Article(id=1317125639732318394, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.02.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956823522, onlineDateStr=2026-10-14, pubDate=1770652800000, pubDateStr=2026-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956823522, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956823522, creator=13701087609, updateTime=1791956823522, updator=13701087609, issue=Issue{id=1317125500041015883, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='2', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956790217, creator='13701087609', updateTime=1791958795145, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133909368877755, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133909373072060, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=80, endPage=84, ext={EN=ArticleExt(id=1317125639912673467, articleId=1317125639732318394, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress of Qing'e Pill（青娥丸）in Regulating Bone Metabolism to Treat Osteoporosis, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Osteoporosis（OP）has complex etiology and its incidence is on the rise. Delayed treatment will increase the risk of fractures and other complications. Qing'e Pill（青娥丸）is an effective prescription for treating kidney-deficiency low back pain. Its formulation has few ingredients but specific effects，with the functions of warming and tonifying kidney Yang，securing the essence and nourishing blood，tonifying liver and kidney，and strengthening muscles and bones. Modern pharmacological studies have shown that Duzhong（Eucommiae Cortex），Buguzhi（Psoraleae Fructus），Hetaoren（Juglandis Semen）and Dasuan（Allii Sativi Bulbus）in the prescription all have the effect of treating OP. As a traditional Chinese medicine compound，Qing'e Pill has the characteristics of “multi-component and multi-target”. For the treatment of OP，it can exert the estrogen-like effects，promote the bone formation，inhibit the bone resorption，affect the intestinal flora and inhibit the ferroptosis. Clinical studies have shown that Qing’e Pill can improve the clinical symptoms of OP. This article elaborated on the regulatory effect and research status of Qing’e Pill on bone metabolism in OP research from the aspects of the pharmacological mechanism of each ingredient of Qing’e Pill，the overall pharmacological mechanism and clinical research，in order to provide reference for the research and development of anti-osteoporosis drugs and the scientific understanding，inheritance and development of traditional Chinese medicine.

, authors=Xilan MA^{1, 2}, Lifu YUAN², Xiaonan QI³, Jiaxuan ZHAO², Zhong CHAI², Jian ZHANG², Xu LIANG², Shixuan WANG², authorsList=Xilan MA, Lifu YUAN, Xiaonan QI, Jiaxuan ZHAO, Zhong CHAI, Jian ZHANG, Xu LIANG, Shixuan WANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125640290160828, articleId=1317125639732318394, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=青娥丸调控骨代谢治疗骨质疏松的研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

骨质疏松症（osteoporosis，OP）病因复杂，且发病率呈上升趋势，延误治疗会增加骨折等风险。青娥丸为治疗肾虚腰痛良方，其组方味少效专，具有温补肾阳、固精养血、补肝益肾、强筋壮骨的功效。现代药理学研究表明，方中杜仲、补骨脂、核桃仁和大蒜均具有治疗OP的作用。青娥丸作为中药复方，具有“多组分、多靶点”的特点，针对OP的治疗，能发挥雌激素样作用、促进骨形成、抑制骨吸收、影响肠道菌群和抑制铁死亡等。临床研究显示青娥丸可改善OP的临床症状。从青娥丸各味药的药理作用机制，整体药理学作用机制以及临床研究方面，阐述了青娥丸在OP研究中对于骨代谢的调控作用及研究现状，以期本方能为治疗OP药物的研发以及科学认识、传承和发展中医药提供参考和借鉴。

, authors=马熙蘭^{1, 2}, 袁立夫², 戚晓楠³, 赵佳萱², 柴忠², 张健², 梁旭², 王世轩², authorsList=马熙蘭, 袁立夫, 戚晓楠, 赵佳萱, 柴忠, 张健, 梁旭, 王世轩, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=PglZyx/fjwFHfBELrdR+OA==, magXml=GAqnpFZK5lz16od6XrkxOg==, pdfUrl=null, pdf=OLo03qeBA9GT2mdLdGeU4Q==, pdfFileSize=1754358, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=5WU3rGA1LKm9OS+eT4Mriw==, mapNumber=null, fund=null)}, authors=[Author(id=1319631030831661458, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319631030915547541, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631030831661458, language=EN, stringName=Xilan MA, firstName=Xilan, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China
^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319631030995239318, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631030831661458, language=CN, stringName=马熙蘭, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.辽宁中医药大学，辽宁沈阳 110847
^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319631030542254472, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=1., ext=[AuthorCompanyExt(id=1319631030550643081, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030542254472, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China), AuthorCompanyExt(id=1319631030559031690, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030542254472, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.辽宁中医药大学，辽宁沈阳 110847)]), AuthorCompany(id=1319631030630334859, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=2., ext=[AuthorCompanyExt(id=1319631030638723468, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China), AuthorCompanyExt(id=1319631030647112077, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034)])]), Author(id=1319631031074931096, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319631031142039962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031074931096, language=EN, stringName=Lifu YUAN, firstName=Lifu, middleName=null, lastName=YUAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319631031217537435, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031074931096, language=CN, stringName=袁立夫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319631030630334859, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=2., ext=[AuthorCompanyExt(id=1319631030638723468, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China), AuthorCompanyExt(id=1319631030647112077, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034)])]), Author(id=1319631031297229213, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319631031381115295, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031297229213, language=EN, stringName=Xiaonan QI, firstName=Xiaonan, middleName=null, lastName=QI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110032，Liaoning，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319631031448224160, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031297229213, language=CN, stringName=戚晓楠, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.辽宁中医药大学附属医院，辽宁沈阳 110032, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319631030726803854, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=3., ext=[AuthorCompanyExt(id=1319631030730998159, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030726803854, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110032，Liaoning，China), AuthorCompanyExt(id=1319631030739386768, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030726803854, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.辽宁中医药大学附属医院，辽宁沈阳 110032)])]), Author(id=1319631031527915938, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319631031595024804, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031527915938, language=EN, stringName=Jiaxuan ZHAO, firstName=Jiaxuan, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319631031666327973, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031527915938, language=CN, stringName=赵佳萱, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319631030630334859, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=2., ext=[AuthorCompanyExt(id=1319631030638723468, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China), AuthorCompanyExt(id=1319631030647112077, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034)])]), Author(id=1319631031741825447, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319631031808934313, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031741825447, language=EN, stringName=Zhong CHAI, firstName=Zhong, middleName=null, lastName=CHAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319631031884431786, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031741825447, language=CN, stringName=柴忠, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319631030630334859, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=2., ext=[AuthorCompanyExt(id=1319631030638723468, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China), AuthorCompanyExt(id=1319631030647112077, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034)])]), Author(id=1319631031968317868, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319631032094146990, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031968317868, language=EN, stringName=Jian ZHANG, firstName=Jian, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319631032173838767, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631031968317868, language=CN, stringName=张健, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319631030630334859, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=2., ext=[AuthorCompanyExt(id=1319631030638723468, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China), AuthorCompanyExt(id=1319631030647112077, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034)])]), Author(id=1319631032236753329, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319631032320639411, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631032236753329, language=EN, stringName=Xu LIANG, firstName=Xu, middleName=null, lastName=LIANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319631032379359668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631032236753329, language=CN, stringName=梁旭, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319631030630334859, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=2., ext=[AuthorCompanyExt(id=1319631030638723468, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China), AuthorCompanyExt(id=1319631030647112077, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034)])]), Author(id=1319631032454857142, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319631034115801528, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631032454857142, language=EN, stringName=Shixuan WANG, firstName=Shixuan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319631034187104697, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, authorId=1319631032454857142, language=CN, stringName=王世轩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319631030630334859, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=2., ext=[AuthorCompanyExt(id=1319631030638723468, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China), AuthorCompanyExt(id=1319631030647112077, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034)])])], keywords=[Keyword(id=1319631034333905338, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, language=EN, orderNo=1, keyword=Qing’e Pill（青娥丸）), Keyword(id=1319631034401014203, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, language=EN, orderNo=2, keyword=osteoporosis), Keyword(id=1319631034480705980, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, language=EN, orderNo=3, keyword=bone metabolism), Keyword(id=1319631034577174973, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, language=EN, orderNo=4, keyword=mechanism of action), Keyword(id=1319631034652672446, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, language=CN, orderNo=1, keyword=青娥丸), Keyword(id=1319631034728169919, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, language=CN, orderNo=2, keyword=骨质疏松), Keyword(id=1319631034799473088, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, language=CN, orderNo=3, keyword=骨代谢), Keyword(id=1319631034874970561, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, language=CN, orderNo=4, keyword=作用机制)], refs=[Reference(id=1319631034979828162, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［1］, rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=REID I R，BILLINGTON E O. Drug therapy for osteoporosis in older adults［J］. Lancet，2022，399（10329）：1080-1092., articleTitle=null, refAbstract=null), Reference(id=1319631035059519939, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［2］, rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=ANAM A K，INSOGNA K. Update on osteoporosis screening and management［J］. Med Clin North Am，2021，105（6）：1117-1134., articleTitle=null, refAbstract=null), Reference(id=1319631035122434500, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［3］, rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=CAO G，HU S Q，NING Y，et al. Traditional Chinese medicine in osteoporosis：from pathogenesis to potential activity［J］. Front Pharmacol，2024，15：1370900., articleTitle=null, refAbstract=null), Reference(id=1319631035223097797, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［4］, rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=梁伟乔，钟诚，李宇明.骨质疏松症的中医病因病机认识与治疗进展［J］.中国骨质疏松杂志，2020，26（1）：135-139., articleTitle=null, refAbstract=null), Reference(id=1319631035306983878, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［5］, rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=谢雁鸣，刘峘，姜俊杰，等.绝经后骨质疏松症中医临床实践指南（征求意见稿）［J］.中国中药杂志，2021，46（22）：5992-5998., articleTitle=null, refAbstract=null), Reference(id=1319631035382481351, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［6］, rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=孙坤坤，韩学超，孙娜，等.青娥丸治疗绝经后骨质疏松症的作用机制［J］.中国骨质疏松杂志，2022，28（5）：776-780., articleTitle=null, refAbstract=null), Reference(id=1319631035445395912, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［7］, rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=彭孟凡，刘保松，闫培培，等.杜仲的化学成分、药理作用、质量控制现状及质量标志物预测分析［J］.中国中药杂志，2025，50（4）：946-958., articleTitle=null, refAbstract=null), Reference(id=1319631035512504777, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［8］, rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=SONG J Y，ZHANG Y F，ZHU Y F，et al. Structural characterization and anti-osteoporosis effects of polysaccharide purified from Eucommia ulmoides Oliver cortex based on its modulation on bone metabolism［J］. Carbohydr Polym，2023，306：120601., articleTitle=null, refAbstract=null), Reference(id=1319631035592196554, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［9］, rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=兰波，刘亭，谢玉敏，等.两种杜仲黄酮类化合物对成骨细胞OPG/RANKL及成骨相关转录因子的影响［J］.中国实验方剂学杂志，2014，20（22）：180-184., articleTitle=null, refAbstract=null), Reference(id=1319631035663499723, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［10］, rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN L，HUANG X F，LI X C，et al. Geniposide promotes the proliferation and differentiation of MC3T3-E1 and ATDC5 cells by regulation of microRNA-214［J］. Int Immunopharmacol，2020，80：106121., articleTitle=null, refAbstract=null), Reference(id=1319631035764163020, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［11］, rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG R，PAN Y L，HU S J，et al. Effects of total lignans from Eucommia ulmoides barks prevent bone loss in vivo and in vitro［J］. J Ethnopharmacol，2014，155（1）：104-112., articleTitle=null, refAbstract=null), Reference(id=1319631035835466189, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［12］, rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=杨秀伟，许青霞，吕倩，等.补骨脂化学成分研究进展［J］.中国现代中药，2024，26（4）：733-748., articleTitle=null, refAbstract=null), Reference(id=1319631035940323790, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［13］, rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=杨琳，曾英，李劲平，等.补骨脂素对去势雌鼠E₂、ER_β、TNF-α、IL-17的影响［J］.中国骨质疏松杂志，2016，22（4）：387-392，395., articleTitle=null, refAbstract=null), Reference(id=1319631036003238351, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［14］, rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=LI F M，LI Q H，HUANG X Q，et al. Psoralen stimulates osteoblast proliferation through the activation of nuclear factor-κB-mitogen-activated protein kinase signaling［J］. Exp Ther Med，2017，14（3）：2385-2391., articleTitle=null, refAbstract=null), Reference(id=1319631036137456080, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［15］, rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=CHAI L J，ZHOU K，WANG S X，et al. Psoralen and bakuchiol ameliorate M-CSF plus RANKL-induced osteoclast differentiation and bone resorption via inhibition of AKT and AP-1 pathways in vitro［J］. Cell Physiol Biochem，2018，48（5）：2123-2133., articleTitle=null, refAbstract=null), Reference(id=1319631036254896593, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［16］, rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=张有为，黄晨，黄廷锐，等.异补骨脂素介导BMP2/Runx2/Os_x信号通路促进成骨细胞增殖和分化的研究［J］.世界科学技术-中医药现代化，2023，25（8）：2677-2683., articleTitle=null, refAbstract=null), Reference(id=1319631036351365586, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［17］, rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=王军，王剑，鲁敏，等.异补骨脂素通过PPAR-γ-Axin2-Wnt信号通路调节对大鼠骨代谢的影响［J］.世界中医药，2021，16（9）：1413-1416., articleTitle=null, refAbstract=null), Reference(id=1319631036485583315, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［18］, rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU X，XU X S，LIJP，et al. Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-κB/NFATc1 signaling pathway in BMMs cells［J］. Biosci Biotechnol Biochem，2023，87（9）：960-971., articleTitle=null, refAbstract=null), Reference(id=1319631036607218132, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［19］, rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=王健，张驰.基于Wnt/β-连环素通路探讨补骨脂素对骨质疏松症大鼠的影响［J］.世界中医药，2022，17（12）：1697-1702., articleTitle=null, refAbstract=null), Reference(id=1319631036770795989, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［20］, rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=魏晨旭，朱星宇，陆金兰，等.补骨脂二氢黄酮甲醚对破骨细胞分化的影响及机制［J］.中国骨质疏松杂志，2022，28（7）：942-947., articleTitle=null, refAbstract=null), Reference(id=1319631036942762454, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［21］, rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=YU A X，XU M L，YAO P，et al. Corylin，a flavonoid derived from Psoralea Fructus，induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways［J］. FASEB J，2020，34（3）：4311-4328., articleTitle=null, refAbstract=null), Reference(id=1319631038637261272, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［22］, rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=ELSIED M A，SHARAW I Z W，AL-AMRAH H，et al. Walnut kernel oil and defatted extracts enhance mesenchymal stem cell stemness and delay senescence［J］. Molecules，2023，28（17）：6281., articleTitle=null, refAbstract=null), Reference(id=1319631038763090393, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［23］, rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=张成明，刘绍鹏，胡润红，等.大蒜活性成分及药理作用研究进展［J］.山东化工，2023，52（9）：69-71., articleTitle=null, refAbstract=null), Reference(id=1319631038909891034, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［24］, rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN Y Q，SUN J J，DOU C，et al. Alliin attenuated RANKL-induced osteoclastogenesis by scavenging reactive oxygen species through inhibiting Nox1［J］. Int J Mol Sci，2016，17（9）：1516., articleTitle=null, refAbstract=null), Reference(id=1319631039056691675, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［25］, rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=YANG J，TANG R H，YI J，et al. Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesisviaNF-κB-NFATc1 signal pathway［J］. FASEB J，2019，33（6）：7261-7273., articleTitle=null, refAbstract=null), Reference(id=1319631041007043036, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=邸学士，陈昭，贾育松，等.基于网络药理学探讨青娥丸治疗绝经后骨质疏松症的作用机制［J］.中国骨质疏松杂志，2021，27（3）：364-371., articleTitle=null, refAbstract=null), Reference(id=1319631041074151901, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［27］, rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=李宁，黄秀峰，屈国栋，等. ERα及ERβ基因多态性与骨质疏松症相关性研究进展［J］.中国骨质疏松杂志，2025，31（4）：564-569., articleTitle=null, refAbstract=null), Reference(id=1319631041145455070, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［28］, rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=王晓燕，常时新，李冠武，等.经方青娥丸对去势大鼠骨质疏松作用机制的实验研究［J］.中国骨质疏松杂志，2017，23（2）：197-202., articleTitle=null, refAbstract=null), Reference(id=1319631041199981023, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［29］, rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=XIONG J L，CAI X Y，ZHANG Z J，et al. Elucidating the estrogen-like effects and biocompatibility of the herbal components in the Qing'E formula［J］. J Ethnopharmacol，2022，283：114735., articleTitle=null, refAbstract=null), Reference(id=1319631041262895584, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［30］, rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=LEE W C，GUNTUR A R，LONG F X，et al. Energy metabolism of the osteoblast：implications for osteoporosis［J］. Endocr Rev，2017，38（3）：255-266., articleTitle=null, refAbstract=null), Reference(id=1319631041330004449, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［31］, rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=翁泽斌，颜翠萍，张志杰，等.不同炮制品入药的青娥丸含药血清对人成骨细胞增殖、分化及矿化的影响［J］.中国实验方剂学杂志，2015，21（6）：165-168., articleTitle=null, refAbstract=null), Reference(id=1319631041397113314, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［32］, rfOrder=31, authorNames=null, journalName=null, refType=null, unstructuredReference=SHUAI B，ZHU R，YANG Y P，et al. Positive effects of qing’e pill on trabecular microarchitecture and its mechanical properties in osteopenic ovariectomised mice［J］. Chin J Integr Med，2019，25（4）：270-277., articleTitle=null, refAbstract=null), Reference(id=1319631043066446307, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［33］, rfOrder=32, authorNames=null, journalName=null, refType=null, unstructuredReference=饶艳玲，黄威.青娥丸调控Wnt1/β-catenin信号通路治疗糖尿病性骨质疏松症［J］.中国骨质疏松杂志，2023，29（8）：1167-1171，1181., articleTitle=null, refAbstract=null), Reference(id=1319631043141943780, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［34］, rfOrder=33, authorNames=null, journalName=null, refType=null, unstructuredReference=王柄棋，罗文娟，孙雨晴，等.青娥方对去卵巢大鼠血清MMP-9、TRACP5b、Cath-K及骨组织形态结构的影响［J］.福建中医药，2018，49（1）：46-49., articleTitle=null, refAbstract=null), Reference(id=1319631043225829861, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［35］, rfOrder=34, authorNames=null, journalName=null, refType=null, unstructuredReference=陈帆，魏戌，崔鑫，等.青娥丸治疗绝经后骨质疏松症的系统评价及Meta分析［J］.中国骨质疏松杂志，2021，27（2）：179-189., articleTitle=null, refAbstract=null), Reference(id=1319631043301327334, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［36］, rfOrder=35, authorNames=null, journalName=null, refType=null, unstructuredReference=戴燚，李浩，范彦博.青娥方调节MMP2/EGFR通路影响成骨细胞凋亡的实验研究［J］.中国中医骨伤科杂志，2018，26（11）：7-12., articleTitle=null, refAbstract=null), Reference(id=1319631043364241895, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［37］, rfOrder=36, authorNames=null, journalName=null, refType=null, unstructuredReference=DING K，HUA F，DING W G. Gut microbiome and osteoporosis［J］. Aging Dis，2020，11（2）：438-447., articleTitle=null, refAbstract=null), Reference(id=1319631043435545064, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［38］, rfOrder=37, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHENG X Q，GUAN Z Y，ZHANG Y D，et al. Different role of the gut microbiota in postmenopausal and senile osteoporosis［J］. Bone Res，2025，13（1）：63., articleTitle=null, refAbstract=null), Reference(id=1319631043515236841, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［39］, rfOrder=38, authorNames=null, journalName=null, refType=null, unstructuredReference=XIE H，HUA Z Y，GUO M Y，et al. Gut microbiota and metabonomics used to explore the mechanism of Qing’e Pills in alleviating osteoporosis［J］. Pharm Biol，2022，60（1）：785-800., articleTitle=null, refAbstract=null), Reference(id=1319631043582345706, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［40］, rfOrder=39, authorNames=null, journalName=null, refType=null, unstructuredReference=HAO J，BEI J X，LI Z H，et al. Qing'e pill inhibits osteoblast ferroptosis via ATM serine/threonine kinase（ATM）and the PI3 K/AKT pathway in primary osteoporosis［J］. Front Pharmacol，2022，13：902102., articleTitle=null, refAbstract=null), Reference(id=1319631043645260267, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［41］, rfOrder=40, authorNames=null, journalName=null, refType=null, unstructuredReference=卞庆来，邹小娟，沈霖.青娥丸治疗绝经后骨质疏松症肾虚血瘀证的疗效观察［J］.中华中医药杂志，2018，33（1）：308-312., articleTitle=null, refAbstract=null), Reference(id=1319631043708174828, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［42］, rfOrder=41, authorNames=null, journalName=null, refType=null, unstructuredReference=黄海卫，王宇.青蛾丸治疗绝经后肾虚血瘀型骨质疏松症临床观察［J］.辽宁中医药大学学报，2018，20（12）：138-140., articleTitle=null, refAbstract=null), Reference(id=1319631043779477997, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［43］, rfOrder=42, authorNames=null, journalName=null, refType=null, unstructuredReference=王欣燕，刘建红，黄显元.青娥丸对绝经后骨质疏松症患者骨密度、骨代谢指标和骨硬化蛋白的影响［J］.中国骨质疏松杂志，2020，26（3）：412-415., articleTitle=null, refAbstract=null), Reference(id=1319631043838198254, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［44］, rfOrder=43, authorNames=null, journalName=null, refType=null, unstructuredReference=陆思成，向昱阳，唐正.青娥丸联合钙尔奇D3治疗绝经后骨质疏松症肾阳虚型临床观察［J］.实用中医药杂志，2019，35（12）：1428-1430., articleTitle=null, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1319631030542254472, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=1., ext=[AuthorCompanyExt(id=1319631030550643081, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030542254472, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China), AuthorCompanyExt(id=1319631030559031690, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030542254472, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.辽宁中医药大学，辽宁沈阳 110847)]), AuthorCompany(id=1319631030630334859, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=2., ext=[AuthorCompanyExt(id=1319631030638723468, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China), AuthorCompanyExt(id=1319631030647112077, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030630334859, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.辽宁省中医药研究院，辽宁中医药大学附属第二医院，辽宁沈阳 110034)]), AuthorCompany(id=1319631030726803854, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, xref=3., ext=[AuthorCompanyExt(id=1319631030730998159, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030726803854, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110032，Liaoning，China), AuthorCompanyExt(id=1319631030739386768, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125639732318394, companyId=1319631030726803854, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.辽宁中医药大学附属医院，辽宁沈阳 110032)])], figs=null, attaches=null, journal=Journal(id=1255846881855815682, delFlag=0, nameCn=中华中医药学刊, nameEn=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, issn=1673-7717, eissn=null, cn=21-1546/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=v4T+dd+NLAnioIpGAbkcEQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Archives of Traditional Chinese Medicine, journalRemark=null, publicationField=null, createdTime=1777346829146, updatedTime=1788949222391, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=v4T+dd+NLAnioIpGAbkcEQ==, picEn=RAy5vuC40hwJB+Y0pEARug==, jcr=null, cjcr=null, exts=[JournalExt(id=1304510846391050374, language=CN, name=中华中医药学刊, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222419, updatedTime=1788949222419, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304510846449770631, language=EN, name=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222433, updatedTime=1788949222433, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1255847919539208197, websiteList=[Website(id=1255847989868900719, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN, language=CN, createTime=1777347093312, createBy=18614031015, updateTime=1777347427646, updateBy=18614031015, name=中华中医药学刊-中文, tplId=1146099689490845704, title=中华中医药学刊, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849512594170105, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=articleTextType, value=kx, createTime=1777347456358, updateTime=1777347456358, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512564809974, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=banner, value=null, createTime=1777347456352, updateTime=1777347456352, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512631918844, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=grayFlag, value=0, createTime=1777347456367, updateTime=1777347456367, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512552227061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347456348, updateTime=1777347456348, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512657084670, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=minRunFlag, value=0, createTime=1777347456373, updateTime=1777347456373, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512589975800, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic, createTime=1777347456357, updateTime=1777347456357, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512648696061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=silenceFlag, value=0, createTime=1777347456371, updateTime=1777347456371, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512581587191, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1777347456355, updateTime=1777347456355, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512619335930, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeColor, value=null, createTime=1777347456364, updateTime=1777347456364, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512627724539, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeStyle, value=null, createTime=1777347456366, updateTime=1777347456366, creator=18614031015, updator=18614031015)]), Website(id=1255847989944398211, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN, language=EN, createTime=1777347093330, createBy=18614031015, updateTime=1777347417860, updateBy=18614031015, name=中华中医药学刊-英文, tplId=1146101810881728533, title=Chinese Archives of Traditional Chinese Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849538993119491, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=articleTextType, value=kx, createTime=1777347462652, updateTime=1777347462652, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538972147968, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=banner, value=null, createTime=1777347462647, updateTime=1777347462647, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539047645446, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=grayFlag, value=0, createTime=1777347462665, updateTime=1777347462665, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538930204927, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347462637, updateTime=1777347462637, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539064422664, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=minRunFlag, value=0, createTime=1777347462669, updateTime=1777347462669, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538988925186, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic, createTime=1777347462651, updateTime=1777347462651, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539060228359, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=silenceFlag, value=0, createTime=1777347462668, updateTime=1777347462668, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538980536577, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1777347462649, updateTime=1777347462649, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539001508100, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeColor, value=null, createTime=1777347462654, updateTime=1777347462654, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539039256837, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeStyle, value=null, createTime=1777347462663, updateTime=1777347462663, creator=18614031015, updator=18614031015)])], journalTitle=中华中医药学刊, weixinUrl=null, journalUrl=https://castjournals.cast.org.cn/zhzyyxk, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Archives of Traditional Chinese Medicine, journalPhotoCn=v4T+dd+NLAnioIpGAbkcEQ==, journalPhotoEn=RAy5vuC40hwJB+Y0pEARug==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.02.015, detailUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2026.02.015, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/PDF/10.13193/j.issn.1673-7717.2026.02.015, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/PDF/10.13193/j.issn.1673-7717.2026.02.015, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1770652800000, fullTextJson=null, articleText=null, reference=null)