中华中医药学刊

基于红外热成像技术探讨针刺治疗抑郁模型大鼠对少阳枢机的影响

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刘舰遥 , 任路 , 马贤德 , 王干一 , 吕琴 , 冯诗雨

中华中医药学刊 | 国家项目点击 2026,44(8): 153-158

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中华中医药学刊 |国家项目点击 2026 , 44 (8) : 153 -158

基于红外热成像技术探讨针刺治疗抑郁模型大鼠对少阳枢机的影响

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刘舰遥, 任路, 马贤德, 王干一, 吕琴, 冯诗雨

作者信息

辽宁中医药大学，辽宁　沈阳　110847

通讯作者:

任路（1966-），女，四川巴县人，教授，博士研究生导师，博士，研究方向：中医情志病基础与临床。E-mail：lnzyxkc@sina.com。

作者简介:

刘舰遥（1989-），女，辽宁沈阳人，博士在读，研究方向：针灸治疗情志病机制。

Exploring Effect of Acupuncture Treatment on Shaoyang Pivot in Depression Model Rats Based on Infrared Thermography

Jianyao LIU, Lu REN, Xiande MA, Ganyi WANG, Qin LYU, Shiyu FENG

Affiliations

Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China

出版时间: 2026-08-10 doi: 10.13193/j.issn.1673-7717.2026.08.032

文章导航

摘要

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目的

应用红外热成像技术观察针刺治疗、nNOS-PSD-95复合物对抑郁模型大鼠异常红外热图特征的影响。

方法

选择SPF级SD大鼠，随机分为正常组、模型组（腹腔注射利血平0.2 mg·kg^-1·d^-1）、针刺组、ZL006组，正常组和模型组各9只，余组各8只，观察体质量、肛温变化；采用旷场实验、糖水偏嗜实验、强迫游泳实验观察抑郁样行为；采用机械痛阈测定、挠头次数检测观察痛行为；干预后采用红外热成像仪观察大鼠热图特征；采用酶联免疫吸附法（Elisa）检测各组5-羟色胺（5-hydroxytryptamine，5-HT）表达水平，硝酸还原酶法检测一氧化氮（nitric oxide，NO）表达水平，Western blot检测神经保护因子（brain-derived neurotrophic factor，BDNF）含量。

结果

干预前各组体质量、肛温及行为学差异无统计学意义（P>0.05）；干预后与正常组比较，余组体质量降低（P<0.001），模型组和ZL006组肛温降低（P<0.01，P<0.001）；与模型组相比，针刺组肛温明显上升（P<0.01）；与模型组比较，针刺组和Zl006组改善抑郁样行为（P<0.05，P<0.001）和痛行为（P<0.05，P<0.01，P<0.001），下调海马CA3区NO表达水平（P<0.01），上调BDNF表达水平（P<0.001），针刺组上调海马CA3区5-HT表达水平（P<0.01）；红外热成像图显示，干预后与正常组相比，模型组头部平均温度、躯干部平均温度和尾根部最低温度均降低（P<0.05，P<0.01），风池、阳白平均温度差（△T）升高（P<0.01，P<0.001），肾俞△T降低（P<0.05）；与模型组相比，针刺组和ZL006组躯干部平均温度、尾根部最低温度均升高（P<0.05，P<0.01），少阳经穴风池、阳白△T降低（P<0.01，P<0.001），针刺组肾俞△T升高（P<0.01）。

结论

抑郁模型大鼠红外热成像特征存在体表整体和肾俞穴相对低温而头部部分少阳经穴相对高温的“寒象”，针刺可能通过调节少阳枢机以调整“寒象”并发挥抗抑郁作用，nNOS-PSD-95复合物可能影响少阳枢机功能。

关键词

针刺治疗 / 抑郁 / 红外热成像 / nNOS-PSD-95

Abstract

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Objective

To observe the effects of acupuncture treatment and nNOS-PSD-95 complex on abnormal infrared thermal imaging features in depression model rats using infrared thermography.

Method

Fifty SPF grade SD rats were selected and randomly divided into 6 groups, including normal group, model group (intraperitoneal injection of 0.2 mg·kg^-1·d^-1of reserpine), acupuncture group, ZL006 group. There were 9 rats in the normal group and model group, and 8 rats in each of the remaining groups. The changes in body weight and anal temperature were observed. Open field test, sucrose preference test and forced swimming test were applied to observe depression like behaviors. The mechanical pain threshold measurement and head scratching frequency detection were used to observe thee pain behaviors. After intervention, infrared thermal imaging device was used to observe the characteristics of infrared thermal imaging of the rats. Enzyme linked ELISA was used to detect the expression levels of 5-hydroxytryptamine (5-HT) in each group, nitrate reductase method was used to detect the expression levels of nitric oxide (NO), and Western blot was used to detect the expression levels of brain-derived neurotrophic factor (BDNF) content.

Result

There were no significant differences in body weight, anal temperature or behavior among the groups before intervention (P>0.05). After intervention, compared with those of the normal group, the weight of the remaining groups decreased (P<0.001), and the anal temperature of the model group and ZL006 group decreased (P<0.01, P<0.001). Compared with those in the model group, the anal temperature in the acupuncture group significantly increased (P<0.01). Compared with the model group, the acupuncture group and Zl006 group improved depressive like behavior (P<0.05, P<0.001) and pain behavior (P<0.05, P<0.01, P<0.001), down-regulated the expression levels of NO in the hippocampal CA3 region (P<0.01), up-regulated BDNF expression levels（P<0.001）and up-regulated the expression level of 5-HT in the hippocampal CA3 region in the acupuncture group（P<0.01）. Infrared thermal imaging showed that after intervention，compared with those of the normal group，the mean head temperature，the mean trunk temperature and the minimum tail temperature of the model group decreased（P<0.05，P<0.01），the mean temperature difference（△T）between “Fengchi（GB20？）” and “Yangbai（GB14）” increased（P<0.01，P<0.001），and the △T of “Shenshu（BL23）” decreased（P<0.05）. Compared with those of the model group，the mean trunk temperature and the minimum tail temperature at the tail root of the acupuncture group and ZL006 group increased（P<0.05，P<0.01），the △T of Shaoyang，“Fengchi（GB20）” and “Yangbai（GB14）” decreased（P<0.01，P<0.001），and the △T of “Shenshu（BL23）” increased in the acupuncture group（P<0.01）.

Conclusion

Infrared thermal imaging of depression model rats shows the “cold phenomenon” of relatively low temperature at the overall and “Shenshu（BL23）” on the body surface，while the partial Shaoyang meridian points on the head are relatively high temperature. Acupuncture may regulate the “cold phenomenon” and participate in the antidepressant effects by regulating the Shaoyang pivot，and nNOS-PSD-95 complex may affect Shaoyang pivot function.

Key words

acupuncture treatment / depression / infrared thermal imaging / nNOS-PSD-95

引用本文

刘舰遥, 任路, 马贤德, 王干一, 吕琴, 冯诗雨. 基于红外热成像技术探讨针刺治疗抑郁模型大鼠对少阳枢机的影响. 中华中医药学刊, 2026 , 44 (8) : 153 -158 . DOI: 10.13193/j.issn.1673-7717.2026.08.032

Jianyao LIU, Lu REN, Xiande MA, Ganyi WANG, Qin LYU, Shiyu FENG. Exploring Effect of Acupuncture Treatment on Shaoyang Pivot in Depression Model Rats Based on Infrared Thermography[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (8) : 153 -158 . DOI: 10.13193/j.issn.1673-7717.2026.08.032

基金

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国家自然科学基金项目(82274665)
辽宁省特聘教授项目(辽教发〔2015〕153号)
辽宁省高等学校创新团队项目(辽教函〔2018〕479号)

参考文献

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文献

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2026年第44卷第8期

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doi: 10.13193/j.issn.1673-7717.2026.08.032

首发时间：2026-10-20
出版时间：2026-08-10

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国家自然科学基金项目(82274665)

辽宁省特聘教授项目(辽教发〔2015〕153号)

辽宁省高等学校创新团队项目(辽教函〔2018〕479号)

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辽宁中医药大学，辽宁　沈阳　110847

通讯作者:

任路（1966-），女，四川巴县人，教授，博士研究生导师，博士，研究方向：中医情志病基础与临床。E-mail：lnzyxkc@sina.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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