中华中医药学刊

冠心病患者的眼像特征：一项中医结合现代医学的前瞻性观察研究

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高占群 ¹^,²^,³ , 张迪瑞 ²^,³ , 胡思宁 ²^,³ , 翁子骞 ²^,³ , 刘明皓 ²^,³ , 高语博 ²^,³ , 郝伟 ²^,³ , 赵晨 ²^,³ , 曾明 ²^,³ , 冯雪 ²^,³ , 秦雨涵 ²^,³ , 徐艺硕 ²^,³ , 贾海波 ²^,³ , 张智 ⁴^,⁵ , 房超 ²^,³ , 于波 ²^,³

中华中医药学刊 | 国家项目点击 2026,44(7): 35-39

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中华中医药学刊 |国家项目点击 2026 , 44 (7) : 35 -39

冠心病患者的眼像特征：一项中医结合现代医学的前瞻性观察研究

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高占群¹^,²^,³, 张迪瑞²^,³, 胡思宁²^,³, 翁子骞²^,³, 刘明皓²^,³, 高语博²^,³, 郝伟²^,³, 赵晨²^,³, 曾明²^,³, 冯雪²^,³, 秦雨涵²^,³, 徐艺硕²^,³, 贾海波²^,³, 张智⁴^,⁵, 房超²^,³, 于波²^,³

作者信息

^1.湖南医药学院总医院，湖南　怀化　418000

^2.哈尔滨医科大学第二附属医院，黑龙江　哈尔滨　150086

^3.哈尔滨心肌缺血教育部重点实验室，黑龙江　哈尔滨　150086

^4.北京生物芯片技术国家工程研究中心，北京　102206

^5.北京博奥生物集团有限公司，北京　102206

通讯作者:

于波（1962-），男，黑龙江哈尔滨人，主任医师、教授，博士研究生导师，博士，研究方向：急性冠脉综合征的致病机制、精准诊疗及远期预后。E-mail：yubodr@163.com。

房超（1992-），女，黑龙江哈尔滨人，副教授，博士研究生导师，博士，研究方向：冠心病与动脉粥样硬化的基础与临床。E-mail：fangchaodr@163.com。

作者简介:

高占群（1975-），女，黑龙江佳木斯人，副主任医师，博士，研究方向：中西医结合研究冠心病和眼睛的关系。

Eye-Image Features of Patients with Coronary Heart Disease Assessed by Combination of Traditional Chinese and Western Medicine: A Retrospective Study

Zhanqun GAO¹^,²^,³, Dirui ZHANG²^,³, Sining HU²^,³, Ziqian WENG²^,³, Minghao LIU²^,³, Yubo GAO²^,³, Wei HAO²^,³, Chen ZHAO²^,³, Ming ZENG²^,³, Xue FENG²^,³, Yuhan QIN²^,³, Yishuo XU²^,³, Haibo JIA²^,³, Zhi ZHANG⁴^,⁵, Chao FANG²^,³, Bo YU²^,³

Affiliations

^1.General Hospital of Hunan University of Medicine, Huaihua 418000, Hunan, China

^2.The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China

^3.The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150086, Heilongjiang, China

^4.National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China

^5.Capital Bio Corporation, Beijing 102206, China

出版时间: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.007

文章导航

摘要

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目的

探讨眼像特征与冠心病之间潜在的因果关系。

方法

纳入2021年11月15日—2022年2月27日在心内科住院的疑似冠心病患者。根据冠脉造影结果将入选患者分为两组：冠心病组（至少一处冠状动脉病变狭窄≥50%）和对照组（病变狭窄<50%）。

结果

最终分析包括426例参与者中的342例患者，其中165例患者（48.2%）被诊断患有冠心病。研究发现，左眼区域5（L5）和右眼区域5（R5）的某些特征与冠心病相关，包括左眼粉黯色斑（OR：4.143，95%CI[1.135，15.124]，P=0.031），左眼血管（中医称血脉）迂曲（OR：0.234，95%CI：0.077，0.71，P=0.010），右眼黯红色血管（OR：1.683，95%CI[1.035，2.738]，P=0.036），右眼淡黄色丘（OR：2.083，95%CI[1.221，3.554]，P=0.007）。多因素回归分析显示左眼血管迂曲与冠心病呈负相关。

结论

4种类型的眼像特征，即粉黯色斑，血管迂曲，黯红色血管、淡黄色丘与冠心病相关，血管迂曲和冠心病呈负相关，这可能有助于该疾病的诊断。

关键词

眼像特征 / 冠心病 / 中医

Abstract

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Objective

It aimed to investigate the potential causal relationship between eye-image features and CHD, as examined by coronary angiography (CAG).

Methods

The study selected the patients hospitalized in the Department of Cardiology from November 15, 2021 to February 27, 2022. The selected patients were divided into two groups based on their CAG findings: the CHD group (at least one coronary lesion stenosis≥50%) and the control group (lesion stenosis<50%).

Results

The final analysis included 342 patients out of a total of 426 participants, and 165 (48.2%) were diagnosed with CHD among these participants. The study found that certain characteristics in the left region 5 (L5) and right region (R5) were associated with CHD, including L5 pink dark speckle (OR: 4.143, 95%CI[1.135, 15.124], P=0.031), L5 vascular tortuosity (OR: 0.234, 95%CI[0.077, 0.71], P=0.010), R5 dark red blood vessels (known as blood meridian in TCM)(OR: 1.683, 95%CI[1.035, 2.738], P=0.036) and R5 yellowish mounds (OR: 2.083, 95%CI[1.221, 3.554], P=0.007). Multivariate regression analyses showed that L5 vascular tortuosity had a negative correlation with CHD.

Conclusion

The study revealed that four types of eye-image features, namely pink dark speckle, vascular tortuosity, dark red blood vessels and yellowish mounds, were associated with CHD. A-mong these features, vascular tortuosity showed a negative correlation with CHD, which could potentially aid in the diagnosis of the disease.

Key words

eye-image / coronary heart disease / traditional Chinese medicine

引用本文

高占群, 张迪瑞, 胡思宁, 翁子骞, 刘明皓, 高语博, 郝伟, 赵晨, 曾明, 冯雪, 秦雨涵, 徐艺硕, 贾海波, 张智, 房超, 于波. 冠心病患者的眼像特征：一项中医结合现代医学的前瞻性观察研究. 中华中医药学刊, 2026 , 44 (7) : 35 -39 . DOI: 10.13193/j.issn.1673-7717.2026.07.007

Zhanqun GAO, Dirui ZHANG, Sining HU, Ziqian WENG, Minghao LIU, Yubo GAO, Wei HAO, Chen ZHAO, Ming ZENG, Xue FENG, Yuhan QIN, Yishuo XU, Haibo JIA, Zhi ZHANG, Chao FANG, Bo YU. Eye-Image Features of Patients with Coronary Heart Disease Assessed by Combination of Traditional Chinese and Western Medicine: A Retrospective Study[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 35 -39 . DOI: 10.13193/j.issn.1673-7717.2026.07.007

基金

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国家自然科学基金项目(62135002)

参考文献

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参考文献引证文献

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2026年第44卷第7期

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文章信息

doi: 10.13193/j.issn.1673-7717.2026.07.007

首发时间：2026-10-20
出版时间：2026-07-10

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基金

国家自然科学基金项目(62135002)

作者信息

^1.湖南医药学院总医院，湖南　怀化　418000

^2.哈尔滨医科大学第二附属医院，黑龙江　哈尔滨　150086

^3.哈尔滨心肌缺血教育部重点实验室，黑龙江　哈尔滨　150086

^4.北京生物芯片技术国家工程研究中心，北京　102206

^5.北京博奥生物集团有限公司，北京　102206

通讯作者:

房超（1992-），女，黑龙江哈尔滨人，副教授，博士研究生导师，博士，研究方向：冠心病与动脉粥样硬化的基础与临床。E-mail：fangchaodr@163.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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