中华中医药学刊

龙砂开阖枢针法联合来曲唑、人绒毛膜促性腺激素治疗多囊卵巢综合征不孕临床研究

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王燕美 , 周亚红 , 温丽娜

中华中医药学刊 | 省级项目平台 2026,44(3): 240-243

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中华中医药学刊 |省级项目平台 2026 , 44 (3) : 240 -243

龙砂开阖枢针法联合来曲唑、人绒毛膜促性腺激素治疗多囊卵巢综合征不孕临床研究

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王燕美, 周亚红, 温丽娜

作者信息

无锡市中医医院，江苏无锡 214071

通讯作者:

周亚红（1970 -），女，江苏无锡人，主任中医师，硕士，研究方向：不孕症。E-mail：yhzhoutwo@163.com。

作者简介:

王燕美（1982 -），女，江苏泰兴人，副主任中医师，硕士，研究方向：不孕症的中医治疗。

Clinical Study on Treatment of Infertility in Polycystic Ovary Syndrome by Longsha Opening and Closing Pivot Needle Method Combined with Letrozole and Human Chorionic Gonadotropin

Yanmei WANG, Yahong ZHOU, Lina WEN

Affiliations

Wuxi Hospital of Traditional Chinese Medicine, Wuxi 214071, Jiangsu, China

出版时间: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.046

文章导航

摘要

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目的

研究龙砂开阖枢针法联合来曲唑（letrozole，LE）、人绒毛膜促性腺激素（human chorionic gonadotropin，HCG）治疗多囊卵巢综合征（polycystic ovary syndrome，PCOS）不孕的效果。

方法

纳入2021年6月—2022年10月无锡市中医医院收治的PCOS患者84例，通过随机数字表法分为对照组（42例）与针灸组（42例）。对照组予以LE、HCG治疗，针灸组在对照组基础上接受龙砂开阖六气针法治疗，均治疗6个月经周期。比较两组治疗前、治疗6个月经周期后子宫内膜指标、性激素、代谢指标，治疗6个月经周期后疗效，治疗期间不良反应及妊娠情况。

结果

较治疗前，治疗6个月经周期后两组子宫内膜厚度（endometrial thickness，ET）、子宫内膜分型A型比例，血清雌二醇（estradiol，E2）水平升高，且针灸组更高（P < 0.05）。较治疗前，治疗6个月经周期后，两组搏动指数（pulsing index，PI）、阻力指数（resistance index，RI）、血清睾酮（testosterone，T）、促黄体素（luteinizing hormone，LH）、卵泡刺激素（follicle stimulating hormone，FSH）、空腹血糖（fasting blood glucose，FPG）、胰岛素（insulin，INS）、胰岛素抵抗指数（insulin resistance index，HOMA-IR）、甘油三酯（triglyceride，TG）、总胆固醇（total cholesterol，TC）降低，且针灸组更低（P < 0.05）。与对照组治疗6个月经周期后的疗效比较，针灸组临床疗效优于对照组（P < 0.05）。治疗期间，两组均未因治疗出现明显不良反应而终止治疗，两组不良反应发生率比较，14.29%（6/42）vs 9.52%（4/42），差异无统计学意义（P > 0.05）；针灸组生化妊娠率、临床妊娠率发生率更高（P < 0.05）。

结论

龙砂开阖枢针法联合LE、HCG治疗PCOS不孕，可改善子宫内膜指标，调节性激素、代谢指标，最终改善妊娠情况，疗效确切，安全性良好。

关键词

多囊卵巢综合征 / 不孕 / 龙砂开阖枢针法 / 来曲唑 / 人绒毛膜促性腺激素 / 子宫内膜指标 / 性激素 / 妊娠情况

Abstract

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Objective

To study the effect of Longsha opening and closing pivot needle method combined with letrozole（LE）and human chorionic gonadotropin（HCG）on infertility in polycystic ovary syndrome（PCOS）.

Methods

From June 2021 to October 2022, 84 patients with PCOS admitted to Wuxi Hospital of Traditional Chinese Medicine were divided into the control group（42 cases）and the acupuncture group（42 cases）by random number table method. The control group was treated with LE and HCG, and the acupuncture group was treated with Longsha opening and closing pivot needle method for 6 menstrual cycles. Endometrial indexes, sex hormones and metabolic indexes before and after 6 menstrual cycles of treatment, therapeutic effect after 6 menstrual cycles, adverse reactions and pregnancy during treatment were compared between the two groups.

Results

Compared with those before treatment and after 6 menstrual cycles, the levels of endometrial thickness（ET）and the proportion of endometrial type A and the level of serum estradiol（E2）increased in both groups, and the overall ratio was higher in the acupuncture group（P < 0.05）. Compared with those before treatment and after 6 menstrual cycles, the pulsing index（PI）and resistance index（RI）, the levels of testosterone（T）, luteinizing hormone（LH）, follicle stimulating hormone（FSH）, fasting blood glucose（FPG）, insulin（INS）, insulin resistance index（HOMA-IR）, triglyceride（TG）and total cholesterol（TC）of the two groups decreased, and were lower than those of the acupuncture group（P < 0.05）. After 6 menstrual cycles, the clinical effect of the acupuncture group was better than that of the control group（P < 0.05）. During the treatment period, no significant adverse reactions occurred in the two groups, and the incidence of adverse reactions between the two groups was 14.29%（6/42）vs 9.52%（4/42）, with no statistical significance（P > 0.05）. The incidence of biochemical pregnancy rate and clinical pregnancy rate were higher in the acupuncture group（P < 0.05）.

Conclusion

Longsha opening and closing pivot needle method combined with LE and HCG in the treatment of PCOS infertility could improve the endometrial indexes, regulate the sex hormones and metabolic indexes, and finally improve the pregnancy, with accurate efficacy and good safety.

Key words

polycystic ovary syndrome / infertility / Longsha opening and closing pivot needle method / letrozole / human chorionic gonadotropin / endometrial indicators / sex hormone / pregnancy condition

引用本文

王燕美, 周亚红, 温丽娜. 龙砂开阖枢针法联合来曲唑、人绒毛膜促性腺激素治疗多囊卵巢综合征不孕临床研究. 中华中医药学刊, 2026 , 44 (3) : 240 -243 . DOI: 10.13193/j.issn.1673-7717.2026.03.046

Yanmei WANG, Yahong ZHOU, Lina WEN. Clinical Study on Treatment of Infertility in Polycystic Ovary Syndrome by Longsha Opening and Closing Pivot Needle Method Combined with Letrozole and Human Chorionic Gonadotropin[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 240 -243 . DOI: 10.13193/j.issn.1673-7717.2026.03.046

基金

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江苏省中医药科技发展计划项目(YB2020043)

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2026年第44卷第3期

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doi: 10.13193/j.issn.1673-7717.2026.03.046

首发时间：2026-10-14
出版时间：2026-03-10

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基金

江苏省中医药科技发展计划项目(YB2020043)

作者信息

无锡市中医医院，江苏无锡 214071

通讯作者:

周亚红（1970 -），女，江苏无锡人，主任中医师，硕士，研究方向：不孕症。E-mail：yhzhoutwo@163.com。

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科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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