中华中医药学刊

超声引导下经皮冷冻消融配合补中益气汤与桂枝茯苓丸化裁治疗前列腺癌及对血清PSA、F-PSA、VEGF的影响

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高佳燕 , 董兴红

中华中医药学刊 | 省级项目平台 2026,44(8): 238-241

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中华中医药学刊 |省级项目平台 2026 , 44 (8) : 238 -241

超声引导下经皮冷冻消融配合补中益气汤与桂枝茯苓丸化裁治疗前列腺癌及对血清PSA、F-PSA、VEGF的影响

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高佳燕, 董兴红

作者信息

浙江中医药大学附属江南医院，浙江　杭州　316000

通讯作者:

董兴红（1982-），女，浙江杭州人，副主任技师，学士，研究方向：临床医学检验。E-mail：106405435@qq.com。

作者简介:

高佳燕（1993-），女，浙江杭州人，主管检验师，学士，研究方向：临床医学检验。

Ultrasound-guided percutaneous cryoablation combined with Buzhong Yiqi Decoction (补中益气汤) and Guizhi Fuling Pills (桂枝茯苓丸) in the treatment of prostate cancer and its effect on serum PSA, F-PSA and VEGF

Jiayan GAO, Xinghong DONG

Affiliations

Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 316000, Zhejiang, China

出版时间: 2026-08-10 doi: 10.13193/j.issn.1673-7717.2026.08.049

文章导航

摘要

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目的

探讨超声引导下经皮冷冻消融联合补中益气汤合桂枝茯苓丸化裁方案对前列腺癌患者血清前列腺特异性抗原（PSA）、游离前列腺特异性抗原（F-PSA）、血管内皮生长因子（VEGF）的影响。

方法

回顾性选取2022年2月—2023年1月医院收治的110例前列腺癌气滞血瘀证患者，按入院单双号分为对照组、研究组各55例；对照组仅行超声引导下经皮冷冻消融治疗，研究组冷冻消融术后联合补中益气汤合桂枝茯苓丸化裁方口服，持续服药3个月。分别于治疗前、治疗后1、3、9个月采集空腹静脉血，采用ELISA酶联免疫法检测血清PSA、F-PSA、VEGF水平，同期评估中医证候积分。

结果

治疗前两组PSA、F-PSA、VEGF水平差异无统计学意义（P>0.05）；治疗后1、3个月两组上述3项指标组间对比差异无统计学意义（P>0.05）；治疗9个月时，研究组血清PSA、F-PSA水平低于对照组，中医证候积分优于对照组，差异均有统计学意义（P<0.05）；两组治疗后各时间点VEGF水平对比差异无统计学意义（P>0.05）。

结论

超声引导下经皮冷冻消融联合补中益气汤与桂枝茯苓丸化裁治疗前列腺癌，可显著降低患者远期血清PSA、F-PSA水平，改善中医气滞血瘀证候，但对血清VEGF无明显调控作用。

关键词

前列腺癌 / 经皮冷冻消融 / 补中益气汤 / 桂枝茯苓丸

Abstract

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Objective

To investigate the effects of ultrasound-guided percutaneous cryoablation combined with modified Buzhong Yiqi Decoction (补中益气汤) and Guizhi Fuling Pills (桂枝茯苓丸) on serum total prostate-specific antigen (tPSA), free prostate-specific antigen (F-PSA) and vascular endothelial growth factor (VEGF) in patients with prostate cancer.

Methods

A total of 110 prostate cancer patients with qi stagnation and blood stasis syndrome admitted to our hospital from February 2022 to January 2023 were retrospectively enrolled and divided into control group and study group with 55 cases in each group according to odd and even admission numbers. The control group received ultrasound-guided percutaneous cryoablation alone, while the study group was treated with oral modified Buzhong Yiqi Decoction and Guizhi Fuling Pills for 3 months on the basis of cryoablation. Fasting venous blood was collected before treatment and at 1, 3 and 9 months after treatment. ELISA were used to detect serum tPSA, F-PSA and VEGF levels, and TCM syndrome scores were evaluated simultaneously.

Results

There were no significant differences in serum tPSA, F-PSA and VEGF between the two groups before treatment (P>0.05). No intergroup differences of the three indexes were observed at 1 and 3 months after treatment (P>0.05). At 9 months after treatment, the serum tPSA and F-PSA levels of the study group were lower than those of the control group, and the TCM syndrome scores were significantly improved (all P<0.05). There was no statistical difference in VEGF levels between the two groups at all followup time points (P>0.05).

Conclusion

Ultrasound-guided percutaneous cryoablation combined with modified Buzhong Yiqi Decoction and Guizhi Fuling Pills can effectively reduce long-term serum tPSA and F-PSA levels and improve TCM syndromes in prostate cancer patients, while it has no obvious regulatory effect on serum VEGF.

Key words

prostate cancer / percutaneous cryoablation / Buzhong Yiqi Decoction / Guizhi Fuling Pills

引用本文

高佳燕, 董兴红. 超声引导下经皮冷冻消融配合补中益气汤与桂枝茯苓丸化裁治疗前列腺癌及对血清PSA、F-PSA、VEGF的影响. 中华中医药学刊, 2026 , 44 (8) : 238 -241 . DOI: 10.13193/j.issn.1673-7717.2026.08.049

Jiayan GAO, Xinghong DONG. Ultrasound-guided percutaneous cryoablation combined with Buzhong Yiqi Decoction (补中益气汤) and Guizhi Fuling Pills (桂枝茯苓丸) in the treatment of prostate cancer and its effect on serum PSA, F-PSA and VEGF[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (8) : 238 -241 . DOI: 10.13193/j.issn.1673-7717.2026.08.049

基金

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浙江省卫生创新人才项目(2021RC026)

参考文献

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文献

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参考文献引证文献

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2026年第44卷第8期

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文章信息

doi: 10.13193/j.issn.1673-7717.2026.08.049

首发时间：2026-10-20
出版时间：2026-08-10

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基金

浙江省卫生创新人才项目(2021RC026)

作者信息

浙江中医药大学附属江南医院，浙江　杭州　316000

通讯作者:

董兴红（1982-），女，浙江杭州人，副主任技师，学士，研究方向：临床医学检验。E-mail：106405435@qq.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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