Article(id=1317115258125267186, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.04.037, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954348355, onlineDateStr=2026-10-14, pubDate=1775750400000, pubDateStr=2026-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954348355, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954348355, creator=13701087609, updateTime=1791954348355, updator=13701087609, issue=Issue{id=1317115107243573307, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='4', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1775750400000', pubDateStr='2026-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954312382, creator='13701087609', updateTime=1791958738709, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133672680116252, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133672680116253, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=190, endPage=195, ext={EN=ArticleExt(id=1317115258322399475, articleId=1317115258125267186, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Components And Mechanism of Linggui Zhugan Decoction（苓桂术甘汤）in Treatment of Non-Alcoholic Fatty Liver Disease, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Non-alcoholic fatty liver disease（NAFLD）is a common digestive disease, its pathogenesis is not completely clear, clinical symptoms are often not obvious, and the incidence rate is increasing year by year, so it has become one of the digestive diseases that the world＇s health care system focuses on. In terms of mechanism, the “two strikes”theory of NAFLD is widely accepted, with the first strike being insulin resistance and the second strike being lipid peroxidation and oxidative stress. Western medical treatment is mainly through the regulation of insulin sensitivity, the use of antioxidants and other improvements, and advocates the changes in lifestyle habits and ways of prevention. Although Western medical treatment means are effective, there are still problems such as the development of drug resistance and serious side effects. Traditional Chinese medicine（TCM）is nowadays one of the optimal solutions for the treatment of NAFLD due to a series of advantages such as its holistic nature, versatility, less side effects and equally significant therapeutic effects. This paper reviewed the pharmacological effects and theoretical mechanisms of Linggui Zhugan Decoction in the treatment of NAFLD, aiming to provide a reference for future related studies.

, authors=Zhifu YOU¹, Linglong YANG¹, Tong LIU¹, Heyuan SUN¹, Bin WANG¹, Yang ZHANG², authorsList=Zhifu YOU, Linglong YANG, Tong LIU, Heyuan SUN, Bin WANG, Yang ZHANG, authorCompany=null, correspAuthors=Yang ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115258683109620, articleId=1317115258125267186, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=苓桂术甘汤治疗非酒精性脂肪肝成分与机制的研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

非酒精性脂肪肝病（Non-alcoholic fatty liver disease，NAFLD）是目前临床常见的消化系统疾病，其发病机制尚不完全明确，临床发病症状常常不明显，而发病率逐年上涨，因此已经成为世界医疗系统重点关注的消化类疾病之一。于机制来看，NAFLD发病的“二次打击”学说被广泛接受，一次打击为胰岛素抵抗影响脂质代谢，二次打击为脂质过氧化与氧化应激。西医治疗手段主要是通过调控胰岛素敏感性、使用抗氧化剂等改善，并提倡生活习惯及方式的改变和预防。虽然西医治疗手段效果显著，但仍存在耐药性发展、严重不良反应等问题。中医药因其整体性、多样性、不良反应小、治疗效果同样显著等一系列优势，如今已成为治疗NAFLD的最优解之一。综述苓桂术甘汤在治疗NAFLD的药理作用与理论机制，旨在为今后的相关研究提供参考。

, authors=由智夫¹, 杨玲珑¹, 刘桐¹, 孙鹤员¹, 王斌¹, 张杨², authorsList=由智夫, 杨玲珑, 刘桐, 孙鹤员, 王斌, 张杨, authorCompany=null, correspAuthors=张杨, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=dURks9PDuua9Cwap0uvr+g==, magXml=uM+a04El3w3qCta1QafYWw==, pdfUrl=null, pdf=52kOcziaV0WCdeXpiE+7Ow==, pdfFileSize=1741563, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=kIxVGROB6z596P46BfH5Hw==, mapNumber=null, fund=null)}, authors=[Author(id=1319630753525248442, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115258125267186, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630753609134524, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115258125267186, authorId=1319630753525248442, language=EN, stringName=Zhifu YOU, firstName=Zhifu, middleName=null, lastName=YOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630753693020605, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115258125267186, authorId=1319630753525248442, language=CN, stringName=由智夫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.黑龙江中医药大学，黑龙江 哈尔滨 150040, bio={"content":"

由智夫（2001-），男，黑龙江齐齐哈尔人，硕士在读，研究方向：肝脾胃消化系统的中西医结合临床。

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由智夫（2001-），男，黑龙江齐齐哈尔人，硕士在读，研究方向：肝脾胃消化系统的中西医结合临床。

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