中华中医药学刊

消木丹颗粒联合多烯磷脂酰胆碱治疗非酒精性脂肪肝临床观察

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姜晓倩 ¹ , 席奇 ² , 宋粉莉 ² , 闫瑞娟 ² , 刘亚珠 ²

中华中医药学刊 | 省级项目平台 2026,44(8): 200-203

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中华中医药学刊 |省级项目平台 2026 , 44 (8) : 200 -203

消木丹颗粒联合多烯磷脂酰胆碱治疗非酒精性脂肪肝临床观察

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姜晓倩¹, 席奇², 宋粉莉², 闫瑞娟², 刘亚珠²

作者信息

^1.宝鸡市人民医院，陕西　宝鸡　721000

^2.陕西中医药大学附属医院肝病医院，陕西　咸阳　712000

通讯作者:

刘亚珠（1978-），女，山东夏津人，副主任医师，硕士，研究方向：中药单体和复方治疗脂肪肝和高脂血症的临床与机制。E-mail：923466563@qq.com。

作者简介:

姜晓倩（1985-），女，陕西宝鸡人，副主任医师，学士，研究方向：中西医结合治疗肝病。

Clinical Observation of Xiaomudan Granules (消木丹颗粒) Combined with Polyene Phosphatidylcholine in Treatment of Non-Alcoholic Fatty Liver

Xiaoqian JIANG¹, Qi XI², Fenli SONG², Ruijuan YAN², Yazhu LIU²

Affiliations

^1.Baoji People's Hospital, Baoji 721000, Shaanxi, China

^2.Hepatology Hospital, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi, China

出版时间: 2026-08-10 doi: 10.13193/j.issn.1673-7717.2026.08.040

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摘要

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目的

观察消木丹颗粒联合多烯磷脂酰胆碱胶囊治疗非酒精性脂肪性肝病的临床疗效及对肠道细菌菌落数的影响。

方法

选取2016年3月—2017年2月收治的106例非酒精性脂肪性肝病患者，随机分为对照组和治疗组，每组53例。对照组口服多烯磷脂酰胆碱胶囊，治疗组在对照组的基础上加用消木丹颗粒，两组均治疗12周。比较两组患者临床症状、肝功能、血脂及肠道细菌菌落数的变化。

结果

治疗组临床证候疗效总有效率为88.68%（47/53），高于对照组的73.58%（39/53），差异有统计学意义（P<0.05）。治疗后两组中医证候积分均较治疗前降低，治疗组低于对照组（P<0.05）。治疗后两组肝功能水平均较治疗前降低，治疗组指标水平低于对照组（P<0.05）。两组治疗后总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）均较治疗前降低，高密度脂蛋白胆固醇（HDL-C）较治疗前升高，治疗组改善优于对照组（P<0.05）。治疗组肠道菌群数量改善优于对照组（P<0.05）。

结论

消木丹颗粒联合多烯磷脂酰胆碱胶囊在改善非酒精性脂肪性肝病患者临床症状、肝功能、血脂、调节肠道细菌菌落数等方面疗效显著。

关键词

非酒精性脂肪性肝病 / 肠道菌群 / 消木丹颗粒 / 临床观察

Abstract

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Objective

To observe the clinical efficacy of Xiaomudan Granules (消木丹颗粒) combined with polyene phosphatidylcholine capsules in the treatment of non-alcoholic fatty liver disease and its effect on intestinal bacterial colony count.

Method

A total of 106 patients with non-alcoholic fatty liver disease (March 2016 to February 2017) were selected from the hospital and randomly divided into a control group and a treatment group, with 53 patients in each group. The control group took polyene phosphatidylcholine capsules orally, while the treatment group received Xiaomudan Granules in addition to polyene phosphatidylcholine capsules. Both groups were treated for 12 weeks. The changes in clinical symptoms, liver function, blood lipids and gut bacterial colony count were compared between two groups.

Result

The total effective rate of the clinical symptoms in the treatment group was 88.68% (47/53), which was higher than that in the control group [73.58% (39/53), P<0.05]. After treatment, the TCM syndrome scores of both groups decreased compared to those before treatment, and the scores of the treatment group were lower than those of the control group (P<0.05). After treatment, the liver function levels of both groups decreased compared to those before treatment, and the indicator levels of the treatment group were lower than those of the control group (P<0.05). After treatment, the levels of TC, TG, and LDL-C in both groups decreased compared to those before treatment, while the HDL-C level increased. The improvement in the treatment group was better than that in the control group (P<0.05). The improvement of gut microbiota in the treatment group was better than that in the control group (P<0.05).

Conclusion

The combination of Xiaomudan Granules and polyene phosphatidylcholine capsules has significant therapeutic effects in improving clinical symptoms, liver function and blood lipids, and regulating intestinal bacterial colony count in the patients with non-alcoholic fatty liver disease.

Key words

non-alcoholic fatty liver disease / gut microbiota / Xiaomudan Granules (消木丹颗粒) / clinical observation

引用本文

姜晓倩, 席奇, 宋粉莉, 闫瑞娟, 刘亚珠. 消木丹颗粒联合多烯磷脂酰胆碱治疗非酒精性脂肪肝临床观察. 中华中医药学刊, 2026 , 44 (8) : 200 -203 . DOI: 10.13193/j.issn.1673-7717.2026.08.040

Xiaoqian JIANG, Qi XI, Fenli SONG, Ruijuan YAN, Yazhu LIU. Clinical Observation of Xiaomudan Granules (消木丹颗粒) Combined with Polyene Phosphatidylcholine in Treatment of Non-Alcoholic Fatty Liver[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (8) : 200 -203 . DOI: 10.13193/j.issn.1673-7717.2026.08.040

基金

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陕西省科技厅项目(2024JC-YBMS-650)

参考文献

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2026年第44卷第8期

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doi: 10.13193/j.issn.1673-7717.2026.08.040

首发时间：2026-10-20
出版时间：2026-08-10

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基金

陕西省科技厅项目(2024JC-YBMS-650)

作者信息

^1.宝鸡市人民医院，陕西　宝鸡　721000

^2.陕西中医药大学附属医院肝病医院，陕西　咸阳　712000

通讯作者:

刘亚珠（1978-），女，山东夏津人，副主任医师，硕士，研究方向：中药单体和复方治疗脂肪肝和高脂血症的临床与机制。E-mail：923466563@qq.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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