Article(id=1317125519632613764, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.02.029, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956794889, onlineDateStr=2026-10-14, pubDate=1770652800000, pubDateStr=2026-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956794889, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956794889, creator=13701087609, updateTime=1791956794889, updator=13701087609, issue=Issue{id=1317125500041015883, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='2', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956790217, creator='13701087609', updateTime=1791958795145, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133909368877755, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133909373072060, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=162, endPage=168, ext={EN=ArticleExt(id=1317125519838134661, articleId=1317125519632613764, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress of Zhenwu Decoction（真武汤）and Its Active Ingredients in Chronic Kidney Disease, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Chronic kidney disease is a serious challenge to global public health. As one of the classic prescriptions of medical saints，Zhenwu Decoction（真武汤），as one of the classic prescriptions of medical sages，is used to tonify and purge and promote diuresis，and is mainly used for treating Yang deficiency and water flooding syndrome. In clinical reports，its modified formulas or combination with traditional Chinese medicine external treatment or combination with Western medicine are usually used to treat a variety of chronic kidney diseases such as nephrotic syndrome，chronic glomerulonephritis，idiopathic membranous nephropathy，IgA nephropathy，diabetic kidney disease，lupus nephritis，hepatitis B virus associated glomerulonephritis，chronic renal failure and cardiorenal syndrome. In addition，the main active ingredients of the drugs in Zhenwu Decoction have demonstrated a variety of pharmacological effects such as antioxidant，anti-inflammation，immune regulation，anti-apoptosis，promoting autophagy，inhibiting iron death，anti-fibrosis，diuretic and regulating intestinal flora. This article summarized the relevant literature reports and systematically analyzed the clinical trials of Zhenwu Decoction，the pharmacological effects of its active ingredients in chronic kidney disease and the basic animal experiments，aiming to provide support for the clinical standardized application and pharmacological research of Zhenwu Decoction.

, authors=Kaili CHEN^{1, 2}, Linqi ZHANG¹, Changbin XIAO^{1, 2}, Siyu HUANG^{1, 2}, Chenpeng SHI^{1, 2}, Yiting SUN^{1, 2}, authorsList=Kaili CHEN, Linqi ZHANG, Changbin XIAO, Siyu HUANG, Chenpeng SHI, Yiting SUN, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125521650073992, articleId=1317125519632613764, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=真武汤及其单味药有效成分在慢性肾脏疾病中的研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

慢性肾脏疾病乃全球公共卫生之严峻挑战。真武汤作为医圣的经典名方之一，补泻并施、辛热渗利，主治阳虚水泛证。临床报道中常被加减运用或联合中医外治或联用西药治疗肾病综合征、慢性肾小球肾炎、特发性膜性肾病、IgA肾病、糖尿病肾病、狼疮性肾炎、乙型病毒性肝炎肾损伤、慢性肾衰竭、心肾综合征等多种慢性肾脏疾病。此外，真武汤中单味药主要活性成分展现出抗氧化、抗炎、免疫调节、抗细胞凋亡、促进自噬、抑制铁死亡、抗纤维化、利尿以及调节肠道菌群等多种药理功效。通过总结有关文献报道，从该方临床试验、其单味药的有效活性成分在慢性肾脏疾病中的药理作用、动物基础实验3个维度进行系统分析，旨在为真武汤的临床规范化应用和药理学研究提供支持。

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