Article(id=1319291220136932213, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.09.020, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473138126, onlineDateStr=2026-10-20, pubDate=1788969600000, pubDateStr=2026-09-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473138126, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473138126, creator=13701087609, updateTime=1792473138126, updator=13701087609, issue=Issue{id=1319291166823142311, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='9', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1788969600000', pubDateStr='2026-09-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792473125414, creator='13701087609', updateTime=1792473357559, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292140618896016, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292140618896017, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=113, endPage=116, ext={EN=ArticleExt(id=1319291220342453110, articleId=1319291220136932213, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Efficacy of Modified Sini Decoction (四逆汤加减) on Lumbar Spinal Stenosis of Yang Deficiency and Cold Coagulation Type, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the clinical efficacy of Modified Sini Decoction (四逆汤加减) in the treatment of Yang deficiency and cold coagulation type of lumbar spinal stenosis.
Methods Ninety-seven patients with lumbar spinal stenosis of Yang deficiency and cold coagulation type in the hospital were selected from April 2021 to April 2024, and were randomly divided into traditional Chinese medicine group (49 cases) and control group (48 cases). The control group was treated with western medicine, while the traditional Chinese medicine group was given Modified Sini Decoction on the basis of the control group. During treatment, 8 patients in the traditional Chinese medicine group and 6 patients in the control group fell off. The efficacy was evaluated, and the traditional Chinese medicine symptom scores, Japanese Orthopedic Association (JOA) lumbar function scale, Oswestry dysfunction index (ODI), oxidative stress indicators, inflammatory factors and adverse reactions were statistically analyzed before and after treatment.
Results The total effective rate in the traditional Chinese medicine group was 95.12% and that in the control group was 80.95%, and the total effective rate in traditional Chinese medicine group was higher (P<0.05). After treatment, the traditional Chinese medicine symptom scores and ODI scores in both groups was decreased while the JOA score was increased (P<0.05), and serum superoxide dismutase level was risen while the levels of serum advanced oxidation protein products and malondialdehyde were reduced (P<0.05), and the levels of serum interleukin-1α, interleukin-6 and tumor necrosis factor-α were declined (P<0.05), and the improvements in traditional Chinese medicine group were greater (P<0.05). There were no obvious differences in the incidence rates of adverse reactions between control group and traditional Chinese medicine group (P>0.05).
Conclusion Modified Sini Decoction has significant efficacy in treating sedentariness-induced lumbar spinal stenosis (Yang deficiency and cold coagulation type). It has obvious advantages in improving lumbar function and relieving oxidative stress and inflammatory response, and has good safety.
, authors=Yiyu FANG, Gang DONG, Dong WANG, Dong XIANG, Junhua LI, Hui ZHOU, authorsList=Yiyu FANG, Gang DONG, Dong WANG, Dong XIANG, Junhua LI, Hui ZHOU, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291220707357559, articleId=1319291220136932213, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=四逆汤加减治疗阳虚寒凝型腰椎管狭窄症临床观察, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探究四逆汤加减治疗阳虚寒凝型腰椎管狭窄症的临床疗效。
方法 选择2021年4月—2024年4月医院收治的阳虚寒凝型腰椎管狭窄症患者97例。随机分组为中药组49例与对照组48例。对照组予以西医治疗，中药组在对照组治疗基础上口服四逆汤加减治疗。治疗过程中，中药组患者脱落8例，对照组患者脱落6例。评价疗效，并对治疗前后中医症状评分、日本骨科协会（Japanese Orthopaedic Association，JOA）评分、Oswestry功能障碍指数（Oswestry disability index，ODI）、氧化应激指标、炎症因子水平以及不良反应情况进行统计分析。
结果 中药组治疗总有效率为95.12%，对照组治疗总有效率为80.95%，两组中中药组更高（P<0.05）；两组患者治疗后的中医症状评分、ODI评分均降低而JOA评分均升高（P<0.05），血清超氧化物歧化酶水平均升高而血清氧化蛋白产物、丙二醛水平均降低（P<0.05），血清白细胞介素1α、白细胞介素6、肿瘤坏死因子α均降低（P<0.05），且两组中中药组改善幅度更大（P<0.05）；对照组和中药组不良反应发生率无统计学意义（P>0.05）。
结论 四逆汤加减治疗久坐引起的腰椎管狭窄症（阳虚寒凝型）疗效显著，在改善患者腰椎功能和减轻患者氧化应激、炎症反应方面具有明显优势，安全性好。
, authors=方宜宥, 董刚, 王栋, 项东, 李俊华, 周辉, authorsList=方宜宥, 董刚, 王栋, 项东, 李俊华, 周辉, authorCompany=null, correspAuthors=null, authorNote=
方宜宥（1986-），男，浙江金华人，主治中医师，硕士，研究方向：中医药治疗腰腿痛。
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方宜宥（1986-），男，浙江金华人，主治中医师，硕士，研究方向：中医药治疗腰腿痛。
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方宜宥（1986-），男，浙江金华人，主治中医师，硕士，研究方向：中医药治疗腰腿痛。
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