.038

首发时间：2026-10-20
出版时间：2026-07-10

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基金

上海市医学专科重点课题计划项目(ZK2019C08)

作者信息

华中科技大学同济医学院附属协和医院，湖北　武汉　430022

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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