Article(id=1319291190286078060, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.09.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473131009, onlineDateStr=2026-10-20, pubDate=1788969600000, pubDateStr=2026-09-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473131009, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473131009, creator=13701087609, updateTime=1792473131009, updator=13701087609, issue=Issue{id=1319291166823142311, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='9', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1788969600000', pubDateStr='2026-09-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792473125414, creator='13701087609', updateTime=1792473357559, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292140618896016, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292140618896017, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=25, endPage=31, ext={EN=ArticleExt(id=1319291190479016045, articleId=1319291190286078060, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Mechanism of Action and Clinical Research Progress of Guizhi Shaoyao Zhimu Decoction (桂枝芍药知母汤) Against Rheumatic Disease, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Guizhi Shaoyao Zhimu Decoction (桂枝芍药知母汤, GSZD), originating from Jingui Yaolue (Synopsis of the Golden Chamber), and has the effect of regulating the circulation of three Jiao in the body, balancing cold and heat as well as deficiency and excess, and preventing diseases from developing into the organs. It is widely used in the treatment of rheumatic diseases, especially arthritis related rheumatic diseases. It is widely utilized in the treatment of rheumatic diseases, particularly inflammatory arthritis. This review synthesized the literature from the past two decades, revealing that the anti-rheumatic mechanisms of GSZD primarily involved inhibiting inflammatory responses, modulating immune function, regulating bone metabolism, controlling cellular autophagy, suppressing cell proliferation/apoptosis and intervening in gut microbiota and serum metabolic profiles. Clinically, GSZD demonstrates therapeutic efficacy for multiple rheumatic disorders, including rheumatoid arthritis (RA), gouty arthritis (GA), psoriatic arthritis (PsA), systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS). Additionally, it alleviates rheumatic disease-associated complications such as cardiovascular and cerebrovascular damage, pulmonary complications and pannus formation. When combined with Western medicine, it may reduce adverse drug reactions. Current mechanistic studies face challenges including unidentified bioactive components and insufficient molecular-level investigations. Clinical research is constrained by limitations such as simplified syndrome differentiation patterns, undefined optimal dosage and treatment duration, scarce studies on single-formula preparations and predominance of single-center small-sample trials. Further exploration is warranted to fully elucidate its therapeutic value and potential in rheumatic disease management.

, authors=Xueqin ZHOU¹, Zhina ZHAO², Bingsen WANG³, Shangwen WU², Huan LI^{1, 2}, Songwei LI², authorsList=Xueqin ZHOU, Zhina ZHAO, Bingsen WANG, Shangwen WU, Huan LI, Songwei LI, authorCompany=null, correspAuthors=Songwei LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291190894252142, articleId=1319291190286078060, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=桂枝芍药知母汤抗风湿的作用机制及临床研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

桂枝芍药知母汤源自《金匮要略》，具有营卫同调行三焦之痹、寒热虚实兼顾预防疾病向脏腑发展之效，被广泛用于风湿病的治疗，尤其是关节炎性风湿病。研究整理近20年文献发现，桂枝芍药知母汤抗风湿机制主要涉及抑制炎症反应、调节免疫、影响骨代谢、调控细胞自噬、抑制细胞增殖及凋亡、干涉肠道微生物及血清代谢谱等方面，临床上可用于治疗类风湿关节炎（Rheumatoid arthritis，RA）、痛风性关节炎（gouty arthritis，GA）、银屑病关节炎（psoriatic arthritis，PsA）、系统性红斑狼疮（systemic lupus erythematosus，SLE）、干燥综合征（Sjogren's syndrome，SS）等多种风湿病，且能减轻风湿病相关心脑血管损害、肺部损害、血管翳等并发症，辅助西医可降低不良反应。目前机制研究存在药效成分不明、分子层面研究不足等问题，临床研究也面临证型单一、最佳剂量与疗程未明、单方及剂型研究较少、多为单中心小样本等情况，其在风湿病治疗中的价值与潜力有待深入挖掘。

, authors=周雪琴¹, 赵志娜², 王炳森³, 武上雯², 李桓^{1, 2}, 李松伟², authorsList=周雪琴, 赵志娜, 王炳森, 武上雯, 李桓, 李松伟, authorCompany=null, correspAuthors=李松伟, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=4l5j4XysZXmgFXWr9llaVA==, magXml=HgLo0KEpshYLlPgCD0BEyw==, pdfUrl=null, pdf=Z0JCa16c7g4NqxZIzoTMxQ==, pdfFileSize=1717214, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=z/RZ7yioeQYgZzqcAPO78Q==, mapNumber=null, fund=null)}, authors=[Author(id=1319291191338848377, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291190286078060, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291191443705979, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291190286078060, authorId=1319291191338848377, language=EN, stringName=Xueqin ZHOU, firstName=Xueqin, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291193121427580, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291190286078060, authorId=1319291191338848377, language=CN, stringName=周雪琴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.河南中医药大学第一临床医学院，河南　郑州　450046, bio={"content":"

周雪琴（1997-），女，河南正阳人，博士在读，研究方向：中医药防治风湿免疫疾病。

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周雪琴（1997-），女，河南正阳人，博士在读，研究方向：中医药防治风湿免疫疾病。

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