Article(id=1317125587135738168, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.02.037, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956810983, onlineDateStr=2026-10-14, pubDate=1770652800000, pubDateStr=2026-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956810983, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956810983, creator=13701087609, updateTime=1791956810983, updator=13701087609, issue=Issue{id=1317125500041015883, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='2', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956790217, creator='13701087609', updateTime=1791958795145, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133909368877755, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133909373072060, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=215, endPage=220, ext={EN=ArticleExt(id=1317125588830236985, articleId=1317125587135738168, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Zhibai Dihuang Pills（知柏地黄丸）on Bone Density and Bone Metabolism Indicators in Elderly Patients with Prostate Cancer After Drug Castration Treatment, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the effect of Zhibai Dihuang Pills（知柏地黄丸）on bone density and bone metabolism indicators in elderly patients with prostate cancer after drug castration treatment.
Method Eighty-two elderly patients with prostate cancer treated with drug castration were selected from the geriatric medicine department，general medicine department，oncology department，urology department，radiotherapy department and other outpatient departments and wards of Lianyungang Second People's Hospital. The patients were divided into the experiment group（42 cases）and the control group（40 cases）according to the random number method. Both groups received castration medicines. The control group received medication for castration in addition to calcium supplementation without any additional traditional Chinese medicine treatment. On the basis of the control group，the experimental group was additionally treated with Zhibai Dihuang Pills，with an observation period of 12 months. Total Prostate Specific Antigen（PSA），Free Prostate Specific Antigen（FPSA），Bone Density T-values（Lumbar L2～4，Femoral Neck，and Wards Triangle），as well as bone metabolism indicators，including bone glaprotein（BGP），C-terminal cross-linked telopeptides of type I collagen（CTX-I），bone alkaline phosphatase（BALP），25-hydroxyvitamin D［25（OH）D］and other indicators were recorded before treatment and at 3，6 and 12 months after treatment.
Results After 3 months of treatment，there was no significant difference in PSA，FPSA，bone density T-values（lumbar L2～4，femoral neck，Wards triangle）or bone metabolism indicators between the two groups. After 6 months of treatment，the index of BALP in the control group was radically higher than that in the experimental group，and the bone density T-values（lumbar L2～4，femoral neck，Wards triangle）were significantly higher than those in the control group（P<0.05），while there was no significant difference in other indicators. After 12 months of treatment，the levels of BALP and CTX-I in the control group were radically higher than those in the experimental group（P<0.05），bone density T-values（lumbar L2～4，femoral neck，Wards triangle），the levels of 25（OH）D and BGP were significantly higher than those in the control group（P<0.05），and there was no significant difference in other indicators. The comparison results before and after treatment within the experimental group showed significant differences in VAS scores. The bone metabolism indicators of the experimental group before and after treatment showed significant differences，except for the pairwise comparison of BALP treatment at 3 and 6 months，and those at 6 and 12 months（P<0.01，P<0.001）.
Conclusion Zhibai Dihuang Pills can significantly improve osteoporosis in the elderly prostate cancer patients after drug castration treatment，increase the bone density，resist the oxidative stress and help to improve the quality of life of the elderly prostate cancer patients.
, authors=Qinwen BAO, Xiaolei DONG, Dongwei YAO, Xiaozhu SHEN, authorsList=Qinwen BAO, Xiaolei DONG, Dongwei YAO, Xiaozhu SHEN, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125589149004090, articleId=1317125587135738168, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=知柏地黄丸对老年前列腺癌药物去势治疗后骨密度及骨代谢指标的影响, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 观察知柏地黄丸对老年前列腺癌药物去势治疗后骨密度及骨代谢指标的影响。
方法 选取老年前列腺癌药物去势治疗患者82例，使用随机数字表法，将其分为两组，实验组42例、对照组40例。两组患者均给予药物去势治疗，对照组应用药物去势治疗基础上补钙，不加服任何中医药治疗；实验组在对照组的基础上再加服知柏地黄丸，观察时限均为12个月，分别记录治疗前与治疗后3、6、12个月的总前列腺抗原（Prostate specific antigen，PSA）、游离前列腺特异抗原（Free prostate specific antigen，FPSA）、骨密度（Bone mineral density，BMD）T值（腰椎L2～4、股骨颈以及Wards三角），以及骨代谢指标，即骨钙素（Bone glaprotein，BGP）、I型胶原交联C末端肽（C-terminal cross-linked telopeptides of type I collagen，CTX-I）、骨源性碱性磷酸酶（Bone alkaline phosphatase，BALP）、25-羟维生素D［25-hydroxyvitamin D，25（OH）D］等指标。
结果 治疗后3个月，两组PSA、FPSA、骨密度T值（腰椎L2～4、股骨颈以及Wards三角）、骨代谢指标差异无统计学意义；治疗6个月后，实验组BALP指标明显低于对照组、骨密度T值（腰椎L2～4、股骨颈以及Wards三角）明显高于对照组（P<0.05），其余指标差异无统计学意义；治疗后12个月，实验组BALP、CTX明显低于对照组（P<0.05）、骨密度T值（腰椎L2～4、股骨颈以及Wards三角）、25-D及BGP明显高于对照组（P<0.05），其余指标差异无统计学意义。实验组组内治疗前后比较结果为，实验组患者治疗前后VAS评分组内两两比较差异均有显著统计学意义；实验组患者治疗前后骨代谢指标，除了BALP治疗3个月与6个月、6个月与12个月两两比较差异无统计学意义，其余组内两两比较差异均有显著统计学意义（P<0.01，P<0.001）。
结论 知柏地黄丸可显著改善老年前列腺癌药物去势治疗后的骨质疏松，能够增加骨密度，抗氧化应激，有助于提高老年前列腺癌患者的生活质量。
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