中华中医药学刊

肉豆蔻醚通过调控蛋白EEPD1抑制肺鳞癌细胞增殖、迁移和侵袭并促进凋亡的机制研究

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么艺涵 , 崔逸爽 , 张梦诗 , 戈艳蕾 , 甘俊清 , 金叶 , 孙国贵

中华中医药学刊 | 国家项目点击 2026,44(4): 130-135

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中华中医药学刊 |国家项目点击 2026 , 44 (4) : 130 -135

肉豆蔻醚通过调控蛋白EEPD1抑制肺鳞癌细胞增殖、迁移和侵袭并促进凋亡的机制研究

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么艺涵, 崔逸爽, 张梦诗, 戈艳蕾, 甘俊清, 金叶, 孙国贵

作者信息

华北理工大学附属医院，河北唐山 063000

通讯作者:

孙国贵（1980-），男，河北唐山人，主任医师，博士，研究方向：胸腔肿瘤学。E-mail: guogui_sun2021@sina.com。

作者简介:

么艺涵（1997-），男，河北唐山人，硕士在读，研究方向：肿瘤学。

Mechanism of Myristicin Inhibiting Proliferation，Migration and Invasion of Lung Squamous Carcinoma Cells and Promoting Apoptosis by Regulating Protein EEPD1

Yihan YAO, Yishuang CUI, Mengshi ZHANG, Yanlei GE, Junqing GAN, Ye JIN, Guogui SUN

Affiliations

North China University of Science and Technology Affiliated Hospital, Tangshan 063000, Hebei, China

出版时间: 2026-04-10 doi: 10.13193/j.issn.1673-7717.2026.04.028

文章导航

摘要

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目的

旨在探讨肉豆蔻醚（myristicin）通过调控核酸内切酶/核酸外切酶/磷酸酶家族结构域包含蛋白1（endonuclease/exonuclease/phosphatase family domain containing 1，EEPD1）表达，进而对肺鳞状细胞癌的增殖、迁移、侵袭及凋亡过程的影响。

方法

采用分子对接技术分析了myristicin和目标蛋白EEPD1之间的相互作用；采用免疫组化技术检测组织芯片中肺鳞癌和邻近癌旁组织内EEPD1蛋白水平；通过实时荧光定量聚合酶链式反应（real-timk quantitative polymerase chain reaction，qRT-PCR）评估了该基因在细胞系中的表达活性，细胞计数盒（cell counting kit-8，CCK-8）检测myristicin对肺鳞癌细胞KNS-62、NCI-H226增殖的影响；划痕实验和细胞迁移侵袭实验（Transwell）被用来检测myristicin对肺鳞癌细胞迁移和侵袭能力的影响；流式细胞术用来检测myristicin对肺鳞癌细胞凋亡的影响；蛋白印记法（Western blot，WB）用来检测肺鳞癌细胞的EEPD1蛋白表达情况。

结果

研究发现myristicin能够与蛋白EEPD1形成特异性结合；相比于癌旁组织对照区，肺鳞癌组织样本中观察到了更高的EEPD1阳性信号强度；CCK-8测定表明myristicin可显著抑制肺鳞癌细胞增殖；划痕愈合速度减慢表明myristicin能够抑制肺鳞癌细胞迁移；Transwell实验结果同样证明myristicin能够抑制肺鳞癌细胞迁移和侵袭；流式细胞术数据显示myristicin促进了肺鳞癌细胞的凋亡；WB分析结果显示myristicin降低了蛋白EEPD1的表达量。

结论

体外实验证据支持myristicin能够通过下调蛋白EEPD1表达来发挥其抗癌功效，具体表现为抑制肺鳞状细胞癌的增殖、迁移和侵袭，并促进细胞凋亡。

关键词

肉豆蔻醚 / EEPD1蛋白 / 肺鳞癌 / 细胞迁移 / 细胞侵袭 / 细胞增殖

Abstract

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Objective

The aim of this study was to investigate the effects of myristicin on the regulation of endonuclease/exonuclease/phosphatase family domain containing 1（EEPD1）expression and its subsequent impact on the proliferation, migration, invasion and apoptosis of pulmonary squamous cell carcinoma.

Method

Molecular docking techniques were employed to analyze the interaction between myristicin and the target protein EEPD1. Immunohistochemistry method was used to assess the levels of EEPD1 protein in lung squamous carcinoma and adjacent paracancerous tissues on tissue chips. The gene expression activity in cell lines was evaluated using real-time quantitative polymerase chain reaction（qRT-PCR）, while the effect of myristicin on the proliferation of lung squamous carcinoma cells KNS-62 and NCI-H226 was assessed with Cell Counting Kit-8（CCK-8）. Scratch assay and Transwell migration and invasion experiments were conducted to examine the impact of myristicin on the migration and invasion capabilities of lung squamous carcinoma cells. Flow cytometry method was utilized to determine the influence of myristicin on the apoptosis of lung squamous carcinoma cells, and Western blot（WB）was employed to analyze the expression of EEPD1 protein in these cells.

Results

Myristicin could form specific binding with the EEPD1 protein. Higher EEPD1 positive signal intensity was observed in lung squamous carcinoma tissue samples compared to adjacent paracancerous tissue control areas. CCK-8 assay results demonstrated that myristicin significantly inhibited the proliferation of lung squamous carcinoma cells. A slower scratch healing rate suggested that myristicin could inhibit the migration of lung squamous carcinoma cells. Transwell assay results similarly showed that myristicin could inhibit the migration and invasion of lung squamous carcinoma cells. Flow cytometry data revealed that myristicin promoted the apoptosis of lung squamous carcinoma cells, while WB analysis indicated that myristicin reduced the expression level of EEPD1 protein.

Conclusion

In vitro experimental evidence supports that myristicin exerts its anticancer effects by down-regulating the expression of EEPD1 protein, specifically manifested in inhibiting the proliferation, migration and invasion of pulmonary squamous cell carcinoma and promoting cell apoptosis.

Key words

myristicin / EEPD1 protein / lung squamous cell carcinoma / cell migration / cell invasion / cell proliferation

引用本文

么艺涵, 崔逸爽, 张梦诗, 戈艳蕾, 甘俊清, 金叶, 孙国贵. 肉豆蔻醚通过调控蛋白EEPD1抑制肺鳞癌细胞增殖、迁移和侵袭并促进凋亡的机制研究. 中华中医药学刊, 2026 , 44 (4) : 130 -135 . DOI: 10.13193/j.issn.1673-7717.2026.04.028

Yihan YAO, Yishuang CUI, Mengshi ZHANG, Yanlei GE, Junqing GAN, Ye JIN, Guogui SUN. Mechanism of Myristicin Inhibiting Proliferation，Migration and Invasion of Lung Squamous Carcinoma Cells and Promoting Apoptosis by Regulating Protein EEPD1[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (4) : 130 -135 . DOI: 10.13193/j.issn.1673-7717.2026.04.028

基金

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国家自然科学基金面上项目(82172658)
河北省自然科学基金项目(H2023209083)
河北省创新能力提升计划项目(235A2403D)
河北省教育厅河北实验教学及教学实验室建设项目(冀教高函〔2024〕8号)
河北省医学适用技术跟踪项目(GZ2021057)
河北省政府资助临床医学优秀人才培养项目(ZF2024193)
华北理工大学公共卫生学院高水平科研创新团队建设计划项目(KYTD202309)
唐山市市级科技计划项目(24150218C)

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2026年第44卷第4期

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doi: 10.13193/j.issn.1673-7717.2026.04.028

首发时间：2026-10-14
出版时间：2026-04-10

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基金

国家自然科学基金面上项目(82172658)

河北省自然科学基金项目(H2023209083)

河北省创新能力提升计划项目(235A2403D)

河北省教育厅河北实验教学及教学实验室建设项目(冀教高函〔2024〕8号)

河北省医学适用技术跟踪项目(GZ2021057)

河北省政府资助临床医学优秀人才培养项目(ZF2024193)

华北理工大学公共卫生学院高水平科研创新团队建设计划项目(KYTD202309)

唐山市市级科技计划项目(24150218C)

作者信息

华北理工大学附属医院，河北唐山 063000

通讯作者:

孙国贵（1980-），男，河北唐山人，主任医师，博士，研究方向：胸腔肿瘤学。E-mail: guogui_sun2021@sina.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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