Article(id=1317125527815697218, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.02.023, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956796839, onlineDateStr=2026-10-14, pubDate=1770652800000, pubDateStr=2026-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956796839, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956796839, creator=13701087609, updateTime=1791956796839, updator=13701087609, issue=Issue{id=1317125500041015883, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='2', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956790217, creator='13701087609', updateTime=1791958795145, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133909368877755, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133909373072060, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=124, endPage=129, ext={EN=ArticleExt(id=1317125528033801027, articleId=1317125527815697218, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Difference of Quality Characteristics Between Normal and Nematode Infected Dihuang（Rehmanniae Radix）Based on Chemical Composition and Antioxidant Activity, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To study the influence of nematode infection on the quality of Dihuang（Rehmanniae Radix），and to provide the basis for the quality control of Dihuang（Rehmanniae Radix）and the rational utilization of resources of Dihuang（Rehmanniae Radix）infected by nematode.
Methods High Performance Liquid Chromatography（HPLC），High Performance Liquid Chromatography-Evaporative Light Scattering Detection（HPLC-ELSD），1-phenyl-3-methyl-5-pyrazolone（PMP）pre-column derivatization，2，2-Diphenyl-1-picrylhydrazyl（DPPH）antioxidant method combined with SPSS 27 and SIMCA 14.1 were used to systematically analyze the characteristics of iridoid glycosides，phenylethanol glycosides，free monosaccharides，oligosaccharides，polysaccharides，monosaccharide composition and antioxidant activity in normal Dihuang（Rehmanniae Radix）with different degrees of nematode infection.
Results There were significant differences in the chemical quality characteristics of extremely severely infected Dihuang（Rehmanniae Radix），which could be divided into two categories. Rehmanniae A，Cistanche A，oliberoside，hydroxytyrosol，sucrose，glucose，catalcatalol，Rehmanniae D，stacitose and polysaccharide were the main differentiating components. When the sample concentration was more than 0.8 mg·mL-1，the antioxidant activity of extremely severely infected Dihuang（Rehmanniae Radix）was significantly lower than that of the other three Dihuang（Rehmanniae Radix）. Catalpol，echinoside，verbascoside，isocitroside，fructose，stachyose and polysaccharide showed a strong positive or negative correlation with DPPH free radical scavenging rate.
Conclusions Nematode infection has a certain effect on the appearance and quality characteristics of Dihuang（Rehmanniae Radix），and iridoid glycosides and saccharides are the main difference substances between normal Dihuang（Rehmanniae Radix）and nematode infected Dihuang（Rehmanniae Radix）.
, authors=Hanxiao LIU
1, 2, Wei ZHANG
3, Suqing ZHI
4, Bao ZHANG
2, Qingpu LIU
2, Jingwei LEI
2, Juan ZHANG
2, Caixia XIE
1, 2, authorsList=Hanxiao LIU, Wei ZHANG, Suqing ZHI, Bao ZHANG, Qingpu LIU, Jingwei LEI, Juan ZHANG, Caixia XIE, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125528394511172, articleId=1317125527815697218, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=基于化学成分及抗氧化活性的正常地黄与线虫病感染地黄质量特征差异性分析, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 研究线虫病感染对地黄质量的影响，为地黄质量控制及线虫病感染地黄的资源合理利用提供依据。
方法 利用高效液相色谱法（High performance liquid chromatography，HPLC）、高效液相色谱-蒸发光散射检测器（High performance liquid chromatography-evaporative light scattering detection，HPLC-ELSD）、1-苯基-3-甲基-5-吡唑啉酮（1-phenyl-3-methyl-5-pyrazolone，PMP）柱前衍生化法、1，1-二苯基-2-三硝基苯肼（2，2-Diphenyl-1-picrylhydrazyl，DPPH）抗氧化法结合SPSS 27、SIMCA 14.1等软件系统分析正常地黄与不同程度线虫病感染地黄中环烯醚萜苷类、苯乙醇苷类、游离单糖、寡糖、多糖含量及单糖组成和抗氧化活性的特征。
结果 极重度感染地黄与正常地黄、中度感染地黄、重度感染地黄的化学质量特征存在明显差异，可被分为两类，地黄苷A、肉苁蓉苷A、益母草苷、羟基酪醇、蔗糖、葡萄糖、梓醇、地黄苷D、水苏糖、多糖为主要差异性成分；当样品质量浓度>0.8 mg·mL-1时，极重度感染地黄的抗氧化活性明显低于其他3种地黄，梓醇、松果菊苷、毛蕊花糖苷、异类叶升麻苷、果糖、水苏糖、多糖与DPPH自由基清除率呈现较强的正相关或负相关。
结论 线虫病感染对地黄的外观性状及质量特征均产生了一定影响，其中环烯醚萜苷类与糖类为正常地黄与线虫病感染地黄的主要差异性物质。
, authors=刘寒笑
1, 2, 张威
3, 职素青
4, 张宝
2, 刘庆普
2, 雷敬卫
2, 张娟
2, 谢彩侠
1, 2, authorsList=刘寒笑, 张威, 职素青, 张宝, 刘庆普, 雷敬卫, 张娟, 谢彩侠, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=634boOvTNberseW7XFuJ8Q==, magXml=J8qwuAxnxtJCni4fkV8IxQ==, pdfUrl=null, pdf=AALaDX+wgTlc04sHIrhu1Q==, pdfFileSize=1700835, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=T+XcFzCcnJ4HOnPuzqBNMw==, mapNumber=null, fund=null)}, authors=[Author(id=1319630745967120928, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630746084561443, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, authorId=1319630745967120928, language=EN, stringName=Hanxiao LIU, firstName=Hanxiao, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1.Henan University of Chinese Medicine/Henan Province Collaborative Innovation Center for The Whole Industry Chain Research and Development of Yu-Yao，Zhengzhou 450046，Henan，China
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1.河南中医药大学豫药全产业链研发河南省协同创新中心，河南郑州 450046
2.河南中医药大学河南省中药质量控制与评价工程技术研究中心，河南郑州 450046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630745547690515, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, xref=1., ext=[AuthorCompanyExt(id=1319630745556079124, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, companyId=1319630745547690515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1.河南中医药大学豫药全产业链研发河南省协同创新中心，河南郑州 450046)]), AuthorCompany(id=1319630745660936726, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, xref=2., ext=[AuthorCompanyExt(id=1319630745673519639, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, companyId=1319630745660936726, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Henan University of Chinese Medicine/Henan Provincial Engineering Technology Research Center for Quality Control and Evaluation of Traditional Chinese Medicine，Zhengzhou 450046，Henan，China), AuthorCompanyExt(id=1319630745681908248, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, companyId=1319630745660936726, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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3, address=
3.Zhengzhou Health Vocational College，Zhengzhou 450122，Henan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630746420105769, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, authorId=1319630746243944998, language=CN, stringName=张威, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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3.郑州卫生健康职业学院，河南郑州 450122, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630745757405721, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, xref=3., ext=[AuthorCompanyExt(id=1319630745769988634, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, companyId=1319630745757405721, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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3.郑州卫生健康职业学院，河南郑州 450122)])]), Author(id=1319630748081050155, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630748164936237, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, authorId=1319630748081050155, language=EN, stringName=Suqing ZHI, firstName=Suqing, middleName=null, lastName=ZHI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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4.Jiaozuo Jiuru Huai-Yao Intangible Cultural Heritage Research Institute，Jiaozuo 454350，Henan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630748232045102, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, authorId=1319630748081050155, language=CN, stringName=职素青, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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4.焦作市九如怀药非遗研修院，河南焦作 454350, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630745862263324, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, xref=4., ext=[AuthorCompanyExt(id=1319630745874846237, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, companyId=1319630745862263324, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2, address=
2.Henan University of Chinese Medicine/Henan Provincial Engineering Technology Research Center for Quality Control and Evaluation of Traditional Chinese Medicine，Zhengzhou 450046，Henan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630748462731827, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, authorId=1319630748307542576, language=CN, stringName=张宝, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.河南中医药大学河南省中药质量控制与评价工程技术研究中心，河南郑州 450046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630745660936726, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, xref=2., ext=[AuthorCompanyExt(id=1319630745673519639, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, companyId=1319630745660936726, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2, address=
2.Henan University of Chinese Medicine/Henan Provincial Engineering Technology Research Center for Quality Control and Evaluation of Traditional Chinese Medicine，Zhengzhou 450046，Henan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630748731167288, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, authorId=1319630748546617909, language=CN, stringName=刘庆普, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.河南中医药大学河南省中药质量控制与评价工程技术研究中心，河南郑州 450046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630745660936726, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, xref=2., ext=[AuthorCompanyExt(id=1319630745673519639, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125527815697218, companyId=1319630745660936726, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2, address=
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