中华中医药学刊

论黄连在溃疡性结肠炎治疗中的应用

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周恩慧 , 王振亮 , 许菲斐

中华中医药学刊 | 国家项目点击 2026,44(8): 140-144

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中华中医药学刊 |国家项目点击 2026 , 44 (8) : 140 -144

论黄连在溃疡性结肠炎治疗中的应用

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周恩慧, 王振亮, 许菲斐

作者信息

河南中医药大学，河南　郑州　450046

通讯作者:

王振亮（1965-），男，河南林州人，教授、主任医师，博士研究生导师，博士后，研究方向：仲景理法方药防治风湿免疫疾病。E-mail：654467475@qq.com。

许菲斐（1987-），女（回族），河南郑州人，副教授，博士，研究方向：卫生事业管理。E-mail：xufeifei198710@163.com。

作者简介:

周恩慧（1996-），女，河南长垣人，博士在读，研究方向：仲景理法方药防治风湿免疫疾病。

On Application of Huanglian (Coptidis Rhizoma) in Treatment of Ulcerative Colitis

Enhui ZHOU, Zhenliang WANG, Feifei XU

Affiliations

Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China

出版时间: 2026-08-10 doi: 10.13193/j.issn.1673-7717.2026.08.029

文章导航

摘要

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溃疡性结肠炎（Ulcerative colitis，UC）是临床常见的肠胃病，属于中医学“痢疾”的范畴，湿热浊毒内蕴是导致本病反复发作、缠绵不愈的关键。古方以黄连为治痢之最，黄连清热燥湿、泻火解毒之功切合病机。研究表明，黄连在单独应用时能有效减轻症状，而与其他中药配伍应用时能更好地发挥其药效。黄连常与黄芩、黄柏等清热药配伍，以加强清热燥湿之功，治疗一切湿热痢；常与当归、白芍、阿胶等和血药同用，养阴化热，治疗阴虚痢；常与木香、厚朴、陈皮、枳壳等理气药配伍，调气除痛，治疗气滞痢；常与干姜、吴茱萸之温里药配伍，寒热并用，调和阴阳，治疗冷热痢。此外，从虚寒慎用、虚热妄用、中病即止、食物禁忌四个方面探讨了黄连在UC中应用的注意事项。

关键词

黄连 / 溃疡性结肠炎 / 痢疾

Abstract

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Ulcerative colitis (UC) is a common gastrointestinal disease in clinic, which belongs to the category of “dysentery” in traditional Chinese medicine. The connotation of damp-heat and turbid toxin is the key to the recurrence and lingering of UC. In ancient prescriptions, Huanglian (Coptidis Rhizoma) is the best treatment for dysentery, and its functions of clearing heat and drying dampness, purging fire and detoxifying are in line with the pathogenesis. Studies have shown that Huanglian (Coptidis Rhizoma) can effectively relieve symptoms when used alone, but it can better exert its efficacy when used in combination with other Chinese medicines. Huanglian (Coptidis Rhizoma) is often combined with Huangqin (Scutellariae Radix) and Huangbo (Phellodendri Chinensis Cortex) which are heat-clearing drugs to strengthen the function of clearing heat and drying dampness and treat all damp-heat dysentery. It is often used with blood drugs such as Danggui (Angelicae Sinensis Radix), Baishɑo (Paeoniae Radix Alba) and Ejiɑo (Asini Corii Colla) to nourish Yin and remove heat, and treat dysentery due to Yin deficiency. It is often combined with Qi-regulating drugs such as Muxiang (Aucklandiae Radix), Houpo (Magnoliae Officinalis Cortex), Chenpi (Citri Reticulatae Pericarpium) and Zhiqiɑo (Aurantii Fructus) to regulate Qi and relieve pain and treat Qi-stagnation dysentery. It is often combined with drugs for warming the interior like Ganjiang (Zingiberis Rhizoma) and Wuzhuyu (Euodiae Fructus), which can be used for both cold and heat to harmonize Yin and Yang and treat cold and heat dysentery. In addition, this paper discussed the matters needing attention in the application of Huanglian (Coptidis Rhizoma) in UC from four aspects: cautious use of deficiency cold, improper use of deficiency heat, stopping when and food taboos.

Key words

Huanglian (Coptidis Rhizoma) / ulcerative colitis / dysentery

引用本文

周恩慧, 王振亮, 许菲斐. 论黄连在溃疡性结肠炎治疗中的应用. 中华中医药学刊, 2026 , 44 (8) : 140 -144 . DOI: 10.13193/j.issn.1673-7717.2026.08.029

Enhui ZHOU, Zhenliang WANG, Feifei XU. On Application of Huanglian (Coptidis Rhizoma) in Treatment of Ulcerative Colitis[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (8) : 140 -144 . DOI: 10.13193/j.issn.1673-7717.2026.08.029

基金

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国家自然科学基金项目(82274496)
国家中医药管理局科技司“张仲景传承与创新专项”(GZY-KJS-2022-044-1)
河南省重点研发专项-基于仲景症机辨治的AI辅助诊疗平台研发及应用项目(14105167-2023)
河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-16)
郑州市协同创新专项(2023XTCX049)

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2026年第44卷第8期

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doi: 10.13193/j.issn.1673-7717.2026.08.029

首发时间：2026-10-20
出版时间：2026-08-10

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国家自然科学基金项目(82274496)

国家中医药管理局科技司“张仲景传承与创新专项”(GZY-KJS-2022-044-1)

河南省重点研发专项-基于仲景症机辨治的AI辅助诊疗平台研发及应用项目(14105167-2023)

河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-16)

郑州市协同创新专项(2023XTCX049)

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河南中医药大学，河南　郑州　450046

通讯作者:

王振亮（1965-），男，河南林州人，教授、主任医师，博士研究生导师，博士后，研究方向：仲景理法方药防治风湿免疫疾病。E-mail：654467475@qq.com。

许菲斐（1987-），女（回族），河南郑州人，副教授，博士，研究方向：卫生事业管理。E-mail：xufeifei198710@163.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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