中华中医药学刊

瓜蒌薤白半夏汤制备工艺、物质基础、药理作用的研究概述

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边汝涛 ¹ , 张理 ¹ , 徐学功 ¹^,²

中华中医药学刊 | 国家项目点击 2026,44(7): 86-91

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中华中医药学刊 |国家项目点击 2026 , 44 (7) : 86 -91

瓜蒌薤白半夏汤制备工艺、物质基础、药理作用的研究概述

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边汝涛¹, 张理¹, 徐学功¹^,²

作者信息

^1.郑州市中医院，河南　郑州　450000

^2.河南中医药大学附属郑州中医院，河南　郑州　450000

通讯作者:

徐学功（1969-），男，河南信阳人，主任医师，博士研究生导师，研究方向：中医药防治心血管疾病。E-mail：xuxg1115@126.com。

作者简介:

边汝涛（1990-），男，河南新乡人，医师，博士在读，研究方向：中医药防治心血管疾病。

Overview of Preparation Process, Material Basis and Pharmacological Effects of Gualou Xiebai Banxia Decoction (瓜蒌薤白半夏汤)

Rutao BIAN¹, Li ZHANG¹, Xuegong XU¹^,²

Affiliations

^1.Zhengzhou Traditional Chinese Medicine Hospital, Zhengzhou 450000, Henan, China

^2.Zhengzhou Traditional Chinese Medicine Hospital Affiliated to Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China

出版时间: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.017

文章导航

摘要

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瓜蒌薤白半夏汤（Gualou Xiebai Banxia Decoction，GXBD）源自《金匮要略》，由瓜蒌、薤白、半夏辅以酒组成，是治疗胸痹痰浊闭阻证的代表性方药。近年来在临床广泛应用，现将相关研究进行归纳总结。在制备工艺方面，现代技术提升了成分提取效率与质量控制水平，酒煎法较水煎法更利于活性成分溶出，并降低潜在毒性成分。物质基础研究表明方中含有黑麦草内酯、金圣草黄素、芦丁等8种关键成分及95种酒煎特异性成分，且酒煎协同增效作用显著。基于“关键成分-潜在靶点”治疗心血管疾病，其机制包括平衡胆固醇逆向转运关键蛋白表达调控脂代谢，改善血管内皮功能及一氧化氮/环磷酸鸟苷信号级联反应，调节巨噬细胞极化表型发挥抗炎作用，通过干预成纤维细胞转分化抗心肌纤维化，通过改善线粒体功能调节能量代谢等。系统梳理方剂在制备工艺、物质基础及药理作用领域的研究进展，以期为后续研究提供方向性参考，也为制剂标准的建立和开发提供参考。

关键词

瓜蒌薤白半夏汤 / 制备工艺 / 物质基础 / 药理作用 / 概述

Abstract

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Gualou Xiebai Banxia Decoction (瓜蒌薤白半夏汤, GXBD), derived from Jingui Yaolue, consists of Gualou (Trichosanthis Fructus), Xiebai (Allii Macrostemonis Bulbus) and Banxia (Pinelliae Rhizoma), supplemented with wine, and is a representative formula for the treatment of thoracic paralysis with Bi sydnrome of phlegm-turbid obstruction syndrome. In recent years, it has been widely used in clinical practice, and the related research is summarized. In terms of preparation process, modern technology has improved the extraction efficiency and quality control level of components. Compared with water decoction, wine decoction is more conducive to the dissolution of active components and reduces the potential toxic components. The study of material basis showed that this prescription contained 8 key components such as ryegrass lactone, chrysoeriol, rutin and 95 specific components of wine decoction, and the synergistic effect of wine decoction was significant. This prescription is based on “key components-potential targets” for the treatment of cardiovascular diseases. Its mechanisms include balancing the expression of key proteins in reverse cholesterol transport to regulate lipid metabolism, improving vascular endothelial function and nitric oxide/cyclic guanosine monophosphate signaling cascade, regulating macrophage polarization phenotype to exert anti-inflammatory effects, anti-myocardial fibrosis by intervening fibroblast transdifferentiation, and regulating energy metabolism by improving mitochondrial function. This paper systematically reviewed the research progress of this prescription in the fields of preparation technology, material basis and pharmacological action, in order to provide directional reference for follow-up research, and also provide reference for the establishment and development of preparation standards.

Key words

Gualou Xiebai Banxia Decoction (瓜蒌薤白半夏汤) / preparation process / material basis / pharmacological effects / overview

引用本文

边汝涛, 张理, 徐学功. 瓜蒌薤白半夏汤制备工艺、物质基础、药理作用的研究概述. 中华中医药学刊, 2026 , 44 (7) : 86 -91 . DOI: 10.13193/j.issn.1673-7717.2026.07.017

Rutao BIAN, Li ZHANG, Xuegong XU. Overview of Preparation Process, Material Basis and Pharmacological Effects of Gualou Xiebai Banxia Decoction (瓜蒌薤白半夏汤)[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 86 -91 . DOI: 10.13193/j.issn.1673-7717.2026.07.017

基金

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国家中医药管理局张仲景传承创新专项(GZY-KJS-2022-042-1)
河南省科技攻关项目(262102311236)
河南省中医药专项(2024ZY1026)

参考文献

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参考文献引证文献

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2026年第44卷第7期

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doi: 10.13193/j.issn.1673-7717.2026.07.017

首发时间：2026-10-20
出版时间：2026-07-10

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基金

国家中医药管理局张仲景传承创新专项(GZY-KJS-2022-042-1)

河南省科技攻关项目(262102311236)

河南省中医药专项(2024ZY1026)

作者信息

^1.郑州市中医院，河南　郑州　450000

^2.河南中医药大学附属郑州中医院，河南　郑州　450000

通讯作者:

徐学功（1969-），男，河南信阳人，主任医师，博士研究生导师，研究方向：中医药防治心血管疾病。E-mail：xuxg1115@126.com。

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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.07.017

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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