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Article(id=1317125433137672228, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956774266, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956774266, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956774266, creator=13701087609, updateTime=1791956774266, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=67, endPage=69, ext={EN=ArticleExt(id=1317125433334804517, articleId=1317125433137672228, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Experimental Study on Inhibitory Pharmacological Effects of Morusin on RNA Polymerase of SARS-CoV-2 and Prediction of Activity of Related Analogs, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the inhibitory pharmacological effects of Morusin on the function of the RNA polymerase of SARS-CoV-2, and the target enzyme inhibitory activity of 5 kinds of traditional Chinese medicine ingredients similar to mulberry sinin was predicted.

Methods

Molecular docking technology was used to study the binding mode of Morusin to the active site of the RNA polymerase of SARS-CoV-2. The inhibitory activity of Morusin on RNA polymerase was then tested using a cell-based RNA polymerase catalytic system. Five small molecules with structural analogs of morocinin were selected from the components of Morus traditional Chinese medicine, and their interaction patterns with amino acids at the active site of RNA polymerase were studied using molecular docking methods.

Results

Morusin can firmly occupy the NTPs channel of RNA polymerase and block the entry of nucleotides, thereby inhibiting the nucleic acid replication function of RNA polymerase. Pharmacological experiments at the cellular level confirmed that the inhibitory activity of Morusin on RNA polymerase was stronger than that of the control drug remdesivir. At the same time, the 5 kinds of small molecules of the structural analogs of mulberry can also bind to the active site of RNA polymerase and have enzyme inhibitory activity.

Conclusion

This study has found that Morusin has strong inhibitory activity on RNA polymerase, the five analogs are also predicted to have strong RNA polymerase inhibitory activity, and the results can provide a reference for the development of anti-SARS-CoV-2 drugs.

, authors=Qiaona WU1, Xiaohua XIE2, Jinglei LIU3, Yujia WANG4, Kun DI1, Yanlei SU3, Dianxing SUN3, Shan CEN4, authorsList=Qiaona WU, Xiaohua XIE, Jinglei LIU, Yujia WANG, Kun DI, Yanlei SU, Dianxing SUN, Shan CEN, authorCompany=null, correspAuthors=Yanlei SU, Shan CEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125433561296934, articleId=1317125433137672228, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=桑辛素对新型冠状病毒RNA聚合酶抑制作用的实验研究及相关类似物活性预测, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

探讨桑辛素对新型冠状病毒RNA聚合酶功能的抑制作用，并对5种与桑辛素结构类似的桑属中药成分进行靶酶抑制活性预测。

方法

利用分子对接技术研究桑辛素与新型冠状病毒RNA聚合酶活性位点的结合模式；而后应用细胞水平的RNA聚合酶催化体系检测桑辛素对RNA聚合酶的抑制活性。从桑属中药成分中选取5种与桑辛素结构类似物小分子，应用分子对接方法分别研究它们与RNA聚合酶活性位点处氨基酸的相互作用模式。

结果

桑辛素可牢固占据RNA聚合酶NTPs通道而阻碍核苷酸的进入，从而抑制RNA聚合酶的核酸复制功能。细胞水平的药理实验结果证实，桑辛素对RNA聚合酶的抑制活性强于对照药物瑞德西韦。同时，5种桑辛素结构类似物小分子亦可与RNA聚合酶活性位点处结合而具有酶抑制活性。

结论

研究发现桑辛素对RNA聚合酶具有较强的抑制活性，其5种结构类似物小分子亦被预测具有较强的RNA聚合酶抑制活性，结果可为抗新型冠状病毒药物研发提供参考。

, authors=吴巧娜1, 谢小华2, 刘晶磊3, 王宇佳4, 邸琨1, 苏彦雷3, 孙殿兴3, 岑山4, authorsList=吴巧娜, 谢小华, 刘晶磊, 王宇佳, 邸琨, 苏彦雷, 孙殿兴, 岑山, authorCompany=null, correspAuthors=苏彦雷, 岑山, authorNote=

吴巧娜（1984 -），女，河北石家庄人，副主任药师，硕士，研究方向：临床药理学及中药活性成分筛选。

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苏彦雷（1983 -），男，河北石家庄人，副主任药师，硕士研究生导师，研究方向：临床药学及药效活性成分筛选。E-mail：。
岑山（1969 -），男，北京人，高级研究员，博士研究生导师，研究方向：抗感染新药。E-mail：。
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吴巧娜（1984 -），女，河北石家庄人，副主任药师，硕士，研究方向：临床药理学及中药活性成分筛选。

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吴巧娜（1984 -），女，河北石家庄人，副主任药师，硕士，研究方向：临床药理学及中药活性成分筛选。

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桑辛素对新型冠状病毒RNA聚合酶抑制作用的实验研究及相关类似物活性预测
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吴巧娜 1 , 谢小华 2 , 刘晶磊 3 , 王宇佳 4 , 邸琨 1 , 苏彦雷 3 , 孙殿兴 3 , 岑山 4
中华中医药学刊 | 国家项目点击 2026,44(3): 67-69
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中华中医药学刊 |国家项目点击 2026 , 44 (3) : 67 -69
桑辛素对新型冠状病毒RNA聚合酶抑制作用的实验研究及相关类似物活性预测
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吴巧娜（1984 -），女，河北石家庄人，副主任药师，硕士，研究方向：临床药理学及中药活性成分筛选。

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吴巧娜（1984 -），女，河北石家庄人，副主任药师，硕士，研究方向：临床药理学及中药活性成分筛选。

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吴巧娜1, 谢小华2, 刘晶磊3, 王宇佳4, 邸琨1, 苏彦雷3 , 孙殿兴3, 岑山4
作者信息
  • 1.石家庄市第三医院，河北 石家庄 050011
  • 2.河北省人民医院，河北 石家庄 050051
  • 3.联勤保障部队第九八○医院，河北 石家庄 050082
  • 4.中国医学科学院，北京协和医学院医药生物技术研究所，北京 100050
通讯作者:
苏彦雷（1983 -），男，河北石家庄人，副主任药师，硕士研究生导师，研究方向：临床药学及药效活性成分筛选。E-mail：。
岑山（1969 -），男，北京人，高级研究员，博士研究生导师，研究方向：抗感染新药。E-mail：。
作者简介:

吴巧娜（1984 -），女，河北石家庄人，副主任药师，硕士，研究方向：临床药理学及中药活性成分筛选。

Experimental Study on Inhibitory Pharmacological Effects of Morusin on RNA Polymerase of SARS-CoV-2 and Prediction of Activity of Related Analogs
Qiaona WU1, Xiaohua XIE2, Jinglei LIU3, Yujia WANG4, Kun DI1, Yanlei SU3 , Dianxing SUN3, Shan CEN4
Affiliations
  • 1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China
  • 2.Hebei General Hospital, Shijiazhuang 050051, Hebei, China
  • 3.The 980th Hospital of The Joint Logistics Support Force of the Chinese People＇s Liberation Army, Shijiazhuang 050082, Hebei, China
  • 4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
出版时间: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.012
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摘要
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目的

探讨桑辛素对新型冠状病毒RNA聚合酶功能的抑制作用，并对5种与桑辛素结构类似的桑属中药成分进行靶酶抑制活性预测。

方法

利用分子对接技术研究桑辛素与新型冠状病毒RNA聚合酶活性位点的结合模式；而后应用细胞水平的RNA聚合酶催化体系检测桑辛素对RNA聚合酶的抑制活性。从桑属中药成分中选取5种与桑辛素结构类似物小分子，应用分子对接方法分别研究它们与RNA聚合酶活性位点处氨基酸的相互作用模式。

结果

桑辛素可牢固占据RNA聚合酶NTPs通道而阻碍核苷酸的进入，从而抑制RNA聚合酶的核酸复制功能。细胞水平的药理实验结果证实，桑辛素对RNA聚合酶的抑制活性强于对照药物瑞德西韦。同时，5种桑辛素结构类似物小分子亦可与RNA聚合酶活性位点处结合而具有酶抑制活性。

结论

研究发现桑辛素对RNA聚合酶具有较强的抑制活性，其5种结构类似物小分子亦被预测具有较强的RNA聚合酶抑制活性，结果可为抗新型冠状病毒药物研发提供参考。

新型冠状病毒  /  RNA聚合酶  /  桑辛素  /  分子对接  /  药理实验  /  结构类似物
Objective

To investigate the inhibitory pharmacological effects of Morusin on the function of the RNA polymerase of SARS-CoV-2, and the target enzyme inhibitory activity of 5 kinds of traditional Chinese medicine ingredients similar to mulberry sinin was predicted.

Methods

Molecular docking technology was used to study the binding mode of Morusin to the active site of the RNA polymerase of SARS-CoV-2. The inhibitory activity of Morusin on RNA polymerase was then tested using a cell-based RNA polymerase catalytic system. Five small molecules with structural analogs of morocinin were selected from the components of Morus traditional Chinese medicine, and their interaction patterns with amino acids at the active site of RNA polymerase were studied using molecular docking methods.

Results

Morusin can firmly occupy the NTPs channel of RNA polymerase and block the entry of nucleotides, thereby inhibiting the nucleic acid replication function of RNA polymerase. Pharmacological experiments at the cellular level confirmed that the inhibitory activity of Morusin on RNA polymerase was stronger than that of the control drug remdesivir. At the same time, the 5 kinds of small molecules of the structural analogs of mulberry can also bind to the active site of RNA polymerase and have enzyme inhibitory activity.

Conclusion

This study has found that Morusin has strong inhibitory activity on RNA polymerase, the five analogs are also predicted to have strong RNA polymerase inhibitory activity, and the results can provide a reference for the development of anti-SARS-CoV-2 drugs.

SARS-CoV-2  /  RNA polymerase  /  Morusin  /  molecular dock  /  pharmacological experiment  /  analogs
吴巧娜, 谢小华, 刘晶磊, 王宇佳, 邸琨, 苏彦雷, 孙殿兴, 岑山. 桑辛素对新型冠状病毒RNA聚合酶抑制作用的实验研究及相关类似物活性预测. 中华中医药学刊, 2026 , 44 (3) : 67 -69 . DOI: 10.13193/j.issn.1673-7717.2026.03.012
Qiaona WU, Xiaohua XIE, Jinglei LIU, Yujia WANG, Kun DI, Yanlei SU, Dianxing SUN, Shan CEN. Experimental Study on Inhibitory Pharmacological Effects of Morusin on RNA Polymerase of SARS-CoV-2 and Prediction of Activity of Related Analogs[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 67 -69 . DOI: 10.13193/j.issn.1673-7717.2026.03.012
基金
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  • 国家自然科学基金项目(81672041)
  • 河北省卫生健康委员会重点科研攻关计划项目(20231302; 20241343)
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2026年第44卷第3期
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doi: 10.13193/j.issn.1673-7717.2026.03.012
  • 首发时间：2026-10-14
  • 出版时间：2026-03-10
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国家自然科学基金项目(81672041)
河北省卫生健康委员会重点科研攻关计划项目(20231302; 20241343)
作者信息
    1.石家庄市第三医院，河北 石家庄 050011
    2.河北省人民医院，河北 石家庄 050051
    3.联勤保障部队第九八○医院，河北 石家庄 050082
    4.中国医学科学院，北京协和医学院医药生物技术研究所，北京 100050

通讯作者:

苏彦雷（1983 -），男，河北石家庄人，副主任药师，硕士研究生导师，研究方向：临床药学及药效活性成分筛选。E-mail：。
岑山（1969 -），男，北京人，高级研究员，博士研究生导师，研究方向：抗感染新药。E-mail：。
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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