中华中医药学刊

基于Wnt/β-catenin通路探究补肾壮骨方含药血清对IL-1β诱导软骨细胞退变的保护作用

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张辽 , 傅科上 , 史燕红 , 金甬 , 吴权

中华中医药学刊 | 国家项目点击 2026,44(3): 99-104

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中华中医药学刊 |国家项目点击 2026 , 44 (3) : 99 -104

基于Wnt/β-catenin通路探究补肾壮骨方含药血清对IL-1β诱导软骨细胞退变的保护作用

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张辽, 傅科上, 史燕红, 金甬, 吴权

作者信息

浙江中医药大学附属宁波市中医院，浙江宁波 315000

作者简介:

张辽（1985 -），男，浙江宁波人，副主任中医师，硕士，研究方向：骨与关节疾病的基础与临床。

Investigating Protective Effect of Serum Containing Bushen Zhuanggu Prescription（补肾壮骨方）on IL-1β-Induced Chondrocyte Degeneration via Wnt/β-catenin Pathway

Liao ZHANG, Keshang FU, Yanhong SHI, Yong JIN, Quan WU

Affiliations

Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo 315000, Zhejiang, China

出版时间: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.019

文章导航

摘要

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目的

探究补肾壮骨方对大鼠软骨细胞退变的保护作用及其作用机制。

方法

分离大鼠原代软骨细胞并给予不同浓度白细胞介素-1β（IL-1β）刺激，探索IL-1β诱导骨关节炎（OA）细胞模型的最佳浓度，同时制备高中低浓度梯度的补肾壮骨方含药血清或盐酸氨基葡萄糖胶囊血清，作为细胞干预手段。检测软骨退化相关蛋白以及Wnt/β-catenin信号通路相关蛋白的mRNA及蛋白质表达，并使用透射电镜评价细胞超微结构变化。

结果

经过IL-1β刺激后，软骨细胞的软骨退化相关蛋白以及Wnt/β-catenin通路相关蛋白表达明显异常，超微结构也可观察到细胞严重损伤。而补肾壮骨方通过抑制Wnt/β-catenin信号通路的激活，改善降低IL-1β诱导的炎症因子和基质金属蛋白酶（MMP）的表达，并促进了Collagen Ⅱ和Aggrecan的表达，从而保护软骨细胞。

结论

补肾壮骨方含药血清能够通过抑制Wnt/β-catenin通路减少退变相关蛋白的异常表达，从而发挥保护作用。

关键词

补肾壮骨方 / Wnt/β-catenin信号通路 / 骨关节炎 / 软骨细胞

Abstract

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Objective

To explore the protective effect of Bushen Zhuanggu Prescription（补肾壮骨方）on chondrocyte degeneration in rats and its mechanism of action.

Methods

Primary chondrocytes from rats were isolated and stimulated with various concentrations of interleukin-1β（IL-1β）to identify the optimal concentration for inducing an osteoarthritis（OA）cell model. Concurrently, the serum containing Bushen Zhuanggu Formula at high, medium and low concentration gradients, or serum containing hydrochloric aminoglucose capsules, was prepared as a cellular intervention. The expressions of mRNA and proteins related to cartilage degeneration and the Wnt/β-catenin signaling pathway were measured, and the transmission electron microscopy was used to evaluate the changes in cellular ultrastructure.

Results

After stimulation with IL-1β, the expressions of proteins related to cartilage degeneration and the Wnt/β-catenin pathway in chondrocytes was significantly abnormal, and the severe cellular damage was observed under ultrastructural examination. However, Bushen Zhuanggu Formula, by inhibiting the activation of the Wnt/β-catenin signaling pathway, reduced the expressions of inflammatory factors and MMPs induced by IL-1β and promoted the expressions of Collagen Ⅱ and Aggrecan, thereby protecting the chondrocytes.

Conclusion

Serum containing Bushen Zhuanggu Formula can reduce the abnormal expression of degeneration-related proteins by inhibiting the Wnt/β-catenin pathway, thus exerting a protective effect.

Key words

Bushen Zhuanggu Formula（补肾壮骨方） / Wnt/β-catenin signaling pathway / osteoarthritis / chondrocytes

引用本文

张辽, 傅科上, 史燕红, 金甬, 吴权. 基于Wnt/β-catenin通路探究补肾壮骨方含药血清对IL-1β诱导软骨细胞退变的保护作用. 中华中医药学刊, 2026 , 44 (3) : 99 -104 . DOI: 10.13193/j.issn.1673-7717.2026.03.019

Liao ZHANG, Keshang FU, Yanhong SHI, Yong JIN, Quan WU. Investigating Protective Effect of Serum Containing Bushen Zhuanggu Prescription（补肾壮骨方）on IL-1β-Induced Chondrocyte Degeneration via Wnt/β-catenin Pathway[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 99 -104 . DOI: 10.13193/j.issn.1673-7717.2026.03.019

基金

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国家自然科学基金青年科学基金项目(82104885)
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教发〔2016〕42号)
国家中医药管理局科技司-浙江省中医药管理局共建科技计划项目（重大项目）(GZY-ZJ-KJ-23037)
浙江省中医药科技计划项目(2024ZL144; 2018ZB119)
宁波市医学重点学科建设计划项目(2022-Z09)
宁波市卫生健康青年技术骨干人才培养专项(甬卫发〔2020〕95号)
宁波市名中医药专家学术经验继承项目(甬卫办中医〔2020 〕150号)
宁波市自然科学基金项目(2021J300)

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2026年第44卷第3期

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doi: 10.13193/j.issn.1673-7717.2026.03.019

首发时间：2026-10-14
出版时间：2026-03-10

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国家自然科学基金青年科学基金项目(82104885)

国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教发〔2016〕42号)

国家中医药管理局科技司-浙江省中医药管理局共建科技计划项目（重大项目）(GZY-ZJ-KJ-23037)

浙江省中医药科技计划项目(2024ZL144; 2018ZB119)

宁波市医学重点学科建设计划项目(2022-Z09)

宁波市卫生健康青年技术骨干人才培养专项(甬卫发〔2020〕95号)

宁波市名中医药专家学术经验继承项目(甬卫办中医〔2020 〕150号)

宁波市自然科学基金项目(2021J300)

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浙江中医药大学附属宁波市中医院，浙江宁波 315000

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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.03.019

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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