中华中医药学刊

强心汤联合益心化浊方对气虚血瘀型慢性心力衰竭临床预后及心功能的影响

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张蓓 ¹ , 李国文 ²

中华中医药学刊 | 国家项目点击 2026,44(1): 63-66

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中华中医药学刊 |国家项目点击 2026 , 44 (1) : 63 -66

强心汤联合益心化浊方对气虚血瘀型慢性心力衰竭临床预后及心功能的影响

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张蓓¹, 李国文²

作者信息

^1.上海中医药大学，上海 201203

^2.上海中医药大学附属上海市中西医结合医院，上海 200082

Effect of Qiangxin Decoction（强心汤）Combined with Yixin Huazhuo Decoction（益心化浊方）on Clinical Prognosis and Cardiac Function of Chronic Heart Failure with Qi Deficiency and Blood Stasis

Bei ZHANG¹, Guowen LI²

Affiliations

^1.Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

^2.Pharmacy Department of Shanghai Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China

出版时间: 2026-01-10 doi: 10.13193/j.issn.1673-7717.2026.01.014

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摘要

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目的

探讨强心汤联合益心化浊方对气虚血瘀型慢性心力衰竭临床预后及心功能的影响。

方法

选择医院2021年3月—2023年1月收治的104例气虚血瘀型慢性心力衰竭患者作为研究对象，患者入院时发放随机信封，按照单双号简单随机方法分为研究组和对照组，每组52例。对照组接受常规西医治疗，研究组在对照组的基础上接受强心汤联合益心化浊方治疗，4周为1个疗程，两组均治疗2个疗程。比较两组临床疗效、治疗前后中医症状积分、心功能指标［血浆N终端脑钠肽（N terminal brain natriuretic peptide，NT-proBNP）、左室舒张末期内径（left ventricular end-diastolic diameter，LVEDD）、左室收缩末期内径（left ventricular end-systolic diameter，LVESD）、左室射血分数（left ventricular ejection fraction，LVEF）］、血管内皮细胞功能［内皮素-1（endothelin-1，ET-1）、一氧化氮（nitric oxide，NO）］，并比较两组不良反应情况。

结果

研究组总有效率为80.77%（42/52），明显高于对照组（61.54%，32/52），差异具有统计学意义（P<0.05）；两组治疗后气短乏力、心悸、胸闷胸痛以及下肢水肿积分均明显低于治疗前（P<0.05），研究组明显低于对照组（P<0.05）；治疗后两组LVEDD、LVESD、NT-proBNP均低于治疗前，研究组明显低于对照组（P<0.05），两组LVEF均高于治疗前，研究组高于对照组（P<0.05）；治疗后两组NO均明显高于治疗前，ET-1均明显低于治疗前，研究组较对照组变化更加明显（P<0.05），两组治疗期间不良反应发生情况差异无统计学意义（P>0.05）。

结论

强心汤联合益心化浊方治疗气虚血瘀型慢性心力衰竭可明显提升治疗疗效，改善患者心功能，且具有较高的安全性，适合推广应用。

关键词

强心汤 / 益心化浊方 / 气虚血瘀型 / 慢性心力衰竭 / 预后 / 心功能 / 血管内皮细胞功能

Abstract

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Objective

To investigate the effect of Qiangxin Decoction（强心汤）combined with Yixin Huazhuo Decoction（益心化浊方）on clinical prognosis and cardiac function of chronic heart failure with Qi deficiency and blood stasis.

Methods

A total of 104 patients with chronic heart failure with Qi deficiency and blood stasis admitted to the hospital from March 2021 to January 2023 were selected as research objects. The patients were given random envelopes upon admission and divided into study group and control group with 52 cases in each group according to odd-even simple random method. The control group received conventional Western medicine treatment. Qiangxin Decoction and Yixin Huazhuo Decoction were used for 1 course of treatment（4 weeks），and both groups were treated for 2 courses of treatment. The clinical efficacy，TCM symptom scores before and after treatment，cardiac function indexes［N terminal brain natriuretic peptide（NT-pro BNP），left ventricular end-diastolic diameter（LVEDD），left ventricular end-systolic diameter（LVESD），left ventricular ejection fraction（LVEF）］，vascular endothelial cell function［endothelin-1（ET-1），nitric oxide（NO）］and adverse reactions in the two groups were compared.

Results

The total effective rate of the study group was 80.77%（42/52），which was significantly higher than that of the control group（61.54%，32/52），with statistical significance（P<0.05）. After treatment，the scores of shortness of breath，palpitation，chest tightness，chest pain and lower limb edema were significantly lower in both groups than those before treatment（P<0.05），and those in the study group were significantly lower than those in the control group（P<0.05）. After treatment，the levels of LVEDD，LVESD and NT-proBNP in both groups were lower than those before treatment，and the levels of the study group were significantly lower than those of the control group（P<0.05）. The levels of LVEF in both groups were higher than those before treatment，and the level of LVEF of the study group was higher than that of the control group（P<0.05）. After treatment，the levels of NO in both groups were significantly higher than those before treatment，the levels of ET-1 were significantly lower than those before treatment，and the change in the study group was more obvious than that in the control group（P<0.05），and there was no significant difference in the occurrence of adverse reactions between the two groups during treatment（P>0.05）.

Conclusion

Qiangxin Decoction combined with Yixin Huazhuo Decoction can significantly improve the therapeutic effect and cardiac function of patients with chronic heart failure with Qi deficiency and blood stasis and has a high safety，suitable for popularization and application.

Key words

Qiangxin Decoction（强心汤） / Yixin Huazhuo Decoction（益心化浊方） / Qi deficiency and blood stasis type / chronic heart failure / prognosis / heart function / vascular endothelial cell function

引用本文

张蓓, 李国文. 强心汤联合益心化浊方对气虚血瘀型慢性心力衰竭临床预后及心功能的影响. 中华中医药学刊, 2026 , 44 (1) : 63 -66 . DOI: 10.13193/j.issn.1673-7717.2026.01.014

Bei ZHANG, Guowen LI. Effect of Qiangxin Decoction（强心汤）Combined with Yixin Huazhuo Decoction（益心化浊方）on Clinical Prognosis and Cardiac Function of Chronic Heart Failure with Qi Deficiency and Blood Stasis[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (1) : 63 -66 . DOI: 10.13193/j.issn.1673-7717.2026.01.014

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2026年第44卷第1期

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doi: 10.13193/j.issn.1673-7717.2026.01.014

首发时间：2026-10-14
出版时间：2026-01-10

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^1.上海中医药大学，上海 201203

^2.上海中医药大学附属上海市中西医结合医院，上海 200082

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科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
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