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Glycosides of Roucongrong (Cistanches Herba) (GCs), as a natural active substance extracted from Roucongrong (Cistanches Herba), show promising applications in the treatment of osteoporosis (OP). In this paper, it reviewed the studies on the mechanisms related to the improvement of OP by GCs. In terms of antioxidant effects, GCs have antioxidant functions, which can scavenge free radicals in the body and reduce the damage of oxidative stress on bones. GCs can inhibit the release of inflammatory mediators and relive inflammatory response, thus reducing the inflammatory response in OP. GCs can promote the proliferation and differentiation of osteoblasts, inhibit osteoclast activity, increase bone density and reduce the risk of fracture. In addition, GCs can directly or indirectly affect osteoblast and osteoclast activity and regulate bone metabolism in vivo by regulating sex hormone levels, regulating the balance of calcium and phosphorus metabolism, etc. GCs can regulate bone metabolism in vivo by regulating the levels of osteoprotegerin (OPG)/receptor activator of nuclear factor-κB ligand (GCs). OPG/receptor activator of nuclear factor-κB ligand (RANKL)/receptor activator of nuclear factor-κB (RANK), Wnt/β-catenin and other signaling pathways, which inhibit bone resorption and promote bone formation. GCs have shown good therapeutic effects in the treatment of OP, and have good safety and tolerability. GCs have significant therapeutic effects and broad application prospects in improving OP, and in-depth research on the pharmacological mechanism of GCs is of great significance, with a view to finding innovative drugs that are safe and effective in the treatment of OP.

, authors=Qiang LI¹, Yihong SUN^{2, 3}, Jiaojiao HUO¹, Hao LI¹, Xue LYU¹, Jianxin JIA^{2, 3}, authorsList=Qiang LI, Yihong SUN, Jiaojiao HUO, Hao LI, Xue LYU, Jianxin JIA, authorCompany=null, correspAuthors=Jianxin JIA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291177485063162, articleId=1319291176927220728, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=肉苁蓉总苷治疗骨质疏松症研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

肉苁蓉总苷（glycosides of cistanche，GCs）作为一种从肉苁蓉中提取的天然活性物质，在治疗骨质疏松症（osteoporosis，OP）方面展现出良好的应用前景。文章综述了GCs改善OP的相关机制研究。在抗氧化作用方面，GCs具有抗氧化功能，可以清除体内的自由基，减轻氧化应激对骨骼的损伤。GCs可以抑制炎症介质的释放，降低炎症反应水平，从而减轻OP的炎症反应。GCs可以促进成骨细胞增殖、分化，抑制破骨细胞活性，增加骨密度，降低骨折风险。此外，GCs可以通过调节性激素水平、调节钙磷代谢平衡等方面，直接或间接影响成骨细胞、破骨细胞活性，调节体内骨代谢。GCs可以通过调节骨保护素（osteoprotegerin，OPG）/核因子-κB受体活化因子配体（receptor activator of nuclear factor-κB lig-and，RANKL）/核因子-κB受体活化因子（receptor activator of nuclear factor-κB，RANK）、Wnt/β-catenin等信号通路，抑制骨吸收，促进骨形成。GCs在临床应用中已显示出良好的治疗OP的效果，且具有良好的安全性和耐受性。GCs在改善OP方面具有显著治疗效果和广阔的应用前景，GCs药理作用机制的深入研究也具有重要意义，以期寻找治疗OP安全、有效的创新药物。

, authors=李强¹, 孙毅红^{2, 3}, 霍娇娇¹, 李浩¹, 吕雪¹, 贾建新^{2, 3}, authorsList=李强, 孙毅红, 霍娇娇, 李浩, 吕雪, 贾建新, authorCompany=null, correspAuthors=贾建新, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=h1EQ9wSIAFDHfdZOmwtzfg==, magXml=wZ3nn+qUWUgLoysA6bvqNQ==, pdfUrl=null, pdf=k5Uhr/eroR3OMaBy01mq0g==, pdfFileSize=1619851, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=kEgBnC0mU52Hl0kqi0jX2A==, mapNumber=null, fund=null)}, authors=[Author(id=1319291177942241284, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291176927220728, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291178017738758, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291176927220728, authorId=1319291177942241284, language=EN, stringName=Qiang LI, firstName=Qiang, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Inner Mongolia University of Science and Technology, Graduate School of Baotou Medical College, Baotou 014040, Inner Mongolia, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291179657711623, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291176927220728, authorId=1319291177942241284, language=CN, stringName=李强, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.内蒙古科技大学包头医学院研究生院，内蒙古　包头　014040, bio={"content":"

李强（1994-），男，内蒙古赤峰人，硕士在读，研究方向：中枢神经系统退行性疾病的防治。

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李强（1994-），男，内蒙古赤峰人，硕士在读，研究方向：中枢神经系统退行性疾病的防治。

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