中华中医药学刊

复元活血汤配合自然铜丸、磁疗对老年桡骨远端骨折患者VAS评分及血清胶原、miR-188、miR-206表达的影响

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孔祥颖 , 夏阳 , 秦泗锋

中华中医药学刊 | 国家项目点击 2026,44(8): 28-32

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中华中医药学刊 |国家项目点击 2026 , 44 (8) : 28 -32

复元活血汤配合自然铜丸、磁疗对老年桡骨远端骨折患者VAS评分及血清胶原、miR-188、miR-206表达的影响

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孔祥颖, 夏阳, 秦泗锋

作者信息

南京中医药大学连云港附属医院，连云港市中医院，江苏　连云港　222000

通讯作者:

夏阳（1987-），男，江苏连云港人，副主任中医师，学士，研究方向：中医骨伤。E-mail：52399678@qq.com。

作者简介:

孔祥颖（1982-），男，江苏连云港人，副主任医师，硕士，研究方向：创伤、关节。

Effect of Fuyuan Huoxue Decoction (复元活血汤) Combined with Natural Copper Pills and Magnetic Therapy on VAS Score and Expressions of Serum Collagen, miR-188 and miR-206 in Elderly Patients with Distal Radius Fracture

Xiangying KONG, Yang XIA, Sifeng QIN

Affiliations

Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine, Lianyungang Hospital of Traditional Chinese Medicine, Lianyungang 222000, Jiangsu, China

出版时间: 2026-08-10 doi: 10.13193/j.issn.1673-7717.2026.08.006

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摘要

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目的

探讨复元活血汤配合自然铜丸、磁疗对老年桡骨远端骨折患者疼痛程度视觉模拟评分法（Visual analogue scale，VAS）评分及血清胶原、miR-188、miR-206表达的影响。

方法

研究收集2021年5月—2024年1月期间接受治疗的123例老年桡骨远端骨折患者，随机分为3组，每组41例。3组均接受内固定治疗，术后对照A组予以复元活血汤治疗，对照B组予以自然铜丸、磁疗治疗，观察组予以复元活血汤配合自然铜丸、磁疗。观察对比3组骨痂评分、骨折愈合时间及治疗前后疼痛程度、消肿指数、血清I型胶原相关指标[I型胶原氨基端前肽（Propeptide of type I procollagen，PINP）、I型胶原羧基端肽β特殊序列（Special sequence of carboxy terminal peptide beta of type I collagen，β-CTX）]、D-二聚体（D-dimer，D-D）、纤维蛋白原（Fibrinogen，FIB）、miR-188、miR-206表达、改良Mayo腕关节功能评分。

结果

观察组骨痂评分高于对照A、B组，骨折愈合时间短于对照A、B组（P<0.05），对照A、B组相比，差异无统计学意义（P>0.05）；治疗1、4周后，观察组VAS评分低于对照A、B组，消肿指数高于对照A、B组（P<0.05），对照A、B组相比，差异无统计学意义（P>0.05）；治疗1、4周后，观察组FIB、D-D水平、miR-188、miR-206表达低于对照A、B组，PINP、β-CTX水平高于对照A、B组（P<0.05），对照A、B组相比，差异无统计学意义（P>0.05）；观察组治疗后3、6个月改良Mayo腕关节功能评分高于对照A、B组（P<0.05），对照A、B组相比，差异无统计学意义（P>0.05）。

结论

复元活血汤配合自然铜丸、磁疗治疗老年桡骨远端骨折术后患者，可明显减轻患者肿胀程度，改善凝血功能及腕关节功能，降低VAS评分及miR-188、miR-206表达，提高血清胶原相关指标水平及骨痂质量，缩短骨折愈合时间，效果较为显著。

关键词

复元活血汤 / 自然铜丸 / 磁疗 / 桡骨远端骨折 / VAS评分 / 血清胶原 / miR-188 / miR-206

Abstract

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Objective

To investigate the effect of Fuyuan Huoxue Decoction (复元活血汤) combined with natural copper pills and magnetic therapy on the pain degree (VAS) score and the expressions of serum collagen, miR-188 and miR-206 in the elderly patients with distal radius fractures.

Methods

This study collected 123 elderly patients with distal radius fractures who received treatment in the hospital from May 2021 to January 2024. They were randomly divided into three groups, with 41 patients in each group. All 3 groups received internal fixation treatment. After operation, control group A was treated with Fuyuan Huoxue Decoction, control group B was treated with natural copper pills and magnetic therapy, and the observation group was treated with Fuyuan Huoxue Decoction combined with natural copper pills and magnetic therapy. The callus score, fracture healing time, pain degree, swelling index, the serum levels of type I collagen-related indicators [type I collagen amino terminal propeptide (PINP), type I collagen carboxy terminal peptide β special sequence (β-CTX)], D-dimer (D-D), fibrinogen (FIB), miR-188 and miR-206 and improved Mayo wrist function score before and after treatment of the three groups were observed and compared.

Results

The callus score of the observation group was higher than that of the control group A and B, and the fracture healing time was shorter than that of the control group A and B (P<0.05). The comparison between control group A and B had no significant difference (P>0.05). After 1 and 4 weeks of treatment, the VAS score of the observation group was lower than that of the control groups A and B, and the swelling index was higher than that of the control groups A and B (P<0.05). The comparison between control group A and B had no significant difference (P>0.05). After 1 and 4 weeks of treatment, the expressions of FIB, D-D, miR-188 and miR-206 in the observation group were lower than those in the control group A and B, and the levels of PINP andβ-CTX were higher than those in the control group A and B (P<0.05). The comparison between control group A and B had no significant difference (P>0.05). The modified Mayo wrist function of the observation group was higher than that of the control group A and B at 3 and 6 months after treatment (P<0.05), and there was no significant difference compared with those of the control group A and B (P>0.05).

Conclusion

Fuyuan Huoxue Decoction, natural copper pills and magnetic therapy for the elderly patients with distal radius fractures after surgery can significantly reduce the swelling of the patients and improve the coagulation function and wrist joint function, reduce the VAS score and the expressions of miR-188 and miR-206, increase the serum collagen-related index level and the quality of the callus, and shorten the healing time of fractures. The effect is more significant.

Key words

Fuyuan Huoxue Decoction (复元活血汤) / natural copper pills / magnetic therapy / distal radius fracture / VAS score / serum collagen / miR-188 / miR-206

引用本文

孔祥颖, 夏阳, 秦泗锋. 复元活血汤配合自然铜丸、磁疗对老年桡骨远端骨折患者VAS评分及血清胶原、miR-188、miR-206表达的影响. 中华中医药学刊, 2026 , 44 (8) : 28 -32 . DOI: 10.13193/j.issn.1673-7717.2026.08.006

Xiangying KONG, Yang XIA, Sifeng QIN. Effect of Fuyuan Huoxue Decoction (复元活血汤) Combined with Natural Copper Pills and Magnetic Therapy on VAS Score and Expressions of Serum Collagen, miR-188 and miR-206 in Elderly Patients with Distal Radius Fracture[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (8) : 28 -32 . DOI: 10.13193/j.issn.1673-7717.2026.08.006

基金

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国家自然科学基金项目(81801213)

参考文献

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2026年第44卷第8期

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doi: 10.13193/j.issn.1673-7717.2026.08.006

首发时间：2026-10-20
出版时间：2026-08-10

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国家自然科学基金项目(81801213)

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南京中医药大学连云港附属医院，连云港市中医院，江苏　连云港　222000

通讯作者:

夏阳（1987-），男，江苏连云港人，副主任中医师，学士，研究方向：中医骨伤。E-mail：52399678@qq.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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