Article(id=1319291495333614234, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.07.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473203738, onlineDateStr=2026-10-20, pubDate=1783612800000, pubDateStr=2026-07-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473203738, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473203738, creator=13701087609, updateTime=1792473203738, updator=13701087609, issue=Issue{id=1319291472856338924, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='7', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1783612800000', pubDateStr='2026-07-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473198379, creator='13701087609', updateTime=1792473406504, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292345858773669, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292345858773670, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=131, endPage=136, ext={EN=ArticleExt(id=1319291495551718043, articleId=1319291495333614234, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress of Huangqi (Astragali Radix) Active Ingredient in Treating Diabetic Kidney Disease Based on “Treating Qi First for Treating Water”, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes mellitus (DM), and also one of the main causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD). In recent years, traditional Chinese medicine has played an important role in the treatment and prevention of DKD. Based on the theory of “treating Qi first for treating water”, the author explored the main mechanism of the holy medicine Huangqi (Astragali Radix) and its active ingre-dients in the treatment of DKD. Studies have shown that Huangqi (Astragali Radix) and its active ingredients, such as total Astragalus flavones (TFA), calycosin, Astragaloside Ⅳ (AS-Ⅳ) and Astragalus polysaccharide (APS), can be prevented by improving insulin resistance, inhibiting oxidative stress, anti-inflammation, delaying renal fibrosis, anti-apoptosis, inhibiting iron death, regulating autophagy, regulating intestinal flora and so on to treat DKD, in order to provide new drug ideas and methods for TCM treatment of DKD.

, authors=Jiawei ZHANG1, 2, Zhifen ZHAO1, 2, Xiangge REN1, 2, Jianye REN1, 2, Tengfei SONG1, 2, Shoudao LI1, 2, Wensheng ZHAI1, 2, authorsList=Jiawei ZHANG, Zhifen ZHAO, Xiangge REN, Jianye REN, Tengfei SONG, Shoudao LI, Wensheng ZHAI, authorCompany=null, correspAuthors=Wensheng ZHAI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291495904039580, articleId=1319291495333614234, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=基于“治水者必先治气”探讨黄芪活性成分治疗糖尿病肾病的研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

糖尿病肾病(diabetic kidney disease,DKD)是糖尿病(diabetes mellitus,DM)常见的微血管并发症之一,也是慢性肾脏病(chronic kidney disease,CKD)和终末期肾病(end-stage renal disease,ESRD)的主要原因之一。近年来,中医药在DKD的治疗和预防中发挥了重要的作用,基于“治水者必先治气”理论探究了补气圣药“黄芪”及其活性成分在治疗DKD中的主要作用机制。研究发现黄芪及其活性成分如黄芪总黄酮(total flavonoids of astragalus,TFA)、毛蕊异黄酮(calycosin)、黄芪甲苷Ⅳ(astragaloside Ⅳ,AS-Ⅳ)、黄芪多糖(astragalus polysaccharide,APS)等可以通过改善胰岛素抵抗、抑制氧化应激、抗炎、延缓肾纤维化、抗细胞凋亡、抑制铁死亡、调节自噬、调控肠道菌群等多种途径防治DKD,为中医药治疗DKD提供新的用药思路和方法。

, authors=张佳伟1, 2, 赵志芬1, 2, 任相阁1, 2, 任建业1, 2, 宋腾飞1, 2, 李首道1, 2, 翟文生1, 2, authorsList=张佳伟, 赵志芬, 任相阁, 任建业, 宋腾飞, 李首道, 翟文生, authorCompany=null, correspAuthors=翟文生, authorNote=

张佳伟(1998-),男,河南焦作人,博士在读,研究方向:中医药防治儿童肾脏疾病及风湿免疫疾病。

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翟文生(1965-),男,河南南阳人,教授,博士研究生导师,博士,研究方向:中医药防治儿童肾脏疾病及风湿免疫疾病。E-mail:。
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张佳伟(1998-),男,河南焦作人,博士在读,研究方向:中医药防治儿童肾脏疾病及风湿免疫疾病。

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张佳伟(1998-),男,河南焦作人,博士在读,研究方向:中医药防治儿童肾脏疾病及风湿免疫疾病。

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基于“治水者必先治气”探讨黄芪活性成分治疗糖尿病肾病的研究进展
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张佳伟 1, 2 , 赵志芬 1, 2 , 任相阁 1, 2 , 任建业 1, 2 , 宋腾飞 1, 2 , 李首道 1, 2 , 翟文生 1, 2
中华中医药学刊 | 国家项目点击 2026,44(7): 131-136
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中华中医药学刊 |国家项目点击 2026 , 44 (7) : 131 -136
基于“治水者必先治气”探讨黄芪活性成分治疗糖尿病肾病的研究进展
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张佳伟(1998-),男,河南焦作人,博士在读,研究方向:中医药防治儿童肾脏疾病及风湿免疫疾病。

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张佳伟(1998-),男,河南焦作人,博士在读,研究方向:中医药防治儿童肾脏疾病及风湿免疫疾病。

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张佳伟1, 2, 赵志芬1, 2, 任相阁1, 2, 任建业1, 2, 宋腾飞1, 2, 李首道1, 2, 翟文生1, 2
作者信息
  • 1.河南中医药大学第一附属医院儿科医院,河南 郑州 450000
  • 2.河南中医药大学儿科医学院,河南 郑州 450000
通讯作者:
翟文生(1965-),男,河南南阳人,教授,博士研究生导师,博士,研究方向:中医药防治儿童肾脏疾病及风湿免疫疾病。E-mail:。
作者简介:

张佳伟(1998-),男,河南焦作人,博士在读,研究方向:中医药防治儿童肾脏疾病及风湿免疫疾病。

Research Progress of Huangqi (Astragali Radix) Active Ingredient in Treating Diabetic Kidney Disease Based on “Treating Qi First for Treating Water”
Jiawei ZHANG1, 2, Zhifen ZHAO1, 2, Xiangge REN1, 2, Jianye REN1, 2, Tengfei SONG1, 2, Shoudao LI1, 2, Wensheng ZHAI1, 2
Affiliations
  • 1.Pediatric Hospital, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China
  • 2.College of Pediatrics, Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China
出版时间: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.024
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糖尿病肾病(diabetic kidney disease,DKD)是糖尿病(diabetes mellitus,DM)常见的微血管并发症之一,也是慢性肾脏病(chronic kidney disease,CKD)和终末期肾病(end-stage renal disease,ESRD)的主要原因之一。近年来,中医药在DKD的治疗和预防中发挥了重要的作用,基于“治水者必先治气”理论探究了补气圣药“黄芪”及其活性成分在治疗DKD中的主要作用机制。研究发现黄芪及其活性成分如黄芪总黄酮(total flavonoids of astragalus,TFA)、毛蕊异黄酮(calycosin)、黄芪甲苷Ⅳ(astragaloside Ⅳ,AS-Ⅳ)、黄芪多糖(astragalus polysaccharide,APS)等可以通过改善胰岛素抵抗、抑制氧化应激、抗炎、延缓肾纤维化、抗细胞凋亡、抑制铁死亡、调节自噬、调控肠道菌群等多种途径防治DKD,为中医药治疗DKD提供新的用药思路和方法。

黄芪  /  糖尿病肾病  /  活性成分  /  黄芪甲苷Ⅳ  /  黄芪多糖

Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes mellitus (DM), and also one of the main causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD). In recent years, traditional Chinese medicine has played an important role in the treatment and prevention of DKD. Based on the theory of “treating Qi first for treating water”, the author explored the main mechanism of the holy medicine Huangqi (Astragali Radix) and its active ingre-dients in the treatment of DKD. Studies have shown that Huangqi (Astragali Radix) and its active ingredients, such as total Astragalus flavones (TFA), calycosin, Astragaloside Ⅳ (AS-Ⅳ) and Astragalus polysaccharide (APS), can be prevented by improving insulin resistance, inhibiting oxidative stress, anti-inflammation, delaying renal fibrosis, anti-apoptosis, inhibiting iron death, regulating autophagy, regulating intestinal flora and so on to treat DKD, in order to provide new drug ideas and methods for TCM treatment of DKD.

Huangqi (Astragali Radix)  /  diabetic kidney disease  /  active ingredients  /  Astragaloside Ⅳ  /  Astragalus polysaccharide
张佳伟, 赵志芬, 任相阁, 任建业, 宋腾飞, 李首道, 翟文生. 基于“治水者必先治气”探讨黄芪活性成分治疗糖尿病肾病的研究进展. 中华中医药学刊, 2026 , 44 (7) : 131 -136 . DOI: 10.13193/j.issn.1673-7717.2026.07.024
Jiawei ZHANG, Zhifen ZHAO, Xiangge REN, Jianye REN, Tengfei SONG, Shoudao LI, Wensheng ZHAI. Research Progress of Huangqi (Astragali Radix) Active Ingredient in Treating Diabetic Kidney Disease Based on “Treating Qi First for Treating Water”[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 131 -136 . DOI: 10.13193/j.issn.1673-7717.2026.07.024
  • 国家自然科学基金项目(81873339; 82274577)
  • 河南省科技攻关项目(232102310284)
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2026年第44卷第7期
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doi: 10.13193/j.issn.1673-7717.2026.07.024
  • 首发时间:2026-10-20
  • 出版时间:2026-07-10
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国家自然科学基金项目(81873339; 82274577)
河南省科技攻关项目(232102310284)
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    1.河南中医药大学第一附属医院儿科医院,河南 郑州 450000
    2.河南中医药大学儿科医学院,河南 郑州 450000

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翟文生(1965-),男,河南南阳人,教授,博士研究生导师,博士,研究方向:中医药防治儿童肾脏疾病及风湿免疫疾病。E-mail:。
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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