Article(id=1317115249937994727, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.05.026, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954346403, onlineDateStr=2026-10-14, pubDate=1778342400000, pubDateStr=2026-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954346403, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954346403, creator=13701087609, updateTime=1791954346403, updator=13701087609, issue=Issue{id=1317115025307845060, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1778342400000', pubDateStr='2026-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954292847, creator='13701087609', updateTime=1791958713604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133567340171275, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133567340171276, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=138, endPage=143, ext={EN=ArticleExt(id=1317115250147709928, articleId=1317115249937994727, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Mechanism of Chinese Herbal Saponins Inhibiting Colorectal Cancer, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

The incidence and mortality of colorectal cancer (CRC) are on the rise. Although the existing therapeutic means can curb the progression of the disease to a certain extent, there are problems such as large adverse reactions, immunosuppression, reduced quality of life and drug resistance, which can not fully meet the clinical needs. As an outstanding representative of Chinese civilization, traditional Chinese medicine has integrated with modern medicine and gradually shown new vitality. Traditional Chinese medicine (TCM) has been widely used in anti-CRC because of its multi-level, multi-target and multi-pathway advantages, and the active components of TCM saponins have become the focus of anti-tumor research in recent years. A large number of studies have shown that Chinese herbal saponins, such as ginsenosides, polyphyllin and anemoside, can inhibit CRC by regulating signaling pathways including Notch-Hes1, Hippo and STAT6, inhibiting CRC cell proliferation, migration, invasion and epithelial mesenchymal transformation, inducing apoptosis and autophagy, regulating energy metabolism, improving macrophage polarization and regulating intestinal guts. Based on this, this paper mainly summarized the mechanism of action and pharmacological activity of Chinese pharmaceutical saponins in the intervention of CRC in recent years, in order to provide a new idea for the drug therapy research and clinical new drug development of CRC, and also provide reference for further mechanism research.

, authors=Yifan LIU¹, Chengzhi WANG¹, Zuowu XI², authorsList=Yifan LIU, Chengzhi WANG, Zuowu XI, authorCompany=null, correspAuthors=Zuowu XI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115250420339689, articleId=1317115249937994727, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=中药皂苷类成分抗结直肠癌作用机制研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

结直肠癌（Colorectal cancer，CRC）的发病率和病死率呈显著上升趋势，现有的治疗手段虽在一定程度上可以遏制病情进展，但存在不良反应大、免疫抑制、生活质量降低以及耐药等问题，不能完全满足临床需要。中医药作为中华文明的杰出代表，与现代医学相互融合，并逐渐展现出新的生命力。中医药因其多层次、多靶点、多通路的优势在抗CRC中应用广泛，中药皂苷类活性成分近年来更是成为抗肿瘤研究的热点。大量研究表明，人参皂苷、重楼皂苷、白头翁皂苷等中药皂苷类成分通过调控Notch-Hes1、Hippo、STAT6等信号通路，抑制CRC细胞增殖和迁移侵袭、抑制上皮间质转化、诱导细胞凋亡自噬、调控能量代谢、改善巨噬细胞极化、调节肠道菌群等，来发挥显著的抗CRC作用。基于此，总结了近年来中药皂苷类成分干预CRC的作用机制及药理活性，以期为CRC在药物治疗研究和临床新药研发上提供新的思路，同时也为后续更深入的机制研究提供参考和借鉴。

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刘一帆（1998-），女，河南平顶山人，博士在读，研究方向：中医药防治肛肠疾病。

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刘一帆（1998-），女，河南平顶山人，博士在读，研究方向：中医药防治肛肠疾病。

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