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Article(id=1317125432189768443, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.028, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956774040, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956774040, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956774040, creator=13701087609, updateTime=1791956774040, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=154, endPage=159, ext={EN=ArticleExt(id=1317125432655336188, articleId=1317125432189768443, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Optimization of Extraction Process，Structural Characterization and Antioxidant Activity of Polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To optimize the process conditions for extracting polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）using water extraction and alcohol precipitation method.

Method

Water extraction and alcohol precipitation were used to extract polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）, and a three-factor experiment was conducted. On this basis, a Box Benhnken（BBD）response surface experiment was designed, integrating the experimental results and fitting the data. A fitting model was established for the degree of influence between factors and response values, and its water extraction and alcohol precipitation process were optimized. And it preliminarily characterized the structure of its polysaccharides and determined their antioxidant activity.

Result

The optimal extraction conditions for water extraction and alcohol extraction of polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）were a solid-liquid ratio of 1∶22.11（g/mL）, reflux time of 129 min 36 s, 3 times. The average extraction rate of 5 times was 4.324%, which was close to the system＇s predicted value of 4.313%. After PMP derivatization and HPLC analysis, the results showed that the polysaccharides of Yejiaoteng（Tuber Fleeceflower Stem）were mainly composed of Man, Rha, Glc and Gal, with a molar ratio of 29.87∶3.36∶51.25∶39.98. The infrared spectrum showed characteristic peaks of polysaccharides at 3420, 1600, 1000 cm-1. The clearance rates of polysaccharides（Y-TD）on DPPH and ABTS free radicals were 78.2% and 85.4%, respectively.

Conclusion

Box-Behnken response surface design optimization of water extraction and alcohol precipitation extraction process is stable and reliable, and can be used to extract polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）with antioxidant activity.

, authors=Qimao HAN1, Zixin PANG2, Lu CHEN1, Shijia ZHANG2, Hongcai ZHANG2, authorsList=Qimao HAN, Zixin PANG, Lu CHEN, Shijia ZHANG, Hongcai ZHANG, authorCompany=null, correspAuthors=Hongcai ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125432915383037, articleId=1317125432189768443, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=夜交藤多糖提取工艺优化、结构表征及抗氧化活性研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

优化水提醇沉法提取夜交藤多糖工艺条件。

方法

利用水提醇沉法提取夜交藤多糖，进行三因素实验。在此基础上，设计响应面实验（Box-Benhnken Design，BBD），进行数据拟合，优化其水提醇沉工艺。并对其多糖进行结构初步表征，抗氧化活性测定。

结果

夜交藤多糖水浸醇提的最佳提取条件∶料液比1∶22.11（g/mL），回流时间129 min 36 s，次数为3次。5次提取率的平均值为4.324%，与系统预测值4.313%相近。经PMP衍生后HPLC分析，结果表明，夜交藤多糖主要是由Man、Rha、Glc、Gal组成，其摩尔比为29.87∶3.36∶51.25∶39.98。红外光谱可见多糖3420、1600、1000 cm-1特征峰。多糖（Y-TD）对DPPH、ABTS自由基的清除率分别为78.2%和85.4% 。

结论

Box-Behnken响应面设计优化水提醇沉提取工艺稳定可靠，可用于提取具有抗氧化活性的夜交藤多糖。

, authors=韩其茂1, 庞子鑫2, 陈璐1, 张诗嘉2, 张洪财2, authorsList=韩其茂, 庞子鑫, 陈璐, 张诗嘉, 张洪财, authorCompany=null, correspAuthors=张洪财, authorNote=

韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

, correspAuthorsNote=
张洪财（1983 -），男，黑龙江绥芬河人，副研究员，硕士研究生导师，博士，研究方向：中药化学成分提取工艺优化及活性。E-mail：。
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韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

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韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

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pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［2］, rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=乔春梅，瞿迁，方铁根，等.基于数据挖掘《中华医典》清代治疗不寐的用药规律研究［J］.现代医学，2023，51（2）：196-201., articleTitle=null, refAbstract=null), Reference(id=1319724590948012752, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［3］, rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=严静，潘以丰，陈升捷，等.从风药论治腹泻型肠易激综合征经验［J］.中国中西医结合消化杂志，2023，31（2）：142-145., articleTitle=null, refAbstract=null), Reference(id=1319724591052870353, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［4］, rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=张董晓，付娜，黄巧，等.赵炳南“四藤”组合组方思路在乳腺疾病中的应用与发展［J］.中医杂志，2021，62（4）：4., articleTitle=null, refAbstract=null), Reference(id=1319724591124173522, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［5］, rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=郑玉娇，张培，林家冉，等.首乌藤的临床应用及其用量［J］.长春中医药大学学报，2020，36（2）：3., articleTitle=null, refAbstract=null), Reference(id=1319724591191282387, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［6］, rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=佟一鑫，柏强.基于网络药理学和分子对接技术探究夜交藤治疗失眠的作用机制［J］.中医临床研究，2021，13（26）：1-5., articleTitle=null, refAbstract=null), Reference(id=1319724591270974164, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［7］, rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=谭铖，罗洪斌，黄胜.首乌藤治疗阿尔茨海默病的网络药理学研究［J］.中南民族大学学报（自然科学版），2021，40（6）：605-613., articleTitle=null, refAbstract=null), Reference(id=1319724591342277333, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［8］, rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=孙洲亮，文莉.夜交藤不同提取物对抗焦虑作用的比较［J］.中国医院药学杂志，2008，28（2）：164-165., articleTitle=null, refAbstract=null), Reference(id=1319724591409386198, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［9］, rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=许晓伍，陈群，郝木峰等.夜交藤提取物对失眠大鼠额叶皮层神经元线粒体结构和功能的影响［J］.广州中医药大学学报，2013，30（6）：872-875., articleTitle=null, refAbstract=null), Reference(id=1319724591472300759, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［10］, rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=单明东.夜交藤多酚高效提取及其体外抗氧化活性初步分析［D］.镇江：江苏大学，2021., articleTitle=null, refAbstract=null), Reference(id=1319724591539409624, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［11］, rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=陶丽宇，高月求，韦靖，等.首乌藤相关药理作用及临床运用的研究进展［J］.时珍国医国药，2018，29（10）：2486-2488., articleTitle=null, refAbstract=null), Reference(id=1319724591606518489, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［12］, rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=李明超，付亚轩，张新宇，等.夜交藤化学成分及其药理活性研究进展［J］.云南中医中药杂志，2018，39（3）：81-84., articleTitle=null, refAbstract=null), Reference(id=1319724591669433050, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［13］, rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=李金花，农石生，黄锁义.分光光度法测定夜交藤中多糖［J］.理化检验.化学分册，2012，48（9）：2., articleTitle=null, refAbstract=null), Reference(id=1319724591740736219, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［14］, rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=汲广全，杨娟，杨小生.夜交藤改善睡眠活性成分研究［J］.中成药，2011，33（3）：514-516., articleTitle=null, refAbstract=null), Reference(id=1319724591812039388, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［15］, rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=陶遵威，郑夺，邸明磊等.植物多糖的研究进展［J］.药物评价研究，2010，33（2）：149-152., articleTitle=null, refAbstract=null), Reference(id=1319724591874953949, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［16］, rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=BOX G E P, BEHNKEN D W. Some new three level designs for the study of quantitative variables［J］. Technometrics, 1960, 2（4）：455-475., articleTitle=null, refAbstract=null), Reference(id=1319724591950451422, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［17］, rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=RAIS S, ISLAM A, AHMAD I, et al. Preparation of a new magnetic ion-imprinted polymer and optimization using Box-Behnken design for selective removal and determination of Cu（Ⅱ）in food and wastewater samples［J］. Food Chem, 2021, 334：127563., articleTitle=null, refAbstract=null), Reference(id=1319724592038531807, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［18］, rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG H J, HONG W, LI X Y, et al. Optimization of nanostructured lipid carriers of fenofibrate using aBox-behnken design for oral bioavailability enhancement［J］. Curr Drug Deliv, 2022, 19（7）：773-787., articleTitle=null, refAbstract=null), Reference(id=1319724592114029280, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［19］, rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG Z, GUO S C, CHEN C D, et al. Optimization of extraction and bioactivity detection of celery leaf flavonoids using BP neural network combined with genetic algorithm and response［J］. Prep Biochem Biotechnol, 2022, 52（6）：648-656., articleTitle=null, refAbstract=null), Reference(id=1319724592189526753, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［20］, rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=JOJO G M, KUPPUSAMY G, DE A, et al. Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer’s disease using Box-Behnken design［J］. Drug Dev Ind Pharm, 2019, 45（7）：1061-1072., articleTitle=null, refAbstract=null), Reference(id=1319724592252441314, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［21］, rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=王文姌，王韫格，张洪财等. Box-Behnken响应面法优化赤芍多糖的提取工艺［J］.化学工程师，2023，37（4）：88-92., articleTitle=null, refAbstract=null), Reference(id=1319724593917580003, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［22］, rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=江丽洁，温乐乐，石佳艺，等.常山胡柚果皮精油提取工艺模型筛选优化、化学成分及抗氧化活性研究［J］.天然产物研究与开发，2024，36（7）：1101-1111., articleTitle=null, refAbstract=null), Reference(id=1319724594005660388, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［23］, rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=赵小亮，牟翮，张晶，等.苦参多糖的提取工艺优化及体外抗氧化、降血脂活性分析［J］.食品工业科技，2024，45（13）：212-220., articleTitle=null, refAbstract=null), Reference(id=1319724594085352165, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［24］, rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=刘永玲，刘向炼，陶欣，等.八月瓜果皮多糖提取工艺优化及其体外抗氧化、降糖活性分析［J］.食品工业科技，2024，45（19）：17-24., articleTitle=null, refAbstract=null), Reference(id=1319724594148266726, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［25］, rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=胡建燃，李平，王俊瑶.熟地黄多糖的提取及其体外抗氧化活性研究［J］.中华中医药学刊，2021，39（12）：37-41., articleTitle=null, refAbstract=null), Reference(id=1319724594219569895, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=黎江华，李涛，黄永亮，等.熟三七多糖的结构分析及抗氧化活性研究［J］.中华中医药学刊，2018，36（6）：1380-1383., articleTitle=null, refAbstract=null), Reference(id=1319724594299261672, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［27］, rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=TERFASSI S, DAUVERGNE X, CÉRANTOLA S, et al. First report on phytochemical investigation, antioxidant and antidiabetic activities of Helianthemum getulum［J］. Nat Prod Res, 2022, 36（11）：2806-2813., articleTitle=null, refAbstract=null), Reference(id=1319724594387342057, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［28］, rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=WONGWAD E, JADSADAJERM S, MUNGMAI L, et al. Antioxidant, cytotoxic, anti-glycation, and anti-tyrosinase compounds from the leaves of Uvaria siamensis［J］. Chem Biodivers, 2024, 21（4）：e202400319., articleTitle=null, refAbstract=null), Reference(id=1319724594471228138, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［29］, rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=ONG E S, OH C L Y, TAN J C W, et al. Pressurized hot water extraction of okra seeds reveals antioxidant, antidiabetic and vasoprotective activities［J］. Plants, 2021, 10（8）：1645., articleTitle=null, refAbstract=null), Reference(id=1319724594538337003, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［30］, rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=LOU H Y, LIU H F, WANG H, et al. Diverse flavonoids from the roots of Indigofera stachyodes［J］. Chem Biodivers, 2022, 19（10）：e202200676., articleTitle=null, refAbstract=null), Reference(id=1319724594601251564, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125432189768443, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［31］, rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=FATMAWATI S, AUWALIYAH F, YULIANA, et al. Antioxidant and α-glucosidase inhibitory activities of compound isolated from Stachytarpheta jamaicensis（L）Vahl. leaves［J］. 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夜交藤多糖提取工艺优化、结构表征及抗氧化活性研究
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韩其茂 1 , 庞子鑫 2 , 陈璐 1 , 张诗嘉 2 , 张洪财 2
中华中医药学刊 | 国家项目点击 2026,44(3): 154-159
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中华中医药学刊 |国家项目点击 2026 , 44 (3) : 154 -159
夜交藤多糖提取工艺优化、结构表征及抗氧化活性研究
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韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

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韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

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韩其茂1, 庞子鑫2, 陈璐1, 张诗嘉2, 张洪财2
作者信息
  • 1.黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150040
  • 2.黑龙江中医药大学，黑龙江 哈尔滨 150040
通讯作者:
张洪财（1983 -），男，黑龙江绥芬河人，副研究员，硕士研究生导师，博士，研究方向：中药化学成分提取工艺优化及活性。E-mail：。
作者简介:

韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

Optimization of Extraction Process，Structural Characterization and Antioxidant Activity of Polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）
Qimao HAN1, Zixin PANG2, Lu CHEN1, Shijia ZHANG2, Hongcai ZHANG2
Affiliations
  • 1.The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China
  • 2.Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China
出版时间: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.028
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摘要
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目的

优化水提醇沉法提取夜交藤多糖工艺条件。

方法

利用水提醇沉法提取夜交藤多糖，进行三因素实验。在此基础上，设计响应面实验（Box-Benhnken Design，BBD），进行数据拟合，优化其水提醇沉工艺。并对其多糖进行结构初步表征，抗氧化活性测定。

结果

夜交藤多糖水浸醇提的最佳提取条件∶料液比1∶22.11（g/mL），回流时间129 min 36 s，次数为3次。5次提取率的平均值为4.324%，与系统预测值4.313%相近。经PMP衍生后HPLC分析，结果表明，夜交藤多糖主要是由Man、Rha、Glc、Gal组成，其摩尔比为29.87∶3.36∶51.25∶39.98。红外光谱可见多糖3420、1600、1000 cm-1特征峰。多糖（Y-TD）对DPPH、ABTS自由基的清除率分别为78.2%和85.4% 。

结论

Box-Behnken响应面设计优化水提醇沉提取工艺稳定可靠，可用于提取具有抗氧化活性的夜交藤多糖。

夜交藤  /  多糖  /  设计响应面实验（BBD）  /  结构表征  /  抗氧化
Objective

To optimize the process conditions for extracting polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）using water extraction and alcohol precipitation method.

Method

Water extraction and alcohol precipitation were used to extract polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）, and a three-factor experiment was conducted. On this basis, a Box Benhnken（BBD）response surface experiment was designed, integrating the experimental results and fitting the data. A fitting model was established for the degree of influence between factors and response values, and its water extraction and alcohol precipitation process were optimized. And it preliminarily characterized the structure of its polysaccharides and determined their antioxidant activity.

Result

The optimal extraction conditions for water extraction and alcohol extraction of polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）were a solid-liquid ratio of 1∶22.11（g/mL）, reflux time of 129 min 36 s, 3 times. The average extraction rate of 5 times was 4.324%, which was close to the system＇s predicted value of 4.313%. After PMP derivatization and HPLC analysis, the results showed that the polysaccharides of Yejiaoteng（Tuber Fleeceflower Stem）were mainly composed of Man, Rha, Glc and Gal, with a molar ratio of 29.87∶3.36∶51.25∶39.98. The infrared spectrum showed characteristic peaks of polysaccharides at 3420, 1600, 1000 cm-1. The clearance rates of polysaccharides（Y-TD）on DPPH and ABTS free radicals were 78.2% and 85.4%, respectively.

Conclusion

Box-Behnken response surface design optimization of water extraction and alcohol precipitation extraction process is stable and reliable, and can be used to extract polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）with antioxidant activity.

Yejiaoteng（Tuber Fleeceflower Stem）  /  polysaccharide  /  Box-Behnken designed（BBD）surface response methodology  /  structural characterization  /  antioxidant
韩其茂, 庞子鑫, 陈璐, 张诗嘉, 张洪财. 夜交藤多糖提取工艺优化、结构表征及抗氧化活性研究. 中华中医药学刊, 2026 , 44 (3) : 154 -159 . DOI: 10.13193/j.issn.1673-7717.2026.03.028
Qimao HAN, Zixin PANG, Lu CHEN, Shijia ZHANG, Hongcai ZHANG. Optimization of Extraction Process，Structural Characterization and Antioxidant Activity of Polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 154 -159 . DOI: 10.13193/j.issn.1673-7717.2026.03.028
基金
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  • 国家自然科学基金项目(81803711)
  • 黑龙江省自然科学基金项目(PL2024H210)
  • 黑龙江省中医药科研项目(ZHY2023-166)
  • 黑龙江中医药大学科研基金项目(2019MS08)
文献
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参考文献 引证文献
排序方式：
［1］
国家药典委员会.中华人民共和国药典：一部［S］.北京：中国医药科技出版社，2020：277.
［2］
乔春梅，瞿迁，方铁根，等.基于数据挖掘《中华医典》清代治疗不寐的用药规律研究［J］.现代医学，2023，51（2）：196-201.
［3］
严静，潘以丰，陈升捷，等.从风药论治腹泻型肠易激综合征经验［J］.中国中西医结合消化杂志，2023，31（2）：142-145.
［4］
张董晓，付娜，黄巧，等.赵炳南“四藤”组合组方思路在乳腺疾病中的应用与发展［J］.中医杂志，2021，62（4）：4.
［5］
郑玉娇，张培，林家冉，等.首乌藤的临床应用及其用量［J］.长春中医药大学学报，2020，36（2）：3.
［6］
佟一鑫，柏强.基于网络药理学和分子对接技术探究夜交藤治疗失眠的作用机制［J］.中医临床研究，2021，13（26）：1-5.
［7］
谭铖，罗洪斌，黄胜.首乌藤治疗阿尔茨海默病的网络药理学研究［J］.中南民族大学学报（自然科学版），2021，40（6）：605-613.
［8］
孙洲亮，文莉.夜交藤不同提取物对抗焦虑作用的比较［J］.中国医院药学杂志，2008，28（2）：164-165.
［9］
许晓伍，陈群，郝木峰等.夜交藤提取物对失眠大鼠额叶皮层神经元线粒体结构和功能的影响［J］.广州中医药大学学报，2013，30（6）：872-875.
［10］
单明东.夜交藤多酚高效提取及其体外抗氧化活性初步分析［D］.镇江：江苏大学，2021.
［11］
陶丽宇，高月求，韦靖，等.首乌藤相关药理作用及临床运用的研究进展［J］.时珍国医国药，2018，29（10）：2486-2488.
［12］
李明超，付亚轩，张新宇，等.夜交藤化学成分及其药理活性研究进展［J］.云南中医中药杂志，2018，39（3）：81-84.
［13］
李金花，农石生，黄锁义.分光光度法测定夜交藤中多糖［J］.理化检验.化学分册，2012，48（9）：2.
［14］
汲广全，杨娟，杨小生.夜交藤改善睡眠活性成分研究［J］.中成药，2011，33（3）：514-516.
［15］
陶遵威，郑夺，邸明磊等.植物多糖的研究进展［J］.药物评价研究，2010，33（2）：149-152.
［16］
BOX G E P, BEHNKEN D W. Some new three level designs for the study of quantitative variables［J］. Technometrics, 1960, 2（4）：455-475.
［17］
RAIS S, ISLAM A, AHMAD I, et al. Preparation of a new magnetic ion-imprinted polymer and optimization using Box-Behnken design for selective removal and determination of Cu（Ⅱ）in food and wastewater samples［J］. Food Chem, 2021, 334：127563.
［18］
WANG H J, HONG W, LI X Y, et al. Optimization of nanostructured lipid carriers of fenofibrate using aBox-behnken design for oral bioavailability enhancement［J］. Curr Drug Deliv, 2022, 19（7）：773-787.
［19］
ZHANG Z, GUO S C, CHEN C D, et al. Optimization of extraction and bioactivity detection of celery leaf flavonoids using BP neural network combined with genetic algorithm and response［J］. Prep Biochem Biotechnol, 2022, 52（6）：648-656.
［20］
JOJO G M, KUPPUSAMY G, DE A, et al. Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer’s disease using Box-Behnken design［J］. Drug Dev Ind Pharm, 2019, 45（7）：1061-1072.
［21］
王文姌，王韫格，张洪财等. Box-Behnken响应面法优化赤芍多糖的提取工艺［J］.化学工程师，2023，37（4）：88-92.
［22］
江丽洁，温乐乐，石佳艺，等.常山胡柚果皮精油提取工艺模型筛选优化、化学成分及抗氧化活性研究［J］.天然产物研究与开发，2024，36（7）：1101-1111.
［23］
赵小亮，牟翮，张晶，等.苦参多糖的提取工艺优化及体外抗氧化、降血脂活性分析［J］.食品工业科技，2024，45（13）：212-220.
［24］
刘永玲，刘向炼，陶欣，等.八月瓜果皮多糖提取工艺优化及其体外抗氧化、降糖活性分析［J］.食品工业科技，2024，45（19）：17-24.
［25］
胡建燃，李平，王俊瑶.熟地黄多糖的提取及其体外抗氧化活性研究［J］.中华中医药学刊，2021，39（12）：37-41.
［26］
黎江华，李涛，黄永亮，等.熟三七多糖的结构分析及抗氧化活性研究［J］.中华中医药学刊，2018，36（6）：1380-1383.
［27］
TERFASSI S, DAUVERGNE X, CÉRANTOLA S, et al. First report on phytochemical investigation, antioxidant and antidiabetic activities of Helianthemum getulum［J］. Nat Prod Res, 2022, 36（11）：2806-2813.
［28］
WONGWAD E, JADSADAJERM S, MUNGMAI L, et al. Antioxidant, cytotoxic, anti-glycation, and anti-tyrosinase compounds from the leaves of Uvaria siamensis［J］. Chem Biodivers, 2024, 21（4）：e202400319.
［29］
ONG E S, OH C L Y, TAN J C W, et al. Pressurized hot water extraction of okra seeds reveals antioxidant, antidiabetic and vasoprotective activities［J］. Plants, 2021, 10（8）：1645.
［30］
LOU H Y, LIU H F, WANG H, et al. Diverse flavonoids from the roots of Indigofera stachyodes［J］. Chem Biodivers, 2022, 19（10）：e202200676.
［31］
FATMAWATI S, AUWALIYAH F, YULIANA, et al. Antioxidant and α-glucosidase inhibitory activities of compound isolated from Stachytarpheta jamaicensis（L）Vahl. leaves［J］. Sci Rep, 2023, 13：18597.
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文章信息
doi: 10.13193/j.issn.1673-7717.2026.03.028
  • 首发时间：2026-10-14
  • 出版时间：2026-03-10
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作者
出版历史
基金
国家自然科学基金项目(81803711)
黑龙江省自然科学基金项目(PL2024H210)
黑龙江省中医药科研项目(ZHY2023-166)
黑龙江中医药大学科研基金项目(2019MS08)
作者信息
    1.黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150040
    2.黑龙江中医药大学，黑龙江 哈尔滨 150040

通讯作者:

张洪财（1983 -），男，黑龙江绥芬河人，副研究员，硕士研究生导师，博士，研究方向：中药化学成分提取工艺优化及活性。E-mail：。
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
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