Article(id=1319291447954751735, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.08.031, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473192442, onlineDateStr=2026-10-20, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473192442, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473192442, creator=13701087609, updateTime=1792473192442, updator=13701087609, issue=Issue{id=1319291312826863771, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473160225, creator='13701087609', updateTime=1792473382588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292245547799195, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292245652656796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=149, endPage=152, ext={EN=ArticleExt(id=1319291448177049848, articleId=1319291447954751735, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Pharmacological Effects and Mechanism of Kaempferide, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Kaempferide, as one of the active ingredients in many traditional Chinese medicines, has a wide range of pharmacological effects in various systems. Its mechanisms include inhibiting the proliferation of cancer cells by inducing apoptosis; exerting a neuroprotective effect by increasing the concentration of brain-derived neurotrophic factor and alleviating oxidative stress responses; reducing oxidative stress responses by enhancing the expression of antioxidant genes and inhibiting the release of reactive oxygen species; resisting photoaging by inhibiting the expressions of pro-inflammatory factors, playing a protective role in the heart by exerting anti-inflammatory, antioxidant and anti-apoptotic effects; protecting the kidneys by inhibiting the overexpression of HMGCS2 in renal tubular epithelial cells and alleviating renal interstitial fibrosis. This article comprehensively summarized the pharmacological effects and mechanism studies of kaempferide based on relevant literature in recent years, aiming to provide a theoretical basis for the further development of kaempferide into a monomer drug.

, authors=Yingying GAN, Min HU, Jingyi CHENG, Zhi CHAI, Huijie FAN, authorsList=Yingying GAN, Min HU, Jingyi CHENG, Zhi CHAI, Huijie FAN, authorCompany=null, correspAuthors=Huijie FAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291448529371385, articleId=1319291447954751735, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=山柰素的药理作用及其机制研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

山柰素（Kaempferide，KFD）作为许多中药的活性成分之一，在各个系统具有广泛的药理作用，其机制包括通过诱导细胞凋亡来抑制癌细胞增殖；通过提高脑源性神经营养因子的浓度和减轻氧化应激反应来起到神经保护作用；通过增强抗氧化基因的表达和抑制活性氧的释放来减轻氧化应激反应；通过抑制促炎因子的表达来抗光老化；通过抗炎、抗氧化、抗凋亡发挥对心脏的保护作用；通过抑制肾小管上皮细胞3-羟基-3-甲基戊二酰辅酶A合酶2的过度表达，减轻肾间质纤维化，来发挥对肾脏的保护作用等。综合近年来相关文献，对山柰素的药理作用及其机制研究进行总结，以期为山柰素进一步开发成为单体药物提供理论依据。

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甘颖盈（2000-），女，四川广安人，硕士，研究方向：神经系统疾病的中西医结合研究。

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甘颖盈（2000-），女，四川广安人，硕士，研究方向：神经系统疾病的中西医结合研究。

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