Article(id=1317125478306136123, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.032, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956785035, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956785035, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956785035, creator=13701087609, updateTime=1791956785035, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=175, endPage=179, ext={EN=ArticleExt(id=1317125478557794364, articleId=1317125478306136123, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect and Mechanism of Shengqing Jiangzhuo Capsule(升清降浊胶囊)on Membranous Nephropathy in Rats Based on Wnt1/β-catenin Signaling Pathway, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the effect of Shengqing Jiangzhuo Capsule(升清降浊胶囊, SQJZC)on membranous nephropathy in rats and its specific mechanism.

Methods

The rat model of membranous nephropathy was established, and the rats were treated with different concentrations of SQJZC. Biochemical indicators were determined, including 24-hour proteinuria, blood urea nitrogen(BUN), serum creatinine(SCR), triglyceride(TG), total cholesterol(TC), alanine aminotransferase(ALT)and aspartate aminotransferase(AST). Hematoxylin eosin(HE)and periodic acid silver amine(PASM)staining were conducted to observe the pathological changes of glomerulus. The related indexes of Wnt1/β-catenin signaling pathway were detected by Western blot.

Results

After SQJZC treatment, the 24 h urine protein of the rats decreased(P < 0.05). There were no significant changes in BUN, SCR, AST or ALT in each group. Compared with those in the model group, the levels of TC and TG in the SQJZC group decreased in some degrees(P < 0.05). The pathological staining results showed that SQJZC could alleviate the glomerular capillary basement membrane thickening in rats. Western blot results showed that SQJZC could restore the expression of nephrin protein in renal tissue. Compared with those of the blank group, the expression levels of MMP-7, Cyclin D1, CTGF, Wnt1, c-Myc, β-catenin and active β-catenin in the model group were increased(P < 0.05). Compared with those of the model group, the expression levels of MMP-7, Cyclin D1, CTGF, Wnt1, c-Myc, β-catenin and active β-catenin in the SQJZC group were decreased(P < 0.05).

Conclusion

SQJZC could alleviate the renal injury in rats with membranous nephropathy, and its mechanism may be through Wnt1/β-catenin signaling pathway.

, authors=Xingbo WU1, Baohua LI2, Jiandong ZHANG1, Gangyi CHEN1, Chao WANG1, En ZHANG1, authorsList=Xingbo WU, Baohua LI, Jiandong ZHANG, Gangyi CHEN, Chao WANG, En ZHANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125478855589949, articleId=1317125478306136123, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=基于Wnt1/β-catenin信号通路探讨升清降浊胶囊对膜性肾病大鼠的作用及机制, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

探讨升清降浊胶囊(Shengqing Jiangzhuo Capsule,SQJZC)对膜性肾病大鼠的作用及具体机制。

方法

制备膜性肾病大鼠模型,造模成功后的大鼠给予不同浓度的SQJZC治疗;生化指标检测:24 h蛋白尿、尿素氮(Bloodureanitrogen,BUN)、血肌酐(Serumcreatinine,SCr)、甘油三酯(Triglyceride,TG)、总胆固醇(Totalcholesterol,TC)、丙氨酸氨基转移酶(Alanine aminotransferase,ALT)及天门冬氨酸氨基转移酶(Aspartate aminotransferase,AST);苏木素-伊红(Hematoxylin-eosin,HE)及基底膜六胺银(Periodic acid-silver methenamine,PASM)染色观察病理肾小球病理结构;Western blot法检测Wnt1/β-catenin信号通路相关指标。

结果

SQJZC治疗后的大鼠24 h尿蛋白定量降低(P < 0.05);各组大鼠BUN、Scr、AST及ALT无明显变化;与模型组相比,SQJZC给药组TC与TG水平出现不同程度下降(P < 0.05);病理染色结果显示,SQZJC能够改善大鼠肾小球毛细血管基底膜增厚;Western blot结果显示:SQJZC能够恢复肾组织肾病蛋白(Renal glomerulus-specific cell adhesion receptor,Nephrin)蛋白的表达;与空白组比较,模型组基质金属蛋白酶7(Matrix metalloproteinase 7,MMP-7)、G1/S-特异性周期蛋白-D1(G1/S-specific cyclin-D1,Cyclin D1)、结缔组织生长因子(Connective tissue growth factor,CTGF)、无翅型MMTV整合位点家族成员1(Wingless type MMTV integration site family member 1,Wnt1)、MYC癌基因(Myelocytomatosis viral oncogene homolog,c-Myc)、β-连环蛋白(CTNNB1,β-catenin)、活化的β-catenin(Active β-catenin)表达量均升高(P < 0.05),与模型组比较,SQZJC给药组MMP-7、Cyclin D1、CTGF、Wnt1、c-Myc、β-catenin、Active β-catenin蛋白表达量均有不同程度的下降(P < 0.05)。

结论

SQJZC具有缓解膜性肾病大鼠肾脏损伤的作用,其作用机制可能是通过Wnt1/β-catenin信号通路发挥作用。

, authors=吴兴波1, 李宝华2, 张建东1, 陈刚毅1, 王超1, 张恩1, authorsList=吴兴波, 李宝华, 张建东, 陈刚毅, 王超, 张恩, authorCompany=null, correspAuthors=null, authorNote=

吴兴波(1983 -),男,广东海丰人,主治医师,硕士,研究方向:中医药防治慢性肾病。

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吴兴波(1983 -),男,广东海丰人,主治医师,硕士,研究方向:中医药防治慢性肾病。

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吴兴波(1983 -),男,广东海丰人,主治医师,硕士,研究方向:中医药防治慢性肾病。

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journalId=1255847919539208197, articleId=1317125478306136123, language=CN, orderNo=3, keyword=Wnt1/β-catenin信号通路)], refs=[Reference(id=1319724532953370900, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=RONCO P, BECK L, DEBIEC H, et al. Membranous nephropathy[J]. Nat Rev Dis Primers, 2021, 7:69., articleTitle=null, refAbstract=null), Reference(id=1319724533016285461, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=GU Y, XU H, TANG D M. Mechanisms of primary membranous nephropathy[J]. Biomolecules, 2021, 11(4):513., articleTitle=null, refAbstract=null), Reference(id=1319724533356024086, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=HU R M, QUAN S X, WANG Y Z, et al. Spectrum of biopsy proven renal diseases in Central China:a 10-year retrospective study based on 34, 630 cases[J]. Sci Rep, 2020, 10(1):10994., articleTitle=null, refAbstract=null), Reference(id=1319724533427327255, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU Q Y, LIU J H, LIN B X, et al. Novel biomarkers in membranous nephropathy[J]. Front Immunol, 2022, 13:845767., articleTitle=null, refAbstract=null), Reference(id=1319724533527990552, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU W B, GAO C, DAI H R, et al. Immunological pathogenesis of membranous nephropathy:focus on PLA2R1 and its role[J]. Front Immunol, 2019, 10:1809., articleTitle=null, refAbstract=null), Reference(id=1319724533779648793, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=COUSER W G. Primary membranous nephropathy[J]. Clin J Am Soc Nephrol, 2017, 12(6):983-997., articleTitle=null, refAbstract=null), Reference(id=1319724533838369050, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=曹博宁,王珍.运用风药特性论治膜性肾病[J].北京中医药大学学报,2024,47(4):478-484., articleTitle=null, refAbstract=null), Reference(id=1319724533972586780, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=FERVENZA F C, APPEL G B, BARBOUR S J, et al. Rituximab or cyclosporine in the treatment of membranous nephropathy[J]. N Engl J Med, 2019, 381(1):36-46., articleTitle=null, refAbstract=null), Reference(id=1319724534203273501, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=李鑫,洪素珍,李宝华,等.升清降浊胶囊通过调节肠道菌群对db/db糖尿病肾病小鼠肾脏的保护作用及其机制探讨[J].中药新药与临床药理,2022,33(6):742-753., articleTitle=null, refAbstract=null), Reference(id=1319724534308131102, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=BORDER W A, WARD H J, KAMIL E S, et al. Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen[J]. J Clin Invest, 1982, 69(2):451-461., articleTitle=null, refAbstract=null), Reference(id=1319724534618509599, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=XIONG M Q, WANG L, LIU X T, et al. Kidney biopsies in elderly Chinese patients:a nationwide survey[J]. Am J Kidney Dis, 2020, 76(2):295-297., articleTitle=null, refAbstract=null), Reference(id=1319724534727561504, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=DANTAS M, SILVA L B B, PONTES B T M, et al. Membranous nephropathy[J]. Jornal Brasileiro de Nefrologia, 2023, 45(2):229-423., articleTitle=null, refAbstract=null), Reference(id=1319724535029551393, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=QIU T T, ZHANG C, ZHAO H W, et al. Calcineurin inhibitors versus cyclophosphamide for idiopathic membranous nephropathy:a systematic review and meta-analysis of 21 clinical trials[J]. Autoimmun Rev, 2017, 16(2):136-145., articleTitle=null, refAbstract=null), Reference(id=1319724535113437474, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=常蕊蕊,潘华荣,毛竞宇,等.丹参多酚酸盐通过NLRP3/Caspase-1/GSDMD细胞焦亡通路对膜性肾病大鼠肾损伤的影响[J].环球中医药,2024,17(12):2401-2408., articleTitle=null, refAbstract=null), Reference(id=1319724535172157731, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=张寒,赵幸如,吴宇清,等.中医药治疗膜性肾病大鼠蛋白尿研究进展[J].河南中医,2024,44(5):804-810., articleTitle=null, refAbstract=null), Reference(id=1319724535247655204, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=杨丽影,杨巧芳,牛丽丽.中医治疗膜性肾病的临床进展[J].中华中医药学刊,2017,35(10):2512-2524., articleTitle=null, refAbstract=null), Reference(id=1319724535469953317, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=MIAO H, ZHANG Y M, YU X Y, et al. Membranous nephropathy:Systems biology-based novel mechanism and traditional Chinese medicine therapy[J]. Front Pharmacol, 2022, 13:969930., articleTitle=null, refAbstract=null), Reference(id=1319724535541256486, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=LI X H, DONG X, ZHANG L Y, et al. Astragaloside Ⅳ attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation[J]. Front Pharmacol, 2024, 15:1285797., articleTitle=null, refAbstract=null), Reference(id=1319724535599976743, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=王超,黎志彬,肖幸,等.升清降浊胶囊对5/6肾切除大鼠肾功能及炎症损伤的影响[J].广州中医药大学学报,2018,35(4):679-683., articleTitle=null, refAbstract=null), Reference(id=1319724535662891304, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=苏保林,李敬,陈刚毅,等.升清降浊胶囊改善糖尿病肾病Ⅲ~Ⅳ期患者症状及相关实验室指标的疗效观察[J].中国中西医结合肾病杂志,2020,21(2):150-152., articleTitle=null, refAbstract=null), Reference(id=1319724535864217897, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG Y Q, LIU Q, CAI J Y, et al. Emodin prevents renal ischemia - reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission[J]. Eur J Pharmacol, 2022, 916:174603., articleTitle=null, refAbstract=null), Reference(id=1319724535956492586, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN X L, WEI W, LI Y Z, et al. Hesperetin relieves cisplatin - induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis[J]. Chem Biol Interact, 2019, 308:269-278., articleTitle=null, refAbstract=null), Reference(id=1319724536019407147, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=KAWAKAMI T, REN S Y, DUFFIELD J S. Wnt signalling in kidney diseases:dual roles in renal injury and repair[J]. J Pathol, 2013, 229(2):221-231., articleTitle=null, refAbstract=null), Reference(id=1319724536300425516, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=沈金峰,黄伟,罗富里,等.肾衰泄浊汤及组方对UUO大鼠Wnt4/β-catenin信号通路作用的影响[J].中华中医药学刊,2019,37(7):1637-41,810-814., articleTitle=null, refAbstract=null), Reference(id=1319724536401088813, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHOU L L, LIU Y H. Wnt/β-catenin signaling and renin-angiotensin system in chronic kidney disease[J]. Curr Opin Nephrol Hypertens, 2016, 25(2):100-106., articleTitle=null, refAbstract=null), Reference(id=1319724536489169198, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=MIAO H, WANG Y N, SU W, et al. Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway[J]. Acta Pharmacol Sin, 2024, 45(1):137-149., articleTitle=null, refAbstract=null), Reference(id=1319724536749216047, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG X L, GAO Y B, TIAN N X, et al. Astragaloside Ⅳ improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice[J]. Drug Des Devel Ther, 2018, 12:2431-2442., articleTitle=null, refAbstract=null), Reference(id=1319724536820519216, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125478306136123, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=SCHUNK S J, FLOEGE J, FLISER D, et al. WNT-β-catenin signalling— a versatile player in kidney injury and repair[J]. 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基于Wnt1/β-catenin信号通路探讨升清降浊胶囊对膜性肾病大鼠的作用及机制
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吴兴波 1 , 李宝华 2 , 张建东 1 , 陈刚毅 1 , 王超 1 , 张恩 1
中华中医药学刊 | 国家项目点击 2026,44(3): 175-179
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中华中医药学刊 |国家项目点击 2026 , 44 (3) : 175 -179
基于Wnt1/β-catenin信号通路探讨升清降浊胶囊对膜性肾病大鼠的作用及机制
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510405)])])]
吴兴波1, 李宝华2, 张建东1, 陈刚毅1, 王超1, 张恩1
作者信息
  • 1.广州中医药大学第一附属医院,广东 广州 510405
  • 2.广州中医药大学第一附属医院白云医院,广东 广州 510470
作者简介:

吴兴波(1983 -),男,广东海丰人,主治医师,硕士,研究方向:中医药防治慢性肾病。

Effect and Mechanism of Shengqing Jiangzhuo Capsule(升清降浊胶囊)on Membranous Nephropathy in Rats Based on Wnt1/β-catenin Signaling Pathway
Xingbo WU1, Baohua LI2, Jiandong ZHANG1, Gangyi CHEN1, Chao WANG1, En ZHANG1
Affiliations
  • 1.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China
  • 2.Baiyun Hospital, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510470, Guangdong, China
出版时间: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.032
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目的

探讨升清降浊胶囊(Shengqing Jiangzhuo Capsule,SQJZC)对膜性肾病大鼠的作用及具体机制。

方法

制备膜性肾病大鼠模型,造模成功后的大鼠给予不同浓度的SQJZC治疗;生化指标检测:24 h蛋白尿、尿素氮(Bloodureanitrogen,BUN)、血肌酐(Serumcreatinine,SCr)、甘油三酯(Triglyceride,TG)、总胆固醇(Totalcholesterol,TC)、丙氨酸氨基转移酶(Alanine aminotransferase,ALT)及天门冬氨酸氨基转移酶(Aspartate aminotransferase,AST);苏木素-伊红(Hematoxylin-eosin,HE)及基底膜六胺银(Periodic acid-silver methenamine,PASM)染色观察病理肾小球病理结构;Western blot法检测Wnt1/β-catenin信号通路相关指标。

结果

SQJZC治疗后的大鼠24 h尿蛋白定量降低(P < 0.05);各组大鼠BUN、Scr、AST及ALT无明显变化;与模型组相比,SQJZC给药组TC与TG水平出现不同程度下降(P < 0.05);病理染色结果显示,SQZJC能够改善大鼠肾小球毛细血管基底膜增厚;Western blot结果显示:SQJZC能够恢复肾组织肾病蛋白(Renal glomerulus-specific cell adhesion receptor,Nephrin)蛋白的表达;与空白组比较,模型组基质金属蛋白酶7(Matrix metalloproteinase 7,MMP-7)、G1/S-特异性周期蛋白-D1(G1/S-specific cyclin-D1,Cyclin D1)、结缔组织生长因子(Connective tissue growth factor,CTGF)、无翅型MMTV整合位点家族成员1(Wingless type MMTV integration site family member 1,Wnt1)、MYC癌基因(Myelocytomatosis viral oncogene homolog,c-Myc)、β-连环蛋白(CTNNB1,β-catenin)、活化的β-catenin(Active β-catenin)表达量均升高(P < 0.05),与模型组比较,SQZJC给药组MMP-7、Cyclin D1、CTGF、Wnt1、c-Myc、β-catenin、Active β-catenin蛋白表达量均有不同程度的下降(P < 0.05)。

结论

SQJZC具有缓解膜性肾病大鼠肾脏损伤的作用,其作用机制可能是通过Wnt1/β-catenin信号通路发挥作用。

升清降浊胶囊  /  膜性肾病  /  Wnt1/β-catenin信号通路
Objective

To investigate the effect of Shengqing Jiangzhuo Capsule(升清降浊胶囊, SQJZC)on membranous nephropathy in rats and its specific mechanism.

Methods

The rat model of membranous nephropathy was established, and the rats were treated with different concentrations of SQJZC. Biochemical indicators were determined, including 24-hour proteinuria, blood urea nitrogen(BUN), serum creatinine(SCR), triglyceride(TG), total cholesterol(TC), alanine aminotransferase(ALT)and aspartate aminotransferase(AST). Hematoxylin eosin(HE)and periodic acid silver amine(PASM)staining were conducted to observe the pathological changes of glomerulus. The related indexes of Wnt1/β-catenin signaling pathway were detected by Western blot.

Results

After SQJZC treatment, the 24 h urine protein of the rats decreased(P < 0.05). There were no significant changes in BUN, SCR, AST or ALT in each group. Compared with those in the model group, the levels of TC and TG in the SQJZC group decreased in some degrees(P < 0.05). The pathological staining results showed that SQJZC could alleviate the glomerular capillary basement membrane thickening in rats. Western blot results showed that SQJZC could restore the expression of nephrin protein in renal tissue. Compared with those of the blank group, the expression levels of MMP-7, Cyclin D1, CTGF, Wnt1, c-Myc, β-catenin and active β-catenin in the model group were increased(P < 0.05). Compared with those of the model group, the expression levels of MMP-7, Cyclin D1, CTGF, Wnt1, c-Myc, β-catenin and active β-catenin in the SQJZC group were decreased(P < 0.05).

Conclusion

SQJZC could alleviate the renal injury in rats with membranous nephropathy, and its mechanism may be through Wnt1/β-catenin signaling pathway.

Shengqing Jiangzhuo Capsule(升清降浊胶囊)  /  membranous nephropathy  /  Wnt1/β-catenin signaling pathway
吴兴波, 李宝华, 张建东, 陈刚毅, 王超, 张恩. 基于Wnt1/β-catenin信号通路探讨升清降浊胶囊对膜性肾病大鼠的作用及机制. 中华中医药学刊, 2026 , 44 (3) : 175 -179 . DOI: 10.13193/j.issn.1673-7717.2026.03.032
Xingbo WU, Baohua LI, Jiandong ZHANG, Gangyi CHEN, Chao WANG, En ZHANG. Effect and Mechanism of Shengqing Jiangzhuo Capsule(升清降浊胶囊)on Membranous Nephropathy in Rats Based on Wnt1/β-catenin Signaling Pathway[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 175 -179 . DOI: 10.13193/j.issn.1673-7717.2026.03.032
  • 国家自然科学基金项目(82305114)
  • 广东省中医药局科研项目(20211134)
参考文献 引证文献
排序方式:
[1]
RONCO P, BECK L, DEBIEC H, et al. Membranous nephropathy[J]. Nat Rev Dis Primers, 2021, 7:69.
[2]
GU Y, XU H, TANG D M. Mechanisms of primary membranous nephropathy[J]. Biomolecules, 2021, 11(4):513.
[3]
HU R M, QUAN S X, WANG Y Z, et al. Spectrum of biopsy proven renal diseases in Central China:a 10-year retrospective study based on 34, 630 cases[J]. Sci Rep, 2020, 10(1):10994.
[4]
LIU Q Y, LIU J H, LIN B X, et al. Novel biomarkers in membranous nephropathy[J]. Front Immunol, 2022, 13:845767.
[5]
LIU W B, GAO C, DAI H R, et al. Immunological pathogenesis of membranous nephropathy:focus on PLA2R1 and its role[J]. Front Immunol, 2019, 10:1809.
[6]
COUSER W G. Primary membranous nephropathy[J]. Clin J Am Soc Nephrol, 2017, 12(6):983-997.
[7]
曹博宁,王珍.运用风药特性论治膜性肾病[J].北京中医药大学学报,2024,47(4):478-484.
[8]
FERVENZA F C, APPEL G B, BARBOUR S J, et al. Rituximab or cyclosporine in the treatment of membranous nephropathy[J]. N Engl J Med, 2019, 381(1):36-46.
[9]
李鑫,洪素珍,李宝华,等.升清降浊胶囊通过调节肠道菌群对db/db糖尿病肾病小鼠肾脏的保护作用及其机制探讨[J].中药新药与临床药理,2022,33(6):742-753.
[10]
BORDER W A, WARD H J, KAMIL E S, et al. Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen[J]. J Clin Invest, 1982, 69(2):451-461.
[11]
XIONG M Q, WANG L, LIU X T, et al. Kidney biopsies in elderly Chinese patients:a nationwide survey[J]. Am J Kidney Dis, 2020, 76(2):295-297.
[12]
DANTAS M, SILVA L B B, PONTES B T M, et al. Membranous nephropathy[J]. Jornal Brasileiro de Nefrologia, 2023, 45(2):229-423.
[13]
QIU T T, ZHANG C, ZHAO H W, et al. Calcineurin inhibitors versus cyclophosphamide for idiopathic membranous nephropathy:a systematic review and meta-analysis of 21 clinical trials[J]. Autoimmun Rev, 2017, 16(2):136-145.
[14]
常蕊蕊,潘华荣,毛竞宇,等.丹参多酚酸盐通过NLRP3/Caspase-1/GSDMD细胞焦亡通路对膜性肾病大鼠肾损伤的影响[J].环球中医药,2024,17(12):2401-2408.
[15]
张寒,赵幸如,吴宇清,等.中医药治疗膜性肾病大鼠蛋白尿研究进展[J].河南中医,2024,44(5):804-810.
[16]
杨丽影,杨巧芳,牛丽丽.中医治疗膜性肾病的临床进展[J].中华中医药学刊,2017,35(10):2512-2524.
[17]
MIAO H, ZHANG Y M, YU X Y, et al. Membranous nephropathy:Systems biology-based novel mechanism and traditional Chinese medicine therapy[J]. Front Pharmacol, 2022, 13:969930.
[18]
LI X H, DONG X, ZHANG L Y, et al. Astragaloside Ⅳ attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation[J]. Front Pharmacol, 2024, 15:1285797.
[19]
王超,黎志彬,肖幸,等.升清降浊胶囊对5/6肾切除大鼠肾功能及炎症损伤的影响[J].广州中医药大学学报,2018,35(4):679-683.
[20]
苏保林,李敬,陈刚毅,等.升清降浊胶囊改善糖尿病肾病Ⅲ~Ⅳ期患者症状及相关实验室指标的疗效观察[J].中国中西医结合肾病杂志,2020,21(2):150-152.
[21]
WANG Y Q, LIU Q, CAI J Y, et al. Emodin prevents renal ischemia - reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission[J]. Eur J Pharmacol, 2022, 916:174603.
[22]
CHEN X L, WEI W, LI Y Z, et al. Hesperetin relieves cisplatin - induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis[J]. Chem Biol Interact, 2019, 308:269-278.
[23]
KAWAKAMI T, REN S Y, DUFFIELD J S. Wnt signalling in kidney diseases:dual roles in renal injury and repair[J]. J Pathol, 2013, 229(2):221-231.
[24]
沈金峰,黄伟,罗富里,等.肾衰泄浊汤及组方对UUO大鼠Wnt4/β-catenin信号通路作用的影响[J].中华中医药学刊,2019,37(7):1637-41,810-814.
[25]
ZHOU L L, LIU Y H. Wnt/β-catenin signaling and renin-angiotensin system in chronic kidney disease[J]. Curr Opin Nephrol Hypertens, 2016, 25(2):100-106.
[26]
MIAO H, WANG Y N, SU W, et al. Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway[J]. Acta Pharmacol Sin, 2024, 45(1):137-149.
[27]
WANG X L, GAO Y B, TIAN N X, et al. Astragaloside Ⅳ improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice[J]. Drug Des Devel Ther, 2018, 12:2431-2442.
[28]
SCHUNK S J, FLOEGE J, FLISER D, et al. WNT-β-catenin signalling— a versatile player in kidney injury and repair[J]. Nat Rev Nephrol, 2020, 17(3):172-184.
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doi: 10.13193/j.issn.1673-7717.2026.03.032
  • 首发时间:2026-10-14
  • 出版时间:2026-03-10
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国家自然科学基金项目(82305114)
广东省中医药局科研项目(20211134)
作者信息
    1.广州中医药大学第一附属医院,广东 广州 510405
    2.广州中医药大学第一附属医院白云医院,广东 广州 510470
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
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红菇属 Russula 17 8.13
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