Article(id=1317115233659892707, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.04.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954342521, onlineDateStr=2026-10-14, pubDate=1775750400000, pubDateStr=2026-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954342521, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954342521, creator=13701087609, updateTime=1791954342521, updator=13701087609, issue=Issue{id=1317115107243573307, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='4', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1775750400000', pubDateStr='2026-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954312382, creator='13701087609', updateTime=1791958738709, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133672680116252, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133672680116253, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=86, endPage=89, ext={EN=ArticleExt(id=1317115235266311140, articleId=1317115233659892707, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Zuojin Jiawei Prescription（左金加味方）Combined with Dexzopiclone in Treatment of Gastroesophageal Reflux Disease（Liver-Stomach Stagnation Heat Type）with Insomnia, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the effect of Zuojin Jiawei Prescription（左金加味方）combined with dexzopiclone in the treatment of gastroesophageal reflux disease（liver-stomach stagnation heat type）with insomnia.
Methods A total of 68 patients with gastroesophageal reflux disease（liver-stomach stagnation heat type）with insomnia admitted from June 2021 to January 2024 were included in the study. The patients were divided into two groups by random number table method, namely control group and observation group, with 34 cases in each group. All patients in the group received conventional Western medicine treatment, while the control group received dexzopiclone treatment. The observation group was treated with Zuojin Jiawei Prescription on the basis of control group, and the data of patients in each group was observed and compared, including clinical efficacy, changes of TCMsyndrome scores（acid reflux, heartburn, belching or regurgitation, epigastric burning pain, etc.）before and after treatment, endoscopic esophageal mucosa score and reflux diagnostic questionnaire changes in RDQ scores, the changes in Pittsburgh sleep quality index（PSQI）and short form 36 questionnaire（SF-36）scores and adverse reactions.
Results The total effective rate of the observation group was higher than that of thee control group（P<0.05）. The adverse reaction rate was lower in both groups（P>0.05）. Comparison of TCMsyndrome scores（acid reflux, heartburn, belching or regurgitation, epigastric burning pain, etc）, endoscopic esophageal mucosa score, RDQ score, PSQI score and SF-36 score in both groups before treatment was not significant（P>0.05）. After treatment, TCM syndrome scores（acid reflux, heartburn, belching or regurgitation, epigastric burning pain, etc.）, endoscopic esophageal mucosa scores, RDQ scores, PSQI scores and SF-36 scores were all improved in both groups. And these indexes in the observation group were all better than those in the control group（P<0.05）.
Conclusion Zuojin Jiawei Prescription combined with dexzopiclone has a good effect in the treatment of gastroesophageal reflux disease（liver-stomach stagnation heat type）with insomnia, and can improve the clinical symptoms, sleep quality and quality of life of patients, which is worthy of application.
, authors=Yuanyuan CHEN, Baoying WANG, Yongkang ZHANG, Huaying HUO, authorsList=Yuanyuan CHEN, Baoying WANG, Yongkang ZHANG, Huaying HUO, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115236021285861, articleId=1317115233659892707, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=左金加味方结合右佐匹克隆治疗胃食管反流病（肝胃郁热型）伴失眠效果观察, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 观察左金加味方结合右佐匹克隆治疗胃食管反流病（肝胃郁热型）伴失眠效果。
方法 研究合计纳入2021年6月—2024年1月收治的68例胃食管反流病（肝胃郁热型）伴失眠患者，采取随机数字表法分为两组，对照组34例采取右佐匹克隆治疗，观察组34例在对照组治疗基础上联合左金加味方治疗，观察及对比两组患者数据：临床疗效、治疗前后中医证候积分（反酸、烧心、嗳气或反食、胃脘灼痛等）变化及内镜下食管黏膜评分及反流性疾病问卷（Reflux diagnostic questionnaire，RDQ）评分变化、匹兹堡睡眠指数（Pittsburgh sleep quality index，PSQI）及生活质量（Short form 36 questionnaire，SF-36）评分变化、不良反应。
结果 观察组患者治疗后总有效率高于对照组（P<0.05）。两组不良反应率均较低（P>0.05）。两组患者治疗前中医证候积分（反酸、烧心、嗳气或反食、胃脘灼痛等）、内镜下食管黏膜评分、RDQ评分、PSQI评分及SF-36评分比较，差异无统计学意义（P>0.05），治疗后两组患者中医证候积分（反酸、烧心、嗳气或反食、胃脘灼痛等）、内镜下食管黏膜评分、RDQ评分、PSQI评分及SF-36评分均改善，观察组患者治疗后中医证候积分（反酸、烧心、嗳气或反食、胃脘灼痛等）、内镜下食管黏膜评分、RDQ评分、PSQI评分及SF-36评分等指标均优于对照组（P<0.05）。
结论 左金加味方结合右佐匹克隆治疗胃食管反流病（肝胃郁热型）伴失眠效果良好，可较好改善患者临床症状、睡眠质量、生活质量，值得应用。
, authors=陈园园, 王宝迎, 张永康, 霍华英, authorsList=陈园园, 王宝迎, 张永康, 霍华英, authorCompany=null, correspAuthors=null, authorNote=
陈园园（1987-），女，山西临汾人，主治医师，硕士，研究方向：中医治疗脾胃病。
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陈园园（1987-），女，山西临汾人，主治医师，硕士，研究方向：中医治疗脾胃病。
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陈园园（1987-），女，山西临汾人，主治医师，硕士，研究方向：中医治疗脾胃病。
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