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Article(id=1317125407372067308, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956768124, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956768124, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956768123, creator=13701087609, updateTime=1791956768123, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=26, endPage=33, ext={EN=ArticleExt(id=1317125407766331885, articleId=1317125407372067308, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress of Baitouweng Decoction（白头翁汤）and Pedictive Analysis on Quality Markers, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Baitouweng Decoction（白头翁汤）is a classic prescription for the treatment of heat-toxin-blood dysentery. It has pharmacological effects such as anti-inflammatory, antibacterial, anti-tumor, immunomodulatory and anti-diarrhea activities. In clinical practice, Baitouweng Decoction is mainly used to treat enteritis, colorectal cancer, bacillary dysentery, diarrhea and other diseases. In this article, it summarized the chemical constituents, pharmacological effects and clinical applications of Baitouweng Decoction in recent years, and the quality markers of Baitouweng Decoction were predicted and analyzed from the aspects of quality transfer and traceability, component specificity, effectiveness, measurability and compound compatibility environment. The quality markers of Baitouweng Decoction, such as anemoside A3, anemoside B4, pulsatilla saponin D, fraxetin, berberine, palmatine, coptisine, phellodendrine, esculin and esculetin, which provided the scientific reference for establishing and improving the quality control system of Baitouweng Decoction.

, authors=Sisi CHEN1, 2, 3, 4, Jie LIANG1, 2, 3, 4, Jiali WEI1, 2, 3, 4, Zhidong MA1, 2, 3, 4, Jiawen PENG1, 2, 3, 4, Jingjing XIE1, 2, 3, 4, Yuming MA1, 2, 3, 4, Zhengyi SUN5, authorsList=Sisi CHEN, Jie LIANG, Jiali WEI, Zhidong MA, Jiawen PENG, Jingjing XIE, Yuming MA, Zhengyi SUN, authorCompany=null, correspAuthors=Jie LIANG, Zhengyi SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125408093487598, articleId=1317125407372067308, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=白头翁汤的研究进展及质量标志物预测分析, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

白头翁汤是治疗热毒血痢的经典方剂，具有抗炎、抗菌、抗肿瘤、免疫调节、抗腹泻等药理作用，临床上常用于治疗肠炎、结直肠癌、细菌性痢疾、腹泻等疾病。对近年来白头翁汤的化学成分、药理作用和临床应用研究进行综述，从质量传递与溯源、成分特有性、有效性、可测性和复方配伍环境等5个方面对白头翁汤的质量标志物进行预测分析，筛选出白头翁皂苷A3、白头翁皂苷B4、白头翁皂苷D、秦皮素、小檗碱、巴马汀、黄连碱、黄柏碱、秦皮甲素、秦皮乙素作为白头翁汤的质量标志物，为白头翁汤质量控制体系的建立和完善提供科学参考。

, authors=陈思思1, 2, 3, 4, 梁洁1, 2, 3, 4, 韦佳丽1, 2, 3, 4, 马志东1, 2, 3, 4, 彭嘉文1, 2, 3, 4, 谢晶晶1, 2, 3, 4, 马玉明1, 2, 3, 4, 孙正伊5, authorsList=陈思思, 梁洁, 韦佳丽, 马志东, 彭嘉文, 谢晶晶, 马玉明, 孙正伊, authorCompany=null, correspAuthors=梁洁, 孙正伊, authorNote=

陈思思（2001 -），女，广西贺州人，硕士在读，研究方向：中药分析学。

, correspAuthorsNote=
梁洁（1979 -），女，广西梧州人，教授，博士研究生导师，博士，研究方向：中药药效物质基础与质量控制。E-mail：。
孙正伊（1987 -），女，山东威海人，副研究员，硕士，研究方向：中药民族药质量分析。E-mail：。
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2.Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Nanning 530200, Guangxi, China
3.Guangxi Zhuang Autonomous Region Ethnic Medicine Resources and Application Engineering Research Center, Nanning 530200, Guangxi, China
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2.壮瑶药协同创新中心，广西 南宁 530200
3.广西壮族自治区民族药资源与应用工程研究中心，广西 南宁 530200
4.广西高校中药提取纯化与质量分析重点实验室，广西 南宁 530200, bio={"content":"

陈思思（2001 -），女，广西贺州人，硕士在读，研究方向：中药分析学。

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陈思思（2001 -），女，广西贺州人，硕士在读，研究方向：中药分析学。

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3.Guangxi Zhuang Autonomous Region Ethnic Medicine Resources and Application Engineering Research Center, Nanning 530200, Guangxi, China
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2.壮瑶药协同创新中心，广西 南宁 530200
3.广西壮族自治区民族药资源与应用工程研究中心，广西 南宁 530200
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2.Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Nanning 530200, Guangxi, China
3.Guangxi Zhuang Autonomous Region Ethnic Medicine Resources and Application Engineering Research Center, Nanning 530200, Guangxi, China
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白头翁汤的研究进展及质量标志物预测分析
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陈思思 1, 2, 3, 4 , 梁洁 1, 2, 3, 4 , 韦佳丽 1, 2, 3, 4 , 马志东 1, 2, 3, 4 , 彭嘉文 1, 2, 3, 4 , 谢晶晶 1, 2, 3, 4 , 马玉明 1, 2, 3, 4 , 孙正伊 5
中华中医药学刊 | 国家项目点击 2026,44(3): 26-33
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中华中医药学刊 |国家项目点击 2026 , 44 (3) : 26 -33
白头翁汤的研究进展及质量标志物预测分析
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陈思思（2001 -），女，广西贺州人，硕士在读，研究方向：中药分析学。

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陈思思（2001 -），女，广西贺州人，硕士在读，研究方向：中药分析学。

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陈思思1, 2, 3, 4, 梁洁1, 2, 3, 4 , 韦佳丽1, 2, 3, 4, 马志东1, 2, 3, 4, 彭嘉文1, 2, 3, 4, 谢晶晶1, 2, 3, 4, 马玉明1, 2, 3, 4, 孙正伊5
作者信息
  • 1.广西中医药大学，广西壮瑶药重点实验室，广西 南宁 530200
  • 2.壮瑶药协同创新中心，广西 南宁 530200
  • 3.广西壮族自治区民族药资源与应用工程研究中心，广西 南宁 530200
  • 4.广西高校中药提取纯化与质量分析重点实验室，广西 南宁 530200
  • 5.广西中医药大学附属瑞康医院，广西 南宁 530011
通讯作者:
梁洁（1979 -），女，广西梧州人，教授，博士研究生导师，博士，研究方向：中药药效物质基础与质量控制。E-mail：。
孙正伊（1987 -），女，山东威海人，副研究员，硕士，研究方向：中药民族药质量分析。E-mail：。
作者简介:

陈思思（2001 -），女，广西贺州人，硕士在读，研究方向：中药分析学。

Research Progress of Baitouweng Decoction（白头翁汤）and Pedictive Analysis on Quality Markers
Sisi CHEN1, 2, 3, 4, Jie LIANG1, 2, 3, 4 , Jiali WEI1, 2, 3, 4, Zhidong MA1, 2, 3, 4, Jiawen PENG1, 2, 3, 4, Jingjing XIE1, 2, 3, 4, Yuming MA1, 2, 3, 4, Zhengyi SUN5
Affiliations
  • 1.Guangxi University of Chinese Medicine, Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Nanning 530200, Guangxi, China
  • 2.Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Nanning 530200, Guangxi, China
  • 3.Guangxi Zhuang Autonomous Region Ethnic Medicine Resources and Application Engineering Research Center, Nanning 530200, Guangxi, China
  • 4.Key Laboratory of TCM Extraction and Purification and Quality Analysis(Guangxi University of Chinese Medicine), Education Department of Guangxi Zhuang Autonomous Region, Nanning 530200, Guangxi, China
  • 5.Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi, China
出版时间: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.005
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白头翁汤是治疗热毒血痢的经典方剂，具有抗炎、抗菌、抗肿瘤、免疫调节、抗腹泻等药理作用，临床上常用于治疗肠炎、结直肠癌、细菌性痢疾、腹泻等疾病。对近年来白头翁汤的化学成分、药理作用和临床应用研究进行综述，从质量传递与溯源、成分特有性、有效性、可测性和复方配伍环境等5个方面对白头翁汤的质量标志物进行预测分析，筛选出白头翁皂苷A3、白头翁皂苷B4、白头翁皂苷D、秦皮素、小檗碱、巴马汀、黄连碱、黄柏碱、秦皮甲素、秦皮乙素作为白头翁汤的质量标志物，为白头翁汤质量控制体系的建立和完善提供科学参考。

白头翁汤  /  化学成分  /  药理作用  /  临床应用  /  质量标志物

Baitouweng Decoction（白头翁汤）is a classic prescription for the treatment of heat-toxin-blood dysentery. It has pharmacological effects such as anti-inflammatory, antibacterial, anti-tumor, immunomodulatory and anti-diarrhea activities. In clinical practice, Baitouweng Decoction is mainly used to treat enteritis, colorectal cancer, bacillary dysentery, diarrhea and other diseases. In this article, it summarized the chemical constituents, pharmacological effects and clinical applications of Baitouweng Decoction in recent years, and the quality markers of Baitouweng Decoction were predicted and analyzed from the aspects of quality transfer and traceability, component specificity, effectiveness, measurability and compound compatibility environment. The quality markers of Baitouweng Decoction, such as anemoside A3, anemoside B4, pulsatilla saponin D, fraxetin, berberine, palmatine, coptisine, phellodendrine, esculin and esculetin, which provided the scientific reference for establishing and improving the quality control system of Baitouweng Decoction.

Baitouweng Decoction（白头翁汤）  /  chemical composition  /  pharmacological effects  /  clinical application  /  quality marker
陈思思, 梁洁, 韦佳丽, 马志东, 彭嘉文, 谢晶晶, 马玉明, 孙正伊. 白头翁汤的研究进展及质量标志物预测分析. 中华中医药学刊, 2026 , 44 (3) : 26 -33 . DOI: 10.13193/j.issn.1673-7717.2026.03.005
Sisi CHEN, Jie LIANG, Jiali WEI, Zhidong MA, Jiawen PENG, Jingjing XIE, Yuming MA, Zhengyi SUN. Research Progress of Baitouweng Decoction（白头翁汤）and Pedictive Analysis on Quality Markers[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 26 -33 . DOI: 10.13193/j.issn.1673-7717.2026.03.005
基金
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  • 国家自然科学基金项目(82160771)
  • 国家中医药管理局高水平中医药重点学科建设项目-少数民族药学（壮药学）(zyyzdxk-2023165)
  • 广西中医药重点学科壮药学项目(GZXK-Z-20-64)
  • 广西一流学科中药学（民族药学）项目(桂教科研〔2018〕12号)
  • 广西重点研发计划项目(桂科AB21196016)
  • 广西科技基地和人才专项(桂科AD20238058; 桂科AD21238031)
  • 广西壮族自治区高校黄大年式教师团队“中药学传承创新教师团队”项目(桂教教师〔2023〕31号)
  • 广西高等学校千名中青年骨干教师培育计划项目(桂教人〔2019〕5号)
  • 广西中医药大学第三批“岐黄工程”高层次人才团队培育项目(202406)
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丘海芯，甘金月，王宝林，等.仲景名方白头翁汤的指纹图谱及功效关联物质预测分析［J］. 中草药，2022，53（6）：1740-1750.
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2026年第44卷第3期
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doi: 10.13193/j.issn.1673-7717.2026.03.005
  • 首发时间：2026-10-14
  • 出版时间：2026-03-10
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基金
国家自然科学基金项目(82160771)
国家中医药管理局高水平中医药重点学科建设项目-少数民族药学（壮药学）(zyyzdxk-2023165)
广西中医药重点学科壮药学项目(GZXK-Z-20-64)
广西一流学科中药学（民族药学）项目(桂教科研〔2018〕12号)
广西重点研发计划项目(桂科AB21196016)
广西科技基地和人才专项(桂科AD20238058; 桂科AD21238031)
广西壮族自治区高校黄大年式教师团队“中药学传承创新教师团队”项目(桂教教师〔2023〕31号)
广西高等学校千名中青年骨干教师培育计划项目(桂教人〔2019〕5号)
广西中医药大学第三批“岐黄工程”高层次人才团队培育项目(202406)
作者信息
    1.广西中医药大学，广西壮瑶药重点实验室，广西 南宁 530200
    2.壮瑶药协同创新中心，广西 南宁 530200
    3.广西壮族自治区民族药资源与应用工程研究中心，广西 南宁 530200
    4.广西高校中药提取纯化与质量分析重点实验室，广西 南宁 530200
    5.广西中医药大学附属瑞康医院，广西 南宁 530011

通讯作者:

梁洁（1979 -），女，广西梧州人，教授，博士研究生导师，博士，研究方向：中药药效物质基础与质量控制。E-mail：。
孙正伊（1987 -），女，山东威海人，副研究员，硕士，研究方向：中药民族药质量分析。E-mail：。
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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.03.005
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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