Article(id=1319291478598337032, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.08.043, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473199747, onlineDateStr=2026-10-20, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473199747, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473199747, creator=13701087609, updateTime=1792473199747, updator=13701087609, issue=Issue{id=1319291312826863771, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473160225, creator='13701087609', updateTime=1792473382588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292245547799195, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292245652656796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=212, endPage=214, ext={EN=ArticleExt(id=1319291478829023753, articleId=1319291478598337032, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Modified Shoutai Pill (寿胎丸加味) in Adjuvant Treatment of Patients with Recurrent Spontaneous Abortion and Its Effect on Serum VEGF, sFLT-1 and IL-17, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To study the effect of Modified Shoutai Pill (寿胎丸加味) in adjuvant treatment of the patients with recurrent spontaneous abortion and its effect on serum vascular endothelial growth factor (VEGF), soluble fms-like tyrosine kinase-1 (sFLT-1) and interleukin-17 (IL-17).
Methods Ninety-six patients with recurrent spontaneous abortion treated in the hospital from January 2023 to March 2024 were selected and divided into two groups according to the random number table method, 48 patients in each group. The control group was treated with conventional western medicine, and the observation group was treated with Modified Shoutai Pill on the basis of the control group until 12 weeks of pregnancy. The efficacy, changes of TCM syndrome scores, serum levels of VEGF, sFLT-1 and IL-17, and adverse reactions were compared between the two groups.
Results The cure rate of the observation group was 87.50% (42/48), was higher than that of the control group 70.83% (34/48) (P<0.05). After treatment, the scores of mental fatigue and limb soft, cold limbs, dizziness, tinnitus and frequent nocturia in the two groups were significantly decreased, and the scores in the observation group were lower than those in the control group (P<0.05). After treatment, the levels of serum VEGF in the two groups were significantly increased, and the levels of sFLT-1 and IL-17 were significantly decreased. The level of serum VEGF in the observation group was higher than that in the control group, and the levels of sFLT-1 and IL-17 were lower than those in the control group. The differences were statistically significant (P<0.05). No serious adverse reactions occurred in both groups.
Conclusion The effect of Modified Shoutai Pill in adjuvant treatment of the patients with recurrent spontaneous abortion is satisfactory. It can effectively regulate the serum inflammatory factors and the vascular endothelial related factors, promote the relief of the symptoms, and ensure the safety of pregnancy.
, authors=Xiaoli LYU
1, Ruili LI
2, Xia JI
1, Jinying FU
2, authorsList=Xiaoli LYU, Ruili LI, Xia JI, Jinying FU, authorCompany=null, correspAuthors=Jinying FU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291479160373770, articleId=1319291478598337032, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=寿胎丸加味辅助治疗复发性流产疗效及对血清VEGF、sFLT-1、IL-17的影响, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 研究寿胎丸加味辅助治疗复发性流产患者效果及对血清血管内皮生长因子（vascular endothelial growth factor，VEGF）、可溶性血管内皮生长因子受体-1（soluble fms-like tyrosine kinase-1，sFLT-1）、白细胞介素17（interleukin-17，IL-17）的影响。
方法 选取2023年1月—2024年3月医院治疗的复发性流产患者96例，按照随机数字表法均分为两组，每组48例。对照组采用常规西药治疗，观察组在对照组基础上增加寿胎丸加味辅助治疗，用药至孕12周。比较两组患者的疗效，中医证候积分变化，血清VEGF、sFLT-1、IL-17水平，不良反应发生情况。
结果 观察组治愈率87.50%（42/48），高于对照组的70.83%（34/48）（P<0.05）。治疗后，两组患者神疲肢软、肢体寒冷、头晕耳鸣、夜尿频繁积分均显著降低，观察组低于对照组（P<0.05）。治疗后，两组患者血清VEGF水平明显降低，sFLT-1、IL-17水平明显升高，观察组患者血清VEGF水平高于对照组，sFLT-1、IL-17水平低于对照组，差异有统计学意义（P<0.05）。两组均无严重不良反应发生。
结论 寿胎丸加味辅助治疗复发性流产患者效果满意，能够有效调控血清内炎症因子与血管内皮相关因子，促进患者的症状缓解，保证妊娠安全。
, authors=吕孝丽
1, 李瑞丽
2, 姬霞
1, 傅金英
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吕孝丽（1992-），女，河南驻马店人，主治医师，博士，研究方向：中医药防治复发性流产。
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