Article(id=1319291689680876403, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.07.043, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473250073, onlineDateStr=2026-10-20, pubDate=1783612800000, pubDateStr=2026-07-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473250073, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473250073, creator=13701087609, updateTime=1792473250073, updator=13701087609, issue=Issue{id=1319291472856338924, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='7', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1783612800000', pubDateStr='2026-07-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473198379, creator='13701087609', updateTime=1792473406504, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292345858773669, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292345858773670, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=238, endPage=241, ext={EN=ArticleExt(id=1319291689898980212, articleId=1319291689680876403, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Therapeutic Efficacy of Combining Modified Sijunzi Decoction (四君子汤化裁方) with Budesonide in Treatment of Children with Phlegm and Stasis Accumulating in Lung Type of Occlusive Bronchiolitis Obliterans, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the efficacy of Modified Sijunzi Decoction (四君子汤化裁方) combined with budesonide in the treatment of children with phlegm and stasis accumulating in lung type of occlusive fine bronchitis.
Methods One hundred and sixteen children with occlusive fine bronchiolitis identified by traditional Chinese medicine as phlegm and stasis accumulating in lung type admitted from April 2021 to April 2024 were selected and randomly divided into two groups by using the envelope method. The control group was given budesonide treatment and the observation group was given Modified Sijunzi Decoction on its basis. The differences in TCM symptom scores between the two groups were assessed, the time of improvement of symptoms and signs as well as the time of oxygen intake, hospitalization and adverse reactions were recorded and the immune function, inflammatory factors [interleukin-4 (IL-4), interleukin-12 (IL-12), interleukin-17 (IL-17), tumor necrosis factor-α(TNF-α), interferon-γ(IFN-γ)] and lung function [percentage of forced expiratory volume in one second (FEV1%), maximum mid-expiratory flow (MMEF), tidal volume (VT), inspiratory time/expiratory time (Ti/Te)] were compared.
Results Comparing with those before treatment, there was no difference in TCM symptom scores or immune function between the two groups (P>0.05). Comparing with those before and after treatment, the TCM symptom scores and the CD8+ level of the two groups were lower, and the results of the observation group were lower than those of the control group (P<0.05). The levels of CD4+ and CD3+ of the two groups of the observation group were higher, and the results of the observation group were higher than those of the control group (P<0.05). The time for fever reduction and cough suppression, oxygen intake time, shortness of breath and disappearance of pulmonary rales and hospitalisation time of the observation group were shorter than those of the control group with differences (P<0.05). Comparing with those before treatment, there was no difference in inflammatory factors or lung function between the two groups (P>0.05). Comparing with those before, after treatment, the levels of IL-4, IL-12, IL-17 and TNF-α were lower in both groups, and the levels were lower in the observation group than those in the control group (P<0.05). The IFN-γ level and lung function indexes were higher in both groups, and the results were higher in the observation group than those in the control group (P<0.05).
Conclusion Modified Sijunzi Decoction combined with budesonide in the treatment of children with phlegm and stasis accumulating in lung type of occlusive fine bronchitis improves the lung function, regulates the inflammatory factors and shortens the course of the disease.
, authors=Yun WU, Liping ZHANG, Mengke WEI, Jiaqi GUAN, Haibo PU, authorsList=Yun WU, Liping ZHANG, Mengke WEI, Jiaqi GUAN, Haibo PU, authorCompany=null, correspAuthors=Haibo PU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291690234524534, articleId=1319291689680876403, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=四君子汤化裁方联合布地奈德治疗痰瘀蕴肺型闭塞性细支气管炎疗效观察, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 观察四君子汤化裁方联合布地奈德治疗痰瘀蕴肺型闭塞性细支气管炎患儿的疗效。
方法 选取2021年4月—2024年4月收治的中医辨证为痰瘀蕴肺型的闭塞性细支气管炎患儿116例，采用信封法随机分为两组。对照组给予布地奈德治疗，观察组在其基础上给予四君子汤化裁方治疗。评估两组中医症状评分差异，记录两组症状、体征改善时间及吸氧、住院时间及不良反应，检测两组免疫功能、炎症因子[白细胞介素-4（interleukin-4，IL-4）、白细胞介素-12（interleukin-12，IL-12）、白细胞介素-17（interleukin-17，IL-17）、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）、干扰素-γ（interferon-γ，IFN-γ）]、肺功能[1秒用力呼气容积占预计值百分比（percentage of forced expiratory volume in one second，FEV1%）、最大呼气中段流量（maximum mid-expiratory flow，MMEF）、潮气量（tidal volume，VT）、吸气呼气时间比（inhalation to exhalation time ratio，Ti/Te）]的变化。
结果 治疗前比较，两组中医症状评分、免疫功能差异均无统计学意义（P>0.05）。治疗前后比较，两组中医症状评分及CD8+均降低，且观察组较对照组更低（P<0.05）；两组CD4+及观察组CD3+均升高，且观察组较对照组更高（P<0.05）。观察组退热和止咳时间、吸氧时间、气促和肺啰音消失时间、住院时间均短于对照组，差异有统计学意义（P<0.05）。治疗前比较，两组炎症因子、肺功能差异均无统计学意义（P>0.05）。治疗前后比较，两组IL-4、IL-12、IL-17、TNF-α均降低，且观察组较对照组更低（P<0.05）；两组IFN-γ及肺功能指标均升高，且观察组较对照组更高（P<0.05）。
结论 四君子汤化裁方联合布地奈德治疗痰瘀蕴肺型闭塞性细支气管炎可改善肺功能，调节炎症因子，缩短病程。
, authors=武赟, 张丽平, 卫梦珂, 关家琪, 蒲海波, authorsList=武赟, 张丽平, 卫梦珂, 关家琪, 蒲海波, authorCompany=null, correspAuthors=蒲海波, authorNote=
武赟（1989-），男，河南南阳人，主治医师，学士，研究方向：中西医结合治疗呼吸系统及消化系统疾病。
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武赟（1989-），男，河南南阳人，主治医师，学士，研究方向：中西医结合治疗呼吸系统及消化系统疾病。
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