Article(id=1319291653534364205, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.07.037, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473241456, onlineDateStr=2026-10-20, pubDate=1783612800000, pubDateStr=2026-07-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473241456, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473241456, creator=13701087609, updateTime=1792473241456, updator=13701087609, issue=Issue{id=1319291472856338924, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='7', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1783612800000', pubDateStr='2026-07-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473198379, creator='13701087609', updateTime=1792473406504, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292345858773669, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292345858773670, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=214, endPage=218, ext={EN=ArticleExt(id=1319291653760856622, articleId=1319291653534364205, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Modified Guizhi Fuling Decoction (桂枝茯苓汤加味) on Postoperative Radiotherapy and Chemotherapy of Cervical Cancer and T Lymphocyte, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the effect of Modified Guizhi Fuling Decoction (桂枝茯苓汤加味) on the synergistic effect of radiotherapy and chemotherapy after cervical cancer surgery and the level of T lymphocyte subsets.
Methods The data of 106 patients with cervical cancer admitted to the hospital from January 2017 to May 2020 was retrospectively analyzed. All patients underwent radical cervical cancer resection and were divided into the study group (54 cases) and the control group (52 cases) according to the postoperative treatment method. Both groups were followed up for 3 years. TCM syndrome scores, tumor markers, T lymphocyte subsets, immunoglobulin (Ig), complement, adverse reactions and anti-tumor effect were compared between the two groups.
Results The TCM syndrome scores of the primary and secondary diseases were lower in both groups after treatment (P<0.05), and the scores in the study group were lower in the study group than those of the control group after treatment (P<0.05). The levels of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and squamous cell carcinoma antigen (SCCA) in both groups were lower than those before treatment (P<0.05), and those in the study group were lower after treatment (P<0.05). There were no significant differences in Th1/Th2, Th17/Treg or CD4+/CD8+ before and after treatment in the study group (P>0.05). After treatment, the ratios of Th1/Th2 and Th17/Treg in control group were higher than those before treatment, and CD4+/CD8+ in control group was lower than that before treatment (P<0.05). After treatment, the ratios of Th1/Th2 and Th17/Treg in the study group were lower than those in the control group, and CD4+/CD8+ in the study group was higher than that in the control group (P<0.05). There were no significant differences in the comparison of IgG, IgM, C3 or C4 before and after treatment in the study group (P>0.05), the levels of IgG, IgM, C3 and C4 after treatment in the control group were lower than those before treatment (P<0.05), and the levels of IgG, IgM, C3 and C4 after treatment in the study group were higher than those in the control group (P<0.05). The incidence of skin reaction and radiation cystitis in the study group was lower than that in the control group (P<0.05). The 3-year disease-free survival curve of the study group was better than that of the control group (P<0.05).
Conclusion Modified Guizhi Fuling Decoction can enhance the anti-tumor effect, reduce the levels of tumor markers, maintain the stability of machine immune function and alleviate the toxic side effects in the patients with cervical cancer after radiotherapy and chemotherapy.
, authors=Lei XI, Lichun DENG, Xiaxia SHAO, Chao LU, Simin WANG, Chun WU, Weisheng SHEN, authorsList=Lei XI, Lichun DENG, Xiaxia SHAO, Chao LU, Simin WANG, Chun WU, Weisheng SHEN, authorCompany=null, correspAuthors=Weisheng SHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291654377419311, articleId=1319291653534364205, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=桂枝茯苓汤加味对宫颈癌术后放化疗及T淋巴细胞的影响, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 分析桂枝茯苓汤加味对宫颈癌术后放化疗增效作用及对T淋巴细胞亚群水平的影响。
方法 回顾性分析2017年1月—2020年5月医院收治的106例宫颈癌患者的资料，所有患者均行宫颈癌根治术，根据术后治疗方式分为研究组（54例，术后放化疗联合桂枝茯苓汤加味治疗）、对照组（52例，术后放化疗治疗），两组术后随访3年。对比两组中医证候评分、肿瘤标志物、T淋巴细胞亚群、免疫球蛋白（Immunoglobulin，Ig）、补体及不良反应情况及抗肿瘤效果。
结果 两组治疗后主症、次症中医证候评分均低于治疗前（P<0.05），研究组治疗后更低（P<0.05）。两组治疗后癌胚抗原（Carcinoembryonic Antigen，CEA）、糖类抗原125（Carbohydrate Antigen 125，CA125）、鳞状细胞癌抗原（Squamous Cell Carcinoma Antigen，SCCA）均低于治疗前（P<0.05），研究组治疗后更低（P<0.05）。研究组治疗前后的Th1/Th2、Th17/Treg、CD4+/CD8+对比差异均无统计学意义（P>0.05）；对照组治疗后的Th1/Th2、Th17/Treg均高于治疗前，CD4+/CD8+均低于治疗前（P<0.05）；研究组治疗后Th1/Th2、Th17/Treg低于对照组，CD4+/CD8+高于对照组（P<0.05）。研究组治疗前后的IgG、IgM、C3、C4对比差异均无统计学意义（P>0.05），对照组治疗后的IgG、IgM、C3、C4均低于治疗前（P<0.05），研究组治疗后的IgG、IgM、C3、C4均高于对照组（P<0.05）。研究组的皮肤反应、放射性膀胱炎发生率低于对照组（P<0.05）。研究组的3年无病生存曲线优于对照组（P<0.05）。
结论 桂枝茯苓汤加味治疗用于宫颈癌术后放化疗患者可增强抗肿瘤效果，降低肿瘤标志物，维持机免疫功能稳定，减轻不良反应。
, authors=奚蕾, 邓立春, 邵夏霞, 陆超, 王司敏, 吴春, 沈伟生, authorsList=奚蕾, 邓立春, 邵夏霞, 陆超, 王司敏, 吴春, 沈伟生, authorCompany=null, correspAuthors=沈伟生, authorNote=
奚蕾（1976-），女，江苏江阴人，主任中医师，硕士，研究方向：中西医结合肿瘤内科。
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奚蕾（1976-），女，江苏江阴人，主任中医师，硕士，研究方向：中西医结合肿瘤内科。
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奚蕾（1976-），女，江苏江阴人，主任中医师，硕士，研究方向：中西医结合肿瘤内科。
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