Article(id=1319291402819847049, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.08.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473181680, onlineDateStr=2026-10-20, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473181680, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473181680, creator=13701087609, updateTime=1792473181680, updator=13701087609, issue=Issue{id=1319291312826863771, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473160225, creator='13701087609', updateTime=1792473382588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292245547799195, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292245652656796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=97, endPage=100, ext={EN=ArticleExt(id=1319291403021173642, articleId=1319291402819847049, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Exploring Mechanism of Danhong Injection (丹红注射液) Treating Acute Cerebral Infarction Through SDF-1/CXCR4 Signaling Pathway, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the mechanism of Danhong Injection (丹红注射液) in the treatment of the patients with acute cerebral infarction through the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway.
Methods A total of 104 patients with acute cerebral infarction admitted to Tianjin Fourth Central Hospital from March 2024 to March 2025 were selected. A single-center randomized double-blind controlled trial design was adopted, and they were divided into the control group and the observation group by the random number table method, with 52 cases in each group. The control group was given alteplase, and the observation group was treated with Danhong Injection on the basis of the treatment of the control group. Both groups were given symptomatic treatment for one 10 consecutive days. After 10 days of treatment, the SDF-1/CXCR4 signaling pathways and modified Rankin scale (mRS) scores of the two groups before and after treatment were compared, and the therapeutic effects and adverse reactions of the two groups were recorded.
Results The total effective rate of the observation group was 98.08%, which was higher than that (86.54%) of the control group (P<0.05). Before treatment, the levels of SDF-1 and CXCR4 in the two groups were not significant (P>0.05). After the treatment, the levels of SDF-1 and CXCR4 in the observation group were lower than those in the control group (P<0.05). Before treatment, the mRS scores of the two groups were not significant (P>0.05). After the treatment, the mRS score of the observation group was lower than that of the control group (P<0.05).
Conclusion Danhong Injection can exert its therapeutic effect on acute cerebral infarction through the SDF-1/CXCR4 signaling pathway, with obvious curative effect and worthy of clinical promotion and application.
, authors=Yumei HE, Yu GENG, Fang WANG, Lujing ZHAO, authorsList=Yumei HE, Yu GENG, Fang WANG, Lujing ZHAO, authorCompany=null, correspAuthors=Lujing ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291403390272395, articleId=1319291402819847049, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=通过SDF-1/CXCR4信号通路探讨丹红注射液治疗急性脑梗死作用机制, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 通过基质细胞衍生因子-1（stromal cell-derived factor-1，SDF-1）/特异性受体CXC型趋化因子受体4（CXC chemokine receptor-4，CXCR4）信号通路探讨丹红注射液治疗急性脑梗死患者的作用机制。
方法 选取2024年3月—2025年3月天津市第四中心医院收治的104例急性脑梗死患者，采用单中心随机双盲对照试验设计，采用随机数字表法分为对照组和观察组，每组52例。对照组给予阿替普酶，观察组在对照组治疗的基础上给予丹红注射液治疗，两组均给予对症治疗，连续10 d。治疗10 d，对比治疗前后两组SDF-1/CXCR4信号通路及mRS评分，记录两组疗效及不良反应。
结果 观察组总有效率98.08%（51/52），高于对照组86.54%（45/51）（P<0.05）。治疗前，两组SDF-1、CXCR4水平比较差异无统计学意义（P>0.05）；治疗后，观察组SDF-1、CXCR4水平低于对照组（P<0.05）。治疗前，两组mRS评分比较差异无统计学意义（P>0.05）；治疗后，观察组mRS评分低于对照组（P<0.05）。
结论 丹红注射液能够通过SDF-1/CXCR4信号通路发挥治疗急性脑梗死的作用，疗效明显，值得临床推广应用。
, authors=何玉梅, 耿瑜, 王芳, 赵路静, authorsList=何玉梅, 耿瑜, 王芳, 赵路静, authorCompany=null, correspAuthors=赵路静, authorNote=
何玉梅（1983-），女，河北沧州人，主治医师，硕士，研究方向：急诊危重症。
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