Article(id=1317125580294828312, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.02.039, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956809351, onlineDateStr=2026-10-14, pubDate=1770652800000, pubDateStr=2026-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956809351, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956809351, creator=13701087609, updateTime=1791956809351, updator=13701087609, issue=Issue{id=1317125500041015883, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='2', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956790217, creator='13701087609', updateTime=1791958795145, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133909368877755, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133909373072060, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=226, endPage=229, ext={EN=ArticleExt(id=1317125580684898585, articleId=1317125580294828312, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Xiaoxuming Decoction（小续命汤）on Acute Cerebral Infarction Complicated with SAP Syndrome of Wind-Phlegm Blocking Collateral and Its Effect on TLR4/NF-κB Signaling Pathway, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the curative effect of Xiaoxuming Decoction（小续命汤）on acute cerebral infarction（ACI）complicated with stroke associated related pneumonia（SAP）syndrome of wind-phlegm blocking collateral and its effect on Toll-like receptor 4（TLR4）/nuclear factor kappa-B（NF-κB）signaling pathway.
Methods A total of 90 patients with ACI combined with SAP treated in Changzhou Hospital of Traditional Chinese Medicine from January 2023 to June 2024 were selected and divided into control group（45 cases）and study group（45 cases）by random number table method. The control group was given the conventional Western medicine treatment，and the study group was given the oral treatment of Xiaoxuming Decoction on the basis of the conventional group. The clinical efficacy，TCM syndrome scores，stroke scale and cognitive function score，laboratory indexes and adverse reactions were observed in two groups.
Result The total effective rate of treatment in the study group was higher than that in the conventional group（P<0.05）. After treatment，National Institutes of Health Stroke Scale（NIHSS）and Modified Rankin scale（mRS）scores，levels of serum tumor necrosis factor（TNF-α），pigment-derived factor（PEDF），proad-renomedullin（pro-ADM）and C-reactive protein（CRP），the expressions of TLR4 and NF-κB in the study group were lower than those of the control group（P<0.05）. After treatment，the scores of Mini-Mental State Examination（MMSE）and Montreal Cognitive Assessment（MoCA）in the study group were higher than those in the control group（P<0.05）. There was no significant difference in the total incidence of adverse reactions between the two groups（P>0.05）.
Conclusion In the treatment of acute cerebral infarction complicated with SAP wind-phlegm blocking collateral syndrome，Xiaoxuming Decoction can effectively relieve the clinical symptoms，improve the cognitive function and inflammatory response，and protect the neurological function of patients by regulating TLR4/NF-κB signaling pathway，with high safety.
, authors=Juhua CHEN, Li ZHANG, Liji CHEN, Chunfeng SHEN, authorsList=Juhua CHEN, Li ZHANG, Liji CHEN, Chunfeng SHEN, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125581246935322, articleId=1317125580294828312, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=小续命汤对急性脑梗死合并卒中相关性肺炎风痰阻络证的疗效及对TLR4/NF-κB信号通路的影响, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 观察小续命汤对急性脑梗死（Acute cerebral infarction，ACI）合并卒中相关性肺炎（Stroke associated pneumonia，SAP）风痰阻络证的疗效及对TLR4/NF-κB信号通路的影响。
方法 选择ACI合并SAP患者90例，采用随机数字表法分为两组。对照组45例给予常规西药治疗，研究组45例在对照组基础上加予小续命汤口服治疗。观察两组患者临床疗效、中医证候积分、卒中量表及认知功能评分、实验室指标及不良反应。
结果 研究组患者治疗总有效率高于对照组（P<0.05）；治疗后，研究组患者美国国立卫生研究院卒中量表（National institutes of health stroke scale，NIHSS）及Rankin量表评分（Modified rankin scale，mRS）、血清肿瘤坏死因子（Tumor necrosis factor，TNF-α）、色素上皮衍生因子（Pigment epithelium-derived factors，PEDF）、肾上腺髓质素前体（Proadrenomedullin，pro-ADM）、C-反应蛋白（C-reactive protein，CRP）水平与Toll样受体4（Toll-like receptor 4，TLR4）、核因子-κB（Nuclear factorκB，NF-κB）表达水平均低于对照组（P<0.05）；治疗后，研究组患者简易智力状态检查量表（Mini-mental state examination，MMSE）与蒙特利尔认知评估量表（Montreal cognitive assessment，MoCA）评分均高于对照组（P<0.05）；两组不良反应总发生率差异无统计学意义（P>0.05）。
结论 小续命汤治疗急性脑梗死合并SAP风痰阻络证可通过调节TLR4/NF-κB信号通路有效缓解患者临床症状，提高认知功能，改善炎症反应，保护患者神经功能，且安全性较高。
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