Article(id=1317133190960104238, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.01.040, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791958623876, onlineDateStr=2026-10-14, pubDate=1767974400000, pubDateStr=2026-01-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791958623876, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791958623876, creator=13701087609, updateTime=1791958623876, updator=13701087609, issue=Issue{id=1317133098966433889, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='1', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1767974400000', pubDateStr='2026-01-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791958601943, creator='13701087609', updateTime=1791958824557, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317134032719171723, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317134032719171724, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=208, endPage=214, ext={EN=ArticleExt(id=1317133191161430831, articleId=1317133190960104238, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Pharmacological Effects and Clinical Application of Main Active Ingredients of Danshen（Salviae Miltiorrhizae Radix et Rhizoma）and Chuanxiong（Chuanxiong Rhizoma）in Treatment of Ischemic Stroke, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=

Ischemic stroke，a prevalent type of cerebrovascular disease，is marked by high incidence and mortality rates，with an alarming trend towards younger demographics in China. In this context，tanshinone ⅡA and tetramethylpyrazine have garnered research attention for their multifaceted therapeutic effects and minimal side effects in treating ischemic stroke. These two traditional Chinese medicinal compounds exhibit similar biological effects，including antioxidant，anti-inflammatory，anti-apoptotic properties，protecting blood-brain barrier and promoting neovascularization effects. They also protect the nervous system by modulating key signaling pathways such as Nrf2/HO-1，NF-κB and PI3K/Akt. Clinical studies have demonstrated significant efficacy and good safety profiles for tanshinone ⅡA and tetramethylpyrazine injections in the treatment of stroke. This article aimed to synthesize the research advancements of tanshinone ⅡA and tetramethylpyrazine in ischemic stroke therapy，offering new perspectives for drug development，mechanistic research and treatment strategies for ischemic stroke.

, authors=Qixiu WANG¹, Wei ZHANG², Hongfei ZHOU^{1, 2}, Jun LIU², authorsList=Qixiu WANG, Wei ZHANG, Hongfei ZHOU, Jun LIU, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317133191438254896, articleId=1317133190960104238, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=丹参川芎两药主要活性成分治疗缺血性脑卒中药理作用及临床应用研究, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=

缺血性脑卒，作为脑血管疾病中的常见类型，其发病率和病死率均高居不下，尤其在中国，患者群体正逐渐年轻化。在这一背景下，丹参酮ⅡA和川芎嗪因其在治疗缺血性脑卒中方面的显著多靶点疗效和较低的不良反应，受到研究者的关注。这两种中药单体不仅在抗氧化、抗炎、抗凋亡、保护血脑屏障和促进新生血管形成等方面展现出相似的生物学效应，还通过调控核因子红细胞2相关因子2（Nrf2）/血红素加氧酶-1（HO-1）、核转录因子-κB（NF-κB）、磷脂酰肌醇3激酶（PI3K）/蛋白激酶B（Akt）等关键信号通路，实现对神经系统的保护。临床研究表明，丹参酮ⅡA类注射液和川芎嗪类注射液在治疗脑卒中方面显示出显著的疗效和良好的安全性。旨在梳理丹参酮ⅡA和川芎嗪在缺血性脑卒中治疗领域的研究进展，为药物的开发和机制研究以及缺血性脑卒中的治疗提供新的视角和思路。

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